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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily Choi Michael QJiang ling wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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Hosoya and Merrifield-Simmons Indices in Random Polyphenyl Chains

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Acta Mathematicae Applicatae Sinica 2021年第3期37卷 485-494页

作者： wei-ling YANG School of Mathematical Sciences Xiamen UniversityXiamen 361005China

The Hosoya index of a graph is the total number of matchings in *** the Merrifield-Simmons index is the total number of independent sets in *** are typical examples of graph invariants used in mathematical chemistry for quantifying relevant details of molecular *** this paper,we obtain explicit analytical expressions for the expectations of the Hosoya index and the Merrifield-Simmons index of a random polyphenyl chain.

关键词： Hosoya index Merrifield-Simmons index random polyphenyl chain

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Hosoya and Merrifield-Simmons Indices in Random Polyphenyl Chains

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Acta Mathematicae Applicatae Sinica 2018年第1期34卷 163-172页

作者： wei-ling YANG School of Mathematical Sciences Xiamen University

The Hosoya index of a graph is the total number of matchings in it. And the Merrifield-Simmons index is the total number of independent sets in it. They are typical examples of graph invariants used in mathematical chemistry for quantifying relevant details of molecular structure. In this paper, we obtain explicit analytical expressions for the expectations of the Hosoya index and the Merrifield-Simmons index of a random polyphenyl chain.

关键词： Hosoya index Merrifield-Simmons index random polyphenyl chain

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A Win-Win Effect for Both the Ferromagnetism and the Dopability of p-Type Doping in ZnO:(Cu+N)

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Chinese Physics Letters 2013年第8期30卷 144-147页

作者： wei ling ZHANG wei-Feng Key laboratory of Photovoltaic Techniques School of Physics&ElectronicsHenan UniversityKaifeng 475001

We investigate the electronic structures and magnetic properties of ZnO doped with N,Cu,and(Cu+N)by using a first principles method and considering the strong correlation *** is interesting to compare these three ***:N has weak p-type doping and unstable ferromagnetism,while ZnO:Cu becomes insulating due to the Jahn–Teller *** and N codoping can not only greatly improve the dopability of p-type doping accompanying the Jahn–Teller fading,but also enhance the ferromagnetism at the same *** calculation results indicate that there is a win-win effect between N and Cu dopants in the ZnO:(Cu+N)system,which could possibly find applications in spintronics besides optoelectronics.

关键词： effect dopant doping

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Configurational information entropy analysis of fragment mass cross distributions to determine the neutron skin thickness of projectile nuclei

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Nuclear Science and Techniques 2022年第9期33卷 21-27页

作者： Hui-ling wei Xun Zhu Chen Yuan College of Physics Henan Normal UniversityXinxiang 453007China

Configurational information entropy(CIE)analysis has been shown to be applicable for determining the neutron skin thickness(δnp)of neutron-rich nuclei from fragment production in projectile fragmentation *** BNN+FRACS machine learning model was adopted to predict the fragment mass cross-sections(σ_(A))of the projectile fragmentation reactions induced by calcium isotopes from ^(36)Ca to ^(56)Ca on a ^(9)Be target at 140MeV/*** fast Fourier transform was adopted to decompose the possible information compositions inσA distributions and determine the quantity of CIE(S_(A)[f]).It was found that the range of fragments significantly influences the quantity of S_(A)[f],which results in different trends of S_(A)[f]~δnp *** linear S_(A)[f]~δnp correlation in a previous study[***.33,6(2022)]could be reproduced using fragments with relatively large mass fragments,which verifies that S_(A)[f]determined from fragmentσAis sensitive to the neutron skin thickness of neutron-rich isotopes.

关键词： Neutron skin thickness Mass cross-section distribution Configurational information entropy Projectile fragmentation reaction

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Dynamic Concept of Returns to Scales and Its Characteristics on Production Frontier in Intersection Form

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Acta Mathematicae Applicatae Sinica 2011年第3期27卷 355-366页

作者： Quan-ling wei Hong Yan Institute of Operations Research and Mathematical Economics Renmin University of China Beijin 100872 China Department of Logistics The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong

This paper gives a dynamic concept and a new non-parametric method for evaluating returns to scale（RTS） of economic units with multiple inputs and *** is frequently noticed that when we increase the input of a decision making unit（DMU） with a certain status of RTS,different status of RTS is *** example,when we increase the input of a DMU with constant RTS under the traditional method,a decreasing RTS is often observed instead of the expected constant *** thus define the RTS of each DMU in both input expansion and contraction regions *** research starts from transferring the production possibility set into the intersection form,by giving the explicit linear inequality representation of production *** RTS structural characteristics of DMUs＇ on the production frontier are *** of RTS of those DMUs on the production frontier include increasing RTS,constant RTS,decreasing RTS,saturated RTS and evidence of *** and suficient conditions for RTS evaluation are *** definition and evaluation method given here provide more detailed economic characteristics of DMU for policy makers.

关键词： DEA production possibility set returns to scale

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Symmetry and monotonicity of positive solutions to Schr?dinger systems with fractional p-Laplacians

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Applied Mathematics(A Journal of Chinese Universities) 2022年第1期37卷 52-72页

作者： MA ling-wei ZHANG Zhen-qiu School of Mathematical Sciences Tianjin Normal UniversityTianjin 300387China School of Mathematical Sciences and LPMC Nankai UniversityTianjin 300071China

In this paper,we first establish narrow region principle and decay at infinity theorems to extend the direct method of moving planes for general fractional p-Laplacian *** virtue of this method,we investigate the qualitative properties of positive solutions for the following Schrodinger system with fractional p-Laplacian{(-△)^(s)_(p)u+au^(p-1)=f(u,v),(-△)^(t)_(p)v+bv(p-1)=g(u,v),where 0

关键词： fractional p-Laplacian Schr?dinger systems direct method of moving planes radial symmetry monotonicity nonexistence

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Call admission control scheme for real-time services in packet-switched OFDM wireless networks

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The Journal of China Universities of Posts and Telecommunications 2008年第1期15卷 80-84页

作者： HU Nan WU wei-ling School of Information Engineering Beijing University of Posts and Telecommunications Beijing 100876 China

A call admission control scheme is proposed for real-time services in packet-switched orthogonal frequency division multiplexing （OFDM） wireless cellular networks. The main idea of the proposed scheme is to use maximum acceptance ratio to maintain maximum channel utilization for real-time services according to the desired packet-level and call- level quality-of-service （QoS） requirements. The acceptance ratio is periodically adjusted by using a time discrete Markov chain and Wiener prediction theory according to the varying traffic load. Extensive simulation results show that this algorithm maintains high channel utilization, even as it guarantees packet-level and call-level QoS requirements for real-time services.

关键词： call admission control OFDM packet transmission delay

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Preparation and polymerization mechanism of dihydroxy-capped PCL,poly(CL-b-PEG-b-CL) and poly(DTC-b-CL-b-DTC)

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Science China Chemistry 2005年第4期48卷 334-342页

作者： CHEN wei ling Jun SHEN Zhiquan Institute of Polymer Science Zhejiang UniversityHangzhou 310027China Institute of Polymer ScienceZhejiang UniversityHangzhou 310027China Institute of Polymer ScienceZhejiang UniversityHangzhou 310027China

The ring opening polymerization of ε-caprolactone (CL) was initiated by glycol and yttrium tri(2,6-di-tert-butyl-4-methylphenolate)s (Y(OAr)3),preparing dihydroxy-capped poly (ε-caprolactone) (PCL) with controllable molecular weight.1H NMR and SEC analyses indicate that two kinds of active species and corresponding PCL with different structures exist in the *** the ratio of glycol to Y(OAr)3 benefits the formation of monofunctional active ***,poly(ethylene glycol) (PEG)/Y(OAr)3 system only contains sole bifunctiona active species to synthesize copolymer of CL with PEG (poly(CL-b-PEG-b-CL)).Dihydroxy capped PCL as macroinitiator can further initiate the polymerization of 2,2-dimethyltrimethylene carbonate (DTC).Thus,triblock copolymer of CL with DTC (poly(DTC-b-CL-b-DTC)) has been prepared.

关键词： dihydroxy-capped PCL, DTC, macroinitiator.

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Immunotherapy of tumor by targeting angiogenesis

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Science China(Life Sciences) 2004年第6期47卷 545-552页

作者： HOU Jianmei TIAN ling wei Yuquan Key Laboratory of Biotherapy of Human Diseases of Ministry of Education West China Hospital of Sichuan universityChengdu 610041China Key Laboratory of Biotherapy of Human Diseases of Ministry of EducationWest China Hospital of Sichuan universityChengdu 610041China Key Laboratory of Biotherapy of Human Diseases of Ministry of EducationWest China Hospital of Sichuan universityChengdu 610041China

Tumor growth and metastasis are angiogenesis-dependent. Anti-angiogenic therapy represents a new strategy for the development of anti-cancer therapies. In recent years, there has been made great progress in anti-angiogenic therapy. As far as the passive immunotherapy is concerned, a recombinant humanized antibody to vascular endothelial growth factor (VEGF)— Avastin has been approved by FDA as the first angiogenesis inhibitor to treat colorectal cancer. For active specific immunotherapy, various strategies for cancer vaccines, including whole en- dothelial cell vaccines, dendritic cell vaccines, DNA vaccines, and peptides or protein vaccines, have been developed to break immune tolerance against important molecules associated with tumor angiogenesis and induce angiogenesis-specific immune responses. This article reviews the angiogenesis-targeted immunotherapy of tumor from the above two aspects.

关键词： angiogenesis, tumor, immunotherapy.

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