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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu zhiyi wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Generation of 7-fs laser pulse directly from a compact Ti:sapphire laser with chirped mirrors

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Science China(Physics,Mechanics & Astronomy) 2007年第3期50卷 261-266页

作者： ZHAO YanYing WANG Peng ZHANG wei TIAN JinRong wei zhiyi Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100080China College of Applied Science Beijing University of TechnologyBeijing 100022China

A compact femtosecond Ti:sapphire laser resonator consisting of three chirped mirrors and one output coupler was designed. By accurately balancing the intra- cavity dispersions between Ti:sapphire crystal, air and chirped mirrors, we directly generated the laser pulse shorter than 7 fs at the average power of 340 mW with 3.1 W pump. The repetition rate of the laser oscillator is 173 MHz at the centre wavelength of 791 nm, and the ultrabroaden spectrum covers from 600 nm to 1000 nm. To the best of our knowledge, this is the simplest laser resonator capable of generating sub-10 fs laser pulse.

关键词： Ti:sapphire laser chirped mirror femtosecond few cycles pulse

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Sub-10 fs laser pulses with repetition rate of 1.1 GHz by a Ti:sapphire oscillator

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Chinese Science Bulletin 2009年第20期54卷 3649-3652页

作者： ZHANG Qing ZHAO YanYing wei zhiyi Institute of Physics Chinese Academy of Sciences Beijing 100190 China

We demonstrate a compact Ti:sapphire oscillator with ring cavity *** optimizing the intra-cavity dispersion with chirped mirrors,pulses with repetition rate of 1.1 GHz are coupled out by the uncoated wedges in the *** 7W CW pump laser centered at 532 nm,the average power of the output pulses is about 30 mW,the duration is less than 10fs and the spectrum spans from 670 nm to 920 nm.

关键词：激光脉冲重复率振荡器蓝宝石 GHz 财政 32纳米钛

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Synchronously pumped femtosecond optical parametric oscillator at 1053 nm

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Science China(Physics,Mechanics & Astronomy) 2009年第8期52卷 1187-1190页

作者： ZHONG Xin ZHU JiangFeng ZHOU BinBin wei zhiyi Institute of Physics Chinese Academy of SciencesBeijing 100190China

A femtosecond optical parametric oscillator synchronously pumped by a Ti:Sapphire oscillator is *** the cavity length tuning,the signal wavelength is continuously tuned from 1000 to 1200 *** average output power of 32 mW is obtained at 1053 *** pulse width is measured to be 342 fs by intensity autocorrelation *** addition,we observed bichromatic emission during the cavity length tuning process.

关键词： femtosecond optical parametric oscillator synchronously pump

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Experimental study on generation of high energy few cycle pulses with hollow fiber filled with neon

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Science China(Physics,Mechanics & Astronomy) 2008年第5期51卷 507-511页

作者： ZHU JiangFeng WANG Peng HAN HaiNian TENG Hao wei zhiyi Laboratory of Optical Physics Institute of PhysicsChinese Academy of SciencesBeijing 100080China

25 fs pulses with energy up to 0.8 mJ from a multi-pass amplifier system have been spectrally broadened from 460 nm to 950 nm due to strong self-phase modulation(SPM) effect in a gas filled hollow *** a set of chirped mirrors,the ul-tra-broadband dispersion compensation was achieved,and the compressed pulses reached their transform *** optimized conditions we achieved pulses with duration of 5.1 fs and with energy of 400 μJ,corresponding to the peak power up to 80 GW.

关键词： hollow fiber self-phase modulation super-continuum pulse compression

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Cs_(3)Bi_(2)B_(9)/BiOBr S-scheme heterojunction for selective oxidation of benzylic C-H bonds

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Journal of Materials Science & Technology 2024年第13期180卷 150-159页

作者： Jie Deng Difa Xu Jinfeng Zhang Quanlong Xu Yun Yang zhiyi wei Zhi Su Wenzhou Key Lab of Advanced Energy Storage and Conversion Zhejiang Province Key Lab of Leather EngineeringCollege of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325027China Hunan Key Laboratory of Applied Environmental Photocatalysis Changsha UniversityChangsha 410022China Anhui Key Laboratory of Energetic Materials College of Physics and Electronic InformationHuaibei Normal UniversityHuaibei 235000China School of Energy and Chemical Engineering Xinjiang Institute of TechnologyAkesu 843100China

Converting hydrocarbons into aldehydes in a green and environmentally benign way is of great signif-icance in fine *** this work,all-inorganic Cs_(3)Bi_(2)B_(9) perovskite nanoparticles were uniformly loaded on BiOBr nanosheets via an in-situ growth method,which can selectivity photoactivate aromatic C(sp^(3))-H bond of toluene to generate *** to the in-situ X-ray photoelectron spec-troscopy characterization,the photogenerated electrons of BiOBr transfer to Cs_(3)Bi_(2)B_(9) enforced by the in-ternal electric field under light irradiation,resulting in S-scheme ***,theoretical calculations indicate that toluene molecules are inclined to adsorb on the BiOBr surface,subsequently in-volving the oxidation reaction to generate benzyl radical(PhCH_(2)·)by using the energetic holes of BiOBr,while the remaining photoinduced electrons in the conduction band(CB)of Cs_(3)Bi_(2)B_(9) with powerful reduction ability reduce O2 into·O_(2)^(-),which is the vital oxidative active species working on toluene selective oxidation *** an unexceptionable charge carrier utilization mode and tendentious ad-sorption behavior of reactants contribute to the optimized Cs_(3)Bi_(2)B_(9)/BiOBr heterojunction with excellent photocatalytic performance,achieving a maximum of 22.5%toluene conversion and 96.2%selectivity to-wards benzaldehyde *** work provides a rational photocatalyst heterojunction construction protocol for the selective oxidation of saturated aromatic C-H bonds.

关键词： Cs_(3)Bi_(2)Br_(9)/BiOBr C(sp^(3))–H activation S-scheme heterojunction Selective organic synthesis Photocatalysis

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Wave-front correction of high-intensity fs laser beams by using closed-loop adaptive optics system

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Science China(Physics,Mechanics & Astronomy) 2005年第1期48卷 122-128页

作者： WANG Zhaohua JIN Zhan ZHENG Jiaan WANG Peng wei zhiyi ZHANG Jie Laboratory of Optical Physics Institute of Physics Chinese Academy of Sciences Beijing 100080 China Laboratory of Optical Physics Institute of Physics Chinese Academy of Sciences Beijing 100080 China Laboratory of Optical Physics Institute of Physics Chinese Academy of Sciences Beijing 100080 China Laboratory of Optical Physics Institute of Physics Chinese Academy of Sciences Beijing 100080 China Laboratory of Optical Physics Institute of Physics Chinese Academy of Sciences Beijing 100080 China Laboratory of Optical Physics Institute of Physics Chinese Academy of Sciences Beijing 100080 China

We developed an adaptive optics system to correct the wave-front distortion of an intense fs laser beam from our multi-TW laser system, Jiguang II. In this paper, the instruments of the adaptive optical system are described and the experimental results of the closed-loop wave-front correction are presented. A distorted laser wave-front of 20 wavelengths of P-V values was corrected to 0.15 wavelength of P-V values. The beam quality of the laser system varies from 3.5 diffraction limit to 1.5 diffraction limit.

关键词： Shack-Hartmann wave-front sensor, adaptive optics system, femtosecond laser, diffraction limit.

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Carrier-envelope phase passively stabilized near-infrared laser pulses from a dual-frequency pumped noncollinear optical parametric amplifier

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Chinese Science Bulletin 2014年第10期59卷 1045-1048页

作者： Shuyan Guo weijun Ling Hao Teng wei Zhang Lifeng Wang zhiyi wei Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Department of Physics Tianshui Normal University

By inversing the signal and idler in a two-stage noncollinear optical parametric amplifier which is,respectively,pumped by the second harmonic and fundamental wave of femtosecond Ti:sapphire laser at repetition rate of1 kHz,the carrier-envelope phase(CEP)passively stabilized pulses with a tunable wavelength from 1.1 to 1.6 lm are obtained with maximum energy of 95 lJ at 1.3 lm under the pump energy of 500 *** CEP jitter of pulses is 108 mrad measured by an f-2f *** work demonstrates a new way to efficiently generate tunable near-infrared femtosecond laser pulses with self-stabilized CEP.

关键词： Noncollinear optical parametricamplifier Femtosecond laser Carrier-envelopephase CEP jitter

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Enhancement of isolated attosecond pulse generation by using long gas medium

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Chinese Physics B 2022年第4期31卷 293-298页

作者： Yueying Liang Xinkui He Kun Zhao Hao Teng zhiyi wei Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China University of Chinese Academy of Sciences Beijing 100049China

Isolated attosecond pulse generation in argon is theoretically investigated for different gas pressures and medium *** output of attosecond pulse is effectively enhanced by using a longer gas medium with optimized *** peak intensity of the attosecond pulse by using 6 mm gas medium is doubled compared with that of 1-3 mm gas cell,which is usually used in the *** simulation shows that the distortion of the driving laser waveform and the absorption are the main factors that limit the output of the attosecond pulse for the long gas *** generation condition could be found by balancing the medium length and pressure.

关键词： isolated attosecond pulse high-order harmonic generation

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Carrier-envelope phase locking of 5 fs amplified Ti:sapphire laser pulse at 1 kHz repetition rate

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Chinese Science Bulletin 2008年第5期53卷 671-675页

作者： DU Qiang ZHU JiangFeng TENG Hao YUN ChenXia wei zhiyi Laboratory of Optical Physics Institute of Physics Chinese Academy of Sciences Beijing 100080 China

This paper reports the carrier-envelop phase (CEP) locking for the 5 fs re-compressed laser pulse generated from a chirped pulse amplified (CPA) Ti:sapphire laser at 1 kHz repetition rate. A phase locking feedback system with two loops was designed to control the fast fluctuation arising from the seeding laser and the slow fluctuation arising from the sub-mJ amplified pulse. The principle and structure of the phase control system, including the CEP detection, servo loop design and phase locking result, are analyzed. The experiment shows that our phase locking system can be well used to establish the stable phase locking of few-cycle amplified laser pulse, and the CEP variation of below 53 mrad (rms) was demonstrated during a locking period of more than 3 h.

关键词：兰宝石激光器载波包络锁相环循环脉冲

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