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Journal of Geriatric Cardiology 2016年第5期13卷 431-434页

作者： Doris SF Yu Polly wc li The Nethersole School of Nursing The Chinese University of Hong Kong Hong Kong China

Chronic heart failure （CHF） is a complex clinical syndrome resulting from inefficient myocardial pumping, and is characterised by a typical progressively deteriorating trajectory punctuated by serious episodes of acute disease *** prevalence of hospital admission has been reported.[2] However, around 40% of hospital admissions was avoidable if patients demonstrate consistent self-care.

关键词： Chinese Heart failure life experience Self-care

Molecular characterisation and phylogenetic analysis of Spirometra erinaceieuropaei from snakes in Hunan Province

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Molecular characterisation and phylogenetic analysis of Spir...

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： TF Gong LX Xie JL He F li SY Chen wc li XR Xie YS liu YF Zhou W liu Research Center for Parasites & Vectors College of Veterinary MedicineHunan Agricultural University Orient Science & Technology College of Hunan Agriculture University

Sparganosis is a neglected zoonotic parasitic disease found *** play an important role in sparganosis transmission because they are the most common second intermediate hosts for Spirometra ***,the population genetics of Spirometra isolates from snakes is currently not well *** study obtained 49 Spirometra tapeworms from 15 geographical areas in Hunan Province,Central ***,18 S and 28 S ribosomal DNA(rDNA) fragments were amplified from the isolated parasites,and their sequences were analysed to assess their genetic *** analyses were performed using the maximum likelihood *** results showed that sequence variations amongst these isolates were 0%-2.3% and 0%-0.1% for 18 S and 28 S rDNA,*** analysis showed that all Spirometra isolates from Hunan Province were clustered into the same branch with *** isolated from different regions/hosts ***,phylogenetic trees revealed that Spirometra is closely related to Adenocephalus,Pyramicocephalus,ligula,Dibothriocephalus,Schistocephalus and *** results provide reference values for the future taxonomic status of ***,and the exact phylogenetic position of Spirometra species should be further analysed with more sampling and more useful molecular markers.

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian li Xueer liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng li Jiangtao Sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang Chen Zhifeng Chen Menghua li Weiwei Guo Shuolong Yuan liangwei Xu Chang lin Xi Shi Wei Chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

An Objective Measure to Evaluate Actual Body Shape among Children and Adolescents in China

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Biomedical and Environmental Sciences 2014年第8期27卷 582-593页

作者： FU lian Guo WANG Hai Jun li Xiao Hui WANG Zhi Qiang Patrick wc Lau YANG Yi De MENG Xiang Kun MA Jun Institute of Child and Adolescent Health School of Public Health Peking University Health Science Center Centre for Chronic Disease School of Medicine University of Queensland Department of Physical Education Hong Kong Baptist University

Objective The purpose of this study was to explore an objective measure to assess actual body shape of children and adolescents in China. Methods Based on the Chinese National Survey on Student＇s Constitution and Health （CNSSCH） in 2005, 210 927 children and adolescents＇（7-18 years） body height, body weight, chest circumference, sitting height, chest circumference-height ratio, chest circumference-sitting height ratio, chest circumference-low limb ratio, and sitting height-low limb ratio measurements were used to develop an objective measure by using transformation variables and explored factor analysis （EFA）. Discrimination power of the objective measure was evaluated based on BMI reference and Receiver Operating Characteristic curves （ROC）. Results The objective measure included four dimensions scores：transverse dimension （TD） indicating weight and chest circumference; length dimension （LD） indicating height and sitting height;transverse-length ratio dimension （TLD） indicating chest circumference-height ratio, chest circumference-sitting height and chest circumference-low limb ratio; proportion dimension （PD） indicating sitting height-low limb ratio. The whole dimension （WD） indicating the whole body shape was showed by the average of four dimensions scores. Four dimensions and WD scores were approximately 80 in children and adolescents with normal weight, and higher than those of overweight, obesity, and underweight （all P-values〈0.001）. Areas under ROC of overweight and obesity compared with normal weight ranged from 0.88 to 1.00 for scores of TD, TLD, and WD. Conclusion The objective measure which included four dimensions was explored, and TD, TLD, and WD had significant discrimination power.

关键词： Objective measure Body shape Children and adolescents

Inhibition of angiogenesis and HCT-116 xenograft tumor growth in mice by kallistatin

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World Journal of Gastroenterology 2007年第34期13卷 4615-4619页

作者： Yong Diao Jian Ma Wei-Dong Xiao Jia Luo Xin-Yan li Kin-Wah Chu Peter wc Fung Nagy Habib Farzin Farzaneh Rui-An Xu Molecular Medicine Engineering Research Center of the Ministry of Education Institute of Molecular Medicine Huaqiao University Quanzhou362021 Fujian Province China Department of Medicine Hong Kong University Hong Kong China Department of Pharmacy Chicago UniversityUnited States Department of Transplantation Imperial College London United Kingdom Department of Haematological & Molecular Medicine King's College London London SE5 9NUUnited Kingdom

AIM： TO investigate the inhibitory effect of kallistatin （KAL） on angiogenesis and HCT-116 xenograft tumor growth.METHODS： Heterotopic subcutaneous injection of 2 Seven days later, 2 x 1011 injected intratumorally （n tumors were induced by x 106 HCT-11 cells in mice. rAAV-GFP or rAAV-KAL was = 5 for each group）. The mice were sacrificed at d 28, by which time the tumors in the rAAV-GFP group had grown to beyond 5% of the total body weight. Tumor growth was measured by calipers in two dimensions. Tumor angiogenesis was determined with tumor microvessel density （MVD） by immunohistology. Tumor cell proliferation was assessed by Ki-67 staining.RESULTS： Intratumor injection of rAAV-KAL inhibited tumor growth in the treatment group by 78% （171 ＋ 52 mm^3） at d 21 after virus infection compared to the control group （776 ＋ 241 mm^3）. Microvessel density was significantly inhibited in tumor tissues treated with rAAV-KAL, rAAV-KAL also decreased the proportion of proliferating cells （Ki-67 positive cells） in tumors compared with the control group.CONCLUSION： rAAV-mediated expression of KAL inhibits the growth of colon cancer by reducing angiogenesis and proliferation of tumor cells, and may provide a promising anti-angiogenesis-based approach to the treatment of metastatic colorectal cancer.

关键词： Kallistatin Adeno-associated virus Angiogenesis inhibitors Colon Neoplasm

Nitric Oxide:from a mysterious labile factor to the molecule of the Nobel Prize Recent progress in nitric oxide research

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Cell Research 1998年第4期8卷 251-258页

作者： XU WEI MING li ZHI liU (The Wolfson Institute for Biomedical Research, The Rayne Institute, University College London, 5 University Street,London wc1E 6JJ) The Wolfson Institute for Biomedical Research The Rayne Institute University College London London

NO is now known to be an important messenger molecule in *** regulates a variety of functions within cells and tissues including vasodilation, neurotransmission and immunological process. This review will focus on the... 详细信息

关键词： Nitric oxide NOS gene family genetic study

Crank conditions and rotatability of 3-RRR planar parallel mechanisms

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Science China(Technological Sciences) 2009年第12期52卷 3601-3612页

作者： li RuiQin 1 &DAI Jian S 2 1 College of Mechanical Engineering and Automation,North University of China,Taiyuan 030051,China 2 Department of Mechanical Engineering,King’s College London,University of London,wc2R 2LS,UK College of Mechanical Engineering and Automation North University of China Taiyuan China Department of Mechanical Engineering King’s College London University of London London UK

This paper investigates the rotatability of planar parallel mechanisms by revealing the crank conditions that relate to link *** paper extends the theorem of assemblability and the rotatability criterion and applies these criteria to parallel mechanisms in investigating the crank conditions of a parallel mechanism,leading to classification of three types of crank existing conditions including three-crank’s,six-crank’s and nine-crank’s of 3-RRR planar parallel *** results are summarized as constraint conditions in relation with link parameters with a concluding table and case studies.

关键词： crank rotatability planar parallel mechanism

On 4-order Schrodinger operator and Beam operator

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Frontiers of Mathematics in China 2019年第6期14卷 1197-1211页

作者： Dan li Junfeng li School of Mathematical Sciences Beijing Normal UniversityBeijing 100875China School of Mathematical Sciences Dalian University of TechnologyDalian 116024China

wc show that there is no localization for the 4-order Schrodinger operator Jt,Af and Bearn operator 38%more precisely,on the one hand,we show that the 4-order Schrodinger operator Atf, does not converge pointwise to z... 详细信息

关键词： 4-Order Schrodinger operator Beam operator localization Sobolev space

Conversion of Solar Energy to Fuels by Inorganic Heterogeneous Systems

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催化学报 2011年第6期32卷 879-890页

作者： Kimfung li David MARTIN Department of Chemical Engineering University College LondonTorrington PlaceLondonWC1E 7JEUK

Over the last several years,the need to find clean and renewable energy sources has increased rapidly because current fossil fuels will not only eventually be depleted,but their continuous combustion leads to a dramatic increase in the carbon dioxide amount in *** of the Sun's radiation can provide a solution to both *** fuel can be generated by using solar energy to split water,and liquid fuels can be produced via direct CO2 *** would create an essentially free carbon or at least carbon neutral energy *** this tutorial review,the current progress in fuels' generation directly driven by solar energy is *** mechanisms are discussed with suggestions for future research.

关键词：固体超强碱氧化钙硝酸钾氧化铝氧化锆氢氧化钾硝酸钙