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促红细胞生成素产生细胞与慢性肾脏病贫血及肾纤维化关系的研究进展

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解放军医学杂志 2020年第6期45卷 680-684页

作者：李菲魏日胞南开大学医学院临床医学系天津300071 解放军总医院第一医学中心肾脏病科/全军肾脏病研究所/肾脏疾病国家重点实验室/国家慢性肾病临床医学研究中心/肾脏疾病研究北京市重点实验室北京100853

慢性肾脏病的基本特征是持续性的肾功能下降、细胞外基质的累积以及进行性的组织纤维化。肾间质纤维化和肾性贫血是慢性肾脏病的常见并发症。介导肾间质纤维化的关键细胞是激活的肌成纤维细胞,而介导肾性贫血的重要因素则为肾促红细胞... 详细信息

慢性肾脏病的基本特征是持续性的肾功能下降、细胞外基质的累积以及进行性的组织纤维化。肾间质纤维化和肾性贫血是慢性肾脏病的常见并发症。介导肾间质纤维化的关键细胞是激活的肌成纤维细胞,而介导肾性贫血的重要因素则为肾促红细胞生成素产生细胞的减少,导致促红细胞生成素分泌下降。肾促红细胞生成素产生细胞向肌成纤维细胞的转化是慢性肾脏病贫血与纤维化之间联系的基础,且其转化具有可逆性。近年来研究人员试图为治疗慢性肾脏病贫血与纤维化寻找替代疗法,中药因其独特的优势已越来越多地用于治疗慢性肾脏病。该文主要探讨促红细胞生成素产生细胞与慢性肾脏病贫血和肾纤维化的关系,并对其相关中药研究现状进行阐述。

关键词：促红细胞生成素产生细胞肾性贫血肾间质纤维化慢性肾脏病中药

Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

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Nano-Micro Letters 2025年第1期17卷 281-292页

作者： Xing Wang wei Pi Sheng Hu Haifeng bao Na Yao wei Luo State Key Laboratory of New Textile Materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

血脂代谢紊乱与维持性血液透析患者的心血管并发症

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中国临床康复 2005年第19期9卷 151-153页

作者：申力军魏日胞解放军总医院肾科解放军肾脏病中心暨重点实验室北京市100853

目的:分析血脂主要成分与维持性血液透析患者心血管并发症的关系。资料来源:应用计算机检索Medline数据库1997-01/2004-12与血脂代谢紊乱及终末期肾功能衰竭血液透析心血管并发症相关的文章,检索词“lipid,cardiovasculardisease,chroni... 详细信息

目的:分析血脂主要成分与维持性血液透析患者心血管并发症的关系。资料来源:应用计算机检索Medline数据库1997-01/2004-12与血脂代谢紊乱及终末期肾功能衰竭血液透析心血管并发症相关的文章,检索词“lipid,cardiovasculardisease,chronicrenalfailure”,并限定文章语言种类为English。计算机检索清华全文数据库2001-01/2004-12关于血脂代谢紊乱及终末期肾功能衰竭血液透析心血管并发症相关的文章,限定文章语言种类为中文,检索词“血脂,血液透析,心血管并发症”。资料选择:对资料进行初审,选取包括处理组和对照组的文献,筛除明显不随机的研究,对剩余的文献开始查找全文。纳入标准为①随机对照研究。②实验或临床研究包含平行对照组。排除标准:重复性研究。资料提炼:共收集到329篇关于血脂代谢紊乱及终末期肾功能衰竭血液透析心血管并发症的随机和未随机研究文章,35个实验或临床研究符合纳入标准。排除的294篇文章,211篇为未随机研究或重复性研究,83篇为综述类文章。资料综合:35个试验包括约10521例患者,证实了高三酰甘油、低高密度脂蛋白胆固醇是并发心血管疾病的维持性血液透析患者血脂特点,而血脂异常与老龄、糖尿病等因素一起诱发冠状动脉缺血、动脉粥样斑块形成或动脉硬化等,加速血液透析患者心血管并发症的发生发展。积极的综合康复治疗及药物降脂治疗等可有效纠正血脂异常,并减少终末期肾功能衰竭患者心血管并发症的患病率。结论:血脂代谢紊乱是维持性血液透析患者心血管并发症的主要致病因素之一,通过对血液透析患者采用合适的透析处方、并长期辅以综合康复治疗及药物治疗等措施积极纠正血脂代谢紊乱,可有效降低血液透析患者心血管疾病患病率,提高其生活质量。

关键词：脂类/代谢血液透析心血管疾病/并发症

Protective Effects and Mechanisms of Shenhua Tablet(肾华片)on Toll-Like Receptors in Rat Model of Renal Ischemia-Reperfusion Injury

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Chinese Journal of Integrative Medicine 2019年第1期25卷 37-44页

作者： LI Qing-ping wei ri-bao YANG Xi ZHENG Xiao-yong SU Ting-yu HUANG Meng-jie YIN Zhong CHEN Xiang-mei Department of Nephrology Chinese PLA General Hospital Chinese PLA Institute of Nephrology State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Disease Research

Objective: To investigate the protective effects and potential mechanisms of Shenhua Tablet(肾华片, SHT) on the toll-like receptors(TLRs)-mediated signaling pathways in a rat model of kidney ischemia-reperfusion injury(Iri). Methods: Sixty male Wistar rats were randomly divided into 5 groups: sham surgery, model control, astragaloside(150 mg·kg^(-1)·d^(-1)), low-and high-dose SHT(1.5 and 3.0 g·kg^(-1)·d^(-1), repectively) groups. One week after drug treatment, rats underwent surgery to establish the Iri models. At 24 h and 72 h after the modeling, serum creatinine(Scr) and blood urea nitrogen(BUN) were analyzed; pathological damage were scored after periodic acid-Schiff staining. TLR2, TLR4 and myeloid differentiation factor 88(My D88) protein and m RNA expressions were detected by inmmunohistochemistry, Western blot and qPCR. Tumor necrosis factor α(TNF-α) and interleukin-6(IL-6) protein expressions were detected by enzyme linked immunosorbent assay. Results: Compared with the sham group, the model group exhibited severe change in renal function(Scr: 189.42±21.50, Pries and promote recovery of Iri injuries through suppression of degeneration induced by up-regulation of TLR2 and TLR4 expression leve

关键词： Shenhua Tablet Chinese medicine kidney injury toll-like receptors myeloid differentiation factor 88 ischemia-reperfusion injury

Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： Jie Wang wei Wang Xuheng Chen Junfang bao Qiuyue Hao Heng Zheng Runsheng Xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-wei Li Jian-Hong Shi Tan Li Wan-Su bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

Glycated albumin may be a choice, but not an alternative marker of glycated hemoglobin for glycemic control assessment in diabetic patients undergoing maintenance hemodialysis

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Chinese Medical Journal 2013年第17期126卷 3295-3300页

作者： CHEN Fengskun SUN Xue-feng ZHANG Dong CUI Shao-yuan CHEN Xiang-mei wei ri-bao LU Ju-ming LI Ji-jun LIU Wen-hu ZHANG Dong-liang ZHANG Zhi-min Department of Nephrology First Affiliated Hospital of People's Liberation Army General Hospital Beijing 100048 China Institute of Nephrology People's Liberation Army General Hospital Beijing 100853 China Department of Endocrinology People's Liberation Army General Hospital Beijing 100853 China Department of Nephrology Affiliated Beijing Friendship Hospital of Capital Medical University Beijing 100050 China Department of Nephrology People's Liberation Army the 309th Hospital Beijing 100091 China

Background It has been suggested that glycated hemoglobin （HbAlc） underestimate the actual glycemic control levels in maintenance hemodialysis （MHD） patients, because of anemia and the using of erythropoietin （EPO）; it was recommended that glycated albumin （GA） should be an alternative marker. Therefore, the assessment performances of glycemic control were compared between GA and HbAlc in this research by referring to mean plasma glucose （MPG） in diabetes mellitus （DM） patients undergoing MHD or not. Methods MPG was calculated according to the data registered at enrollment and follow-up 2 months later and corresponding HbAlc, albumin （ALB）, GA, etc. were measured in 280 cases. A case-control study for comparing GA and HbAlc was done among the groups of MHD patients with DM （n=88） and without DM （NDM; n=90）, and non-MHD ones with DM （n=102） using MPG for an actual glycemic control standard. Results In these 3 groups, only for DM patients＇（whether undergoing MHD or not）, GA and HbAlc correlated with MPG significantly （P 〈0.01）. Through linear regression analysis, it could be found that the regression curves of GA almost coincided in MHD and non-MHD patients with DM, because the intercepts （2.418 vs. 2.329） and slopes （0.053 vs. 0.057） were very close to each other. On the contrary, regression curves of HbAlc did not coincide in the two groups, because variance of the slopes （0.036 vs. 0.052） were relatively large. Through comparing receiver operating characteristic （ROC） areas under the curve （AUC）, it could be understood that the assessment performances of GA and HbAlc in MHD patients were lower than those in non-MHD ones, and assessment performance of HbAlc in MHD patients was better than GA （P 〈0.05）. In addition, the effects of Hb and EPO dose on HbAlc, or that of ALB on GA were unobvious in our study. Conclusions Actual glycemic control level in MHD patients with DM may be underestimated by HbAlc, and it could be avoided by GA; however, glycemic evaluating perfo

关键词： maintenance hemodialysis diabetes mellitus glycated albumin glycated hemoglobin

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胰岛素抵抗评价方法及其干预手段的研究进展

中华临床医师杂志（电子版） 2013年第23期7卷 227-229页

作者：王睿魏日胞解放军总医院肾病科肾脏病国家重点学科及国家重点实验室北京100853

胰岛素抵抗是指胰岛素作用的靶器官对胰岛素作用的敏感性下降,即正常剂量的胰岛素产生低于正常生物学效应的一种状态。目前被认为是代谢综合征发生发展的中心环节,与心血管疾病、慢性肾脏病等多种疾病的进展均有关联。胰岛素抵抗的临床... 详细信息

胰岛素抵抗是指胰岛素作用的靶器官对胰岛素作用的敏感性下降,即正常剂量的胰岛素产生低于正常生物学效应的一种状态。目前被认为是代谢综合征发生发展的中心环节,与心血管疾病、慢性肾脏病等多种疾病的进展均有关联。胰岛素抵抗的临床及基础检查评价方法进展相对缓慢,目前确定性好又可操作的方法尚有待研发;近年各科积极着力于探索胰岛素抵抗干预方法,其手段主要涉及药物、饮食及改善生活方式等。在此对胰岛素抵抗评价方法及其干预措施研究进展进行综述。

关键词：胰岛素抵抗诊断干预手段

高糖促进肾小球系膜细胞纤维连接蛋白合成的实验研究

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空军总医院学报 2000年第3期16卷 136-138页

作者：魏日胞杨宏空军总医院肾病科北京100036 军事医学科学院基础医学研究所七室

目的　观察高糖状态下肾小球系膜细胞 (GMC)增殖及纤维连接蛋白 (FN)合成情况。　方法　采用体外 GMC培养 ,噻唑蓝 (MTT)掺入法和细胞计数观察 GMC增殖 ,用 RT— PCR及双抗夹心 EL ISA方法检测 FN的基因及蛋白质水平变化。　结果　高糖... 详细信息

目的　观察高糖状态下肾小球系膜细胞 (GMC)增殖及纤维连接蛋白 (FN)合成情况。　方法　采用体外 GMC培养 ,噻唑蓝 (MTT)掺入法和细胞计数观察 GMC增殖 ,用 RT— PCR及双抗夹心 EL ISA方法检测 FN的基因及蛋白质水平变化。　结果　高糖对 GMC增殖有抑制作用 ,对 FN的合成呈浓度及作用时间依赖性增高。结论　高血糖在糖尿病肾病的发生发展过程中起重要作用。

关键词：肾小球系膜细胞纤维连接蛋白葡萄糖糖尿病性肾病 GMC FN 细胞增殖