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新时代农村基层组织建设推进乡村振兴的逻辑理路与行动策略

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中州学刊 2024年第9期 82-89页

作者：王凯马华山西大学乡村振兴研究院山西太原030006 山西大学政治与公共管理学院山西太原030006

新时代,农村基层组织建设推进乡村振兴作为一项重大的理论与现实问题,不仅是传承与发扬农村基层组织建设推动乡村发展这一党的优良传统,也是实现农村基层组织建设与乡村振兴深度耦合的关键路径,更是破解新发展阶段乡村社会治理难题的内... 详细信息

新时代,农村基层组织建设推进乡村振兴作为一项重大的理论与现实问题,不仅是传承与发扬农村基层组织建设推动乡村发展这一党的优良传统,也是实现农村基层组织建设与乡村振兴深度耦合的关键路径,更是破解新发展阶段乡村社会治理难题的内在要求。整体而言,我国农村基层组织建设推进乡村振兴经历了一个“核心主体重释—基层组织互动—组织体系建构”的良性动态发展过程。然而,在实践中,仍存在整合结构单一、组织力度不强、动员范围有限以及农村基层组织功能分散等具体问题。对此,须以实现农村基层组织增能为前提,以促进农村基层组织与乡村振兴深度融合为关键,以强化农民主体性为保障,以多元组织参与推进乡村治理现代化为目标,持续推动农村基层组织建设与乡村振兴的耦合发展和互促共融。

关键词：农村基层组织建设乡村振兴乡村治理

当代中国建筑实践状况关键词:全球议题与在地智慧

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建筑学报 2024年第1期 21-28页

作者：王凯王颖冯江同济大学建筑与城市规划学院上海200092 华南理工大学建筑学院广州510641

尝试观察过去20年的当代中国建筑话语及其生产过程,讨论如何在全球视野中理解当代中国建筑实践的特征,以及这种特征是否可以提供某种独特的经验,并最终形成某种“中国化”的理论思考;进而指出,基于具体实践条件的对全球性议题的在地化回... 详细信息

尝试观察过去20年的当代中国建筑话语及其生产过程,讨论如何在全球视野中理解当代中国建筑实践的特征,以及这种特征是否可以提供某种独特的经验,并最终形成某种“中国化”的理论思考;进而指出,基于具体实践条件的对全球性议题的在地化回应,是中国建筑实践独特性产生的根源。

关键词：当代中国建筑实践实践观察全球议题在地智慧

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu kai wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

Ganoboninketal C from Ganoderma boninense improves the efficacy of CDDP-based chemotherapy through inhibiting translesion DNA synthesis

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Food Science and Human Wellness 2024年第5期13卷 2982-2992页

作者： Xiaolu Ma Fei Yang Ke Ma Hongyan Shen Junjie Han kai wang Yeran Yang Jiawei Zhu Ruiyuan An Qilin wang Tie-Shan Tang Bo Zhou Hongwei Liu Caixia Guo College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030024China CAS Key Laboratory of Genomics and Precision Medicine Beijing Institute of Genomics/China National Center for BioinformationUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China Institute of Microbiology University of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100101China

Translesion DNA synthesis(TLS)can bypass DNA lesions caused by chemotherapeutic drugs,which usually result in drug *** its key role in mutagenesis and cell survival after DNA damage,inhibition of the TLS pathway has emerged as a potential target for improving the efficacy of DNA-damaging agents such as cisplatin(CDDP),a widely used anticancer ***,few suitable natural TLS inhibitors have been ***,we found that a triterpenoid compound Ganoboninketal C(26-3)from Ganoderma boninense,a traditional Chinese medicine,can impair CDDP-induced TLS polymerase eta(Polη)focus formation,PCNA monoubiquitination as well as ***,26-3 can significantly sensitize tumor cells to CDDP killing and reduce the proportion of cancer stem cells in AGS and promote apoptosis after CDDP ***,26-3 can also sensitize tumor cells to Gefitinib ***,through RNA-seq analysis,we found that 26-3 could abrogate the CDDP-induced upregulation of Polηand PIDD(p53-induced protein with a death domain),2 known factors promoting TLS ***,we found that activating transcription factor 3 is a potential novel TLS *** together,we have identified a natural TLS inhibitor 26-3,which can be potentially used as an adjuvant to improve clinical efficacy.

关键词： Ganoderma boninense Ganoboninketal C Cisplatin chemotherapy Translesion DNA synthesis

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表面横向风流作用下煤体的内部燃烧蔓延规律

工程科学学报 2024年第2期46卷 187-198页

作者：王凯王喆韩涛邓军张嬿妮西安科技大学安全科学与工程学院西安710054 陕西省煤火灾害防治重点实验室西安710054 陕西黄陵二号煤矿有限公司黄陵727300

煤的自燃特性使其在开采、存储和运输过程中存在火灾事故隐患,极大地阻碍了煤炭行业的可持续发展.通过自主搭建的敞车载运煤燃烧蔓延模拟实验装置,分析在表面横向风流作用下的松散煤体内部高温区域演变以及气体蔓延规律.结果表明,表面... 详细信息

煤的自燃特性使其在开采、存储和运输过程中存在火灾事故隐患,极大地阻碍了煤炭行业的可持续发展.通过自主搭建的敞车载运煤燃烧蔓延模拟实验装置,分析在表面横向风流作用下的松散煤体内部高温区域演变以及气体蔓延规律.结果表明,表面横向风流明显加快了本文实验煤样内部高温区域蔓延速度,相比无风状况下,高温蔓延速度加快了0.3倍(风流1 m·s^(-1)时)和0.5倍(风流2 m·s^(-1)时),高温区域峰值温度升高了120±20℃;受表面横向风流影响,燃烧蔓延路径向风流流动方向偏移;在风流0 m·s^(-1)时,燃烧的高温点O2体积分数快速下降阶段所经历的时间随纵深的增加逐渐增大,风流作用会加剧煤氧反应.研究成果可为煤炭在运输与储存过程煤火灾害形成规律研究提供参考借鉴.

关键词：煤自燃表面横向风流温度场气体蔓延敞车载运

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区域视角的城乡历史文化遗产保护思考

城市规划 2024年第6期48卷 4-13页

作者：王凯王军周亚杰中国城市规划设计研究院中国城市规划学会中国城市规划设计研究院历史文化名城保护与发展研究分院中国城市规划设计研究院战略研究中心

改革开放以来,我国的城乡历史文化保护工作取得了显著成效,但也存在城镇布局建设忽视地域文化特色、文化遗产保护缺乏区域视角和系统观念等问题,导致地域文化特色消退、区域文化体系和脉络遭到破坏。作为人类历史上唯一延续至今的灿烂文... 详细信息

改革开放以来,我国的城乡历史文化保护工作取得了显著成效,但也存在城镇布局建设忽视地域文化特色、文化遗产保护缺乏区域视角和系统观念等问题,导致地域文化特色消退、区域文化体系和脉络遭到破坏。作为人类历史上唯一延续至今的灿烂文明,中华文明“九州共贯、多元一体”,具有突出的连续性、统一性特征,从区域视角开展城乡历史文化遗产保护是弘扬中华文明的时代要求和必然选择。树立大历史观、大文化观和大区域观的城乡历史文化遗产保护理念,针对我国自然地理和地域文化多元的特征,提出以“精准适配”为核心思想、以“精准分析-适应布局-动态评估”为方法框架的区域城乡历史文化遗产保护理论方法,并应用于全国总体层面、跨区域跨流域文化廊道和典型文化片区等不同空间维度的保护实践,探索构建了我国区域城乡文化遗产保护的整体框架。

关键词：精准适配区域视角城乡历史文化遗产保护

Traditional Chinese Medicine in colorectal cancer treatment:a bibliometrics study and visualization analysis via CiteSpace

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Cancer Advances 2024年第7期7卷 1-9页

作者： Wen-kai wang Yuan-Yuan Feng Yi-Yang Zhao Zi-Wei wang Chao-Wei wang Xue-Qing Hu Ling Bi Yan wang Department of Medical Oncology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China

Objective:To evaluate the current state of research and areas of interest for traditional Chinese medicine(TCM)in the field of colorectal cancer ***:Related papers published between January 1,2012,and November 27,2021,were found using the Web of Science Core Collection Science Citation Index *** CiteSpace's network map generation capability,we then determined the top writers,organizations,countries,keywords,co-cited writers,journals,references,and research ***:This investigation yielded a total of 336 relevant *** is the most productive *** University of Traditional Chinese Medicine is the leading *** journal with the most popularity and publishing volume is Evidence-based Complementary and Alternative *** author with the most citations and centrality is Lin *** terms"epithelial-mesenchymal transition,""cell cycle arrest,""apoptosis,"and"autophagy"are highly frequent and have a high betweenness ***:According to the results,research on natural products,traditional Chinese medicine(TCM)extracts,and the molecular mechanisms of TCM chemical constituents constitutes the primary focus within TCM cancer treatment *** recent years,there has been a surge of interest in exploring the role of gut microbiota in TCM chemical constituents research,particularly in its ability to induce apoptosis and autophagy in tumor cells,thereby suppressing tumor cell proliferation,metastasis,and ***,due to the intricate composition of TCM and existing technical limitations,the underlying principles guiding TCM's efficacy in treating colorectal cancer remain unclear and warrant further investigation.

关键词： colorectal cancer Traditional Chinese Medicine bibliometrics study visualization analysis CiteSpace

Molecular Conformational Isomerization:An Efficient Way to Design Novel Emitters with Dual-Thermally Activated Delayed Fluorescence Characteristics and Their Optoelectronic and Bioimaging Applications

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CCS Chemistry 2024年第4期6卷 912-922页

作者： Yi-Zhong Shi Ya-Fang Xiao Hao Wu Shao-Li Zhang Xiao-Chun Fan Ye Tian Chang-Qing Ye kai wang Jia Yu Chun-Sing Lee Xiao-Hong Zhang School of Materials Science and Engineering Suzhou University of Science and TechnologySuzhou 215009 Institute of Functional Nano and Soft Materials(FUNSOM) Joint International Research Laboratory of Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123Jiangsu Center of Super-Diamond and Advanced Films(COSDAF) Department of ChemistryCity University of Hong KongHong Kong SAR School of Biomedical Engineering The Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260 Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow UniversitySuzhou 215123Jiangsu Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhou 215123Jiangsu

Single-molecule luminophores with dual-thermally activated delayed fluorescence(TADF)properties are receiving increasing ***,how to achieve these goals requires more in-depth ***,we demonstrate a novel example emitter,10-(5-(2-(pyridin-3-yl)-[4,5′-bipyrimidin]-6-yl)pyridin-2-yl)-10Hphenoxazine(PmPy-PXZ),enabling dual-TADF properties due to its key feature of conformational *** a pyridine bridge can greatly reduce the steric hindrance and facilitate dual-stable conformations in the ground state,where the quasi-axial(QA)forms ***,unlike previously reported TADF molecules with dual confirmations,both theoretical and experimental measurements show that not only the quasi-equatorial(QE)forms but also the QA forms exhibit distinct TADF characteristics,which can be attributed to an additional higher reverse intersystem crossing *** is the first time that dual-TADF properties of single molecules have been achieved based on conformational *** applications in“self-doping”organic light-emitting diode and biomedical imaging have further been *** these results show the good potential of such dual-band TADF emitters based on molecular conformational isomerization.

关键词： dual-thermally activated delayed fluorescence conformational isomerization organic light-emitting diode biomedical imaging self-doping

Integrative analysis of bone-formation associated genes and immune cell infiltration in osteoporosis, and the prediction of active ingredients in targeted traditional Chinese medicine

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Digital Chinese Medicine 2024年第2期7卷 160-170页

作者： wang kai DONG Ping GUO Hongzhang Department of Orthopedics Gansu Provincial HospitalLanzhouGansu 730000China College of Traditional Chinese Medicine Inner Mongolia Medical UniversityHohhotInner Mongolia 010110China

Objective To explore the differential expression and mechanisms of bone formation-related genes in osteoporosis(OP)leveraging bioinformatics and machine learning methodologies;and to predict the active ingredients of targeted traditional Chinese medicine(TCM)*** The Gene Expression Omnibus(GEO)and GeneCards databases were employed to conduct a comprehensive screening of genes and disease-associated loci pertinent to the pathogenesis of *** R package was utilized as the analytical tool for the identification of differentially expressed *** absolute shrinkage and selection operator(LASSO)logis-tic regression analysis and support vector machine-recursive feature elimination(SVM-RFE)algorithm were employed in defining the genetic signature specific to *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses for the selected pivotal genes were *** cell-type identification by estimating rela-tive subsets of RNA transcripts(CIBERSORT)algorithm was leveraged to examine the infiltra-tion patterns of immune cells;with Spearman’s rank correlation analysis utilized to assess the relationship between the expression levels of the genes and the presence of immune *** Medical Database was used to screen out potential TCM herbs for the treatment of *** Toxicogenomics Database(CTD)was employed for forecasting the TCM ac-tive ingredients targeting the key *** Vina 1.2.2 and GROMACS 2020 softwares were employed to conclude analysis results;facilitating the exploration of binding affinity and conformational dynamics between the TCM active ingredients and their biological *** Ten genes were identified by intersecting the results from the GEO and GeneCards *** the application of LASSO regression and SVM-RFE algorithm;four piv-otal genes were selected:coat protein(CP);kallikrein 3(KLK3);polymeraseγ(POLG);and transient receptor potential vanilloid 4(TRPV4).GO and

关键词： Osteoporosis Bone formation Differentially expressed genes Biological information Traditional Chinese medicine(TCM) Active ingredients Molecular mechanism