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The Epidemiology, Diagnosis and Prognosis of Long-COVID

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Biomedical and Environmental Sciences 2022年第12期35卷 1133-1139页

作者： DU Ying ZHANG Jie WU Li Juan ZHANG Qun wang you xin Beijing Key Laboratory of Clinical Epidemiology School of Public HealthCapital Medical UniversityBeijing 100069China Chinese Center for Disease Control and Prevention Beijing 102206China Centre for Precision Medicine Edith Cowan UniversityPerth WA6027Australia

INTRODUCTION As of October 26, 2022, more than 625 million confirmed cases of COVID-19 and more than 6.56 million deaths have been reported to the World Health Organization(WHO), and the natural history,clinical course, and long-term consequences of this new disease are still not completely *** more than two years of fighting against the SARS-CoV-2 pandemic, the number of patients with long-term persistent COVID-19 symptoms after acute infection is noteworthy.

关键词： Epidemiology acute clinical

A Nested Case-Control Study to Explore the Association between Immunoglobulin G N-glycans and Ischemic Stroke

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Biomedical and Environmental Sciences 2023年第5期36卷 389-396页

作者： wang Bi Yan SONG Man Shu ZHANG Jie MENG Xiao Ni xinG Wei Jia wang you xin Beijing Key Laboratory of Clinical Epidemiology School of Public HealthCapital Medical UniversityBeijing 100069China Department of Health Management the Second Affiliated Hospitalthe Fourth Military Medical UniversityXi'an 710003ShaanxiChina School of Medical and Health Sciences Edith Cowan UniversityPerth WA 6027Australia School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117ShandongChina Centre for Precision Medicine Edith Cowan UniversityPerth WA 6027Australia

Objective This study prospectively investigates the association between immunoglobulin G(IgG)N-glycan traits and ischemic stroke(IS) *** A nested case-control study was conducted in the China suboptimal health cohort study,which recruited 4,313 individuals in 2013–2014. Cases were identified as patients diagnosed with IS, and controls were 1:1 matched by age and sex with cases. Ig G N-glycans in baseline plasma samples were *** A total of 99 IS cases and 99 controls were included, and 24 directly measured glycan peaks(GPs) were separated from Ig G N-glycans. In directly measured GPs, GP4, GP9, GP21, GP22, GP23, and GP24 were associated with the risk of IS in men after adjusting for age, waist and hip circumference,obesity, diabetes, hypertension, and dyslipidemia. Derived glycan traits representing decreased galactosylation and sialylation were associated with IS in men(FBG2S2/(FBG2 + FBG2S1 + FBG2S2): odds ratio(OR) = 0.92, 95% confidence interval(CI): 0.87–0.97;G1n: OR = 0.74, 95% CI: 0.63–0.87;G0n: OR =1.12, 95% CI: 1.03–1.22). However, these associations were not found among *** This study validated that altered Ig G N-glycan traits were associated with incident IS in men, suggesting that sex discrepancies might exist in these associations.

关键词： Ischemic stroke Immunoglobulin G N-glycans Nested case-control study

Association between the SUMO4 M55V Polymorphism and Susceptibility to Type 2 Diabetes Mellitus:A Meta-analysis

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Biomedical and Environmental Sciences 2017年第4期30卷 288-295页

作者： ZHANG Qun LIU Di ZHAO Zhong Yao SUN Qi DING Li Xiang wang you xin Chinese Center for Disease Control and Prevention Beijing 102206China Beijing Key Laboratory of Clinical Epidemiology School of Public HealthCapital Medical UniversityBeijing 100069China Department of Orthopedics Surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Objective The aim of this study is to determine whether the SUMO4 M55V polymorphism is associated with susceptibility to type 2 diabetes mellitus （T2DM）. Methods A meta-analysis was performed to detect the potential association of the SUMO4 M55V polymorphism and susceptibility to T2DM under dominant, recessive, co-dominant （homogeneous and heterogeneous）, and additive models. Results A total of eight articles including 10 case-control studies, with a total of 2932 cases and 2679 controls, were included in this meta-analysis. The significant association between the SUMO4 M55V polymorphism and susceptibility to T2DM was observed in the dominant model （GG ＋ GA versus AA： OR = 1.21, 95% CI = 1.05-1.40, P = 0.009）, recessive model （GG versus GA ＋ AA： OR = 1.29, 95% CI = 1.07-1.356, P = 0.010）, homozygous model （GG versus AA： OR = 1.41, 95% CI = 1.06-1.56, P = 0.001）, and additive model （G versus A： OR = 1.18, 95% CI = 1.08-1.29, P = 0.001）, and marginally significant in the heterozygous model （GA versus AA： OR = 1.16, 95% CI = 0.98-1.36, P = 0.080）. In subgroup analyses, significant associations were observed in the Chinese population under four genetic models excluding the heterozygous model, whereas no statistically significant associations were observed in the Japanese population under each of the five genetic models. Conclusion The meta-analysis demonstrated that the G allele of the SUMO4 M55V polymorphism could be a susceptible risk locus to T2DM, mainly in the Chinese population, while the association in other ethnic population needs to be further validated in studies with relatively large samples.

关键词： SUMO4 Type 2 diabetes mellitus (T2DM) Polymorphisms Meta-analysis

Association of C-reactive Protein with Cardiovascular Outcomes: A Mendelian Randomization Study in the Japanese Population

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Biomedical and Environmental Sciences 2022年第2期35卷 126-132页

作者： CAO Ming Yang LIU Di ZHANG Xiao Yu TIAN Qiu Yue ZHANG Qun wang you xin Beijing Key Laboratory of Clinical Epidemiology School of Public HealthCapital Medical UniversityBeijing 100069China Centre for Biomedical Information Technology Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongChina Department of Anesthesiology Sanbo Brain HospitalCapital Medical UniversityBeijing 100093China Chinese Center for Disease Control and Prevention Beijing 102206China Centre for Precision Medicine School of Medical and Health SciencesEdith Cowan UniversityPerth 60127Australia

Objective Traditional epidemiological studies have shown that C-reactive protein(CRP)is associated with the risk of cardiovascular diseases(CVDs).However,whether this association is causal remains ***,Mendelian randomization(MR)was used to explore the causal relationship of CRP with cardiovascular outcomes including ischemic stroke,atrial fibrillation,arrhythmia and congestive heart *** We performed two-sample MR by using summary-level data obtained from Japanese Encyclopedia of Genetic association by Riken(JENGER),and we selected four single-nucleotide polymorphisms associated with CRP level as instrumental *** estimates were calculated with the inverse-variance weighted(IVW),penalized weighted median and weighted ***-Egger regression was used to explore *** No significant causal association of genetically determined CRP level with ischemic stroke,atrial fibrillation or arrhythmia was found with all four MR methods(all Ps>0.05).The IVW method indicated suggestive evidence of a causal association between CRP and congestive heart failure(OR:1.337,95%CI:1.005–1.780,P=0.046),whereas the other three methods did *** clear pleiotropy or heterogeneity were *** Suggestive evidence was found only in analysis of congestive heart failure;therefore,further studies are ***,no causal association was found between CRP and the other three cardiovascular outcomes.

关键词： Mendelian randomization C-reactive protein Cardiovascular diseases East Asians Causal inference

Q estimation based on logarithmic spectral areas with different high and low frequencies

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Applied Geophysics 2021年第1期18卷 75-84,129,130页

作者： An Yong wang xin-you State Key Laboratory of Petroleum Resource and Prospecting China University of Petroleum102249BeijingChina CNPC Key Laboratory of Geophysical Exploration China University of Petroleum102249BeijingChina China Construction Northeast Design and Research Institute Co. Ltd.110000ShenyangChina.

When a seismic wave propagates through subsurface viscoelastic media,the formation absorbs the high-frequency energy of the seismic wave more strongly than the low-frequency *** the depth and the off set increase,the diff erence between the logarithmic spectral areas with high and low frequencies gradually *** on this seismic wave characteristic,we have developed a novel Q-estimation method based on logarithmic spectral area diff erence of high and low frequencies(referred to as the LSAD_LH method).In this paper,we derive the theoretical relationship between the Q value and difference of logarithmic spectral areas with high and low frequencies and prove the applicability of the LSAD_LH method using a single-layer medium numerical *** verify the sensitivity of the LSAD_LH method to bandwidth selection and noise,we compare the LSAD_LH method with two credible methods—the logarithmic spectral ratio(LSR)and logarithmic spectral area diff erence(LSAD)methods using a synthetic model containing the random *** results demonstrate that the LSAD_LH method is not highly dependent on bandwidth,and in terms of noise immunity,it is signifi cantly better than the LSR method and has the same advantages as the LSAD *** further highlight the advantages of the LSAD_LH method,we apply the LSAD_LH and LSAD methods to the vertical seismic profi ling(VSP)numerical simulation of the multilayer media and the fi eld zero-off set VSP *** application of the two cases proves the applicability of the LSAD_LH method and the accuracy of the high Q-value estimation relative to the LSAD ***,via the transmission coeffi cient,the LSAD_LH method overcomes the weakness of the LSAD method.

关键词： Attenuation of high-and low-frequency components Quality factor Logarithmic spectral area diff erence

Association between 25 Hydroxyvitamin D Concentrations and the Risk of COVID-19: A Mendelian Randomization Study

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Biomedical and Environmental Sciences 2021年第9期34卷 750-754页

作者： LIU Di TIAN Qiu Yue ZHANG Jie HOU Hai Feng LI Yuan wang Wei MENG Qun wang you xin Beijing Key Laboratory of Clinical Epidemiology School of Public HealthCapital Medical UniversityBeijing 100069China School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesTai’an 271016ShandongChina Lianyungang Maternal and Child Health Hospital Lianyungang 222055JiangsuChina School of Medical and Health Sciences Edith Cowan UniversityPerth 60127Australia Inner Mongolia Comprehensive Center for Disease Control and Prevention Hohhot 010031Inner Mongolia Autonomous RegionChina

Coronavirus disease 2019(COVID-19),which is caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has become a global pandemic[1].Primary prevention,which is aimed at delaying disease onset by modu... 详细信息

关键词： vitamin prevention acute

Association between IgG N-glycans and Nonalcoholic Fatty Liver Disease in Han Chinese

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Biomedical and Environmental Sciences 2018年第6期31卷 454-458页

作者： ZHAO Zhong Yao LIU Di CAO Wei Jie SUN Ming SONG Man Shu wang Wei wang you xin Beijing Key Laboratory of Clinical Epidemiology School of Public Health Capital Medical University School of Medical and Health Sciences Edith Cowan University

Nonalcoholic fatty liver disease（NAFLD） is a major public health issue worldwide. Immunoglobulin G（IgG） N-glycans are associated with risk factors for NAFLD, such as obesity and diabetes. A cross-sectional study involving 500 Han Chinese adults recruited from a community in Beijing was carried out to explore the association between IgG N-glycans and NAFLD. IgG N-glycosylation was significantly associated with NAFLD, with the disease showing a negative correlation with galactosylation（GP14, GP14n, and G2n）, positive correlation with fucosylation（FBG2n/G2n）, and positive correlation with bisecting N-acetylglucosamine（Glc NAc） [FBG2n/FG2n and FBG2n/（FG2n＋FBG2n）], after controlling age, gender, and prevalence of obesity, type 2 diabetes mellitus, hypertension, and hyperlipidemia. In other words, the present study showed a possible association between NAFLD and the loss of galactose and elevations of fucose and bisecting GlcNAc. Aberrant IgG glycosylation might therefore be a potential biomarker for the primary or secondary prevention of NAFLD.

关键词： NAFLD IgG Association between IgG N-glycans and Nonalcoholic Fatty Liver Disease in Han Chinese FBG

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以诠释学眼光重审《红楼梦》高鹗续书说

湖南大学学报（社会科学版） 2015年第5期29卷 30-37页

作者：王攸欣中南大学文学与新闻传播学院湖南长沙410083

《红楼梦》后四十回乃高鹗续书说是新红学的主要论断之一,笼罩《红楼梦》研究近百年。历来虽有异见,但从无以诠释学眼光对续书说进行系统审视者。本文从各个层面和维度论述高鹗续书说是在20世纪特定文化历史处境中,因为胡适等人诠释《... 详细信息

《红楼梦》后四十回乃高鹗续书说是新红学的主要论断之一,笼罩《红楼梦》研究近百年。历来虽有异见,但从无以诠释学眼光对续书说进行系统审视者。本文从各个层面和维度论述高鹗续书说是在20世纪特定文化历史处境中,因为胡适等人诠释《红楼梦》时的特殊生存状态而提出来的,其观点不能成立。作者通过文本细读和理论思辨,梳理出前人较少关注的系列证据作了较充分的论述,并推测《红楼梦》后四十回主体可能为曹雪芹生前原稿被毁后的重写稿。

关键词：诠释学重审《红楼梦》高鹗续书说曹雪芹

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朱光潜慈慧殿读诗会考论

湖南大学学报（社会科学版） 2011年第3期25卷 66-72页

作者：王攸欣中南大学文学院湖南长沙410083

作为京派文学沙龙的朱光潜慈慧殿读诗会,广受关注,但学界对其描述并不很准确。根据一些原始材料,对这个沙龙发起的缘由,起讫的时间及原因,参与的成员,以及具体的话题、内容作了较详细的梳理,以恢复一个文学史事件、场景的原貌。无意于... 详细信息

作为京派文学沙龙的朱光潜慈慧殿读诗会,广受关注,但学界对其描述并不很准确。根据一些原始材料,对这个沙龙发起的缘由,起讫的时间及原因,参与的成员,以及具体的话题、内容作了较详细的梳理,以恢复一个文学史事件、场景的原貌。无意于对京派的文学观念作出理论辨析。

关键词：朱光潜读诗会京派