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In situ measurement of environmental γ radiation dose rates of key nuclides for large radioactive surface sources

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Nuclear Science and Techniques 2025年第1期36卷 69-79页

作者： Ze-Qian Wu Jian Sun wei-Qi Huang Bai-Rong Wang Jin-Xing Cheng Jiang-Feng Wu Yong-hong Wang Biao Yuan Sheng Qi Kun Shan Institute of NBC Defence Beijing 102205China Beijing New-High Technology Academy Beijing 100094China

To monitor nuclear and radiation emergencies,it is crucial to obtain accurate in situ measurements of the environmentalγ radiation dose rate from key radionuclides,particularly for large radioactive surface *** methods currently used for measuring dose rates are inadequate for obtaining the dose rates of key radionuclides and have large angular response errors when monitoring surface *** address this practical problem,this study proposes three methods for measuring the dose rate:the weighted peak total ratio,mean value regression,and numerical integration *** methods are based on energy-spectrum measurement data,and they were theoretically derived and numerically ***,a 1-m-long hexagonal radioactive surface source was integrated into a larger surface *** situ measurement experiments were conducted on a large radioactive surface source using a dose-rate meter and a portable HPGespectrometer to analyze the errors of the three aforementioned methods and verify their validity.

关键词： Environmentalγradiation dose rate HPGespectrometer Key radionuclides Radioactive surface source

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一类生物流体力学模型的稳定性

力学季刊 2004年第1期25卷 101-106页

作者：陈书宇姚伟丁光宏复旦大学力学与工程科学系上海200433

在研究颅内压集中参数模型的基础上,改进自适应的龙格-库塔法对一类生物流体力学模型进行数值模拟。通过合理控制计算量,得到了微分方程近似解的局部截断误差的估计。使用矩阵特征值分析微分方程的稳定性,在实际生理范围内变化模型参数... 详细信息

在研究颅内压集中参数模型的基础上,改进自适应的龙格-库塔法对一类生物流体力学模型进行数值模拟。通过合理控制计算量,得到了微分方程近似解的局部截断误差的估计。使用矩阵特征值分析微分方程的稳定性,在实际生理范围内变化模型参数,得到特征值随参数变化的关系,指出模型中存在实部为正的特征值。文章还讨论了控制矩阵特征值的变化对数值方法稳定步长的影响,并得到步长的取值范围。通过理论分析,得到控制方程的解随时间的发展和模型中生理参数的选取相关。分析了特征值变化的稳定性和参数的关系,并对模型进行改进,讨论其稳定性的情况。

关键词：生物力学生物流体力学模型数值模拟血液动力学特征值条件数稳定性

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi wei hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

Cauda equina syndrome with urinary retention as a postoperative complication of lumbar spine surgery:A case report

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World Journal of Clinical Cases 2025年第10期13卷 40-45页

作者： Kai-Wu Yang wei-hong Lai Da-wei Huang Department of Urology Chiayi Christian HospitalChiayi 600566Taiwan Department of Neurosurgery Chiayi Christian HospitalChiayi 600566Taiwan

BACKGROUND Cauda equina syndrome(CES)is characterized by a group of symptoms that may be caused by inflammation,spinal cord compression,venous congestion,or *** syndrome is commonly an indication for surgical intervention but has not been determined as a postoperative complication following surgery for lumbar spine *** SUMMARY To report the case of a 54-year-old male patient who had CES following spinal surgery,with no obvious compression lesions found during re-exploration,suggesting that vascular insufficiency may have contributed to the ***,a series of urodynamic studies on bladder recovery patterns in such complications have also been *** Postoperative CES requires urgent imaging and exploration to rule out compression;noncompressive cases,including vascular insufficiency may performed conservative management.

关键词： Cauda equina syndrome Lumbar spine surgery Urinary retention Urodynamic study Postoperative complication Case report

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基因疗法研究的新进展

科技情报开发与经济 2006年第6期16卷 141-142页

作者：孙毅魏红光信阳师范学院生命科学学院河南信阳464000 信阳市第三人民医院河南信阳464000

指出基因疗法是分子生物学与医用分子遗传学结合的产物,介绍了基因疗法临床应用研究进展,展望了基因疗法的前景,特别强调了上海复旦大学新近取得的基因研究重大突破在推动基因疗法快速发展中的作用。

关键词：基因疗法临床应用分子生物学医用分子遗传学

Both 20S and 19S proteasome components are essential for meiosis in male mice

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Zoological Research 2025年第01期 27-40页

作者： Ting-Ting Han Li-Ying Wang Qiu-Xing Zhou wei wei Yan-Jie Ma Ying-hong Chen wei Li Zhen-Yu Ju Chao Liu Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative Medicine Department of Developmental & Regenerative Medicine College of Life Science and Technology Jinan University guangzhou Women and Children's Medical Center Guangzhou Medical University

The proteasome, an evolutionarily conserved proteolytic complex comprising the 20S core particle and 19S regulatory particles, performs both shared and distinct ***, a highly complex developmental process, relies on proteasome activity at multiple stages to regulate protein turnover. In this study, we selected the20S subunit PSMA1 and 19S regulatory subunit PSMD2 to investigate the potential functions of the proteasome in spermatogenesis. Using Psma1-EGFP and Psmd2-mCherry knock-in mouse models, we confirmed the expression of both subunits in all spermatogenic cell types,with pronounced presence in early germ cell *** further clarify their functional significance, we specifically knocked out Psma1 and Psmd2 in germ *** of either PSMA1 or PSMD2 led to disrupted spermatogenesis, characterized by the complete absence of sperm in the epididymis. Subsequent analysis indicated that loss of these proteasome components impaired meiotic initiation. Psma1 and Psmd2 knockout germ cells showed accumulation of DMRT1, a key regulator of mitosis-to-meiosis transition, leading to a reduction in STRA8 levels and consequent disruption of meiosis initiation. This study sheds light on the molecular mechanisms that govern meiotic initiation and identifies potential genes associated with male infertility.

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Uncoupling of nutrient metabolism and cellular redox by cytosolic routing of the mitochondrial G-3-P dehydrogenase Gpd2 causes loss of conidiation and pathogenicity in Pyricularia oryzae

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Journal of Integrative Agriculture 2025年第2期24卷 638-654页

作者： Wenqin Fang Yonghe hong Tengsheng Zhou Yangdou wei Lili Lin Zonghua Wang Xiaohan Zhu State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops College of Plant ProtectionFujian Agriculture and Forestry University Fuzhou Institute of Oceanography Minjiang University Department of Biology College of Arts and ScienceUniversity of Saskatchewan Department of Plant Science University of Manitoba

Oxidation of self-stored carbohydrates and lipids provides the energy for the rapid morphogenetic transformation during asexual and infection-related development in Pyricularia oryzae,which results in intracellular accumulation of reducing equivalents NADH and FADH2,requiring a cytosolic shuttling machinery towards *** previous studies identified the mitochondrial D-lactate dehydrogenase MoDld1 as a regulator to channel the metabolite flow in conjunction with redox ***,the regulator（s） facilitating the cytosolic redox balance and the importance in propelling nutrient metabolite flow remain *** G-3-P shuttle is a conserved machinery transporting the cytosolic reducing power to *** ***,the mitochondrial G-3-P dehydrogenase Gpd2 was required for cellular NAD+/NADH balance and fungal *** this study,we relocate the mitochondrial G-3-P dehydrogenase Gpd2 to the cytosol for disturbing cytosolic redox *** results showed overexpression of cytosolic gpd2Δmtswithout the mitochondrial targeted signal （MTS） driven by Ribosomal protein 27 promoter （PR27） exerted conflicting regulation of cellular oxidoreductase activities compared to theΔModld1 deletion mutant by RNA-seq and prevented the conidiation and pathogenicity of ***,overexpression of gpd2Δmtscaused defects in glycogen and lipid mobilization underlying asexual and infectious structural development associated with decreased cellular NADH production and weakened anti-oxidation ***-seq and non-targeted metabolic profiling revealed down-regulated transcriptional activities of carbohydrate metabolism and lower abundance of fatty acids and secondary metabolites in RP27:gpd2Δ***,our studies indicate the essential role of cytosolic redox control in nutrient metabolism fueling the asexual and infection-related development in ***.

关键词： Pyricularia oryzae mitochondrial G-3-P dehydrogenase NAD + /NADH balance fungal virulence mitochondrial targeted signal

Soil Carbon Restoration and Its Influencing Factors in Coal Mining Areas of Yellow River Basin：A Meta-analysis

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Huanjing Kexue/Environmental Science 2025年第3期46卷 1690-1702页

作者： Sun, hong-wei Yan, Mei-Fang College of Environment and Ecology Taiyuan University of Technology Jinzhong030600 China

Coal mining has caused notable disturbance and destruction to the ecosystem，leading to intensified regional carbon emissions. Ecological restoration of abandoned coal mines can improve the physical and chemical properties of damaged soil and increase soil carbon storage. Therefore，ecological restoration of coal mine areas is crucial for improving regional carbon sink levels and environments. Currently，most studies on ecological restoration in Chinese coal mining areas are scattered across the major coal-producing provinces in the Yellow River Basin. Its effect on soil carbon sequestration at a basin scale must be crucially elucidated. In this study，we focused on changes in soil physicochemical properties and enzyme activities after vegetation restoration using an integrated analysis method，combined with climate and soil characteristics in the Yellow River Basin’s coal mining areas to reveal the major factors affecting soil carbon restoration. Our results showed that：① Soil physicochemical properties and enzyme activities were improved significantly after ecological restoration;however，some differences were present among different soil layers. ② Soil organic carbon（SOC），total nitrogen，and alkali-hydrolyzed nitrogen increased by 62.2%，40.5%，and 36.0%，respectively，showing an overall increasing trend with increasing restoration years. From the perspective of vegetation type，mixed forest had the largest increment in SOC. ③ The increase in nitrogen and phosphorus content improved soil fertility and helped to increase soil carbon input from vegetation litter，thus promoting the restoration of the soil organic carbon pool. In addition，average annual temperature and precipitation along with soil type also played important roles affecting soil C restoration. In the future，based on climate and soil characteristics of specific mining areas，suitable vegetation types should be selected from a perspective of C sequestration to enhance C sink of the whole basin. © 2025 Science Press

关键词： Carbon sequestration

Development and application prospect of stem cell combined with 3D printing technology for oral disease

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BIOCELL 2025年第1期49卷 45-59页

作者： YIXIAN YOU YIHUNG LEE YUSHIN HU YOUHUI XU JOUCHEN CHEN wei JIANG CHANGHAI LIU ENQIANG CHEN hong TANG HUA ZHANG DONGBO WU Center of Infectious Diseases West China Hospital of Sichuan UniversityChengdu610041China West China College of Stomatology Sichuan UniversityChengdu610041China West China School of Medicine Sichuan UniversityChengdu610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengdu610041China

With organ transplantation facing many dilemmas,tissue and organ regeneration as an alternative has bright *** regenerative medicine,Three-dimensional(3D)printing technology and stem cells has been widely applied to the treatment of diseases related to tissue or organ replacement in dentistry,***,there are very few studies on the combination of the two,and even fewer clinical studies have been reported in *** this review,the current oral tissue engineering in vivo and in vitro based on 3D printing and stem cell technology will be summarized,and the discussion on the development prospects of this research direction will be ***,the working principles and advantages&disadvantages of several types of 3D printers,as well as the mechanism of stem cells in tissue engineering will be *** review provides clinicians and researchers with the current state of research and trends in the combination of stem cells and 3D printing technology to treat oral-related *** the future,3D bioprinters are poised for ongoing innovation with the advancement of relevant technologies,catalyzing an increase in clinical studies focused on treating oral diseases using stem cells and 3D ***,these developments will further advance the field of oral tissue engineering.

关键词： Stem cells 3D printing Tissue engineering Oral diseases