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In situ autophagy regulation in synergy with phototherapy for breast cancer treatment

Acta Pharmaceutica Sinica B 2024年第5期14卷 2317-2332页

作者： Huijuan Zhang Xiangyang Xuan yaping wang Zijun Qi Kexuan Cao Yingmei Tian Chaoqun wang Junbiao Chang Zhenzhong Zhang Lin Hou School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou 450001China Collaborative Innovation Center of New Drug Research and Safety Evaluation Zhengzhou 450001China School of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou 450001China

Autophagy is an important factor in reducing the efficacy of tumor phototherapy(including PTT and PDT).Accurate regulation of autophagy in tumor cells is a new strategy to improve the anti-tumor efficiency of PTT/*** project intended to construct a tumor-activated autophagy regulator to efficiently block PTT/PDT-induced autophagy and realize synergistic sensitization to tumor *** achieve this goal,we first synthesized TRANSFERRIN(Tf)biomimetic mineralized nano-tellurium(Tf-Te)as photosensitizer and then used disulfide bond reconstruction technology to induce Tf-Te *** autophagy inhibitor hydroxychloroquine(HCQ)and iron ions carried by Tf were simultaneously loaded to prepare a tumor-responsive drug reservoir Tf-Te/*** entering breast cancer cells through the“self-guidance system”,Tf-Te/HCQ can generate hyperpyrexia and ROS under NIR laser irradiation,to efficiently induce PTT/PDT ***,the disulfide bond broke down in response to GSH,and the nanoparticles disintegrated to release Fe2+and HCQ at fixed *** simultaneously induce lysosomal alkalinization and increased osmotic pressure,effectively inhibit autophagy,and synergistically enhance the therapeutic effect of *** vivo anti-tumor results have proved that the tumor inhibition rate of Tf-Te/HCQ can be as high as 88.6%on 4T1 tumor-bearing *** multifunctional drug delivery system might provide a new alternative for more precise and effective tumor phototherapy.

关键词： Autophagy Tumor phototherapy Synergistic sensitization HCQ TRANSFERRIN Disulfide bond reconstruction GSH Biomimetic mineralized nano-tellurium

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Ti_(3)C_(2)T_(x) MXene in-situ transformed Li_(2)TiO_(3) interface layer enabling 4.5 V-LiCoO_(2)/sulfide all-solid-state lithium batteries with superior rate capability and cyclability

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Chinese Chemical Letters 2024年第6期35卷 195-200页

作者： yaping wang Pengcheng Yuan Zeyuan Xu Xiong-Xiong Liu Shengfa Feng Mufan Cao Chen Cao Xiaoqiang wang Long Pan Zheng-Ming Sun Key Laboratory of Advanced Metallic Materials of Jiangsu Province School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China CALB Technology Co. Ltd.Changzhou 213200China

All-solid-state lithium batteries(ASSLBs)based on sulfide electrolytes promise next-generation energy storage with high energy density and ***,the sulfide electrolytes suffer from phase instability and sluggish interfacial charge transport when pairing with layered oxide cathodes at high ***,a simple and efficient strategy is proposed using two-dimensional Ti_(3)C_(2)T_(x)MXene as starting material to in-situ construct a 15 nm Li_(2)TiO_(3) layer on a typical oxide cathode,LiCoO_(2).The in-situ transformation of Ti_(3)C_(2)T_(x)into Li_(2)TiO_(3) layer occurs at a low temperature of 500℃,avoiding the phase deterioration of LiCoO_(2).The thin Li_(2)TiO_(3) layer is Li^(+)conducting and electrochemically stable,thereby preventing the interfacial decomposition of sulfide electrolytes induced by LiCoO_(2) at high voltages and facilitating Li+transport at the ***,Li_(2)TiO_(3) can stabilize the layer structure of LiCoO_(2) at high ***,the sulfide-based ASSLB using LiCoO_(2)@Li_(2)TiO_(3) cathode can operate stably at a high voltage of up to 4.5 V(***+/Li),delivering an outstanding initial specific discharge capacity of 138.8 m Ah/g with a high capacity retention of 86.2% after 100 cycles at 0.2 *** in-situ transformation strategy may also apply to other MXenes,offering a general approach for constructing other advanced lithiated coatings for oxide cathodes.

关键词： Solid sulfide electrolyte Oxide cathode MXene In-situ transformation Li_(2)TiO_(3) interfacial layer

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Wearable synthetic leather-based high-performance X-ray shielding materials enabled by the plant polyphenol-and hierarchical structure-facilitated dispersion

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胶原与皮革（英文） 2024年第1期6卷 113-126页

作者： Linping Yan Jibo Zhou Hao Li Rui Zhong Junxin Zhuang Xiaohui Xu yaping wang Xuepin Liao Bi Shi College of Biomass Science and Engineering Sichuan UniversityChengdu 610065People's Republic of China Key Laboratory of Radiation Physics and Technology Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610065People's Republic of China Mingxin Automotive Leather Co. Ltd.Jiaxing 314006People's Republic of China Department of Chemistry Materials Innovation FactoryUniversity of LiverpoolLiverpool L7 3NYUK College of Biomass Science and Engineering Sichuan UniversityChengdu 610065People's Republic of China National Engineering Labora-tory for Clean Technology of Leather Manufacture Sichuan UniversityChengdu 610065People's Republic of China

Effective protection against X-ray is the premise of utilizing the X-ray,thus it is critical to develop novel X-ray shield-ing materials with both low density and high X-ray attenuation *** the even distribution of high-Z element components is of great significance for increasing the attenuation efficiency of X-ray shielding materials,in this study,the microfiber membrane(MFM),a type of synthetic leather featuring hierarchical structure was chosen to provide large surface area for the dispersion of rare earth(RE)***,plant polyphenol was utilized to achieve the stable loading and uniform dispersion of the Ce or Er into *** from the assistance of polyphenol and hierarchical structure of MFM,the even dispersion of RE element was successfully *** resultant shielding materials displayed approximately 10％superior X-ray attenuation efficiency compared to that without polyphenol,and an averagely 9％increment in X-ray attenuation efficiency than that without hierarchical ***,the obtained composite with a thickness of 2.8 mm displayed superior X-ray shielding performance compared to 0.25 mm lead sheet in 16-83 keV and retained an ultralow density of 1.4 g *** research results would shed new light on the manufacture of high-performance X-ray shielding materials with excellent X-ray shielding performance.

关键词： X-ray shielding Plant polyphenol Microfiber membrane Synthetic leather Hierarchical structure Dispersity

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Reinforced concrete-like Na_(3.5)V_(1.5)Mn_(0.5)(PO_(4))_(3)@graphene hybrids with hierarchical porosity as durable and high-rate sodium-ion battery cathode

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Chinese Chemical Letters 2024年第4期35卷 214-219页

作者： Tao Long Peng Chen Bin Feng Caili Yang Kairong wang Yulei wang Can Chen yaping wang Ruotong Li Meng Wu Minhuan Lan Wei Kong Pang Jian-Fang Wu Yuan-Li Ding College of Materials Science and Engineering Hunan UniversityChangsha 410082China Department of Physics Xiamen UniversityXiamen 361005China College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Institute for Superconducting&Electronic Materials Faculty of EngineeringUniversity of WollongongWollongongNSW 2522Australia

Realizing high-rate capability and high-efficiency utilization of polyanionic cathode materials is of great importance for practical sodium-ion batteries(SIBs) since they usually suffer from extremely low electronic conductivity and limited ionic diffusion kinetics. Herein, taking Na_(3.5)V_(1.5)Mn_(0.5)(PO_(4))_(3)(NVMP) as an example, a reinforced concrete-like hierarchical and porous hybrid(NVMP@C@3DPG) built from 3D graphene(“rebar”) frameworks and in situ generated carbon coated NVMP(“concrete”) has been developed by a facile polymer assisted self-assembly and subsequent solid-state method. Such hybrids deliver superior rate capability(73.9 m Ah/g up to 20 C) and excellent cycling stability in a wide temperature range with a high specific capacity of 88.4 m Ah/g after 5000 cycles at 15 C at room temperature, and a high capacity retention of 97.1% after 500 cycles at 1 C(-20 ℃), and maintaining a high reversible capacity of 110.3 m Ah/g in full cell. This work offers a facile and efficient strategy to develop advanced polyanionic cathodes with high-efficiency utilization and 3D electron/ion transport systems.

关键词： Sodium-ion battery Polyanionic cathode Hybrid structure Interconnected structure Energy storage

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Unraveling the stereoscopic gene transcriptional landscape of zebrafish using Fish SED,a fish spatial expression database with multispecies scalability

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Science China(Life Sciences) 2024年第4期67卷 843-846页

作者： Cheng Guo Weidong Ye Danying Cao Mijuan Shi Wanting Zhang Yingyin Cheng yaping wang Xiao-Qin Xia Institute of Hydrobiology Chinese Academy of SciencesWuhan 430072China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijingChina The Innovative Academy of Seed Design Chinese Academy of SciencesBeijing 100101China

Dear Editor,The expression profile demonstrates how each gene was expressed in the target tissue or cell at a given *** heterogeneity is a biological concept characterized by the presence of numerous cells with varying functions and expression profiles within organ/tissue *** is also cell-to-cell signaling,which implies that the extracellular environment and spatial location influence intracellular transcription,resulting in spatial heterogeneity of gene expression within the same cell type.

关键词： landscape fish database

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Toluene Processed All-Polymer Solar Cells with 18% Efficiency and Enhanced Stability Enabled by Solid Additive:Comparison Between Sequential-Processing and Blend-Casting

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Energy & Environmental Materials 2024年第4期7卷 247-254页

作者： Guoping Zhang Chaoyue Zhao Liangxiang Zhu Lihong wang Wenzhao Xiong Huawei Hu Qing Bai yaping wang Chen Xie Peng You He Yan Dan Wu Tao Yang Mingxia Qiu Shunpu Li Guangye Zhang College of New Materials and New Energies Shenzhen Technology University Department of Chemistry and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science and Technology State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Center for Advanced Low-dimension Materials College of Materials Science and Engineering Donghua University Julong College Shenzhen Technology University

The emergence of polymerized small molecule acceptors (PSMAs) has significantly improved the performance of all-polymer solar cells (all-PSCs).However,the pace of device engineering lacks behind that of materials deve... 详细信息

关键词： all-polymers solar cells sequential processing solid additive

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Cardiac Piezo1 Exacerbates Lethal Ventricular Arrhythmogenesis by Linking Mechanical Stress with Ca^(2+) Handling After Myocardial Infarction

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Research 2024年第1期2023卷 583-594页

作者： Sheng-an Su Yuhao Zhang Wudi Li Yutao Xi Yunrui Lu Jian Shen Yuankun Ma yaping wang Yimin Shen Lan Xie Hong Ma Yao Xie Meixiang Xiang Department of Cardiology Cardiovascular Key Laboratory of Zhejiang ProvinceThe Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Endocrinology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Texas Heart Institute HoustonTX 77030USA

Ventricular arrhythmogenesis is a key cause of sudden cardiac death following myocardial infarction(MI).Accumulating data show that ischemia,sympathetic activation,and inflammation contribute to ***,the role and mechanisms of abnormal mechanical stress in ventricular arrhythmia following MI remain *** aimed to examine the impact of increased mechanical stress and identify the role of the key sensor Piezo1 in ventricular arrhythmogenesis in *** with increased ventricular pressure,Piezo1,as a newly recognized mechano-sensitive cation channel,was the most up-regulated mechanosensor in the myocardium of patients with advanced heart ***1 was mainly located at the intercalated discs and T-tubules of cardiomyocytes,which are responsible for intracellular calcium homeostasis and intercellular communication.

关键词： ventricular homeostasis Ventricular

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A novel mouse model of calcific aortic valve stenosis

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Animal Models and Experimental Medicine 2024年第4期7卷 523-532页

作者： Ningjing Qian yaping wang wangxing Hu Naifang Cao Yi Qian Jinyong Chen Juan Fang Dilin Xu Haochang Hu Shuangshuang Yang Dao Zhou Hanyi Dai Dongdong Wei Jian'an wang Xianbao Liu Department of Cardiology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina State Key Laboratory of Transvascular Implantation Devices China Cardiovascular Key Laboratory of Zhejiang Province HangzhouChina Department of Cardiovascular Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Endocrinology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Binjiang Institute of Zhejiang University HangzhouChina

Background:Calcific aortic valve stenosis(CAVS)is one of the most challenging heart diseases in clinical with rapidly increasing ***,study of the mecha-nism and treatment of CAVS is hampered by the lack of suitable,robust and efficient models that develop hemodynamically significant stenosis and typical calcium ***,we aim to establish a mouse model to mimic the development and features of ***:The model was established via aortic valve wire injury(AVWI)combined with vitamin D subcutaneous injected in wild type C57/BL6 *** transthoracic echocardiography was applied to evaluate aortic jet peak velocity and mean *** specimens were collected and examined in respect of valve thickening,calcium deposition,collagen accumulation,osteogenic differentiation and ***:Serial transthoracic echocardiography revealed that aortic jet peak velocity and mean gradient increased from 7 days post model establishment in a time depend-ent manner and tended to be stable at 28 *** with the sham group,sim-ple AVWI or the vitamin D group,the hybrid model group showed typical pathological features of CAVS,including hemodynamic alterations,increased aortic valve thicken-ing,calcium deposition,collagen accumulation at 28 *** addition,osteogenic dif-ferentiation,fibrosis and inflammation,which play critical roles in the development of CAVS,were observed in the hybrid ***:We established a novel mouse model of CAVS that could be induced efficiently,robustly and economically,and without genetic *** provides a fast track to explore the underlying mechanisms of CAVS and to identify more effec-tive pharmacological targets.

关键词： animal model calcific aortic valve stenosis valve calcification

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贵州苗族、水族红酸汤滋味与香气差异分析

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食品工业科技 2024年第8期45卷 273-283页

作者：平洪睿王亚萍陈佳妮王金华贵阳学院食品科学与工程学院贵州贵阳550005

为评价水族红酸汤的品质特征,以苗族红酸汤为参比,采用国标法、氨基酸分析法与顶空固相微萃取-气相色谱-质谱联用法(Headspace-Solid phase microextraction-gas chromatography mass spectrometry,HS-SPME-GCMS)对苗族、水族红酸汤的... 详细信息

为评价水族红酸汤的品质特征,以苗族红酸汤为参比,采用国标法、氨基酸分析法与顶空固相微萃取-气相色谱-质谱联用法(Headspace-Solid phase microextraction-gas chromatography mass spectrometry,HS-SPME-GCMS)对苗族、水族红酸汤的理化成分、游离氨基酸及香气成分进行分析。结果表明,水族红酸汤的总酸、还原糖、脂肪和蛋白质等含量均高于苗族红酸汤;两种红酸汤中共检测出19种游离氨基酸,水族红酸汤中呈味氨基酸与总氨基酸含量是苗族红酸汤的2倍,其中丙氨酸和谷氨酸的滋味活度值(taste activity value,TAV)>1,是两种红酸汤的关键呈味氨基酸;在红酸汤中共检测出101种挥发性物质。利用正交偏最小二乘法(orthogonal least partial squares,OPLS-DA)的重要性变量投影(VIP)筛选出十六酸丙酯、4-乙基-2甲氧基苯酚、5-环己基-2戊酮、山梨酸等32个关键差异物。通过相对香气活性值(Relative odor activity value,ROAV)发现苗族红酸汤中酸味较水族红酸汤明显,水族红酸汤果香味特征较苗族红酸汤明显,两种红酸汤中脂香均由水杨酸甲酯提供,但主要呈酒香的挥发性物质不同,苗族红酸汤主要由乙醇提供,而水族红酸汤主要由4-乙基苯酚提供;感官评价显示,水族红酸汤的感官评分高于苗族酸汤。综上所述,水族红酸汤作为贵州红酸汤的一种,其品质和风味较优,具有很高的市场开发价值。

关键词：苗族红酸汤水族红酸汤理化成分游离氨基酸挥发性物质

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考虑步兵头盔动作适应性的颈部生物力学分析及优化

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兵器装备工程学报 2024年第10期45卷 248-257页

作者：安征王亚平曹捷南京理工大学机械工程学院南京210094

针对步兵在佩戴头盔下不同头部动作的适应性问题,建立头部动态“头—颈—盔”肌骨模型,研究头部不同运动下颈部肌群和关节受力特性,获得不同运动下盔上装备位置对颈部肌肉的影响规律。采用多目标粒子群算法,以动态下颈部肌群最大激活度... 详细信息

针对步兵在佩戴头盔下不同头部动作的适应性问题,建立头部动态“头—颈—盔”肌骨模型,研究头部不同运动下颈部肌群和关节受力特性,获得不同运动下盔上装备位置对颈部肌肉的影响规律。采用多目标粒子群算法,以动态下颈部肌群最大激活度为优化目标,进行盔上装备位置优化,获得盔上装备较优位置。结果表明:与头部中立位相比,上仰30°时颈部最大肌肉激活度增加1551.21%,侧弯40°时增加885.42%,旋转40°时增加35.23%;上仰和旋转中T1C7椎间压力最大,与头部中立位相比,T1C7椎间压力在上仰30°时增加357.98%,旋转40°时增加10.71%;侧弯运动中C1C0和T1C7椎间剪切力最大,且大小相同、方向相反,侧弯40°时最大剪切力为104.71 N;多动作适应下盔上装备质心位置较优范围为(0.0017~0.0489 m,0.06~0.08 m,-0.08~0.08 m)。

关键词：头盔肌骨模型生物力学动作适应性优化

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