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Science China Chemistry 2012年第6期55卷 1134-1139页

作者： LI Sen WANG Kuan CHANG Kue-Chieh Alan ZONG Ming WANG Jing CAO YongGang BAI YuHua wei taiming ZHANG ZhiRen School of Pharmacy Daqing Campus Harbin Medical University Daqing 163319 China School of Life Science and Biotechnology Dalian University of Technology Dalian 116024 China Departments of Pharmacy and Cardiology The 2nd Affiliated Hospital of Harbin Medical University Key Laboratories of Ministry of Education for Myocardial lschemia Mechanism and Treatment Harbin Medical University Harbin 150086 China

A novel vehicle for the delivery of aspirin (ASA) was prepared from porous nano-hydroxyapatite/poly(styrene-divinylbenzene) [nano-HAP/P(St-DVB)] composite microspheres by grafting nano-HAP [Ca10(PO4)6(OH)2] onto porous P(St-DVB) microspheres. Four types of porous composite microspheres were prepared, each with different nano-HAP contents. The ASA-loaded composite microspheres prepared with 10% and 15% nano-HAP (mass ratio) exhibited excellent buoyancy with relatively short instantaneous floating time (within 10 min) and a long sustained floating time (12 h) in simulated gastric juice. They also offered good sustained release of ASA (up to 8 h). Furthermore, these composite microspheres displayed good buffering capacity that prevented the buildup of acidity caused by hydrolysis of ASA, keeping the pH of gastric juice within the normal range (pH 0.9 to 1.5). The results showed that porous nano-HAP/P(St-DVB) composite microspheres prepared with 10% and 15% nano-HAP could be used as a novel drug carrier for ASA, providing a sustained release dose without leading to stomach irritation, a side effect that is often associated with ASA medication.

关键词：纳米羟基磷灰石多孔微球阿司匹林药物载体二乙烯苯苯乙烯制备 ST-DVB

小学口腔健康教育课程SWOT分析及对策研究

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中国医疗管理科学 2024年第3期14卷 111-116页

作者：张旭彤杨威戴泰鸣贵州大学医学院贵阳550025 贵阳市口腔医院

小学阶段是儿童常见口腔疾病的高发时期,学校开展口腔健康教育课程是提升小学生口腔健康素养、预防常见口腔疾病的重要途径。利用SWOT分析法梳理我国小学校开展口腔健康教育课程的优势、劣势、机会和挑战,根据分析结果提出对策建议:协... 详细信息

小学阶段是儿童常见口腔疾病的高发时期,学校开展口腔健康教育课程是提升小学生口腔健康素养、预防常见口腔疾病的重要途径。利用SWOT分析法梳理我国小学校开展口腔健康教育课程的优势、劣势、机会和挑战,根据分析结果提出对策建议:协同多方以营造口腔健康支持性环境;丰富内容并建设口腔健康教育师资力量;满足需求以探索多层次口腔健康教育及管理模式。

关键词：小学生口腔疾病防治口腔健康教育课程 SWOT分析

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乳香挥发性成分GC-MS分析

中国中药杂志 2011年第8期36卷 1050-1053页

作者：赵金凤周春兰周凤琴魏太明山东中医药大学山东济南250355 哈尔滨医科大学黑龙江大庆163319

目的:提取分析乳香挥发油成分,为乳香的外用制剂的研究提供科学依据。方法:提取乳香挥发油,通过GC-MS对其进行分析鉴定。结果:共鉴定出100种成分,占挥发油总量的91.26%。挥发油主要成分为乙酸辛酯、β-榄香烯等,还含有一定量的经皮吸收... 详细信息

目的:提取分析乳香挥发油成分,为乳香的外用制剂的研究提供科学依据。方法:提取乳香挥发油,通过GC-MS对其进行分析鉴定。结果:共鉴定出100种成分,占挥发油总量的91.26%。挥发油主要成分为乙酸辛酯、β-榄香烯等,还含有一定量的经皮吸收促进剂。结论:乳香挥发油的化学成分复杂;固有的经皮吸收促进剂为乳香外用剂型的使用提供可能性。

关键词：乳香挥发油促进剂 β-榄香烯

剪花与摘花对杧果二次成花及产量、品质的影响

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中国南方果树 2024年第3期53卷 140-145页

作者：杨谨瑛农婵娟钟勇梁晶晶韦淑丹黄慧俐蒋强黄台明百色市现代农业技术研究推广中心广西百色533612 百色市田阳区种子管理站广西百色533600 广西职业技术学院南宁530226 百色市田阳区科学技术情报研究所广西百色533600

为减少恶劣天气对杧果开花着果的不利影响,探索了剪花、摘花及两者组合调节杧果花期技术,研究其对杧果二次开花、产量和品质的影响。试验设置了3个处理,即剪花处理(T1)、摘花处理(T2)和剪花与摘花组合处理(T3),以保留原花序作为对照(CK... 详细信息

为减少恶劣天气对杧果开花着果的不利影响,探索了剪花、摘花及两者组合调节杧果花期技术,研究其对杧果二次开花、产量和品质的影响。试验设置了3个处理,即剪花处理(T1)、摘花处理(T2)和剪花与摘花组合处理(T3),以保留原花序作为对照(CK)。结果表明,与对照相比,3个处理均能形成二次花序,延迟花期,提高产量。其中T3处理形成3批花序,枝条二次成花率最高,达59.99%~65.85%,3年平均二次成花率62.87%,极显著高于其他处理;平均株产达46.21~48.44 kg,3年平均产量47.53 kg,显著高于其他处理;各处理的果实品质无显著差异。因此,剪花与摘花组合能更有效地应对杧果花期恶劣天气,形成稳定的产量和品质,可作为生产应用参考。

关键词：杧果剪花摘花二次成花产量品质

Dynamic mechanical behaviors of Fangshan marble

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第5期9卷 807-817页

作者： wei Yao taiming He Kaiwen Xia State Key Laboratory of Hydraulic Engineering Simulation and Safety School of Civil EngineeringTianjin University Department of Civil Engineering University of Toronto Institute of Geophysics China Earthquake Administration

Dynamic strength parameters are extensively used in mining engineering and rock ***,there are no widely accepted dynamic failure models for *** this study,the dynamic punching shear strength,uniaxial compressive strength(UCS) and tensile strength of fine-grained Fangshan marble(FM)are first measured by using a split Hopkinson pressure bar(SHPB) *** pulse-shaping technique is then implemented to maintain the dynamic force balance in SHPB *** results show that the dynamic punching shear strength,UCS and tensile strength increase with the loading rate.A recently developed dynamic Mohr-Coulomb theory is then used to interpret the testing *** this model,the angle of internal friction φ is assumed to be independent of loading rate and is obtained using the static strength *** to the dynamic Mohr-Coulomb theory,the dynamic UCS and the dynamic tensile strength are predicted from the dynamic punching shear ***,based on this dynamic theory,the dynamic UCS is predicted from the dynamic tensile *** consistency between the predicted and measured dynamic strengths demonstrates that the dynamic Mohr-Coulomb theory is applicable to FM.

关键词： Dynamic strengths Split Hopkinson pressure bar(SHPB) Dynamic Mohr-Coulomb model Fangshan marble

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神奇“魔法条”之新冠病毒的快速检测

大学化学 2024年第4期39卷 373-381页

作者：杨迪魏嘉怡翟红王昕孙太明宋浩乐王海雁山西大同大学化学与化工学院山西大同037009

胶体金作为商业化的即时检验POCT(point-of-care test)免疫层析技术中最广泛的标记物之一,具有显著的颜色特征,后期无需可视化改造,且形态稳定、环境友好。本文试纸条制作过程简单,不需要大型贵重仪器。采用柠檬酸三钠还原氯金酸制备胶... 详细信息

胶体金作为商业化的即时检验POCT(point-of-care test)免疫层析技术中最广泛的标记物之一,具有显著的颜色特征,后期无需可视化改造,且形态稳定、环境友好。本文试纸条制作过程简单,不需要大型贵重仪器。采用柠檬酸三钠还原氯金酸制备胶体金,将胶体金标记在新冠病毒的核衣壳N蛋白抗体上,通过在免疫层析试纸条可视区形成类似三明治结构的抗体-抗原-抗体夹心复合物,并以此复合物的红色检测线作为新冠病毒的定性分析依据。该检测方法裸眼可测、操作简单、且快速(10 min)、灵敏(检测限为0.5 ng∙mL^(−1))、低成本(每条不超过5元)。实验过程可以引导学生体验生命体系中抗原抗体相互作用引发的特异性生命化学反应,激发学生对化学、生物、生命科学和纳米材料等学科相互融合的可视化快检技术的浓厚研究兴趣。

关键词：胶体金 POCT 免疫层析新冠病毒

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Comparative study of carbonic anhydrase activity in waters among different geological eco-environments of Yangtze River basin and its ecological significance

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Journal of Environmental Sciences 2018年第4期30卷 173-181页

作者： Sila Onesmus Nzung'a weizhi Pan taiming Shen wei Li Xiaoqun Qin Chenwei Wang Liankai Zhang Longjiang Yu Institute of Resource Biology and Biotechnology Department of Biotechnology College of Life Science & Technology Huazhong Universityof Science & Technology Wuhan 430074 China Institute of Karst Geology Chinese Academy of Geological Sciences Guilin 541004 China Key Laboratory of Karst Dynamics Ministry of Land and Resources/Guangxi Zhuang Autonomous Region Guilin 541004 China Teachers Searvice Commission-Kenya P.O. Box Private Bag 00100 Nairobi Kenya

This study provides the presence of carbonic anhydrase（CA） activity in waters of the Yangtze River basin, China, as well as the correlation of CA activity with HCO-3 concentration and CO2 sink flux. Different degrees of CA activity could be detected in almost all of the water samples from different geological eco-environments in all four seasons. The CA activity of water samples from karst areas was significantly higher than from non-karst areas（PP3-concentration（r = 0.672, P2 sink flux（r = 0.602, P = 0.076） in karst areas. This suggests that CA in waters might have a promoting effect on carbon sinks for atmospheric CO2 in karst river basins. In conditions of similar geological type, higher CA activity was generally detected in water samples taken from areas that exhibited better eco-environments, implying that the CA activity index of waters could be used as an indicator for monitoring ecological environments and protection of river basins. These findings suggest that the role of CA in waters in the karst carbon sink potential of river basins is worthy of further in-depth studies.

关键词： Yangtze River basin Carbon sink Eco-environments Water body Carbonic anhydrase(CA)

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抑郁症患者血清补体通路差异蛋白的研究

医学综述 2018年第18期24卷 3719-3723页

作者：石珊珊于春月王琪张建赵希武王炎魏太明哈尔滨医科大学大庆校区黑龙江大庆163319 大庆市第三医院心理科黑龙江大庆163712

目的探究补体差异蛋白与抑郁症的潜在联系。方法选取2015年1月至2016年7月大庆市第三医院收治的22例抑郁症患者作为抑郁症组,并纳入20例大庆市健康市民作为健康组,提取血清。利用同位素相对标记与绝对定量(i TRAQ)技术和独创通路分析(I... 详细信息

目的探究补体差异蛋白与抑郁症的潜在联系。方法选取2015年1月至2016年7月大庆市第三医院收治的22例抑郁症患者作为抑郁症组,并纳入20例大庆市健康市民作为健康组,提取血清。利用同位素相对标记与绝对定量(i TRAQ)技术和独创通路分析(IPA)通路富集,得到补体通路及其补体通路中的差异表达蛋白。用酶联免疫吸附测定法(ELISA)对差异表达蛋白进行验证。从基因表达数据库(GEO)中获取重度抑郁症患者和健康人全血基因表达芯片数据集GSE19738,各21例。采用R包对数据做预处理和差异性表达基因(DEGs)的筛选,应用ClueGO进行生物过程富集分析。结果用ELISA验证出5个蛋白在抑郁症组中的表达显著升高,分别是补体因子I(CFI)、补体成分(C)2、C4A、C5、C6。对芯片数据集GSE98793分析,得到442个DEGs,其中102个基因表达上调,340个基因表达下调。经过ClueGO富集分析得到差异表达基因在生物过程中,主要参与翻译蛋白靶向到膜,线粒体呼吸链复合体组装,凋亡细胞;在细胞组成中,差异基因主要参与核糖体亚基,线粒体内膜。在分子功能方面,主要参与细胞色素C氧化酶活性,RNA聚合酶1活性,蛋白质通道活性。结论抑郁症患者血清补体通路中5个差异表达蛋白(CFI、C2、C4A、C5和C6)的表达量显著增加。这些差异补体蛋白可能与抑郁症存在密切联系,为疾病的病因、诊断和药物研究提供重要线索。

关键词：抑郁症补体蛋白生物信息学分析生物标志物

Long-term inorganic plus organic fertilization increases yield and yield stability of winter wheat

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The Crop Journal 2018年第6期6卷 589-599页

作者： Huan Chen Aixing Deng weijian Zhang wei Li Yuqiang Qiao taiming Yang Chengyan Zheng Chengfu Cao Fu Chen College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Crop Research Institute Anhui Academy of Agricultural SciencesHefei 230031AnhuiChina Anhui Center of Agricultural Meteorology Hefei 230031AnhuiChina

An understanding of wheat yield and yield stability response to fertilization is important for sustainable wheat production. A 36-year long-term fertilization experiment was employed to evaluate the yield and yield stability of winter wheat. Five fertilization regimes were compared,including(1) CK, no fertilizer;(2) NPK, inorganic fertilizer only;(3) O, organic fertilizer only;(4)NPKO, 50% of NPK plus 50% of O, and(5) HNPKO, 80% of NPK plus 80% of O. The greatest yield increase was recorded in HNPKO, followed by NPKO, with O producing the lowest mean yield increase. Over the 36 years, the rate of wheat yield increase in fertilized plots ranged from95.31 kg ha-1 year-1 in the HNPKO to 138.65 kg ha-1 year-1 in the O. Yield stability analysis using the additive main effects and multiplicative interactions(AMMI) method assigned 62.3%, 26.3%,and 11.4% of sums of squares to fertilization effect, environmental effect, and fertilization ×environment interaction effect, respectively. The combination of inorganic and organic fertilization(NPKO and HNPKO) appeared to produce more stable yields than O or NPK, with lower coefficients of variation and AMMI stability value. However, wheat grown with O seemed to be the most susceptible to climate change and the least productive among the fertilized *** correlations of grain yield with soil properties and with mean air temperature were observed. These findings suggest that inorganic + organic fertilizer can increase wheat yield and its stability by improvement in soil fertility and reduction in variability to climate change.

关键词： Winter wheat Grain yield Yield stability AMMI analysis Long-term fertilization

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编码激励在岩石衰减(1/Q)检测中的应用

地球物理学报 2022年第1期65卷 384-392页

作者：朱维王尚旭吴何珍翟鸿宇和泰名李长征中国石油大学(北京)油气资源与探测国家重点实验室北京102249 中国地震局地球物理研究所北京100081 黄河水利科学研究院郑州450003

通过测量超声波衰减能够检测岩石强度,但超声信号的低信噪比特征一直是精确测量衰减的瓶颈.编码激励技术能够在不损失分辨率的情况下提高信噪比,因此成为超声检测岩石强度的关键.为了促进编码激励技术在实验室检测中的应用,我们系统研... 详细信息

通过测量超声波衰减能够检测岩石强度,但超声信号的低信噪比特征一直是精确测量衰减的瓶颈.编码激励技术能够在不损失分辨率的情况下提高信噪比,因此成为超声检测岩石强度的关键.为了促进编码激励技术在实验室检测中的应用,我们系统研究了编码激励的原理和方法,通过数值和物理实验获得了该技术的使用条件.物理实验表明,编码激励技术能够抑制噪声,提高衰减测量的精度;对有机玻璃、人造砂岩和天然砂岩的衰减测量结果说明,对于幅度削减线性调频信号和相同时间带宽积的正弦调制巴克码信号,当衰减较大时,前者激发的信号测量岩石品质因子Q值的误差大于后者.根据编码信号在三轴压缩岩石衰减监测中的实际应用,得出正弦调制巴克码比幅度削减线性调频信号更适合于监测压缩岩石的变形过程的结论.

关键词：编码激励衰减检测巴克编码线性调频编码