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3种包皮环切器的临床应用比较分析

中华男科学杂志 2021年第8期27卷 729-732页

作者：张铭 wei li-juan 重庆大学附属三峡医院泌尿外科重庆404000 Department of Pharmacy Three Gorges Hospital of Chongqing UniversityChongqing 404000China

目的:比较一次性枪式钛钉包皮环切吻合器、一次性包皮环切吻合器和一次性双手柄包皮缝合器环切术治疗包皮过长或包茎患者的临床效果对比。方法:回顾性分析2018年9月至2020年7月在各科室及门诊行包皮环切术的150例患者临床资料。分为一... 详细信息

目的:比较一次性枪式钛钉包皮环切吻合器、一次性包皮环切吻合器和一次性双手柄包皮缝合器环切术治疗包皮过长或包茎患者的临床效果对比。方法:回顾性分析2018年9月至2020年7月在各科室及门诊行包皮环切术的150例患者临床资料。分为一次性枪式钛钉包皮环切吻合器组(枪式吻合器组,n=50)、一次性包皮环切吻合器(环切吻合器组,n=50)和一次性双手柄包皮缝合器(手柄缝合器组,n=50)。比较3种手术的手术时间,术中出血量,伤口完全愈合时间,术中、术后1 h和7 d的视觉疼痛评分,患者术后外观满意度及术后并发症发生率等指标。结果:枪式吻合器组和手柄缝合器组患者手术时间显著长于环切吻合器组(P0.05)。环切吻合器组和手柄缝合器组术中及术后1 h和7 d的视觉模拟评分、术后并发症发生率均大于枪式吻合器组(P<0.05)。手柄缝合器组的脱钉速度显著慢于枪式吻合器组(P<0.05)。结论:枪式吻合器治疗包皮过长或包茎患者的临床效果更具优势,在根据患者包皮结构情况和尊重患者意愿前提下,值得临床推广应用。

关键词：包皮环切器包皮环切术包茎包皮过长临床效果

Hydrothermal Synthesis and Characterization of Double Perovskites RSrMnFeO_6(R=La,Pr,Nd,Sm)

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Chemical Research in Chinese Universities 2010年第4期26卷 517-521页

作者： ZHANG Gang-hua YUAN Hong-ming CHEN Yan li wei-juan YANG Mei-qi FENG Shou-hua State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China

A series of double perovskites RSrMnFeO6（R=La, Pr, Nd, Sm） was synthesized under mild hydrothermal conditions. Crystal growths of the samples were sensitive to alkalinity, temperature, filling fraction, and composition of initial reaction mixture. The desired series of compounds belongs to the class of AA＇BB＇O6 perovskites with a random distribution of Mn and Fe atoms over the B-cation sub-lattice. Their structures show the distorted orthorhombic symmetry with space group Pnma. The shapes and sizes of the crystals were analyzed on a Rigaku JSM-6700F by scanning electron microscopy. Analysis done by XPS, Mossbauer spectroscopy and iodometric titration reveals that Mn and Fe ions have ＋4 and ＋3 oxidation states, respectively.

关键词： Double perovskites Orthorhombic Hydrothermal synthesis

liTAF Promotes Atherosclerotic Plaque Formation by Stimulating the NF-κB Inflammatory Pathway

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Current Medical Science 2023年第6期43卷 1201-1205页

作者： wei-juan li Wen-ping ZHOU Xu-yong li Xiao-li JIANG Yun-chao DENG Jie SHEN Han XIE Gang TAN ling HUANG Hui ZHANG Department of Cardiology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430014China

Objective lipopolysaccharide-induced tumor necrosis factor-αfactor(liTAF)protein is a newly discovered inflammatory *** study aims to study the role of liTAF in the formation of *** A total of 10 C57BL/6J mice and 10 C57BL/6J mice with knockout of liTAF gene(C57BL/6J–liTAF–)were divided into two groups:the control group and the liTAF^(−/−)*** animals were accommodated for 16 weeks and then euthanized with their hearts and aortas isolated ***,the roots of the mouse aorta were cryosectioned and stained with Oil Red O staining and immunohistochemical staining(CD68,α-SMA,and Masson),*** area of Oil Red O staining and the proportion of positive expression after immunohistochemical staining were then compared between the control and liTAF^(−/−)*** the same time,the blood of mice was collected for the extraction of proteins and *** proteins and RNA were used to detect the expression of major molecules of the NF-κB inflammatory pathway in mice in the control group and the liTAF^(−/−)group by Western blotting and *** Oil Red O staining of the aortic root sections of the mice in each group revealed that the area of atherosclerotic plaques in the liTAF^(−/−)group was substantially lower than that in the control group(PliTAF^(−/−)group was significantly lower than that in the control group,whereas the results were reversed following Masson staining(PliTAF^(−/−)group than in the control group(PliTAF^(−/−)*** liTAF might participate in the formation of atherosclerotic plaque through the NF-κB pathway and play a promoting role in the formation of atherosclerosis.

关键词： lipopolysaccharide-induced tumor necrosis factor-αfactor nuclear factor-kappaB inflammation atherosclerosis apoptosis

Arterioles in cerebral amyloid angiopathy and vascular dementia

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Chinese Medical Journal 2009年第24期122卷 2985-2988页

作者： ZHU Guang-ming ZHANG wei-wei liU Ying li juan Department of Neurology Beijing Military General HospitalBeijing 100700 China

Background Small cerebrovascular lesions are one of the most important factors in cerebral amyloid angiopathy （CAA） and vascular dementia （VaD）. We analyzed the difference of arteriolar pathology between CAA patients （CAAs） and vascular dementia patients without CAA （VaDs）. Methods Ten deceased CAAs and twelve deceased VaDs were available for this study. Five deceased patients without known cerebrovascular diseases served as controls. These patients were all autopsy cases. All transversely cut arterioles in the gray matter and white matter with an external diameter equal to or larger than 30 um and with a maximum of 300 um were examined. The internal and external diameters of arterioles were measured. Results The external diameter of gray matter arterioles in the CAAs was significantly greater than in controls. In gray matter arterioles, the diameter of the lumen in VaDs was markedly smaller than in the CAAs, whereas there was no significant difference between CAAs and controls. CAAs and VaDs may cause remarkable thickening of the arteriolar walls in either white matter or gray matter. The sclerotic index of arterioles in VaDs was significantly greater than in CAAs and controls. Conclusions Stenosis of arterioles occurred in both CAA and VaD, but the tendency was greater in VaD. Arterioles of CAA were also expanded in gray matter, which may be related to lobar hemorrhage. The loss and/or degeneration of vascular smooth muscle cells was predominant in CAA, while the over-proliferation of vascular smooth muscle cells was areater in VaD.

关键词： arterioles cerebral amyloid angiopathy vascular dementia

Sequence-activated chemiluminescence probes: programmable illumination for high-contrast in vivo sensing and imaging

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Science China Chemistry 2025年第01期 26-34页

作者： Yutao Zhang juan li wei-Hong Zhu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

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Therapeutic effect of interleukin-10 on CCI_4-induced hepatic fibrosis in rats

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World Journal of Gastroenterology 2006年第9期12卷 1386-1391页

作者： Yue-Hong Huang Hei-Na Shi wei-Da Zheng li-juan Zhang Zhi-Xin Chen Xiao-Zhong Wang Department of Gastroenterology Union Hospital of Fujian Medical University Fuzhou 350001 Fujian Province China

AIM： To study the therapeutic effect of exogenous interleuldn-10 on CCl4-induced hepatic fibrosis in rats and its passible mechanisms. METHODS： Fourty-seven SD rats were randomly divided into control group （group N） and CCl4-induced hepatic fibrosis model group （group C）. After CCl4 was given for 9 wk, the model group was divided into three groups. Rats in group H were put to death immediately, rats in group T were treated with IL-10 for another three wk and then put to death, rats in group R recovered after three weeks and were then killed. The degree of hepatic fibrosis was measured by HE staining and histological activity index （HAI）. Histological activity index （HAI）, change of collagen types Ⅰ and Ⅲ were measured by Picrosirius staining. The expression of TNF-α, HHP-2 and TIMP-1 in liver tissue was measured by S-P immunohis tochemistry.RESULTS： CCl4- induced experimental rat hepatic fibrosis model was established successfully. The degree of hepatic fibrosis was markedly lower in group T than in groups H and R, and there was no difference between the two groups. The expression of collagen types I and III was significantly suppressed in group T and was slightly suppressed in groups H and R. The positive levels of TNF-α, HHP-2 and TIHP-1 in group H increased significantly compared to those in group N （P〈0.01）. The positive signals decreased significantly in groups T and R （P〈0.01）, but positive score was significantly lower in group T than in group R （P〈 0.01）. CONCLUS10N： Exogenous IL-10 can reverse CCl4-induced hepatic fibrosis in rats. IL-10 may exert its reversible effects on hepatic fibrosis by blocking CCl4-induced inflammation, inhibiting expression of HHP-2 and TIMP-1 and promoting resolution of collagen types Ⅰ and Ⅲ.

关键词： Animals Carbon Tetrachloride Collagen Type I Collagen Type III Immunohistochemistry Interleukin-10 liver liver Cirrhosis Male Matrix Metalloproteinase 2 Rats Rats, Sprague-Dawley Tissue Inhibitor of Metalloproteinase-1 Tumor Necrosis Factor-alpha

奥氏体变形条件下低碳微合金钢中的贝氏体相变

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金属热处理 2005年第6期30卷 70-73页

作者：李维娟李胜利王方鞍山科技大学材料科学与工程学院辽宁鞍山114044

采用Gleeble1500热模拟机对低碳MnNbTi钢进行了奥氏体区变形和变形后的冷却试验,借助于光学显微镜和扫描电镜分析了变形和冷却速度对显微组织的影响。结果表明,随着奥氏体形变量的增大,奥氏体向铁素体的相变增加,向贝氏体的相变减少,贝... 详细信息

采用Gleeble1500热模拟机对低碳MnNbTi钢进行了奥氏体区变形和变形后的冷却试验,借助于光学显微镜和扫描电镜分析了变形和冷却速度对显微组织的影响。结果表明,随着奥氏体形变量的增大,奥氏体向铁素体的相变增加,向贝氏体的相变减少,贝氏体中的铁素体和小岛由细长条状逐渐向近等轴状变化,铁素体板条间的小岛逐渐变化为存在于某些铁素体的晶界上。随着变形后的奥氏体冷却速度增大,铁素体量减少,贝氏体量增加,粒状贝氏体也逐渐由板条贝氏体所取代。

关键词：低碳微合金钢奥氏体变形贝氏体

压应力对Cr-Mo钢连续冷却贝氏体相变的影响

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材料热处理学报 2007年第B08期28卷 161-164页

作者：渠秀娟李维娟巨东英辽宁科技大学材料科学与工程学院

采用Gleeble-1500热模拟试验机测量了Cr-Mo钢在1～90℃/s的冷却速度下奥氏体连续冷却过程中的温度-膨胀曲线,用origin软件进行数据处理,获得了实验钢的CCT曲线;同时测量了施加轴向载荷为0、40MPa、80MPa和120MPa的压应力时奥氏体连续冷... 详细信息

采用Gleeble-1500热模拟试验机测量了Cr-Mo钢在1～90℃/s的冷却速度下奥氏体连续冷却过程中的温度-膨胀曲线,用origin软件进行数据处理,获得了实验钢的CCT曲线;同时测量了施加轴向载荷为0、40MPa、80MPa和120MPa的压应力时奥氏体连续冷却过程中的温度.膨胀曲线,冷却速度分别为50℃/s、70℃/s和90℃/s。利用杠杆定律,根据不同温度下的膨胀量计算得到贝氏体相变动力学曲线,研究了压应力对贝氏体相变动力学和贝氏体相变温度的影响。结果表明,在以冷却速度为50℃/s和70℃/s连续冷却时,压应力抑制前期阶段的贝氏体相变,促进后期阶段的贝氏体相变:在以冷却速度为90℃/s连续冷却时,压应力对整个贝氏体相变过程都有促进作用,特别是应力较大时;压应力使贝氏体相变开始温度B_s升高,贝氏体相变终了温度B_f降低。

关键词： Cr-Mo钢压应力贝氏体相变动力学

从《歧路灯》看古代女性在家庭教育中的尴尬地位

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河南大学学报（社会科学版） 2009年第4期49卷 64-69页

作者：魏娟莉许昌学院文学院河南许昌461000

《歧路灯》在表现家庭教育时,除父亲外的另一主要施教者母亲,对其子的误入歧途没有尽到应有的教育职责。究其原因,中国传统"女教"所赋予女性的"三从四德"等规范要求与其在家庭中"相夫教子"的职责是极其矛盾的,古代女性在家庭教育中所担... 详细信息

《歧路灯》在表现家庭教育时,除父亲外的另一主要施教者母亲,对其子的误入歧途没有尽到应有的教育职责。究其原因,中国传统"女教"所赋予女性的"三从四德"等规范要求与其在家庭中"相夫教子"的职责是极其矛盾的,古代女性在家庭教育中所担负的责任与所拥有的权力以及自身的能力也是极不相称的。如此矛盾现象使得古代女性在家庭教育中处于一种极其尴尬的地位,由此也形成了家庭子女教育的一种严重缺憾。

关键词：《歧路灯》古代女性家庭教育女教三从四德