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Gut microbiome and metabolic-associated fatty liver disease:Current status and potential applications

World Journal of Hepatology 2023年第7期15卷 867-882页

作者： Gong-Jing Guo Fei Yao wei-peng Lu Hao-Ming Xu Gastroenterology Department of The Second Affiliated Hospital School of MedicineThe Chinese University of Hong KongShenzhen&Longgang District People’s Hospital of ShenzhenShenzhen 518172Guangdong ProvinceChina Department of Science and Education The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370Guangdong ProvinceChina The First Clinical School Guangzhou Medical UniversityGuangzhou 510120Guangdong ProvinceChina Department of Gastroenterology and Hepatology Guangzhou First People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180Guangdong ProvinceChina

Metabolic-associated fatty liver disease(MAFLD)is one of the most common chronic liver diseases *** recent years,the occurrence rate of MAFLD has been on the rise,mainly due to lifestyle changes,high-calorie diets,and imbalanced dietary structures,thereby posing a threat to human health and creating heavy social and economic *** the development of 16S sequencing and integrated multi-omics analysis,the role of the gut microbiota(GM)and its metabolites in MAFLD has been further *** GM plays a role in digestion,energy metabolism,vitamin synthesis,the prevention of pathogenic bacteria colonisation,and *** gut-liver axis is one of the vital links between the GM and the *** substances in the intestine can enter the liver through the portal vascular system when the intestinal barrier is severely *** liver also influences the GM in various ways,such as bile acid *** gut-liver axis is essential in maintaining the body’s normal physiological state and plays a role in the onset and prognosis of many diseases,including *** article reviews the status of the GM and MAFLD and summarizes the GM characteristics in *** relationship between the GM and MAFLD is discussed in terms of bile acid circulation,energy metabolism,micronutrients,and signalling *** MAFLD treat ments targeting the GM are also listed.

关键词： Metabolic-associated fatty liver disease Gut microbiota Current status Application

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Immunotherapy of DC-CIK cells enhances the efficacy of chemotherapy for solid cancer: a meta-analysis of randomized controlled trials in Chinese patients

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第9期16卷 743-756页

作者： Xiao-peng LAN You-gen CHEN Zheng WANG Chuan-wei YUAN Gang-gang WANG Guo-liang LU Shao-wei MAO Xun-bo JIN Qing-hua XIA Minimally Invasive Urology Center Shandong Provincial Hospital Affiliated to Shandong University

Objective： Professional antigen-presenting dendritic cells （DCs） and cytokine-induced killer （CIK） cells, components of anti-cancer therapy, have shown clinical benefits and potential to overcome chemotherapeutic re- sistance. To evaluate whether DC-CIK cell-based therapy improves the clinical efficacy of chemotherapy, we reviewed the literature on DC-CIK cells and meta-analyzed randomized controlled trials （RCTs）. Methods： We searched several databases and selected studies using predeflned criteria. RCTs that applied chemotherapy with and without DC-CIK cells separately in two groups were included. Odds ratio （OR） and mean difference （MD） were reported to measure the pooled effect. Results： Twelve reported RCTs （826 patients）, which were all performed on Chinese patients, were included. Combination therapy exhibited better data than chemotherapy： 1-year overall survival （OS）（OR=0.22, P〈0.01）, 2-year OS （OR=0.28, P〈0.01）, 3-year OS （OR=0.41, P〈0.01）, 1-year disease-free survival （DFS）（OR=0.16, P〈0.05）, 3-year DFS （OR=0.32, P〈0.01）, objective response rate （ORR）（OR=0.54, P〈0.01）, and disease control rate （DCR）（OR=0.46, P〈0.01）. Moreover, the levels of CD3＋ T-lymphocytes （MD=-11.65, P〈0.05） and CD4＋ T-lymphocytes （MD=-8.18, P〈0.01） of the combination group were higher. Conclusions： Immunotherapy of DC-CIK cells may enhance the efficacy of chemotherapy on solid cancer and induces no specific side effect. Further RCTs with no publishing bias should be designed to confirm the immunotherapeutic effects of DC-CIK cells.

关键词： Solid carcinoma Meta-analysis Dendritic cells Cytokine-induced killer cells Immunotherapy

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长链非编码RNA基因多态性与原发性肝癌遗传易感性的相关性研究

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癌症进展 2024年第7期22卷 719-722,726页

作者：黄雪娟杨正敏孙浩梁雪萌彭鑫常巍昆明医科大学公共卫生学院昆明6505000

目的探讨长链非编码RNA(lncRNA)基因单核苷酸多态性(SNP)与原发性肝癌遗传易感性的相关性,为原发性肝癌的早诊断、早预防、开展肝癌遗传易感机制研究提供依据。方法选取41例原发性肝癌患者和83例健康志愿者分别作为病例组和对照组,对浆... 详细信息

目的探讨长链非编码RNA(lncRNA)基因单核苷酸多态性(SNP)与原发性肝癌遗传易感性的相关性,为原发性肝癌的早诊断、早预防、开展肝癌遗传易感机制研究提供依据。方法选取41例原发性肝癌患者和83例健康志愿者分别作为病例组和对照组,对浆细胞瘤变体易位基因1(PVT1)、结肠癌相关转录本1(CCAT1)、结肠癌相关转录本2(CCAT2)、肿瘤易感性8(CASC8)、前列腺癌相关非编码RNA 1(PRNCR1)中的13个SNP位点进行基因分型,比较两组患者的基因型分布。结果病例组与对照组lncRNA PVT1基因RS2392885位点的基因型分布比较,差异有统计学意义(P﹤0.05),其他位点基因型分布比较,差异均无统计学意义(P﹥0.05)。lncRNA PVT1基因上RS2392885位点的基因型为CC、CT和TT型,其中病例组各基因型占比分别为12.2%、68.3%和19.5%,对照组各基因型占比分别为19.3%、42.2%和38.6%。结论lncRNA PVT1中的RS2392885位点的基因型可能与原发性肝癌的遗传易感性有关。

关键词：原发性肝癌长链非编码RNA 基因多态性

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Dynamic analysis of a flexible rotor supported by ball bearings with damping rings based on FEM and lumped mass theory

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Journal of Central South University 2020年第12期27卷 3684-3701页

作者： ZHU Hai-min CHEN wei-fang ZHU Ru-peng ZHANG Li GAO Jie LIAO Mei-jun National Key Laboratory of Science and Technology on Helicopter Transmission Nanjing University of Aeronautics and AstronauticsNanjing 210016China Faculty of Engineering and Environment Northumbria UniversityNewcastle NE17RUUK AECC Hunan Aviation Powerplant Research Institute Zhuzhou 412000China

A dynamic model of a flexible rotor supported by ball bearings with rubber damping rings was proposed by combining the finite element and the mass-centralized *** the proposed model,the rotor was built with the Timoshenko beam element,while the supports and bearing outer rings were modelled by the mass-centralized ***,the influences of the rotor’s gravity,unbalanced force and nonlinear bearing force were *** governing equations were solved by precise integration and the Runge-Kutta hybrid numerical *** verify the correctness of the modelling method,theoretical and experimental analysis is carried out by a rotor-bearing test platform,where the error rate between the theoretical and experimental studies is less than 10%.Besides that,the influence of the rubber damping ring on the dynamic properties of the rotor-bearing coupling system is also *** conclusions obtained are in agreement with the real-world *** this basis,the bifurcation and chaos behaviors of the coupling system were carried out with rotational speed and rubber damping ring’s *** results reveal that as rotational speed increases,the system enters into chaos by routes of crisis,quasi-periodic and intermittent ***,the paths of crisis,quasi-periodic bifurcation,and Hopf bifurcation to chaos were detected under the parameter of rubber damping ring’s ***,the bearing gap affects the rotor system’s dynamic ***,the excessive bearing gap will make the system’s periodic motion change into chaos,and the rubber damping ring’s stiffness has a substantial impact on the system motion.

关键词： finite element method Timoshenko beam rubber damping ring bifurcation chaos

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铅电解设备相关技术改进与应用

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有色冶金设计与研究 2024年第4期45卷 24-27,57页

作者：彭宏道刘文彬杨广卫东东程道顺中国瑞林工程技术股份有限公司江西南昌330038 江西瑞林装备有限公司江西南昌330032

针对铅电解机组在电解精炼生产中存在铅阴极导电棒寿命较短、焊接质量差、悬垂度差等相关问题,基于弯曲整形、神经网络控制等理论,研发了析出铅板与导电棒的高效能棒—板分离技术、动态多特征值融合的BP神经网络电阻焊控制技术、刚度强... 详细信息

针对铅电解机组在电解精炼生产中存在铅阴极导电棒寿命较短、焊接质量差、悬垂度差等相关问题,基于弯曲整形、神经网络控制等理论,研发了析出铅板与导电棒的高效能棒—板分离技术、动态多特征值融合的BP神经网络电阻焊控制技术、刚度强化的板面压纹技术,并应用于国内某大型铅冶炼企业的新建项目上。实践证明,技术优化后,导电棒的使用寿命可延长12.8%以上,短路率降低至0.43%。

关键词：铅电解电解短路棒—板分离导电棒寿命

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广西三叉苦林下种植及病虫害防治技术措施

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广东蚕业 2024年第5期58卷 27-29页

作者：郑庆斌彭雪迪韦林宏陆江赵滑广西盛麒科技有限公司广西南宁530000 广西壮族自治区国有维都林场广西来宾546100

随着广西的三叉苦产业逐渐形成规模,人工种植面积不断增加,林下种植得到广泛推广,同时,三叉苦的病虫害问题越来越严重,对三叉苦药材的产量和品质造成威胁。文章介绍了目前广西三叉苦林下种植的概况,总结了三叉苦病虫害的常见种类、危害... 详细信息

随着广西的三叉苦产业逐渐形成规模,人工种植面积不断增加,林下种植得到广泛推广,同时,三叉苦的病虫害问题越来越严重,对三叉苦药材的产量和品质造成威胁。文章介绍了目前广西三叉苦林下种植的概况,总结了三叉苦病虫害的常见种类、危害症状及其防治技术与防治措施。

关键词：三叉苦林下种植病虫害防治技术广西

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A cytotoxic pyrrolidinoindoline diketopiperazine dimer from the algal fungus Eurotium herbariorum HT-2

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Chinese Chemical Letters 2013年第12期24卷 1049-1052页

作者： Ye Li Kun-Lai Sun Yi Wang peng Fu Pei-Pei Liu Chen Wang wei-Ming Zhu Key Laboratory of Marine Drugs Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of China

A new cytotoxic pyrrolidinoindoline diketopiperazine dimer, cristatumin E （1）, was isolated from the fermentation broth of the algal fungus Eurotium herbariorum HT-2 associated with the marine algae, Enteromorpha prolifera. The structure was determined by spectroscopic analyses and Marfey＇s amino acid analysis. Cristatumin E （1） showed cytotoxicity against K562 tumor cell line and antibacterial activity against Enterobacter aerogenes and Escherichia coli with IC50 and MIC values of 8.3, 44.0 and 44.0 μmol/L, respectively.

关键词： Cristatumin E Pyrrolidinoindoline diketopiperazine dimer Eurotium herbariorum Algal fungus Cytotoxicity Enteromorpha prolifera Marine algae

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基于CFD的某核电厂通风系统改造模拟验证

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电工技术 2024年第7期 230-232页

作者：翟连付魏砚学李绪生田鹏赵润松核工业工程研究设计有限公司北京101300

在核电厂中,通风系统在维系核岛厂房空气质量环节中扮演着重要角色。某核电厂通风系统易被空气污染物堵塞,为此研发净化装置安装在通风系统进风口。使用CFD技术对安装净化装置的通风系统进行仿真模拟,验证了安装净化装置后的流场符合通... 详细信息

在核电厂中,通风系统在维系核岛厂房空气质量环节中扮演着重要角色。某核电厂通风系统易被空气污染物堵塞,为此研发净化装置安装在通风系统进风口。使用CFD技术对安装净化装置的通风系统进行仿真模拟,验证了安装净化装置后的流场符合通风系统设计要求。

关键词： CFD 气流组织核岛通风仿真模拟

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Histopathological Features of Middle Cerebral Artery and Superficial Temporal Artery from Patients with Moyamoya Disease and Enlightenments on Clinical Treatment

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2016年第6期36卷 871-875页

作者： shou-jia SUN Jian-jian ZHANG Zheng-wei LI Zhong-wei XIONG Xiao-lin WU Sheng WANG Kai SHU Jin-cao CHEN Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan 430030China Department of Neurosurgery Zhongnan HospitalWuhan University Wuhan 430071 China

The histopathological features of the middle cerebral artery（MCA） and superficial temporal artery（STA） from moyamoya disease（MMD） and their relationships with gender,age,angiography stage were *** causes and the clinical significance of vasculopathy of STA were also *** clinical data and specimens of MCA and STA from 30 MMD patients were *** samples of MCA and STA from non-MMD patients served as control *** examination was then performed by measuring the thickness of intima and media,and statistical analysis was *** MCA and STA specimens from MMD group had apparently thicker intima and thinner media than those from the control *** was no significant pathological difference between the hemorrhage group and non-hemorrhage group,and between the males and females in MMD *** the age nor the digital subtraction angiography（DSA） stage was correlated with the thickness of intima in MCA and *** is a systemic vascular disease involving both intracranial and extracranial *** external carotid arteriography,especially super-selective arteriography of the STA,benefits the selection of donor vessel.

关键词： moyamoya disease middle cerebral artery superficial temporal artery vasculopathy

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钢丝网复合砂浆加固混凝土受弯构件非线性分析

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工程力学 2005年第3期22卷 118-125页

作者：尚守平曾令宏彭晖湖南大学土木工程学院湖南长沙410082

对用钢丝网复合砂浆加固的钢筋混凝土梁进行了正截面抗弯试验研究。试验包括16根用钢丝网加固的梁和两根未加固的对比梁,采用U形三面的加固方式(钢丝网复合砂浆包裹了梁的受拉面及两个侧面)。试验中对比了加固与未加固构件的裂缝开展情... 详细信息

对用钢丝网复合砂浆加固的钢筋混凝土梁进行了正截面抗弯试验研究。试验包括16根用钢丝网加固的梁和两根未加固的对比梁,采用U形三面的加固方式(钢丝网复合砂浆包裹了梁的受拉面及两个侧面)。试验中对比了加固与未加固构件的裂缝开展情况、跨中挠度以及极限荷载。试验结果表明,钢丝网复合砂浆薄层可以明显地提高钢筋混凝土梁的抗弯承载力,提高抗裂性能,增强构件的抗弯刚度。理论部分采用非线性的方法得到加固构件的荷载-挠度曲线,与试验结果比较,有较好的吻合。

关键词：混凝土受弯构件钢丝网复合砂浆复合砂浆加固非线性分析

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