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Flavonoid moiety-incorporated carbon dots for ultrasensitive and highly selective fluorescence detection and removal of Pb^2＋

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Nano Research 2018年第7期11卷 3648-3657页

作者： Jing Xu Xu Jie Fengfeng Xie Haimei Yang weili wei Zhining Xia School of Pharmaceutical Sciences and Innovative Drug Research Centre Chongqing University Chongqing 400013 China

A new type of self-targeting carbon dot （CD-Fla） for the detection of the toxic heavy metal ion Pb^2＋ was synthesized via a one-pot hydrothermal route using flavonoid extracts of Ginkgo biloba leaves as the starting material. As-prepared CD-Fla exhibited excellent biocompatibility and strong blue emission with a quantum yield of 16.1% and significant fluorescence quenching selectivity for Pb^2＋ without using any additional targeting molecules. CD-Fla could detect Pb^2＋ quantitatively within the range 0.1-20.0 nM, with an ultrahigh sensitivity of 55 pM. The selectivity of CD-FIa for Pb^2＋ was nearly one order of magnitude higher than that for other relevant metal ions. This was much better than ever reported CD-based metal ion sensors. The high sensitivity and selectivity were due to the incorporation of certain flavonoid-like moieties into CD-Fla. CD-Fla was also demonstrated to be a good probe for fluorescence tracing of intracellular Pb^2＋. The capability of CD-Fla was further improved when it was doped on agarose hydrogel. CD-Fla-doped agarose hydrogel （CD-AHG） allowed for visual fluorescence detection and removal of Pb^2＋ from water. This was confirmed by testing CD-AHG in actual water samples taken from the Jialing River （Chongqing, China）. The Pb^2＋ adsorbed CD-AHG was regenerable in HC1 solution. This study will open a new avenue for synthesizing intelligent materials capable of simultaneously targeting, detecting, and treating heavy metal ions.

关键词： flavonoid carbon dot fuorescence lead ion removal

Electrostatic interaction mechanism on the separation of phenols by non-aqueous capillary electrophoresis

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Science China Chemistry 2007年第1期50卷 47-53页

作者： wei weili YIN YongGuang XIA ZhiNing CHEN ZhiTao LIU weiQi Department of Pharmaceutics College of Chemistry and Chemical EngineeringChongqing UniversityChongqing 400044China Research Center for Eco-Environmental Science Chinese Academy of SciencesBeijing 100081China Key Laboratory for Biomechanics&Tissue Engineering of Ministry of Education Chongqing UniversityChongqing 400044China

The electrostatic interaction between additive and analyte is of great importance to non-aqueous cap- illary electrophoresis(NACE)*** tetraalkylammonium bromides and acetonitrile were applied as additives and running solvent *** effect of alkyl chain length and concentra- tion of additive on electrostatic interactions was investigated by the separation of *** sepa- ration ability was found to increase with decreasing alkyl chain length of the additive,and the resolu- tion values were increased with increasing additive *** separation was seriously dete- riorated after a little amount of water was added in the running ***,the electrostatic interaction is strong under the conditions of low electron cloud density,weak steric hindrance and multi-interaction ***,the separation result can be predicted by theoretical analysis,which is helpful for the separation of other substances in NACE based on electrostatic interaction.

关键词： non-aqueous capillary electrophoresis electrostatic interaction tetraalkylammoniums phenol compounds

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Culture Gains Strategic Muscle

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ChinAfrica 2012年第7期4卷 42-44页

作者： Liu wei and Hou weili

SOUTH African Minister of Arts and Culture Paul Mashatile becomes excited when discussing Chinese culture. He knows Jackie Chan and Bruce Lee, well- known Chinese kungfu stars, and can make a long list of Chinese food... 详细信息

关键词： Culture Gains Strategic Muscle

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代数双曲B样条基的几乎严格全正性

计算机辅助设计与图形学学报 2014年第2期26卷 258-262,271页

作者：魏炜立汪国昭浙江大学数学系杭州310027

样条基的几乎严格全正性和曲线插值适定性关系密切,是几何造型中一个基本且重要的问题.文中证明了代数双曲B样条基具有几乎严格全正性:首先引入代数双曲B样条函数,通过嵌入节点算法推导出函数的零点数和变差数之间的关系;进一步,利用数... 详细信息

样条基的几乎严格全正性和曲线插值适定性关系密切,是几何造型中一个基本且重要的问题.文中证明了代数双曲B样条基具有几乎严格全正性:首先引入代数双曲B样条函数,通过嵌入节点算法推导出函数的零点数和变差数之间的关系;进一步,利用数学归纳法证明了该基具有几乎严格全正性.文中的证明方法直观且具有几何性,为造型中使用代数双曲B样条基奠定了更为完备的理论基础.

关键词：嵌入节点算法几乎严格全正性系数变差代数双曲B样条基

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Biomolecular Recognitions and Their Applications

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Biomolecular Recognitions and Their Applications

Multiple Pulmonary Metastases with Endobronchial Spread from Skin Melanoma:a Case report

第八届全国化学生物学学术会议

作者： Can Xu Meng Li Li Wu Chuanqi Zhao weili wei Xiaogang Qu Laboratory of Chemical Biology Division of Biological Inorganic ChemistryState Key Laboratory of Rare Earth Resource UtilizationChangchun Institute of Applied ChemistryGraduate School of the Chinese Academy of SciencesChinese Academy of Sciences

＜正＞Recent studies have demonstrated that many biological important processes are related to the conformation and assembly state of specific gene,involved proteins and *** we summarize our recent research progress i...

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Multiple Pulmonary Metastases with Endobronchial Spread from...

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

中华医学会呼吸病学年会——2013（第十四次全国呼吸病学学术会议）

作者： weili wei Ruilin Liu Jingjing Hou Siwei Liang Zhongmin Yang Hanjing Lv Zhongmin Qiu Department of Respiratory Medicine Tongji HospitalSchool of MedicineTongji University

A 58-year-old women was diagnosed with multiple pulmonary metastasis with endobronchial spread of skin malignant *** presented with 3 months history of cough,sputum production and hemoptysis without chest pain or shortness of breath and was admitted to hospital for further investigation in January *** was unilateral presenting on the right side of the thorax,The thoracal computed tomography showed two nodular lesions

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu wei Huang Jiayi Wen Xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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