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Temperature field calculation of rail flash welding

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High-Speed Railway 2024年第2期2卷 116-121页

作者： Rui Xu Min Zhang Zhenkun Gao guo Zhao wei ding Shouming Wang peng Zhang Xiang Liu Jingjing Li Material science&Engineering Research Center School of MechanicalElectronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Institute of Metals and Chemistry China Academy of Railway Sciences Group Co.Ltd.Beijing 100081China department of Industrial and Manufacturing Engineering Pennsylvania State UniversityUniversity ParkPA 16802USA

The forging stage of rail flash welding has a decisive influence on joint strength,and the study of the temperature distribution in the process has an important role in further improving joint *** this paper,three calculation methods for the temperature field are ***,the finite element model of the temperature field before forging rail flash welding is established by using the transient heat module of Ansys software and verified by infrared temperature ***,the temperature distribution of different parts of the rail before flash welding is obtained by using infrared thermal imaging ***,Matlab software is used to calculate the temperature of the non-measured ***,the temperature distribution function along the rail axis is fitted through the temperature measurement *** temperature distribution before the top forging of the rail flash welding can be used to analyze the joint and heat-affected zone organization and properties effectively and to guide the parameter setting and industrial production.

关键词： Flash welding Temperature field Joint strength Software calculation

A novel model-free approach for reconstruction of time-delayed gene regulatory networks

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中国科学：生命科学英文版 2006年第2期49卷 190-200页

作者： JIANG wei1,2, LI Xia1,2,3,4, guo Zheng1,2,3, LI Chuanxing1, WANG Lihong1 & RAO Shaoqi1,5 1. department of Bioinformatics, Harbin Medical university, Harbin 150086, china 2. department of computer science, Harbin Institute of technology, Harbin 150080, china 3. School of Life science and technology, Tongji university, Shanghai 200092, china 4. Biomedical Engineering Institute, Capital university of Medical sciences, Beijing 100054, china 5. departments of Cardiovascular Medicine and Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA department of Bioinformatics Harbin Medical University Harbin 150086 China department of computer science Harbin Institute of Technology Harbin 150080 China School of Life science technology Tongji University Shanghai 200092 China Biomedical Engineering Institute Capital University of Medical Sciences Beijing 100054 China departments of Cardiovascular Medicine Molecular Cardiology Cleveland Clinic Foundation Cleveland Ohio 44195 USA

Reconstruction of genetic networks is one of the key scientific challenges in functional genomics. This paper describes a novel approach for addressing the regulatory dependencies be-tween genes whose activities can be delayed by multiple units of time. The aim of the proposed ap-proach termed TdGRN (time-delayed gene regulatory networking) is to reversely engineer the dy-namic mechanisms of gene regulations, which is realized by identifying the time-delayed gene regu-lations through supervised decision-tree analysis of the newly designed time-delayed gene expres-sion matrix, derived from the original time-series microarray data. A permutation technique is used to determine the statistical classification threshold of a tree, from which a gene regulatory rule(s) is ex-tracted. The proposed TdGRN is a model-free approach that attempts to learn the underlying regula-tory rules without relying on any model assumptions. Compared with model-based approaches, it has several significant advantages: it requires neither any arbitrary threshold for discretization of gene transcriptional values nor the definition of the number of regulators (k). We have applied this novel method to the publicly available data for budding yeast cell cycling. The numerical results demonstrate that most of the identified time-delayed gene regulations have current biological knowledge supports.

关键词： gene regulatory networks, time delayed, decision tree.

Phase-Dislocation-Mediated High-Dimensional Fractional Acoustic-Vortex Communication

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Research 2024年第3期2023卷 575-584页

作者： Ruijie Cao Gepu guo wei Yue Yang Huang Xinpeng Li Chengzhi Kai Yuzhi Li Juan Tu Dong Zhang peng Xi Qingyu Ma School of computer and Electronic Information Nanjing Normal UniversityNanjing 210023China department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing 100871China nstitute of Acoustics Nanjing UniversityNanjng 210093China National Biomedical Imaging Center Peking UniversityBeijing 100871China

With unlimited topological modes in mathematics,the fractional orbital angular momentum(FOAM)demonstrates the potential to infinitely increase the channel capacity in acoustic-vortex(AV)***,the accuracy and stability of FOAM recognition are still limited by the nonorthogonality and poor anti-interference of fractional AV *** popular machine learning,widely used in optics based on large datasets of images,does not work in acoustics because of the huge engineering of the 2-dimensional point-by-point ***,we report a strategy of phase-dislocation-mediated high-dimensional fractional AV communication based on pair-FOAM multiplexing,circular sparse sampling,and machine *** unique phase dislocation corresponding to the topological charge provides important physical guidance to recognize FOAMs and reduce sampling points from theory to practice.A straightforward convolutional neural network considering turbulence and misalignment is further constructed to achieve the stable and accurate communication without involving experimental *** experimentally present that the 32-point dual-ring sampling can realize the 10-bit information transmission in a limited topological charge scope from±0.6 to±2.4 with the FOAM resolution of 0.2,which greatly reduce the divergence in AV *** infinitely expanded channel capacity is further verified by the improved FOAM resolution of *** with other milestone works,our strategy reaches 3-fold OAM utilization,4-fold information level,and 5-fold OAM *** of the extra advantages of high dimension,high speed,and low divergence,this technology may shed light on the next-generation AV communication.

关键词： infinitely topological fractional

Reconstruction of incomplete satellite SST data sets based on EOF method

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Acta Oceanologica Sinica 2009年第2期28卷 36-44页

作者： ding Youzhuan wei Zhihui MAO Zhihua WANG Xiaofei PAN Delu department of computer Nanjing University of Science and Technology Nanjing 210094 China State Key Laboratory of Satellite Ocean Envionment Dynamics Second Institute of Oceanography State Oceanic Administration Hangzhou 310012 China

As for the satellite remote sensing data obtained by the visible and infrared bands myers,on, the clouds coverage in the sky over the ocean often results in missing data of inversion products on a large scale, and thin clouds difficult to be detected would cause the data of the inversion products to be abnormal. Alvera et a1.（2005） proposed a method for the reconstruction of missing data based on an Empirical Orthogonal Functions （EOF） decomposition, but his method couldn＇t process these images presenting extreme cloud coverage（more than 95%）, and required a long time for recon- struction. Besides, the abnormal data in the images had a great effect on the reconstruction result. Therefore, this paper tries to improve the study result. It has reconstructed missing data sets by twice applying EOF decomposition method. Firstly, the abnormity time has been detected by analyzing the temporal modes of EOF decomposition, and the abnormal data have been eliminated. Secondly, the data sets, excluding the abnormal data, are analyzed by using EOF decomposition, and then the temporal modes undergo a filtering process so as to enhance the ability of reconstruct- ing the images which are of no or just a little data, by using EOF. At last, this method has been applied to a large data set, i.e. 43 Sea Surface Temperature （SST） satellite images of the Changjiang River （Yangtze River） estuary and its adjacent areas, and the total reconstruction root mean square error （RMSE） is 0.82℃. And it has been proved that this improved EOF reconstruction method is robust for reconstructing satellite missing data and unreliable data.

关键词： EOF SST Changjiang River estuary Missing data sets

Chinese Medicine Prolongs Overall Survival of Chinese Patients with Advanced Gastric Cancer: Treatment Pattern and Survival Analysis of a 20-Year Real-World Study

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Chinese Journal of Integrative Medicine 2024年第6期30卷 489-498页

作者： CAO Ni-da ZHU Xiao-hong MA Fang-qi XU Yan DONG Jia-huan QIN Meng-meng LIU Tian-shu ZHU Chun-chao guo wei-jian ding hong-hua guo Yuan-biao LIU Li-kun SONG Jin-jie WU Ji-ping CHENG Yue-lei ZENG Lin ZHAO Ai-guang Oncology department I Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai200032China Oncology department Zhongshan HospitalFudan UniversityShanghai200032China Gastrointestinal Surgery department Renji HospitalShanghai Jiaotong University School of MedicineShanghai200127China Oncology department Fudan University Shanghai Cancer CenterShanghai200032China Oncology department Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200080China Traditional Chinese Medicine department Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai200025China Oncology department Shanxi Traditional Chinese Medicine HospitalTaiyuan030012China Oncology department Xiyuan HospitalChina Academy of Chinese Medical ScienceBeijing102445China Oncology department Yunnan Province Hospital of Traditional Chinese MedicineKunming650021China Oncology department Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Shanghai NewCore Biotechnology Co. Ltd.Shanghai200240China

Objective To describe the treatment patterns and survival status of advanced gastric cancer(AGC)in china in the past two decades,and objectively evaluate the impact of standardized Chinese medicine(CM)treatment on the survival of AGC *** This multicenter registry designed and propensity score analysis study described the diagnosis characteristics,treatment-pattern development and survival status of AGC from 10 hospitals in china between January 1,2000 and July 31,*** survival(OS)was evaluated between non-CM cohort(standard medical treatment)and CM cohort(integrated standard CM treatment≥3 months).Propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)were performed to adjust any difference in average outcomes for *** A total of 2,001 patients histologically confirmed locally advanced and/or metastasis stomach and gastroesophageal junction adenocarcinoma were *** them,1,607 received systemic chemotherapy,215(10.74%)accepted molecular targeted therapy,44(2.2%)received checkpoint inhibitor therapy,and 769(38.43%)received ***-drug regimen was the main choice for first-line treatment,with fluoropyrimidine plus platinum as the most common regimen(530 cases,60.09%).While 45.71%(16 cases)of patients with HER2 amplification received trastuzumab in *** application of apatinib increased(33.33%)in *** application of checkpoint inhibitors has increased since *** analysis showed that Lauren mixed type(P=0.017),cycles of first-line treatment>6(P=0.000),CM(P=0.000),palliative gastrectomy(P=0.000),trastuzumab(P=0.011),and apatinib(P=0.008)were independent prognostic factors for the OS of *** PSM and IPTW,the median OS of CM cohort and non-CM cohort was 18.17 and 12.45 months,respectively(P1).Conclusions In real-world practice for AGC in china,therapy choices consisted with ***-drug regimen was the main first-line *** CM treatment was an independent

关键词： advancedgastriccancer real-world study treatment pattern survival analysis Chinese medicine

Structures and ion transport mechanisms of plant high-affinity potassium transporters

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Molecular Plant 2024年第3期17卷 409-422页

作者： Jiangqin Wang Yanping Luo Fan Ye Zhong Jie ding Shao Jian Zheng Shuai Qiao Yong Wang Jiangtao guo wei Yang Nannan Su international Institutes of Medicine the Fourth Affiliated HospitalZhejang University School of MedicineYiwuZhejiang 322000China department of Biophysics and department of Neurology of the Fourth Affiliated Hospital Zhejiang University School of MedicineHangzhouZhejang 310058China State Key Laboratory of Plant Environmental Resilience College of Life SciencesZhejang UniversityHangzhouZhejang 310058China College of Life sciences Zhejiang UniversityHangzhouZhejiang 310058China NHC and CAMS Key Laboratory of Medical Neurobiology MOE Frontier Science Center for Brain Science and Brain-machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang 310058China Nanhu Brain-computer Interface Institute Hangzhou.Zheiang 311100.China

Plant high-affinity K^(+) transporters(HKTs)mediate Na^(+) and K^(+) uptake,maintain Na^(+)/K^(+) homeostasis,and therefore play crucial roles in plant salt *** this study,we present cryoelectron microscopy structures of HKTs from two classes,classI HKT1;1 from Arabidopsis thaliana(AtHKT1;1)and class II HKT2;1 from Triticum aestivum(TaHKT2;1),in both Na^(+) -and K^(+) -bound states at 2.6-to 3.0-A ***1;1and TaHKT2;1function *** HKT subunit consists of four tan-dem domain units(D1-D4)with a repeated K^(+) -channel-like M-P-M *** each subunit,D1-D4 assemble into an ion conduction pore with a pseudo-four-fold *** both TaHKT2;1and AtHKT1;1 have only one putative Na^(+) ion bound in the selectivity filter with a similar coordination pattern,the two HKTs display different K^(+) binding modes in the ***2;1 has three K^(+) ions bound in the selec-tivity filter,but AtHKT1;1 has only two K^(+) ions bound in the filter,which has a narrowed external entrance due to the presence of a Ser residue in the first filter *** structures,along with compu-tational,mutational,and electrophysiological analyses,enable us to pinpoint key residues that are critical for the ion selectivity of *** findings provide new insights into the ion selectivity and ion transport mechanisms of plant HKTs and improve our understanding about how HKTs mediate plant salt tolerance and enhance crop growth.

关键词： HKTs structure ion selectivity mechanism salt tolerance

Coordinated Frequency Control for Isolated Power Systems with High Penetration of DFIG-Based Wind Power

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1399-1414页

作者： Xin ding wei Lin Jian Xu Yuanzhang Sun Liangzhong Yao Beilin Mao School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China department of Electrical Engineering and computer science Case Western Reserve UniversityClevelandOH 44106 USA

This paper proposes a coordinated frequency control scheme for emergency frequency regulation of isolated power systems with a high penetration of wind *** proposed frequency control strategy is based on the novel nonlinear regulator theory,which takes advantage of nonlinearity of doubly fed induction generators(DFIGs)and generators to regulate the frequency of the power *** deviations and power imbalances are used to design nonlinear feedback controllers that achieve the reserve power distribution between generators and DFIGs,in various wind speed *** effectiveness and dynamic performance of the proposed nonlinear coordinated frequency control method are validated through simulations in an actual isolated power grid.

关键词： Frequency control isolated power systems nonlinear feedback nonlinear regulator theory wind power

Mild synthesis of ultra-bright carbon dots with solvatochromism for rapid lipid droplet monitoring in varied physiological processes

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Regenerative Biomaterials 2024年第3期3卷 30-42页

作者： Borui Su Dong Gao Nini Xin Kai Wu Mei Yang Shichao Jiang Yusheng Zhang Jie ding Chengheng Wu Jing Sun Dan wei hongsong Fan Zhenzhen guo National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengduSichuan 610064China Institute of Regulatory science for Medical Devices Sichuan UniversityChengduSichuan 610064China department of Gastroenterology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610o72China

Lipid droplets(LDs)participating in various cellular activities and are increasingly being *** imaging provides powerful tool for dynamic tracking of LDs,however,most current LDs probes remain inconsistent performance such as low Photoluminescence Quantum Yield(PLQY),poor photostability and tedious washing ***,a novel yellow-emissive carbon dot(OT-cD)has been synthesized conveniently with high PLQY up to 90%.Besides,OT-CD exhibits remarkable amphiphilicity and solvatochromic property with lipid-water partition coefficient higher than 2,which is much higher than most LDs *** characters enable OT-CD high brightness,stable and wash-free LDs probing,and feasible for in vivo ***,detailed observation of LDs morphological and polarity variation dynamically in different cellular states were recorded,including ferroptosis and other diseases ***,fast whole imaging of zebrafish and identifed LD enrichment in injured liver indicate its further feasibility for in vivo *** contrast to the reported studies to date,this approach provides a versatile conventional synthesis system for high-performance LDs targeting probes,combing the advantages of easy and high-yield production,as well as robust brightness and stability for long-term imaging,facilitating investigations into organelle interactions and LD-associated diseases.

关键词： lipid droplet probe carbon dots fluorescence imaging wash-free dynamic monitoring

The application of geographic information technology to coastal geomorphology

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Acta Oceanologica Sinica 2009年第5期28卷 49-57页

作者： guo wei LI Shuheng ZHU Dakui School of Human Settlements and Civil Engineering Xi＇an Jiaotong University Xi＇an 710049 China department of computer sciences Xi＇an Jiaotong University Xi＇an 710049 China department of Urban and Resources sciences Northwest University Xi＇an 710032 China Faculty of Environmental sciences University of Waterloo Waterloo N2L3G1 Canada Key Laboratory of Coast ＆ Island Development of Ministry of Education Nanjing University Nanjing 210093 China

With the development of modern oceanic observation technologies, coastal survey data have been experiencing a substantial growth. The integration management of the data from different disciplines, different sources and different formats has become a major research field in coastal geomorphology by using Geographic Information System （GIS）. This paper puts forward a new methodology framework of GIS techniques in coastal ocean geomorphology, including data acquisition, process, analysis, and representation. It focuses on some major GIS techniques to study the land-ocean interaction mechanism, such as spatial analysis, submarine topography model and three-dimension （3D） visualization, and apply its result to coastal urban planning, harbor site selection and geomorphology environment about coral reef and islands on the continental shelf. The case studies cover the whole coastal ocean to serve the social community, economical development and diplomatic rights for decision-making all round in the coastal zone. The research shows clearly that the application of coastal multi-source geospatial platform has changed the traditional coastal geomorphology science dramatically from its research scope, fields and methods, however, as made clear in this paper, extracting accurate information from remote sensing data and GIS databases for coastal geomorphological applications is a nontrivial challenge that requires the combined knowledge and skills of information scientists and geomorphologists.

关键词： coastal geomorphology geographic information system (GIS) spatial analysis threedimensional visualization