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Bone tissue engineering scaffold materials: Fundamentals, advances, and challenges

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Chinese Chemical Letters 2024年第2期35卷 176-186页

作者： Chang Xu Zhize Liu xi Chen Yang Gao Wenjun wang xijing Zhuang Hao Zhang Xufeng Dong Department of Cardiovascular Surgery Central Hospital of Dalian University of TechnologyDalian 116089China School of Materials Science and Engineering Dalian University of TechnologyDalian 116024China Department of Orthopaedics Central Hospital of Dalian University of TechnologyDalian 116089China Department of Dermatology Allergologyand VenereologyUniversity of LübeckLübeck 23562Germany

Bone damage caused by trauma and tumors is a serious problem for human health, therefore, three-dimensional (3D) scaffolding materials that stimulate and promote the regeneration of broken bone tissues have become the focus of current research in the field of bone damage *** this regard, a preferential combination of materials and preparation techniques is considered crucial for the preparation of advanced bone tissue engineering scaffolds to better facilitate the regeneration of broken *** this review, current research advances and challenges in bone tissue engineering scaffolds are discussed and analyzed in ***, we elucidated the structure and self-healing mechanism of bone ***, the main applications of different materials, including inorganic and organic materials, in bone tissue engineering scaffolds are ***, we overview the latest research progress of the mainstream preparation strategies of bone tissue engineering scaffolds, and provide an in-depth analysis of the different advantages of each ***, promising future directions and challenges of bone tissue engineering scaffolds are systematically discussed.

关键词： Biomaterials Bone defects Tissue engineering Scaffolds Osteogenesis

Long noncoding RNA protein-disulfide isomerase-associated 3 regulated high glucose-induced podocyte apoptosis in diabetic nephropathy through targeting miR-139-3p

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World Journal of Diabetes 2024年第2期15卷 260-274页

作者： Yin-xi He Ting wang Wen-xian Li Yan-xia Chen Department of Orthopaedic Trauma The Third Hospital of ShijiazhuangShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology The First Hospital of ZhangjiakouZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Podocyte apoptosis plays a vital role in proteinuria pathogenesis in diabetic nephropathy(DN).The regulatory relationship between long noncoding RNAs(lncRNAs)and podocyte apoptosis has recently become another research hot spot in the DN *** To investigate whether lncRNA protein-disulfide isomerase-associated 3(Pdia3)could regulate podocyte apoptosis through miR-139-3p and revealed the underlying *** Using normal glucose or high glucose(HG)-cultured podocytes,the cellular functions and exact mechanisms underlying the regulatory effects of lncRNA Pdia3 on podocyte apoptosis and endoplasmic reticulum stress(ERS)were *** Pdia3 and miR-139-3p expression were measured through quantitative real-time polymerase chain *** cell viability was detected through the cell counting kit-8 colorimetric *** podocyte apoptosis rate in each group was measured through flow *** interaction between lncRNA Pdia3 and miR-139-3p was examined through the dual luciferase reporter ***,western blotting was performed to detect the effect of lncRNA Pdia3 on podocyte apoptosis and ERS via *** The expression of lncRNA Pdia3 was significantly downregulated in HG-cultured ***,lncRNA Pdia3 was involved in HG-induced podocyte ***,the dual luciferase reporter assay confirmed the direct interaction between lncRNA Pdia3 and *** Pdia3 overexpression attenuated podocyte apoptosis and ERS through miR-139-3p in HG-cultured *** Taken together,this study demonstrated that lncRNA Pdia3 overexpression could attenuate HG-induced podocyte apoptosis and ERS by acting as a competing endogenous RNA of miR-139-3p,which might provide a potential therapeutic target for DN.

关键词： Long noncoding RNAs Diabetic nephropathy Podocyte apoptosis Endoplasmic reticulum stress Competing endogenous RNA

Alcohothermal synthesis of sulfidated zero-valent iron for enhanced Cr(Ⅵ)removal

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Chinese Chemical Letters 2024年第7期35卷 192-195页

作者： Zhongsen wang Lijun Qiu Yunhua Huang Meng Zhang xi Cai Fanyu wang Yang Lin Yanbiao Shi xiao Liu Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of ChemistryCentral China Normal UniversityWuhan 430079China

Sulfidation of zero-valent iron(ZVI)has attracted broad attention in recent years for improving the sequestration of contaminants from ***,sulfidated ZVI(S-ZVI)is mostly synthesized in the aqueous phase,which usually causes the formation of a thick iron oxide layer on the ZVI surface and hinders the efficient electron transfer to the *** this study,an alcohothermal strategy was employed for S-ZVI synthesis by the one-step reaction of iron powder with elemental *** is found that ferrous sulfide(FeS)with high purity and fine crystallization was formed on the ZVI surface,which is extremely favorable for electron ***(Ⅵ)removal experiments confirm that the rate constant of SZVI synthesized by the alcohothermal method was 267.1-and 5.4-fold higher than those of un-sulfidated ZVI and aqueous-phase synthesized S-ZVI,*** characterizations proved that Cr(Ⅵ)was reduced and co-precipitated on S-ZVI in the form of a Fe(Ⅲ)/Cr(Ⅲ)/Cr(Ⅵ)composite,suggesting its environmental benignancy.

关键词： Zero-valent iron Sulfidation Alcohothermal method Cr(Ⅵ)removal

Occurrence and prevention of incisional hernia following laparoscopic colorectal surgery

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 1973-1980页

作者： xi-Wen Wu Ding-Quan Yang Ming-Wei wang Yan Jiao The First Operating Room The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Gastrointestinal and Colorectal Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Ministry of Health Key Laboratory of Radiobiology School of Public Health of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

Among minimally invasive surgical procedures,colorectal surgery is associated with a notably higher incidence of incisional hernia(IH),ranging from 1.7% to 24.3%.This complication poses a significant burden on the healthcare system annually,necessitating urgent attention from *** a study published in the World Journal of Gastrointestinal Surgery,Fan et al compared the incidence of IH among 1614 patients who underwent laparoscopic colorectal surgery with different extraction site locations and evaluated the risk factors associated with its *** editorial analyzes the current risk factors for IH after laparoscopic colorectal surgery,emphasizing the impact of obesity,surgical site infection,and the choice of incision location on its ***,we summarize the currently available preventive measures for *** the low surgical repair rate and high recurrence rate associated with IH,prevention deserves greater research and attention compared to treatment.

关键词： Incisional hernia Laparoscopy Colorectal surgery Risk factor Prevention

Manufacturing task data chain-driven production logistics trajectory analysis and optimization decision making method

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Advances in Manufacturing 2024年第1期12卷 185-206页

作者： Lin Ling Zhe-Ming Song xi Zhang Peng-Zhou Cao xiao-Qiao wang Cong-Hu Liu Ming-Zhou Liu School of Mechanical Engineering Hefei University of TechnologyHefei230009People’s Republic of China Guobo Electronics Co.Ltd. Nanjing211111People’s Republic of China School of Mechanical and Electronic Engineering Suzhou UniversitySuzhou234000AnhuiPeople’s Republic of China Sino-US Global Logistics Institute Shanghai Jiao Tong UniversityShanghai200030People’s Republic of China

Production logistics(PL)is considered as a critical factor that affects the efficiency and cost of production operations in discrete manufacturing *** effectively utilize manufacturing big data to improve PL efficiency and promote job shop floor economic benefits,this study proposes a PL trajectory analysis and optimization decision making method driven by a manufacturing task data chain(MTDC).First,the manufacturing task chain(MTC)is defined to characterize the discrete production process of a *** handle manufacturing big data,the MTC data paradigm is designed,and the MTDC is ***,the logistics trajectory model is presented,where the various types of logistics trajectories are extracted using the MTC as the search engine for the *** on this,a logistics efficiency evaluation indicator system is proposed to support the optimization decision making for the ***,a case study is applied to verify the proposed method,and the method determines the PL optimization decisions for PL efficiency without changing the layout and workshop equipment,which can assist managers in implementing the optimization decisions.

关键词： Production logistics(PL) Logistics trajectory analysis Logistics optimization Data driven Manufacturing task data chain(MTDC)

Face animation based on multiple sources and perspective alignment

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虚拟现实与智能硬件（中英文） 2024年第3期6卷 252-266页

作者： Yuanzong MEI Wenyi wang xi LIU Wei YONG Weijie WU Yifan ZHU Shuai wang Jianwen CHEN School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute(Quzhou) University of Electronic Science and Technology of ChinaQuzhou 324000China

Background Face image animation generates a synthetic human face video that harmoniously integrates the identity derived from the source image and facial motion obtained from the driving *** technology could be beneficial in multiple medical fields,such as diagnosis and privacy *** studies on face animation often relied on a single source image to generate an output *** a significant pose difference between the source image and the driving frame,the quality of the generated video is likely to be suboptimal because the source image may not provide sufficient features for the warped feature *** In this study,we propose a novel face-animation scheme based on multiple sources and perspective alignment to address these *** first introduce a multiple-source sampling and selection module to screen the optimal source image set from the provided driving *** then propose an inter-frame interpolation and alignment module to further eliminate the misalignment between the selected source image and the driving *** The proposed method exhibits superior performance in terms of objective metrics and visual quality in large-angle animation scenes compared to other state-of-the-art face animation *** indicates the effectiveness of the proposed method in addressing the distortion issues in large-angle animation.

关键词： Face animation Multiple-source driving Generative adversarial network Medical diagnostics

Highly dispersive tetrahedral vanadium species on pure silica ZSM-12 zeolite boosting the selective oxidation of cyclohexane into cyclohexanone

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Science China Chemistry 2024年第7期67卷 2206-2214页

作者： Menglin xie Ting Li Chao Wu xiaoling Liu Jinling Ni Siqin Yao Yu Zhou Shibo xi Jun wang State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Institute of Sustainability for Chemicals Energy and Environment(ISCE2)Agency for ScienceTechnology and Research(A*STAR)Singapore 627833Republic of Singapore College of Materials Science and Engineering Sichuan UniversityChengdu 610065China

The selective oxidation of cyclohexane is a promising green route for the production of KA oil(cyclohexanol and cyclohexanone),but remains a huge challenge to design high-performing heterogeneous catalysts under mild ***,a pure silica ZSM-12(MTW topology)zeolite was applied as the support to immobilize highly dispersive tetrahedrally coordinated vanadium(V)species and the constructed catalyst 1%V/SZ-12 exhibited high efficiency in the fast and selective oxidation of cyclohexane into cyclohexanone with H_(2)O_(2).The reaction completed within 30 s,affording the selectivity of 99%towards cyclohexanone and the extremely high turnover frequency(TOF)of 5,891 h^(-1).1%V/SZ-12 was facilely reused with stable activity and feasibly extended to the oxidation of various cyclohexane *** one-dimensional 12-membered ring microchannels contributed to the formation and accessibility of tetrahedrally coordinated high valent V5+species as the robust active centers,which activated H_(2)O_(2) to generate V–O–O·,the active oxygen species for the electrophilic attack on cyclohexane to produce cyclohexanone as the sole product.

关键词： zeolite metal doping cyclohexane oxidation heterogeneous catalysis

Influence of misting system on the thermal environment and thermal comfort of seated people in semi-outdoor space in xi’an,China

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Frontiers of Architectural Research 2024年第3期13卷 668-681页

作者： Xu xie Zhen Sun xi Zhu Shengkai Zhao Zun wang Yongchao Zhai College of Architecture Xi’an University of Architecture and TechnologyXi’an 710055China State Key Laboratory of Green Building Xi’an University of Architecture and TechnologyXi’an 710055China

In summer,factors such as solar radiation could make semi-outdoor spaces uncomfortable,and the use of misting systems for evaporative cooling is a low-energy improvement *** investigate the impact of misting system on the thermal environment and thermal comfort of seated people improvement,a field study was conducted at a semi-outdoor cafeteria in xi’*** results indicated that the misting system was capable of reducing the ambient air temperature by 2.4-4.9℃and increasing the relative humidity by 17.1%-17.8%.Participants in misting condition reported lower thermal sensation and higher thermal acceptability,thermal preference,humidity sensation,humidity preference and humidity *** no misting condition,the upper SET*limit acceptable to 80%of the population was 28.5℃.However,in the misting condition,the acceptable percentage of participants in each SET)interval was more than 90%.When SET)was 22.1-23.7℃,the improvement in human thermal comfort through misting system was not *** SET)was 23.7-28.5℃,the misting system significantly improve human thermal ***,two control temperature thresholds of the misting system were provided according to the relationship between 80%,the maximum(89.3%)acceptable percentage and the air temperature,which were 30.1℃and 26.5℃,respectively.

关键词： Misting system Thermal environment Thermal response Acceptable temperature Control strategy

Reversing artemisinin resistance by leveraging thermo-responsive nanoplatform to downregulating GSH

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Chinese Chemical Letters 2024年第6期35卷 392-397页

作者： Yong-Dan Zhao Yidan wang Rongrong wang Lina Chen Hengtong Zuo xi wang Jihong Qiang Geng wang Qingxia Li Canqi Ping Shuqiu Zhang Hao wang School of Pharmacy Shanxi Medical UniversityTaiyuan 030001China National Center for Nanoscience and Technology Beijing 100190China Artemisinin Research Center Institute of Chinese Materia MedicaBeijing 100700China

Artemisinin(ART)resistance has been an emerging clinical problem,severely compromising antimalarial efficacy and threatening the global malaria elimination *** intensive studies about the molecular mechanism for ART resistance are under way,no effective therapeutic targets for reversing resistance have been ***,we explore glutathione(GSH)as a therapeutic target to develop a thermo-responsive nanoplatform to specifically co-deliver ART and GSH synthesis inhibitor(L-buthionine sulfoximine,BSO)in a sustained manner,effectively reversing ART resistance in *** combining with BSO,ART exerts increased antimalarial activity with reduced half-maximal inhibitory concentration(IC50)by 7.43-fold in ART-resistant *** work reveals that the GSH in ART-resistant parasites can be a promising therapeutic target for reversing ART resistance,paving the way for developing drug candidates and intelligent nanomedicines in malaria therapy.

关键词： Nanomedicines Drug delivery Artemisinins resistance Malaria Glutathione