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Diagnostic value of two dimensional shear wave elastography combined with texture analysis in early liver fibrosis

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World Journal of Clinical Cases 2019年第10期7卷 1122-1132页

作者： Zhao-Cheng Jian Jin-Feng Long Yu-Jiang liu Xiang-Dong Hu Ji-Bin liu Xian-Quan Shi wei-sheng li lin-Xue Qian Department of Ultrasound Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Medical Imaging Center Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina Institute of Ultrasound Thomas Jefferson University HospitalPhiladelphiaPA 19107United States

BACKGROUND Staging diagnosis of liver fibrosis is a prerequisite for timely diagnosis and therapy in patients with chronic hepatitis B.In recent years,ultrasound elastography has become an important method for clinical noninvasive assessment of liver fibrosis stage,but its diagnostic value for early liver fibrosis still needs to be further improved.In this study,the texture analysis was carried out on the basis of two dimensional shear wave elastography(2D-SWE),and the feasibility of 2D-SWE plus texture analysis in the diagnosis of early liver fibrosis was discussed.AIM To assess the diagnostic value of 2D-SWE combined with textural analysis in liver fibrosis staging.METHODS This study recruited 46 patients with chronic hepatitis B.Patients underwent 2DSWE and texture analysis;Young's modulus values and textural patterns were obtained,respectively.Textural pattern was analyzed with regard to contrast,correlation,angular second moment(ASM),and homogeneity.Pathological results of biopsy specimens were the gold standard;comparison and assessment of the diagnosis efficiency were conducted for 2D-SWE,texture analysis and their combination.RESULTS 2D-SWE displayed diagnosis efficiency in early fibrosis,significant fibrosis,severe fibrosis,and early cirrhosis(AUC>0.7,Pliver fibrosis stage(AUC>0.7,Plimited values.AUC of contrast and homogeneity were respectively 0.906(0.779-0.973),0.835(0.693-0.930),0.807(0.660-0.910)and 0.925(0.805-0.983),0.789(0.639-0.897),0.736(0.582-0.858),0.705(0.549-0.883)and 0.798(0.650-0.904)in four liver fibrosis stages,which exhibited equivalence to 2D-SWE in diagnostic efficiency(P>0.05).Combined diagnosis(PRE)displayed diagnostic efficiency(AUC>0.7,P<0.01)for all fibrosis stages with respective AUC of 0.952(0.841-0.994),0.896(0.766-0.967),0.978(0.881-0.999),0.947(0.83

关键词： Elastography Two-dimensional shear wave Texture analysis liver fibrosis,Staging

MLH1 c.199G>A, a Known Mutation for Lynch Syndrome, Is Also Associated with Sebaceous Neoplasm

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International Journal of Dermatology and Venereology 2021年第2期4卷 94-96页

作者： wei-sheng li Yan li Nai-Hui Zhou Jing-liu liu Zi-liang Yang Miao Sun Min li Institute for Fetology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215006China Department of Dermatology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215006China

Introduction:Muir-Torre syndrome is a phenotypic variant of Lynch syndrome characterized by a predisposition for the development of visceral malignant disease and sebaceous gland neoplasms,and it is caused by germline mutations in the mismatch repair genesMSH2 andMLH1.Case presentation:The proband was a 42-year-old man who had undergone surgical resection of colorectal adenocarcinoma at 28 years.He presented with macular rashes and red papule.Histological examination of the lesion on his head revealed a sebaceoma at 37 years.Follow-up of the family history revealed that the proband’s 65-year-old mother had been highly suspected to have Lynch syndrome with colorectal cancer at 40 years of age.The proband’s daughter underwent colonoscopy because of blood in the stool at the age of 13 years,but no abnormalities were found.Discussion:We have herein reported a pathogenic missense mutation c.199G>A(p.Gly67Arg)in exon 2 ofMLH1 in patients with MTS.This mutation has been reported in patients with Lynch syndrome who have no skin tumors.However,we also found that some patients with MTS had no history of any internal malignancy or skin tumor.Our data support the idea that a hiatus of many years may pass before both elements-a sebaceous neoplasm and an internal cancer-are present in a patient,thus finally allowing the diagnosis of MTS.Conclusion:A pathogenic Lynch syndrome mutation c.199G>A in exon 2 of theMLH1 gene was found in a patient with MTS who presented with a sebaceous neoplasm.

关键词： case report MLH1 gene Muir-Torre syndrome mutation sebaceous neoplasm

Distribution patterns of the contents of five biologically activate ingredients in the root of Scutellaria baicalensis

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Chinese Journal of Natural Medicines 2017年第2期15卷 152-160页

作者： liU Rong-Xiu SONG Guo-Hu WU Pei-Gen ZHANG Xue-Wen HU Hui-Juan liU Jia MIAO Xiao-Su HOU Zhi-Yan WANG Wen-Quan wei sheng-li School of Chinese Pharmacy Beijing University of Chinese Medicine Chengde Pharmaceutical Co. Ltd Affiliated to China National Group Corp.of Traditional & Herbal Medicine National Engineering Laboratory for Breeding of Endangered Medicinal Materials Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical College

As an important herbaceous plant, Scutellaria baicalensis Georgi(Chinese skullcap) is geographically widespread and commonly used throughout the world. In the Chinese medicine market, S. baicalensis has been divided into two primary types, "Ku Qin"(WXR) and "Tiao Qin"(TST). Moreover, TST is also divided into different grades according to the diameter of roots. To explore the distribution patterns of the contents of five biologically activate ingredients(FBAI), we used six-year-old cultivated S. baicalensis and analyzed its growth characteristics as well as the quality difference among different types and diameters in roots. Throughout the entire root, we discovered that contents of the FBAI all initially increased and subsequently decreased from the top to the bottom of the roots. The baicalin content of WXR was less than that of TST. On the contrary, the contents of baicalein, wogonin, and oroxylin A in WXR were up to about two times higher than that in TST. We also found that the 0 to 40 cm part of the S. baicalensis root possessed about 87% of the root biomass and about 92% of the contents of the active ingredients.

关键词： Scutellaria baicalensis Distribution patterns Type Diameter Biologically active ingredients

基于中药监管科学创新技术体系破解国家中药类产品集中带量采购难点

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中国食品药品监管 2024年第1期 108-117页

作者：魏胜利李大宁徐安龙北京中医药大学国家药品监督管理局中药监管科学研究院中药材规范化生产教育部工程研究中心三明采购联盟省际中药(材)采购联盟专家组委员会

在国家推动药品集中带量采购(以下简称集采)工作常态化背景下,中成药大品种在全国范围内的集采已经落地开展,中药饮片的省际联合采购也正在进行,而未来中药配方颗粒纳入集采也是大势所趋。然而,中药不同于化学药品,其原料来源于天然资源... 详细信息

在国家推动药品集中带量采购(以下简称集采)工作常态化背景下,中成药大品种在全国范围内的集采已经落地开展,中药饮片的省际联合采购也正在进行,而未来中药配方颗粒纳入集采也是大势所趋。然而,中药不同于化学药品,其原料来源于天然资源,组成成分复杂、功效主治多样,是一个多功效、多组分的复杂体系,加之中药类产品生产过程复杂,产品质量良莠不齐,生产成本相差悬殊,如何在中药类产品集采中科学评价产品质量,体现优质优价,以及如何科学评估中药类产品的生产成本,制定合理的最高限价,都是中药集采工作执行中亟待解决的难点问题。针对上述难点,笔者提出基于中药监管科学体系,创新制定中药类产品质量等级标准以及构建全产业链溯源与供应保障平台,从而确保中药类产品集采保质、提级、稳供、高质量发展的新思路。

关键词：中药集采中成药中药饮片精准药材精准饮片

基于拟靶向代谢组学的3种基原大黄的差异成分研究

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中国中药杂志 2024年第9期49卷 2393-2401页

作者：赵江怡唐进程陈欣欣周易刘文清张媛刘凤波赵婷魏胜利北京中医药大学中药学院北京102488 中药材规范化生产教育部工程研究中心北京100102

大黄是典型的多基原大宗中药材,研究不同基原大黄药效成分含量和比例的差异,以期实现对不同基原大黄药材质量的精准评价,为大黄在临床上的精准用药提供理论依据。该研究以相同生长年限(四年生)的唐古特大黄、掌叶大黄和药用大黄为材料,... 详细信息

大黄是典型的多基原大宗中药材,研究不同基原大黄药效成分含量和比例的差异,以期实现对不同基原大黄药材质量的精准评价,为大黄在临床上的精准用药提供理论依据。该研究以相同生长年限(四年生)的唐古特大黄、掌叶大黄和药用大黄为材料,采用拟靶向代谢组学技术测定3种基原大黄中蒽醌、蒽酮及鞣质类共计220个成分的相对含量,并运用多元统计方法对差异成分进行筛选。主成分分析(PCA)结果显示,大黄样品按照基原明显聚为3类。通过正交偏最小二乘法判别分析(OPLS-DA),最终筛选出117种差异成分,其中包括:游离蒽醌类8种,结合蒽醌类18种,蒽酮类80种,鞣质类11种。综合比较,28种成分在唐古特大黄中含量较高,主要为番泻苷类、结合蒽醌类和原花青素类化合物;35种成分在药用大黄中含量较高,主要为游离蒽醌类和儿茶素类化合物;54种成分在掌叶大黄中含量较高,主要为二蒽酮类化合物,但其结构暂不能确定。通过对3种基原大黄差异成分的分析,根据差异成分在3种基原大黄中的含量分布情况可推测出:唐古特大黄的泻下攻积之力最强,药用大黄的清热泻火功效最强,且两者的逐瘀通经功效强于掌叶大黄。

关键词：大黄多基原拟靶向代谢组学差异成分精准中药

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苏合香品种变迁考

中国中药杂志 2024年第6期49卷 1690-1698页

作者：丁一明吴孟华 ERIC Brand 孙鑫刘越郭晓晗魏胜利马双成赵中振北京中医药大学中药学院北京100029 北京中医药大学本草纲目研究所北京100029 中国食品药品检定研究院北京102629 暨南大学岭南传统中药研究中心广东广州510632 北京中医药大学中医学院北京100029 香港浸会大学中医药学院中国香港00852

苏合香为我国常用进口中药材,在汉代即传入我国,苏合香作为中药始载于《名医别录》。该文通过梳理古今中外本草、现代文献资料,并结合对苏合香产地的实地考察结果,对苏合香的名称、质量评价、基原、产地及采收加工进行了系统的品种变迁... 详细信息

苏合香为我国常用进口中药材,在汉代即传入我国,苏合香作为中药始载于《名医别录》。该文通过梳理古今中外本草、现代文献资料,并结合对苏合香产地的实地考察结果,对苏合香的名称、质量评价、基原、产地及采收加工进行了系统的品种变迁考证。结果表明,自古以来苏合香便存在基原不明、产地不清的情况。我国历代医药学家多从质地、黏稠度、气味浓度、颜色4个方面对苏合香进行质量评价。苏合香品种共发生过2次变迁,第一次变迁可能在隋唐时期,基原由南欧安息香Sty⁃rax officinalis变迁为苏合香树liquidambar orientalis。第二次变迁在近现代,基原由苏合香树变迁为北美枫香树L.styraciflua。在基原第二次变迁的同时,产地发生了第一次变迁,由小亚细亚南部地区的土耳其、叙利亚等国变迁为中美洲地区及北美洲南部地区的洪都拉斯、危地马拉等国。该文对苏合香质量评价、基原、产地、性状与采收加工等多方面的历史沿革进行了考证,同时对苏合香在西方国家的应用进行了综述,可为苏合香的进一步开发利用提供历史依据。

关键词：苏合香品种基原进口药材质量评价

Development of a prognostic scoring system for hepatic vena cava Budd-Chiari syndrome with hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 370-375页

作者： sheng-Yan liu Lu-Hao li Zhao-Chen liu Su-Xin li Xiao-wei Dang Department of Hepatopancreatobiliary Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Budd-Chiari Syndrome Diagnosis and Treatment Center of Henan Province Zhengzhou 450052China

Background:Hepatocellular carcinoma(HCC)is a serious complication of hepatic vena cava Budd-Chiari syndrome(HVC-BCS)that significantly reduces the survival time of patients.Our study aimed to analyze the prognostic factors influencing the survival of HVC-BCS patients with HCC and to develop a prognostic scoring system.Methods:The clinical and follow-up data of 64 HVC-BCS patients with HCC who received invasive treatment at the First Affiliated Hospital of Zhengzhou University between January 2015 and December 2019 were retrospectively analyzed.Kaplan-Meier curves and log-rank tests were used to analyze the survival curve of patients and the difference in prognoses between the groups.Univariate and multivariate Cox regression analyses were performed to analyze the influence of biochemical,tumor,and etiological characteristics on the total survival time of patients,and a new prognostic scoring system was developed according to the regression coefficients of the independent predictors in the statistical model.The prediction efficiency was evaluated using the time-dependent receiver operating characteristics curve and concordance index.Results:Multivariate analysis showed that serum albumin level7 cm(HR=8.623,95%CI:3.771-19.715,Plinical evaluation of patient prognosis.

关键词： Budd-Chiari syndrome Hepatocellular carcinoma Prognostic factors Inferior vena cava stenosis Prognostic scoring system

High Speed Sintering:Assessing the Influence of Energy Input on Microstructure and Mechanical Properties of Polyether Block Amide(PEBA)Parts

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Chinese Journal of Polymer Science 2024年第5期42卷 675-682,I0004,I0010页

作者： Jiang-Tao Sun Zhi-Yong Fan Yi-wei Mao wei li wei Zhu Dao-sheng Cai Qing-Song wei State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074China State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430074China National Engineering Research Centre for High Efficiency Grinding Hunan UniversityChangsha410082China Wuhan EasyMFG Technology CO. LTDWuhan430074China

High speed sintering,a new powder-bed fusion additive manufacturing technology,utilizes infrared lights(IR)to intensely heat and melt polymer powders.The presence of defects such as porosity,which is associated with particle coalescence,is highly dependdent on the level of energy input.This study investigate the influcence of energy input on porosity and its subsequent effects on the mechanical properties and microstructures of PEBA parts.The parts were manufactured with a variety of lamp powers,resulting in a range of energy input levels spanning from low to high.Subsequebtly,they underwent testing using Archimedes’method,followed by tensile testing.The porosity,mechanical characteristics,and energy input exhibit a strong correlation;inadequate energy input was the primary cause of pore formation.Using the reduced IR light power resulted in the following outcomes:porosity,ultimate tensile strength,and elongation of 1.37%,7.6 MPa,and 194.2%,respectively.When the energy input was further increased,the porosity was reduced to as low as 0.05%and the ultimate tensile strength and elongation were increased to their peak values of 233.8%and 9.1 MPa,respectively.

关键词： High speed sintering Additive manufacturing Energy input Powder bed fusion PEBA

Intra-arterial tenecteplase during thrombectomy for acute stroke(BRETIS-TNK II):rationale and design

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Stroke & Vascular Neurology 2024年第1期9卷 59-65页

作者： Zi-Ai Zhao Jing Qiu wei li Thanh Nguyen Shouchun Wang Huaizhang Shi Ming wei Feng Wang Di li Hui-sheng Chen Department of Neurology General Hospital of Northern Theater CommandShenyangLiaoning ProvinceChina Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Department of Neurology First Affiliated Hospital of Jilin UniversityChangchunJilinChina Department of Neurosurgery First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurosurgery Tianjin Huanhu HospitalTianjinTianjinChina Department of Interventional Therapy First Affiliated Hospital of Dalian Medical UniversityDalianChina Neurological Intervention Department Dalian Municipal Central HospitalDalianLiaoningChina

Background Our recent pilot study suggests intra-arterial tenecteplase(TNK)during the first pass of endovascular treatment(EVT)seems safe,may increase first-pass reperfusion and good outcome in acute ischaemic stroke(AIS)patients with large-vessel occlusion(LVO).Aims To determine the efficacy and safety of intra-arterial TNK administration during EVT in AIS-LVO patients presenting up to 24 hours from symptom onset.Sample size estimates A maximum of 380 patients are required to test the superiority hypothesis with 80%power according to a two-side 0.05 level of significance,stratified by age,gender,baseline systolic blood pressure,prestroke modified Rankin Scale(mRS),baseline National Institute of Health stroke scale,baseline ASPECTS,time from onset to groin puncture,intravenous thrombolysis before EVT,stroke territory and stroke aetiology.Design Intra-arterial TNK during thrombectomy for acute stroke(BRETIS-TNK II)study is a prospective,randomised,adaptive enrichment,open-label,blinded end point,multicentre study.Eligible AIS-LVO patients are randomly assigned into the experimental group and control group with a ratio of 1:1.The experimental group will be treated with intra-arterial infusion of TNK during EVT.The control group will be treated with standard EVT.Outcome The primary end point is a favourable outcome,defined as an mRS score of 0–2 at 90 days.The primary safety end point is symptomatic intracranial haemorrhage within 48 hours,which is defined as an increase in the National Institutes of Health Stroke Scale score of≥4 points as a result of the intracranial haemorrhage.Conclusions The results of BRETIS-TNK II will provide evidence for the efficacy and safety of intra-arterial TNK administration during EVT in AIS patients with LVO.

关键词： rational stratified TNK