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Spectrum of venous thromboembolism in adult patients with ulcerative colitis in Pakistan:A single center retrospective study

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World Journal of Clinical Cases 2025年第6期13卷 9-13页

作者： Masood Muhammad Karim Hafsa Shaikh Faisal wasim Ismail Department of Medicine The Aga Khan University HospitalKarachi 74800Pakistan Department of General Surgery The Aga Khan University HospitalKarachi 74800Pakistan

BACKGROUND Patients with inflammatory bowel disease are at a 2-8-fold higher risk of deve-loping venous thromboembolism(VTE)as compared to the general *** the exact pathogenesis is unclear,the literature suggests that increased risk of thromboembolic events in such patients occurs as a result of increased coagulation factors,inflammatory cytokines,and reduction in anticoagulants leading to a prothrombotic *** To assess the prevalence,risk factors,management,and outcome of ulcerative colitis(UC)patients who develop *** This was a retrospective chart review done in The Gastroenterology Department of The Aga Khan University *** was collected from medical records for all patients admitted with a diagnosis of UC from January 2012 to December *** Seventy-four patients fulfilled the inclusion *** mean±SD of age at presentation of all UC patients was 45 years±10 years whereas for those who developed VTE,it was 47.6 years±14.7 *** and diabetes were the most common co-morbid seen among UC patients with a frequency of 17(22.9%)and 12(16.2%),respectively.A total of 5(6.7%)patients developed *** venous thrombosis was the most common thromboembolic phenomenon seen in 3(60%)*** the patients with UC and concomitant VTE were discharged home(5;100%).CONCLUSION The prevalence of VTE with UC in Pakistani patients corresponds with the international ***,multi-centric studies are required to further explore these results.

关键词： Deep venous thrombosis Inflammatory bowel disease Low-middle-income country Anticoagulation Protein C deficiency

Rising incidence of acute hepatitis A among adults and clinical characteristics in a tertiary care center of Pakistan

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World Journal of Virology 2025年第1期14卷 73-82页

作者： Yumna Shahid Amna Subhan Butt Iqra Jamali Faisal wasim Ismail Division of Gastroenterology Department of MedicineAga Khan University HospitalKarachi 74800Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan

BACKGROUND For decades,hepatitis A virus(HAV)has been a leading cause of acute hepatitis among children and was less prevalent among ***,recently a paradigm shift has been observed in the epidemiology of HAV,as evident by cases of acute hepatitis due to HAV among *** To estimate frequency of HAV in acute viral hepatitis and compare characteristics in HAV and hepatitis E virus(HEV)*** This was a trend analysis conducted at Aga Khan University Hospital Karachi(Sindh,Pakistan)from February 2024 to May *** aged 18 years and older diagnosed with acute viral hepatitis attributed to hepatotropic viruses in 2024 were *** compare the trend patients admitted with acute hepatitis during 2019-2023 were also *** regarding clinical and laboratory parameters were *** yearly trend of acute hepatitis due to HAV and HEV was analyzed,and comparative analysis was done between HAV and HEV cases among *** A total of 396 patients were found to have acute hepatitis during our study *** was diagnosed in 234 patients(59%)while 157 patients(39.6%)were found to have acute HEV ***,acute hepatitis B virus infection was identified in 3 patients(0.7%),whereas acute hepatitis C virus infection was found in 2(0.5%)cases of acute *** trends showed increasing occurrence of HAV infection among adults over last 5 *** patients with acute HAV were younger than patients with HEV(28 years±8 years vs 30 years±8 years;P<0.01).Higher levels of total bilirubin were seen in HEV infection,while higher levels of alanine transaminase were seen in HAV ***,a higher proportion of acute liver failure(ALF),coagulopathy,and mortality were observed in *** An increase in acute hepatitis A cases among adults shows less severity than hepatitis E,highlighting the need for better sanitation,hygiene,and adult hepatitis A vaccination programs.

关键词： Acute hepatitis Hepatitis A virus Hepatitis E virus Acute liver failure Hepatotropic virus Vaccination

Integer quantum Hall effect in Kekulé-patterned graphene

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Chinese Physics B 2022年第1期31卷 553-560页

作者： yawar Mohammadi Samira Bahrami Department of Physics Farhangian UniversityTehranIran

Y-shaped Kekulébond textures in a honeycomb lattice on a graphene-copper superlattice have recently been experimentally *** this paper,the effects of such a bond modulation on the transport coefficients of Kekulé-patterned graphene are investigated in the presence of a perpendicular magnetic *** expressions are derived for the Hall and longitudinal conductivities using the Kubo *** is found that the Y-shaped Kekulébond texture lifts the valley degeneracy of all Landau levels except that of the zero mode,leading to additional plateaus in the Hall conductivity accompanied by a split of the corresponding peaks in the longitudinal ***,the Hall conductivity is quantized as±ne^(2)/h for n=2,4,6,8,10,...,excluding some plateaus that disappear due to the complete overlap of the Landau levels of different *** results also suggest that DC Hall conductivity measurements will allow us to determine the Kekulébond texture amplitude.

关键词： AAA-stacked trilayer graphene integer quantum Hall effect Kubo formula Hall conductivity

Airship aerodynamic model estimation using unscented Kalman filter

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Journal of Systems Engineering and Electronics 2020年第6期31卷 1318-1329页

作者： wasim Muhammad ALI Ahsan Department of Electrical Engineering University of Engineering and TechnologyTaxila 47080Pakistan

An airship model is made-up of aerostatic,aerodynamic,dynamic,and propulsive forces and *** others,the computation of aerodynamic forces and torques is ***,wind tunnel experimentation and potential flow theory are used for their ***,the limitations of these methods pose difficulties in their accurate *** this work,an online estimation scheme based on unscented Kalman filter(UKF)is proposed for their *** proposed method introduces six auxiliary states for the complete aerodynamic *** uses an extended model and provides an estimate of a complete state vector along with auxiliary *** proposed method uses the minimum auxiliary state variables for the approximation of the complete aerodynamic model that makes it computationally less *** estimation performance is evaluated by developing a nonlinear simulation environment for University of Engineering and Technology,Taxila(UETT)*** performance is vali􀅫dated by performing the error analysis based on estimation error and 2-σ uncertainty *** the same problem,the extended Kalman filter(EKF)is also implemented and its results are compared with *** simulation results show that UKF successfully estimates the forces and torques due to the aerodynamic model with small estimation error and the comparative analysis with EKF shows that UKF improves the estimation re􀅫sults and also it is more suitable for the under-consideration problem.

关键词： airship unscented Kalman filter(UKF) extend Kalman filter(EKF) state estimation aerodynamic model estimation

A review on application of dielectric barrier discharge plasma technology on the abatement of volatile organic compounds

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Frontiers of Environmental Science & Engineering 2019年第2期13卷 1-19页

作者： Wenjing Lu yawar Abbas Muhammad Farooq Mustafa Chao Pan Hongtao Wang School of Environment Tsinghua UniversityBeijing 100084China Department of Environmental Design Health and Nutritional SciencesAllama Iqbal Open UniversityIslamabad 44000Pakistan

Volatile organic compounds(VOCs)released from the waste treatment facilities have become a significant issue because they are not only causing odor nuisance but may also hazard to human ***-thermal plasma(NTP)technologies are newly developed methods and became a research trend in recent years regarding the removal of VOCs from the air *** to its unique characteristics,such as rapid response at room temperature,bulk homogenized volume,high reaction efficiency,dielectric barrier discharge(DBD)plasma technology is considered one of the most promising techniques of *** paper reviews recent progress of DBD plasma technology for abatement of *** principle of plasma generation in DBD and its configurations(electrode,discharge gap,dielectric barrier material,etc.)are discussed in *** on previously published literature,attention has been paid on the effect of DBD configuration on the removal of *** of various process parameters such as initial concentration,gas feeding rate,oxygen content and input power on VOCs removal are also ***,the role of catalysis and inhibitors in VOCs removal by DBD system are ***,a modified configuration of the DBD reactor,*** dielectric barrier discharge(DDBD)for the abatement of VOCs is *** was suggested that the DDBD plasma reactor could be used for higher conversion efficiency as well as for avoiding solid residue deposition on the *** depositions can interfere with the performance of the reactor.

关键词： Non-thermal plasma (NTP) Dielectric barrier discharge (DBD) Volatile organic compounds (VOCs) Abatement Input power

Extent, reasons and consequences of off-labeled and unlicensed drug prescription in hospitalized children: a narrative review

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World Journal of Pediatrics 2021年第4期17卷 341-354页

作者： wasim Shuib Xin-Yin Wu Fang Xiao Xiangya School of Public Health Central South UniversityChangsha410078China

Background Off-label and unlicensed prescriptions pose a severe safety concern among the pediatric *** aimed to summarize the up-to-date evidence on the extent,reasons,and consequences of off-label and unlicensed drugs in hospitalized pediatric *** We systematically searched PubMed,EMBASE,SCOPUS,Web of Science and Google Scholar between 1990 and 2020 in which the last search was conducted on 12 February *** included studies with the following inclusion criteria:(1)observational studies in design;(2)target population was hospitalized pediatric patients whether admitted in the intensive care unit or in the general ward;(3)study reporting the prevalence of off-label,unlicensed prescriptions or both;and(4)published in *** A total of 47 studies were eligible for *** proportion of off-label and unlicensed prescriptions ranged from 7.4%to 99.5%and 0.1%to 74.4%,*** most frequent category of off-label prescriptions was prescription outside the age range,with the most commonly reported reason for off-label prescriptions being the lack of information specifically for pediatrics on the drug information *** consequences of off-label and unlicensed prescriptions ranged from minor and bearable skin reactions to debilitating renal failure,risking *** Off-label and unlicensed prescriptions are extensive and require progressively meditative ***,the pediatric population is currently a“therapeutic orphan”.Unless adequate pediatric clinical trials and licensed drugs become available,off-label and unlicensed drug prescription should not entirely be banned but rather promoted in an organized manner.

关键词： Licensed medicines Off-label prescribing Pediatrics Unlicensed prescribing

Understanding the Impact of H_(2) Diffusion Energy on the Formation Efficiency of H_(2) on the Interstellar Dust Grain Surface

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Research in Astronomy and Astrophysics 2024年第9期24卷 190-198页

作者： Xiaoying Guo wasim Iqbal Qiang Chang Xiao-Hu Li School of Physics and Optoeletronic Engineering Shandong University of TechnologyZibo 255000China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesUrumqi 830011China

We use microscopic Monte Carlo simulation techniques to investigate the impact of H_(2)diffusion energy on the recombination efficiency of H_(2)on interstellar dust grain surfaces under diffuse and translucent cloud *** constructed five models representing different possible conditions encountered by adsorbed H and H_(2)on interstellar dust *** implemented adsorption sites with multiple binding energies for surface species;the Encounter-Desorption mechanism was also *** study focused on silicate surfaces in diffuse clouds and water ice surfaces in translucent *** results show that the recombination efficiency of H_(2)on dust surfaces decreases as H_(2)diffusion energy *** interesting finding of this work is that considering different binding sites for H and H_(2)gives rise to multiple steady phases,during which the recombination efficiency remains constant with a change in H_(2)diffusion energy.

关键词： astrochemistry atomic processes ISM:molecules

Adipose-derived regenerative therapies for the treatment of knee osteoarthritis

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World Journal of Stem Cells 2024年第4期16卷 324-333页

作者： Ilias E Epanomeritakis wasim S Khan Division of Trauma and Orthopaedic Surgery Addenbrooke’s HospitalCambridge University Hospitals NHS Foundation TrustCambridge CB20QQUnited Kingdom Division of Trauma and Orthopaedic Surgery Department of SurgeryUniversity of CambridgeCambridge CB20QQUnited Kingdom

Knee osteoarthritis is a degenerative condition with a significant disease burden and no disease-modifying *** treatment ultimately requires joint *** capable of regenerating cartilage could significantly reduce financial and clinical *** regenerative potential of mesenchymal stromal cells(MSCs)has been extensively studied in the context of knee *** has yielded promising results in human studies,and is likely a product of immunomodulatory and chondroprotective biomolecules produced by MSCs in response to ***-derived MSCs(ASCs)are becoming increasingly popular owing to their relative ease of isolation and high proliferative *** vascular fraction(SVF)and micro-fragmented adipose tissue(MFAT)are produced by the enzymatic and mechanical disruption of adipose tissue,*** avoids expansion of isolated ASCs ex vivo and their composition of heterogeneous cell populations,including immune cells,may potentiate the reparative function of *** this editorial,we comment on a multicenter randomized trial regarding the efficacy of MFAT in treating knee *** discuss the study’s findings in the context of emerging evidence regarding adipose-derived regenerative *** underlying mechanism of action of ASCs is proposed while drawing important distinctions between the properties of isolated ASCs,SVF,and MFAT.

关键词： Knee osteoarthritis Mesenchymal stromal cells Adipose tissue Stromal vascular fraction Micro-fragmented adipose tissue Regeneration

Sex-Dependent Glial Signaling in Pathological Pain:Distinct Roles of Spinal Microglia and Astrocytes

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Neuroscience Bulletin 2018年第1期34卷 98-108页

作者： Gang Chen Xin Luo M.yawar Qadri Temugin Berta Ru-Rong Ji Department of Anesthesiology Duke University Medical Center Key Laboratory of Neuroregeneration of Jiangsu and the Ministry of Education Co-Innovation Center of Neuroregeneration Nantong University Pain Research Center Department of AnesthesiologyUniversity of Cincinnati Medical Center Department of Neurobiology Duke University Medical Center

Increasing evidence suggests that spinal micro- glia regulate pathological pain in males. In this study, we investigated the effects of several microglial and astroglial modulators on inflammatory and neuropathic pain follow- ing intrathecal injection in male and female mice. These modulators were the microglial inhibitors minocycline and ZVEID （a caspase-6 inhibitor） and the astroglial inhibitors L-α-aminoadipate （L-AA, an astroglial toxin） and car- benoxolone （a connexin 43 inhibitor）, as well as U0126 （an ERK kinase inhibitor） and D-JNKI-1 （a c-Jun N-terminal kinase inhibitor）. We found that spinal administration of minocycline or ZVEID, or Caspase6 deletion, reduced formalin-induced inflammatory and nerve injury-induced neuropathic pain primarily in male mice. In contrast, intrathecal L-AA reduced neuropathic pain but not inflam- matory pain in both sexes. Intrathecal U0126 and D-JNKI- 1 reduced neuropathic pain in both sexes. Nerve injury caused spinal upregulation of the astroglial markers GFAP and Connexin 43 in both sexes. Collectively, our data confirmed male-dominant microglial signaling but also revealed sex-independent astroglial signaling in the spinal cord in inflammatory and neuropathic pain.

关键词： Astrocytes - Microglia Sex difference Spinal cord