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益气化痰活血类中药干预2型糖尿病伴颈动脉病变的Meta分析

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世界中西医结合杂志 2025年第1期20卷 16-27页

作者：肖瑶潘欣渝徐明君曾贵兴魏军平北京中医药大学北京100029 中国中医科学院广安门医院北京100053

目的系统评价益气化痰活血类中药治疗2型糖尿病(Type 2 diabetes mellitus,T2DM)伴颈动脉病变的疗效和安全性。方法检索中国知网(CNKI)、万方数据库(Wanfang Data)、维普中文期刊数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed、Web... 详细信息

目的系统评价益气化痰活血类中药治疗2型糖尿病(Type 2 diabetes mellitus,T2DM)伴颈动脉病变的疗效和安全性。方法检索中国知网(CNKI)、万方数据库(Wanfang Data)、维普中文期刊数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed、Web of science、the Cochrane Library建库至2023年9月18日期间,公开发表的中医益气化痰活血类中药治疗T2DM伴颈动脉病变的随机对照试验。由两名评价员独立进行文献筛选和资料提取,并采用Cochrane偏倚风险评估工具对纳入的研究进行文献质量评价。运用RevMan 5.4软件进行Meta分析。结果共纳入27篇研究,2574例受试者。Meta分析结果显示:与对照组相比,益气化痰活血类中药联合西药常规治疗在提高总有效率[OR=2.69,95%CI(2.09,3.46)]、降低颈动脉内膜中层厚度(Carotid intima-media thickness,CIMT)[MD=-0.15,95%CI(-0.20,-0.10)]、斑块面积[MD=-0.25,95%CI(-0.38,-0.12)]、斑块积分[MD=-0.39,95%CI(-0.56,-0.21)]、改善胰岛素抵抗[MD=-0.48,95%CI(-0.59,-0.37)]、糖化血红蛋白[MD=-0.45,95%CI(-0.70,-0.19)]、总胆固醇[MD=-0.43,95%CI(-0.66,-0.21)]、低密度脂蛋白胆固醇[MD=-0.32,95%CI(-0.43,-0.21)]、降低同型半胱氨酸[MD=-2.30,95%CI(-3.15,-1.44)]和高敏C反应蛋白[MD=-1.67,95%CI(-2.38,-0.95)]方面更具优势,差异有统计学意义(P<0.01),且安全性与单纯西药常规治疗无明显差异[MD=0.82,95%CI(0.43,1.55),P=0.53]。结论益气化痰活血类中药可以有效治疗T2DM伴颈动脉病变,且不增加不良反应风险。然而由于所纳入文献质量欠佳,该结论还有待大样本、多中心、高质量的随机对照临床试验进一步证实。

关键词：益气化痰活血 2型糖尿病颈动脉硬化临床疗效安全性 Meta分析

Sharp Isolated Toughness Bound for Fractional(k,m)-Deleted Graphs

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Acta Mathematicae Applicatae Sinica 2025年第1期41卷 252-269页

作者： wei GAO wei-fan WANG Yao-jun CHEN School of Mathematics Hohai UniversityNanjing 210098China Department of Mathematics Zhejiang Normal UniversityJinhua 321004China Department of Mathematics Nanjing UniversityNanjing 210093China

A graph G is a fractional(k,m)-deleted graph if removing any m edges from G,the resulting subgraph still admits a fractional *** k≥2 and m≥1 be ***[2m/k]^(*)=[2m/k]if 2m/k is not an integer,and[2m/k]^(*)=[2m/k]-1 if 2m/k is an *** this paper,we prove that G is a fractional(k,m)-deleted graph if δ(G)≥k+m and isolated toughness meets I(G)>{3-1/m,if k=2 and m≥3,k+[2m/k]^(*)m+1-[2m/k]^(*);***,we show that the isolated toughness bound is tight.

关键词： graph isolated toughness fractional k-factor fractional(k,m)-deleted graph

Hausdorff Measure of Space Anisotropic Gaussian Processes with Non-stationary Increments

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Acta Mathematicae Applicatae Sinica 2025年第1期41卷 114-132页

作者： jun WANG Zhen-long CHEN wei-jie YUAN Guang-jun SHEN School of Mathematics and Physics Anhui Polytechnic UniversityWuhu 241000China School of Statistics and Mathematics Zhejiang Gongshang UniversityHangzhou 310018China Department of Mathematics Anhui Normal UniversityWuhu 241000China

Let X={X(t),t∈R+} be a centered space anisotropic Gaussian process values in R^(d) with non-stationary increments,whose components are independent but may not be identically *** certain conditions,then almost surely c_(1)≤ϕ-m(X([0,1]))≤c_(2),where ϕ denotes the exact Hausdorff measure associated with function ϕ(s)=s1/α_(k)+Σ_(i=1)k(1-αi/αk)log log 1/s for some 1≤k≤d,(α_(1),…,α_(d))∈(0,1]^(d).We also obtain the exact Hausdorff measure of the graph of X on[0,1].

关键词： Hausdorff measure self-similar Gaussian processes non-stationary increment Lamperti theorem

Approved delivery strategies for biopharmaceuticals

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Chinese Chemical Letters 2025年第2期36卷 69-79页

作者： Makhloufi Zoulikha Zhongjian Chen jun Wu wei He School of Pharmacy China Pharmaceutical University Shanghai Skin Disease Hospital Tongji University School of Medicine Department of Geriatric Cardiology Jiangsu Provincial Key Laboratory of Geriatrics The First Affiliated Hospital of Nanjing Medical University

In recent years, biopharmaceuticals have witnessed remarkable advancements, transforming the landscape of therapeutic interventions. Biopharmaceuticals encompassing therapeutics generated through cutting-edge biotechnological methods have shown promising therapeutic outcomes. However, their clinical success hinges significantly on overcoming drug delivery challenges related to stability, intracellular delivery, immunogenicity, and pharmacokinetic properties. Herein, we provide an overview of various marketed macromolecules, including nucleic acids, and immunotherapeutic agents such as cytokines and monoclonal antibodies, as well as other therapeutic peptides/proteins like enzymes, hormones, and coagulation factors. Our primary focus is on elucidating the delivery challenges associated with these macromolecules and highlighting the pivotal role played by drug delivery platforms in the development of currently marketed products, offering valuable insights for both scientific research and the pharmaceutical industry.

关键词： Biopharmaceuticals Drug delivery Monoclonal antibodies Nucleic acids Proteins

中西医结合防治糖尿病临床研究现状及发展趋势

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中国中西医结合杂志 2021年第1期41卷 13-15页

作者：魏军平中国中医科学院广安门医院内分泌科北京100053

糖尿病作为与生活方式和环境因素密切相关的慢性非传染性疾病,患者数量迅速增长。2019年国际糖尿病联盟发布的最新报告,目前全球糖尿病粗患病率为9.3%,患者人数约4.63亿,预计到2030年患病率将持续增长至10.2%,患者将达到5.784亿,每10名... 详细信息

糖尿病作为与生活方式和环境因素密切相关的慢性非传染性疾病,患者数量迅速增长。2019年国际糖尿病联盟发布的最新报告,目前全球糖尿病粗患病率为9.3%,患者人数约4.63亿,预计到2030年患病率将持续增长至10.2%,患者将达到5.784亿,每10名成年人中就有1人患糖尿病,全世界12%健康相关医疗支出被糖尿病所占据,中国位居第二,大约为1090亿美元[1]。

关键词：慢性非传染性疾病医疗支出患者数量粗患病率持续增长环境因素国际糖尿病联盟中西医结合防治

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan ping Yu Emily Choi Michael QJiang Ling wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

Use of forestry waste as an alternative raw material for generating metallurgical coke

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Journal of Iron and Steel Research International 2025年第1期32卷 25-39页

作者： Lin-bo Qin wei Qin An-yi Wang Ling Shi jun Han College of Resources and Environment Engineering Wuhan University of Science and TechnologyWuhan430081HubeiChina Hubei Key Laboratory of Industrial Fume and Dust Pollution Control Jianghan UniversityWuhan430056HubeiChina Hubei Key Laboratory for Efficient Utilization and Agglomeration of Metallurgic Mineral Resources Wuhan University of Science and TechnologyWuhan430081HubeiChina

Forestry waste(FW)is a significant renewable energy source in *** substitution of coal blends(BC)with forestry waste to produce metallurgical coke was investigated aiming at expanding alternative resources and reducing CO_(2)emissions in ironmaking *** BC with different ratios of FW were carbonized in a fixed bed reactor,and the physicochemical structure of the coke derived from FW/BC co-carbonization was characterized by Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,solid-state^(13)C nuclear magnetic resonance,optical microscopy,and scanning electron *** results reveal that the suitable incorporation of FW in BC is 10 wt.%,and the index of coke quality exhibits a good correlation with the optical anisotropy index and the aromaticity of the as-obtained *** partial substitution of BC with FW exhibits potential benefits for colloid formation,owing to the higher hydrogen in ***,as the substitution ratio of BC with FW increases,it inhibits coke agglomeration due to more tortuous stacked structures formation during volatile releasing ***,it was identified that the substitution of higher BC ratios with FW results in the partial replacement of aromatic carbons by oxygenlinked carbons and aliphatic *** substitution leads to a reduction in the aromaticity of the as-obtained coke.

关键词： Metallurgical coke Forestry waste Coal blend Co-carbonization Chemical structure

A Multi-Condition Sequential Network Ensemble for Industrial Energy Storage Prediction Considering the Condition Switching Characteristics

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IEEE/CAA Journal of Automatica Sinica 2025年第2期12卷 369-380页

作者： Tianyu Wang Fan Zhou Yangjie Wu jun Zhao wei Wang IEEE the School of Control Science and Engineering Dalian University of Technology the School of Information Science and Engineering Dalian Polytechnic University

As a crucial storage and buffering apparatus for balancing the production and consumption of byproduct gases in industrial processes, accurate prediction of gas tank levels is essential for optimizing energy system scheduling. Considering that the continuous switching of the pressure and valve status(mechanism knowledge) would bring about multiple working conditions of the equipment, a multi-condition time sequential network ensembled method is proposed. In order to especially consider the time dependence of different conditions, a centralwise condition sequential network is developed, where the network branches are specially designed based on the condition switching sequences. A branch combination transfer learning strategy is developed to tackle the sample imbalance problem of different condition data. Since the condition or status data are real-time information that cannot be recognized during the prediction process, a pre-trained and ensemble learning approach is further proposed to fuse the outputs of the multi-condition networks and realize a transient-state involved prediction. The performance of the proposed method is validated on practical energy data coming from a domestic steel plant, comparing with the state-of-the-art algorithms. The results show that the proposed method can maintain a high prediction accuracy under different condition switching cases, which would provide effective guidance for the optimal scheduling of the industrial energy systems.

关键词： Ensemble learning industrial energy prediction multi-working condition structural deep network transfer learning

Comparisons of{100}texture improvement and formability in hot-rolled non-oriented electrical steel by austenite-ferrite phase transformation and shear deformation

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Journal of Iron and Steel Research International 2025年第1期32卷 171-185页

作者： Chi-hao Yu Hong-jiang Pan Yan-ping Zhao De-ting Tang Hai-jun Wang Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093YunnanChina School of Electronics and Information Engineering Anshun UniversityAnshun561000GuizhouChina School of Metallurgical Engineering Anhui University of TechnologyMa’anshan243032AnhuiChina

Over the years,the high magnetic induction of industrial Mn-added electrical steel is assumed to be the enhancement of{100}texture derived from its austenite-ferrite phase transformation during hot rolling(phase transformation(PT)method).However,it is still undetermined without straightforward experimental *** reason for{100}texture improvement of Mn-added electrical steel is experimentally confirmed due to the recrystallization induced by the austenite-ferrite phase transformation during hot ***,a more promising methodology to further improve{100}texture and formability of hot-rolled electrical steel is promoted by the control of hot rolling deformation condition(shear deformation(SD)method).The results show that the nucleation mechanisms of{100}oriented recrystallized grains are different in the samples by SD and PT methods,which are in-depth shear deformation and austenite-ferrite phase transformation,*** this case,coarse{100}oriented recrystallized grains and low residual stress are obtained in the sample by SD method,which is responsible for its superior{100}texture and *** contrast,the sample by PT method forms fine recrystallized grains with random orientations and accumulates severe residual stress.

关键词： Non-oriented electrical steel {100}texture Formability Austenite-ferrite phase transformation Shear deformation