检索结果-南通市图书馆

Effectiveness and Safety of Qishen Yiqi Dripping Pill in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention:3-Year Results from a Multicentre Cohort Study

引用

Chinese Journal of Integrative Medicine 2024年第10期30卷 877-885页

作者： BAI Rui-na GU Feng CHE Qian-zi ZHANG Xuan CAI Ya-jie XI Rui-xi ZHAO Yang GUO Ming DONG Guo-ju GAO Zhu-ye FU Chang-geng wang pei-li DU Jian-peng ZHANG Da-wu DUAN Wen-hui li li-zhi YANG Qiao-ning SHI Da-zhuo Department of Cardiovascular Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China National Clinical Research Center for Chinese Medicine Cardiology Beijing100091China Department of Evidence-Based Medicine Basic Research Laboratory Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical SciencesBeijing100700China Department of Traditional Chinese Medicine Beijing Shangdi HospitalBeijing100193China National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Traditional Chinese MedicineBeijing100091China

Objectives:To evaluate the effectiveness and safety of Qishen Yiqi Dripping Pill(QSYQ)in patients with acute coronary syndrome(ACS)after percutaneous coronary intervention(PCI).Methods:This multicentre prospective cohort study was conducted at 40 centers in *** with ACS after PCI entered either the QSYQ or Western medicine(WM)groups naturally based on whether they had received QSYQ before *** group received QSYQ(0.52 g,3 times a day for 12 months)in addition to *** primary endpoint included cardiac death,non-fatal myocardial infarction,and urgent *** secondary endpoint included rehospitalization due to ACS,heart failure,stroke,and other thrombotic *** of life was assessed by the Seattle Angina Questionnaire(SAQ).Results:A total of 936 patients completed follow-up of the primary endpoint from February 2012 to December ***,487 patients received QSYQ and *** a median follow-up of 566 days(inter quartile range,IQR,517–602),the primary endpoint occurred in 46(9.45%)and 65(14.48%)patients in QSYQ and WM groups respectively[adjusted hazard ratio(HR)0.60,95%confidence interval(CI)0.41–0.90;P=0.013].The secondary endpoint occurred in 61(12.53%)and 74(16.48%)patients in QSYQ and WM groups,respectively(adjusted HR 0.76,95%CI 0.53–1.09;P=0.136).In sensitivity analysis,the results still demonstrated that WM combined with QSYQ reduced the risk of the primary endpoint(HR 0.67,95%CI 0.46–0.98;P=0.039).Moreover,QSYQ improved the disease perception domain of the SAQ(P<0.05).Conclusions:In patients with ACS after PCI,QSYQ combined with WM reduced the incidence of the primary *** findings provide a promising option for managing ACS after PCI and suggest the potential treatment for reducing the risk of primary endpoint included cardiac death,non-fatal myocardial infarction,and urgent revascularization through intermittent administration of QSYQ.(Registration *** CTR-OOC-14005552).

关键词： Qishen Yiqi Dripping Pill acute coronary syndrome percutaneous coronary intervention primary and secondary endpoint

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Machining Error Control by Integrating Multivariate Statistical Process Control and Stream of Variations Methodology

引用

Chinese Journal of Aeronautics 2012年第6期25卷 937-947页

作者： wang pei ZHANG Dinghua li Shan CHEN Bing Key Laboratory of Contemporary Design and Integrated Manufacturing Technology Ministry of Education Northwestern Polyteehnical University Xi'an 710072 China

For aircraft manufacturing industries, the analyses and prediction of part machining error during machining process are very important to control and improve part machining quality. In order to effectively control machining error, the method of integrating multivariate statistical process control （MSPC） and stream of variations （SoV） is proposed. Firstly, machining error is modeled by multi-operation approaches for part machining process. SoV is adopted to establish the mathematic model of the relationship between the error of upstream operations and the error of downstream operations. Here error sources not only include the influence of upstream operations but also include many of other error sources. The standard model and the predicted model about SoV are built respectively by whether the operation is done or not to satisfy different requests during part machining process. Secondly, the method of one-step ahead forecast error （OSFE） is used to eliminate autocorrelativity of the sample data from the SoV model, and the T2 control chart in MSPC is built to realize machining error detection according to the data characteristics of the above error model, which can judge whether the operation is out of control or not. If it is, then feedback is sent to the operations. The error model is modified by adjusting the operation out of control, and continually it is used to monitor operations. Finally, a machining instance containing two operations demonstrates the effectiveness of the machining error control method presented in this paper.

关键词： machining error multivariate statistical process control stream of variations error modeling one-step ahead forecast error error detection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quantitative Trait Loci for Resistance Against Fusarium Wilt Based on Three Cotton F_2 Populations

引用

Agricultural Sciences in China 2010年第12期9卷 1799-1806页

作者： wang pei-zheng SHI li-fang SU li HU Bao-min Xinjiang Condy Seed Science ＆ Technology Development Co. Ltd Urumqi 830011 P.R.China

Fusarium wilt （FW） is one of the most common cotton diseases in the world. Identification of QTLs conferring resistance to FW is key for the incorporation of resistance genes into elite cultivars. Two intraspecific （cross between Gossypium hirsuturn L.） and one interspecific （cross between Gossypium hirsutum L. and Gossypium bardence L.） F2 populations were constructed by using a highly resistant cultivar and crossing it to a susceptible cultivar with 154, 79, and 148 offsprings, respectively. Simple sequence repeats （SSR） were used to screen genomic regions closely linked to FW resistance. The results showed that five QTLs associated with FW resistance were detected in two intraspecific populations using a composite interval mapping method under four different conditions. Four of these loci located on Chr. 2/Chr. 17 neighboring markers JESPR304 or CIR305 which explained 13.1 to 45.9% of the phenotypic effect. Furthermore, JESPR304 and CIR305 were previously testified and found to be tightly linked. It is possible that these four QTLs detected under different conditions were the same resistance QTL/gene. We consider that there is the possibility of a major FW resistant gene in intraspecific populations. In the interspecific mapping populations two QTLs were detected on Chr. 9 and Chr. 12/26 which explained great phenotypic variance of 49.4 and 45.7%. As the location of QTLs for FW resistance among the intraspecific and the interspecfic populations were totally different, it is suggested that there may be different resistance mechanisms between G. bardence L. and G. hursutum L. Thus, the present research provides an opportunity to understand the genetic control of resistance to FW in Gossypium hirsutum and Gossypium bardence and to conduct MAS in breeding programs to develop FW resistant cultivars.

关键词： cotton Fusarium wilt resistance QTL molecular mapping

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Bufalin on Up-regulating Methylation of Wilm's Tumor 1 Gene in Human Erythroid Leukemic Cells

引用

Chinese Journal of Integrative Medicine 2017年第4期23卷 288-294页

作者： wang li-pei ZHAO Yan-na SUN Xin GAO Rui-lan College of Basic Medical Sciences Zhejiang Chinese Medical University Institution of Oncology Zhejiang Provincial People's Hospital

Objective To explore the effects of bufalin on inhibiting proliferation, up-regulating methylation of Wilm’ tumor 1 gene (WT1) as well as its possible mechanisms in human erythroid leukemic (HEL) cells. Methods The HEL cells were treated with bufalin at various concentrations to observe cellular morphology, proliferation assay and cell cycle. The mRNA and protein expression levels of WT1 were detected by reverse transcription polymerase chain reaction (RT-PCR), Western blot and immunocytochemistry, DNA methylation of WT1 and protein expression levels of DNA methyltransferase 3a (DNMT3a) and DNMT3b were analyzed by methylation-specific PCR, and Western blot respectively. Results The bufalin was effective to inhibit proliferation of HEL cells in a dose-dependent manner, their suppression rates were from 23.4%±2.1% to 87.2%±5.4% with an half maximal inhibit concentration (IC50) of 0.046 μmol/L. Typical apoptosis morphology was observed in bufalin-treated HEL cells. The proliferation index of cell cycle decreased from 76.4%±1.9% to 49.7%±1.3%. The expression levels of WT1 mRNA and its protein reduced gradually with increasing doses of bufalin, meanwhile, the methylation status of WT1 gene changed from unmethylated into partially or totally methylated. While, the expression levels of DNMT3a and DNMT3b protein gradually increased by bufalin treatment in a dose-dependent manner. Conclusions Bufalin can not only significantly inhibit the proliferation of HEL cells and arrest cell cycle at G0/G1 phase, but also induce cellular apoptosis and down-regulate the expression level of WT1. Our results provide the evidence of bufalin for anti-leukemia, its mechanism may involve in increasing WT1 methylation status which is related to the up-regulation of DNMT3a and DNMT3b proteins in erythroid leukemic HEL cells.

关键词： bufalin human erythroid leukemic cells Wilm’s tumor 1 gene methylation DNA methyltransferase 3a DNA methyltransferase 3b

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

COMPOSITE MODEliNG APPROACH AND EXPERIMENTAL STUDY FOR SUBSURFACE TRANSPORT OF CONTAMINANTS FROM LAND-DISPOSAL SITES

引用

Journal of Hydrodynamics 2003年第4期15卷 1-9页

作者： wang Chao, wang pei-fang, li Yong Department of Environmental Engineering, Hohai University, Nanjing 210098, China Dept. of Environ. Eng. Hohai Univ. Nanjing 210098 China

A composite modeling approach was presented for simulating thethree-dimensional (3-D) subsurface transport of dissolved contaminants with transformation *** approach was based on vertical infiltration and contaminant transport in the unsaturated zoneand 3-D groundwater flow and contaminant migration in the saturated zone. Moisture movement andgroundwater flow were considered to be steady, but contaminant transport was treated as continuousand transient. The transformed unsaturated zone and saturated zone transport equations were solvednumerically with different techniques. The model contains a 3-D solution to flow and transport inthe saturated zone, as well as two-dimensional solutions to vertical cross-sectional and arealscenarios. In order to verify the composite modeling, extensive experiments were conducted in twolarge-scale variable-slope soil tanks of 1200cm in length, 150cm in width and 150cm in height. Sandsoil was filled in the tank as the porous media. The solutions of KBr or NH_4C1 were introduced intoeach soil tank from 80 X 37cm^2 area sources located on the top of the porous medium. Results fromnumerical simulations were compared with the data from tests. Predicted results are in goodagreement with the experimental data.

关键词： composite modeling groundater flow finite element model experiment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Treatment of End-Stage Coronary Artery Disease with the Mode of Combination of Disease and Syndrome:A Case Report

引用

Chinese Journal of Integrative Medicine 2021年第6期27卷 461-464页

作者： BAI Rui-na wang pei-li GU Feng TAN Juan wang Cheng-long CHEN Ke-ji Cardiovascular Diseases Center Xiyuan HospitalChina Academy of Chinese Medical SciencesNational Clinical Research Center for Chinese Medicine CardiologyBeijing(100091)China

Coronary artery disease(CAD)remains the leading cause of mortality *** advanced pharmacologic development and invasive revascularization therapy,a small but not insignificant number of patients show progression to end... 详细信息

关键词： Coronary mortality therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Graph neural network-based scheduling for multi-UAV-enabled communications in D2D networks

引用

Digital Communications and Networks 2024年第1期10卷 45-52页

作者： pei li lingyi wang Wei Wu Fuhui Zhou Baoyun wang Qihui Wu Nanjing University of Posts and Telecommunications Nanjing210023China Nanjing University of Aeronautics and Astronautics Nanjing210016China

In this paper,we jointly design the power control and position dispatch for Multi-Unmanned Aerial Vehicle(UAV)-enabled communication in Device-to-Device(D2D)*** objective is to maximize the total transmission rate of Downlink Users(DUs).Meanwhile,the Quality of Service(QoS)of all D2D users must be *** comprehensively considered the interference among D2D communications and downlink *** original problem is strongly non-convex,which requires high computational complexity for traditional optimization *** to make matters worse,the results are not necessarily globally *** this paper,we propose a novel Graph Neural Networks(GNN)based approach that can map the considered system into a specific graph structure and achieve the optimal solution in a low complexity ***,we first construct a GNN-based model for the proposed network,in which the transmission links and interference links are formulated as vertexes and edges,***,by taking the channel state information and the coordinates of ground users as the inputs,as well as the location of UAVs and the transmission power of all transmitters as outputs,we obtain the mapping from inputs to outputs through training the parameters of *** results verified that the way to maximize the total transmission rate of DUs can be extracted effectively via the training on ***,it also shows that the performance of proposed GNN-based method is better than that of traditional means.

关键词： Unmanned aerial vehicle D2 Dcommunication Graph neural network Power control Position planning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano metal-photosensitizer based on Aza-BODIPY-Cu complex for CDT-enhanced dual phototherapy

引用

Chinese Chemical Letters 2024年第7期35卷 296-300页

作者： Wenjuan Jin Zelong Chen Yi wang Jiaxuan li Jiahui li Yuxin pei Zhichao pei College of Chemistry&Pharmacy Northwest A&F UniversityYangling 712100China

Chemodynamic therapy(CDT)combined with dual phototherapy(photothermal therapy(PTT)and photodynamic therapy(PDT))is an efficient way to synergistically improve anti-tumor ***,the combination of multiple modes often makes the composition of the system more complex,which is not conducive to clinical *** this study,a dual phototherapy ligand carboxyl-modified Aza-BODIPY(BOD-COOH)and metal active center Cu^(2+)were used to construct multiple-modes metalphotosensitizer nanoparticles(BOD-Cu NPs)via one-step coordination self-assembly for combination therapy of CDT/PDT/*** order to improve delivery efficiency,the targeted hydrophilic molecule pyridinemodified glucose derivative(G-Py)was synthesized and coated onto the BOD-Cu NPs to form a glycosylated nano metal-photosensitizer BOD-Cu@G by electrostatic *** Cu^(2+)in BOD-Cu@G could not only be used as a coordination node for metal-driven self-assembly but also consume intracellular glutathione(GSH),and then catalyze Fenton-like reaction to generate hydroxyl radical(·OH)for *** vitro and in vivo studies revealed that BOD-Cu@G could achieve excellent anti-tumor efficiency by CDTenhanced dual phototherapy.

关键词： Nano metal-photosensitizer Aza-BODIPY-Cu Coordination self-assembly Chemodynamic therapy Dual phototherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

PDE Standardization Analysis and Solution of TypicalMechanics Problems

引用

Computer Modeling in Engineering & Sciences 2024年第10期141卷 171-186页

作者： Ningjie wang Yihao wang Yongle pei Luxian li State Key Laboratory for Strength and Vibration of Mechanical Structures Shaanxi Key Laboratory of Environment and Control for Flight VehicleSchool of Aerospace EngineeringXi’an Jiaotong UniversityXi’an710049China Xi’an Institute of Optics and Precision Mechanics of Chinese Academy of Sciences Xi’an710119China

A numerical approach is an effective means of solving boundary value problems(BVPs).This study focuses on physical problems with general partial differential equations(PDEs).It investigates the solution approach through the standard forms of the PDE module in *** typical mechanics problems are exemplified:The deflection of a thin plate,which can be addressed with the dedicated finite element module,and the stress of a pure bending beamthat cannot be *** procedure for the two problems regarding the three standard forms required by the PDE module is *** results were in good agreement with the literature,indicating that the PDE module provides a promising means to solve complex PDEs,especially for those a dedicated finite element module has yet to be developed.

关键词： Three standard forms expression input PDE module deflection solution stress solution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Probabilistic prediction on three-dimensional roughness of discontinuity based on two-dimensional traces under rock tunnel excavation based on Bayesian theory

引用

Underground Space 2024年第1期14卷 338-356页

作者： Qi Zhang Yuechao pei Xiaojun wang Xiaojun li Yixin Shen School of Civil Engineering Southeast UniversityNanjing 211189China Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China

Three-dimensional(3D)roughness of discontinuity affects the quality of the rock mass,but 3D roughness is hard to be measured due to that the discontinuity is invisible in the ***-dimensional(2D)roughness can be calculated from the visible traces,but it is difficult to obtain enough quantity of the traces to directly derive 3D roughness during the tunnel *** this study,a new method using Bayesian theory is proposed to derive 3D roughness from the low quantity of 2D roughness *** more accurately calculating 3D roughness,a new regression formula of 2D roughness is established firstly based on wavelet *** new JRC3D prediction model based on Bayesian theory is then developed,and Markov chain Monte Carlo(MCMC)sampling is adopted to process JRC3D prediction *** discontinuity sample collected from the literature is used to verify the proposed *** groups with the sampling size of 2,3,4,and 5 of each group are randomly sampled from JRC2D values of 170 profiles of the discontinuity,*** research results indicate that 100%,90%,85%,and 60%predicting JRC3D of the sample groups corresponding to the sampling size of 5,4,3,and 2 fall into the tolerance interval[JRC_(true)–1,JRC_(true)+1].It is validated that the sampling size of 5 is enough for predicting *** sensitivities of sampling results are then analyzed on the influencing factors,which are the correlation function,the prior distribution,and the prior *** discontinuity across the excavation face at ZK78+67.5 of Daxiagu tunnel is taken as the tunnel engineering application,and the results further verify that the predicting JRC3D with the sampling size of 5 is generally in good agreement with JRC3D true values.

关键词： Rock discontinuity Joint roughness coefficient Tunnel excavation Bayesian theory Markov chain Monte Carlo sampling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：