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Bioactive Materials 2021年第4期6卷 990-997页

作者： Na Sun Xiaoqiu Dou Zhimin Tang Dandan Zhang Ni Ni jiajing wang Huiqin Gao Yahan Ju Xiaochan Dai Changli Zhao Ping Gu Jing Ji Chuanliang Feng Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Department of OphthalmologyNinth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China State Key Lab of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiaotong UniversityDongchuan Road 800200240ShanghaiChina

Retinal degeneration is a main class of ocular *** far,retinal progenitor cell(RPC)transplantation has been the most potential therapy for it,in which promoting RPCs neuronal differentiation remains an unmet *** address this issue,innovatively designed L/D-phenylalanine based chiral nanofibers(LPG and DPG)are employed and it finds that chirality of fibers can efficiently regulate RPCs ***,western blot,and immunofluorescence analysis show that right-handed helical DPG nanofibers significantly promote RPCs neuronal differentiation,whereas left-handed LPG nanofibers decrease this *** effects are mainly ascribed to the stereoselective interaction between chiral helical nanofibers and retinol-binding protein 4(RBP4,a key protein in the retinoic acid(RA)metabolic pathway).The findings of chirality-dependent neuronal differentiation provide new strategies for treatment of neurodegenerative diseases via optimizing differentiation of transplanted stem cells on chiral nanofibers.

关键词： Chiral structures Self-assembly Nanofibers Retinal progenitor cell Neuronal differentiation

Verteporfin-mediated on/off photoswitching functions synergistically to treat choroidal vascular diseases

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Bioactive Materials 2022年第8期7卷 402-415页

作者： Yahan Ju Xiaochan Dai Zhimin Tang Zunzhen Ming Ni Ni Dongqing Zhu Jing Zhang Bo Ma jiajing wang Rui Huang Siyu Zhao Yan Pang Ping Gu Department of Ophthalmology Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011PR China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai200011PR China Central Laboratory Shanghai Tenth People’s HospitalTongji UniversityShanghai200072PR China

Choroidal vascular diseases,such as age-related macular degeneration,are the leading cause of vision impairment and are characterized by pathological ***-mediated photodynamic therapy is a current strategy that selectively occludes choroidal ***,the clinically used large-dose systemic administration increases the risk of systemic adverse events,such as phototoxicity to superficial *** this study,we developed an in situ verteporfin delivery system with a photoswitching synergistic function that disassembles in response to intraocular inflammatory *** light-on conditions,verteporfin-mediated photodynamic therapy effectively occurs and this leads to vascular *** light-off conditions,non-photoactive verteporfin negatively regulates vascular endothelial growth factor-induced angiogenesis as a yes-associated protein *** together,our system serves as an intraocular verteporfin reservoir to improve the bioavailability of verteporfin by innovatively exploiting its photochemical and biological *** work provides a promising strategy with synergistic antiangiogenic effects for the treatment of choroidal vascular diseases.

关键词： Pathological neovascularization Photodynamic therapy Bio-responsive release In situ drug delivery

放射性核素偶联药物的研究进展及技术评价层面的思考

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上海医药 2024年第13期45卷 10-13,33页

作者：王佳静张静烨董文彬陈一飞陈桂良颛孙燕上海药品审评核查中心上海201210

随着核医疗、核技术和分子生物学的发展,放射性配体疗法逐渐成为精准医疗的一个重要发展方向。国内通常将放射性配体疗法药物称为放射性核素偶联药物。这类药物通过将靶向配体分子与不同的放射性核素偶联,将放射性核素递送至特定肿瘤部... 详细信息

随着核医疗、核技术和分子生物学的发展,放射性配体疗法逐渐成为精准医疗的一个重要发展方向。国内通常将放射性配体疗法药物称为放射性核素偶联药物。这类药物通过将靶向配体分子与不同的放射性核素偶联,将放射性核素递送至特定肿瘤部位,产生诊断或治疗功能。本文分析放射性核素偶联药物的研究进展及技术评价层面面临的问题,并提出相关思考和研究思路,为我国药品监管部门制定相应的政策和措施提供参考。

关键词：放射性配体疗法放射性核素偶联药物研发

Nonlinear Dynamic Analysis of Flexible Marine-Risers

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China Ocean Engineering 1991年第4期6卷 373-384页

作者： Chen jiajing and wang Dongjiao Professor, South China University of Technology, Guangzhou PhD Student, Hong Kong Polytechnic Formerly, South China University of Technology, Guangzhou

A nonlinear dynamic analysis model is estabilished on the basis of 'lumped mass' approach, which takes the influence of the fluid flow within the pipe into consideration. Numerical results are compared with the published works, and the effects of internal fluid flow, internal pressure, dyanmics as well as the nonlinear characteristics on the behavior of flexible risers are discussed. From this work, some useful conclusions are drawn.

关键词： flexible riser nonlinear dynamic analysis model irregular wave oilfield exploitation

Cytochrome P450 CitCYP97B modulates carotenoid accumulation diversity by hydroxylating b-cryptoxanthin in Citrus

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Plant Communications 2024年第6期5卷 57-72页

作者： Yingzi Zhang jiajing Jin Nan wang Quan Sun Di Feng Shenchao Zhu Zexin wang Shunxin Li Junli Ye Lijun Chai Zongzhou Xie Xiuxin Deng National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory WuhanHubei 430070China

Carotenoids in plant foods provide health benefits by functioning as provitamin *** ofthe vital provitamin A carotenoids,b-cryptoxanthin,is typically plentiful in citrus ***,little is known about the genetic basis of b-cryptoxanthin accumulation in ***,we performed a widely targeted metabolomic analysis of 65 major carotenoids and carotenoid derivatives to characterize carotenoid accumulation in Citrus and determine the taxonomic profile of *** used data from 81 newly sequenced representative accessions and 69 previously sequenced Citrus cultivars to reveal the genetic basis of b-cryptoxanthin accumulation through a genome-wide association *** identified a causal gene,CitCYP97B,which encodes a cytochrome P450 protein whose substrate and metabolic pathways in land plants were *** subsequently demonstrated that CitCYP97B functions as a novel monooxygenase that specifically hydroxylates the b-ring of b-cryptoxanthin in a heterologous expression *** planta experiments provided further evidence that CitCYP97B negatively regulates b-cryptoxanthin *** the sequenced Citrus accessions,we found that two critical structural cis-element variations contribute to increased expression of CitCYP97B,thereby altering b-cryptoxanthin accumulation in ***/introgression appear to have contributed to the prevalence of two cis-element variations in different Citrus types during citrus ***,these findings extend our understanding of the regulation and diversity of carotenoid metabolism in fruit crops and provide a genetic target for production of b-cryptoxanthin-biofortified products.

关键词： carotenoids b-cryptoxanthin cytochrome P450 CYP97B hydroxylation

A Transformer Model-Based Approach to Bearing Fault Diagnosis

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国际计算机前沿大会会议论文集 2021年第1期 65-79页

作者： Zhenshan Bao Jialei Du Wenbo Zhang jiajing wang Tao Qiu Yan Cao Faculty of Information Technology Beijing University of TechnologyBeijing 100124China China North Vehicle Research Institute Beijing 100072China Faculty of Environment and Life Beijing University of TechnologyBeijing 100124China

Bearings are an important component in rotating machinery and theirfailure can lead to serious injuries and economic losses, therefore the diagnosis ofbearing faults and the guarantee of their smooth operation are essential steps inmaintaining the safe and stable operation of modern machinery and *** bearing fault diagnosis methods focus on manually designing complexnoise reduction, filtering, and feature extraction processes, however, theseprocesses are too cumbersome and lack intelligence, making it increasingly difficultto rely on manual diagnosis with large amounts of *** the developmentof information technology, convolutional neural networks have been proposed forbearing fault detection and identification. However, these convolutional modelshave the disadvantage of having difficulty handling fault-time information, leadingto a lack of classification accuracy. So this paper proposes a transformer-basedfault diagnosis method, using the short-time Fourier transform to convert the onedimensionalfault signal into a two-dimensional image, and then input the twodimensionalimage into the transformer model for classification. Experimentalresults show that the fault classification can reach an accuracy of 98.45%.

关键词： Fault diagnosis Transformer Convolutional neural network Deep learning

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基于纹理的SAR图像感知质量评估

哈尔滨工程大学学报 2015年第8期36卷 1137-1142页

作者：王佳婧焦淑红申连洋哈尔滨工程大学信息与通信工程学院 92677部队海军装备部驻沈阳地区军事代表局

传统的SAR(合成孔径雷达)图像质量评价方法没有考虑视觉感知特性,导致主客观评价不一致。为了改善SAR图像质量评估方法的感知特性,提出了一种基于纹理的符合人类视觉系统感知性的SAR图像质量评估方法。由于SAR图像具有很强的纹理性,所... 详细信息

传统的SAR(合成孔径雷达)图像质量评价方法没有考虑视觉感知特性,导致主客观评价不一致。为了改善SAR图像质量评估方法的感知特性,提出了一种基于纹理的符合人类视觉系统感知性的SAR图像质量评估方法。由于SAR图像具有很强的纹理性,所以提取SAR图像的灰度共生矩阵并计算它的对比度,然后利用视觉对比敏感度函数与小波变换的倍频程特性来加权纹理特征的结构信息。仿真实验结果表明:具有感知特性的SAR图像质量评估方法较之传统方法更充分的利用了纹理结构特性,不仅能够反映出干扰对不同纹理区域的影响,而且能与人类视觉系统保持高度一致。通过对SAR图像进行感知质量评估可以为SAR的干扰效能提供更有效的依据,有利于干扰技术和干扰样式的优化。

关键词： SAR图像纹理人类视觉系统图像质量评估感知特性灰度共生矩阵对比敏感度函数

Global Dynamic Molecular Profiling of Stomatal Lineage Cell Development by Single-Cell RNA Sequencing

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Molecular Plant 2020年第8期13卷 1178-1193页

作者： Zhixin Liu Yaping Zhou Jinggong Guo Jiaoai Li Zixia Tian Zhinan Zhu jiajing wang Rui Wu Bo Zhang Yongjian Hu Yijing Sun Yan Shangguan Weiqiang Li Tao Li Yunhe Hu Chenxi Guo Jean-David Rochaix Yuchen Miao Xuwu Sun State Key Laboratory of Crop Stress Adaptation and Improvement State Key Laboratory of Cotton BiologyKey Laboratory of Plant Stress BiologySchool of Life SciencesHenan University85 Minglun StreetKaifeng 475001China College of Life Sciences Shanghai Normal UniversityGuilin Road 100Shanghai200234China Departments of Molecular Biology and Plant Biology University of GenevaGeneva1211Switzerland

The regulation of stomatal lineage cell development has been extensively ***,a comprehensive characterization of this biological process based on single-cell transcriptome analysis has not yet been *** this study,we performed RNA sequencing on 12844 individual cells from the cotyledons of 5-day-old Arabidopsis *** identified 11 cell clusters corresponding mostly to cells at specific stomatal developmental stages using a series of marker *** analysis of genes with the highest variable expression among these cell clusters revealed transcriptional networks that regulate development from meristemoid mother cells to guard mother *** of the developmental dynamics of marker genes via pseudo-time analysis revealed potential interactions between these ***,our study opens the door for understanding how the identified novel marker genes participate in the regulation of stomatal lineage cell development.

关键词： molecular profiling stomatal development single-cell RNA-seq

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幽门螺杆菌的基因分型技术及其应用

浙江大学学报（医学版） 2018年第1期47卷 97-103页

作者：王佳静谷海瀛宁波大学医学院浙江宁波315211

幽门螺杆菌(Hp)可以在人群中广泛传播,并会引发一系列的胃肠道疾病甚至胃癌。不同基因型的Hp感染可能会引发不同类型的疾病,而基因分型技术是研究这类问题的重要方法。本文主要介绍了多位点序列分型、脉冲场凝胶电泳、随机扩增多态DNA... 详细信息

幽门螺杆菌(Hp)可以在人群中广泛传播,并会引发一系列的胃肠道疾病甚至胃癌。不同基因型的Hp感染可能会引发不同类型的疾病,而基因分型技术是研究这类问题的重要方法。本文主要介绍了多位点序列分型、脉冲场凝胶电泳、随机扩增多态DNA、扩增片段长度多态性和全基因组测序这五种基因分型技术,通过综述这几种技术在Hp基因分型中的应用进展,比较它们之间的优缺点,为今后研究Hp的致病机制、传播机制以及流行病学调查提供方法学依据。

关键词：螺杆菌,幽门基因型序列标记位点电泳,凝胶,脉冲场多态性,限制性片段长度随机扩增多态DNA技术聚合酶链反应基因组,细菌综述

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论文作坊的特点与甄别方法

中国科技期刊研究 2022年第8期33卷 1019-1025页

作者：王佳静王蒲生清华大学医院管理研究院广东省深圳市518055 清华大学深圳国际研究生院广东省深圳市518055

【目的】通过深入探究论文作坊的现状及其涉及的学术不端行为,分析论文作坊的特点、行迹和危害,进而设计系统有效的甄别方法,防范论文作坊的滋蔓。【方法】使用Python对撤稿观察数据库中涉嫌论文作坊的撤稿进行撤稿时间趋势和国别对比分... 详细信息

【目的】通过深入探究论文作坊的现状及其涉及的学术不端行为,分析论文作坊的特点、行迹和危害,进而设计系统有效的甄别方法,防范论文作坊的滋蔓。【方法】使用Python对撤稿观察数据库中涉嫌论文作坊的撤稿进行撤稿时间趋势和国别对比分析,并采用案例分析法对国家自然科学基金委员会、撤稿观察网站公布的多个典型案例进行分析。【结果】近年来由论文作坊引起的国际期刊集体撤稿事件频发,被撤稿的作坊论文数量激增,且绝大多数来源于中国学者。论文作坊常通过抄袭剽窃、数据造假、图片重复使用、大规模同行评议造假、不当署名、基金标注不实、一稿多投和重复发表等手段作伪,既会损害科学的独创性,割裂署名的权责关系,还会增加审稿和撤稿环节的时间成本和经济成本,甚至对地域的学术声誉造成重创。【结论】论文作坊近年来有上升势头,且以中国为甚。这种“作坊式作弊”涉及多种学术不端行为,积弊綦深、为害甚烈。可根据写稿、投稿和撤稿环节的异常情况对作坊论文予以甄别。写稿环节数据来源异常,修图痕迹明显;内容质量粗劣,专业素养缺失。投稿过程操作混乱,代投痕迹明显。面对质疑和撤稿问询,作者往往选择消极推诿而非积极申诉;邮件交流中英文表达不畅,回复内容空洞浮泛。

关键词：论文作坊撤销论文学术不端