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中国医学伦理学 2010年第5期23卷 36-37页

作者：王傲雪黄淑凤巴东霞程现昆大连医科大学附属第二医院辽宁大连116027 大连海事大学医院辽宁大连116028 大连医科大学社会科学与管理科学学院辽宁大连116044

随着科技进步、医学发展和医学模式的转变,人文关怀愈显重要。皮肤性病科患者与其他疾病的患者相比,其心理具有独特性,而目前皮肤病和性病诊治中人文关怀尚存在缺失。对皮肤性病科患者的人文关怀,不仅有利于患者的疾病诊治,更是促进患... 详细信息

随着科技进步、医学发展和医学模式的转变,人文关怀愈显重要。皮肤性病科患者与其他疾病的患者相比,其心理具有独特性,而目前皮肤病和性病诊治中人文关怀尚存在缺失。对皮肤性病科患者的人文关怀,不仅有利于患者的疾病诊治,更是促进患者心理健康的需要。

关键词：人文关怀皮肤性病科心理独特性人文缺失性患者心理心理健康

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番茄新品种东农716的选育

中国蔬菜 2011年第16期 103-104页

作者：张贺李景富康立功王傲雪姜景彬许向阳东北农业大学园艺学院黑龙江哈尔滨150030

东农716是以05HN06为母本,以05HN01为父本配制而成的中晚熟番茄一代杂种,高抗ToMV、叶霉病、枯萎病和黄萎病。单果质量220～240 g,果实红色,圆形,颜色鲜艳,果面光滑美观,硬度大,耐贮运,货架期达20 d(天)以上。大棚栽培每667 m2产量达10 ... 详细信息

东农716是以05HN06为母本,以05HN01为父本配制而成的中晚熟番茄一代杂种,高抗ToMV、叶霉病、枯萎病和黄萎病。单果质量220～240 g,果实红色,圆形,颜色鲜艳,果面光滑美观,硬度大,耐贮运,货架期达20 d(天)以上。大棚栽培每667 m2产量达10 000 kg以上,适合露地和大棚栽培。

关键词：番茄东农716 一代杂种耐贮运

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番茄新品种东农714的选育

中国蔬菜 2011年第20期 93-94页

作者：张贺李景富康立功王傲雪姜景彬许向阳东北农业大学园艺学院黑龙江哈尔滨150030

东农714是以HN17为母本,以HN33为父本配制而成的番茄一代杂种。中晚熟,生育期120d(天)左右。高抗ToMV、枯萎病和黄萎病。植株无限生长型,生长势强,单果质量230～260g,果实红色,颜色鲜艳,果面光滑美观,硬度大,耐贮运,货架期达18d(天)以... 详细信息

东农714是以HN17为母本,以HN33为父本配制而成的番茄一代杂种。中晚熟,生育期120d(天)左右。高抗ToMV、枯萎病和黄萎病。植株无限生长型,生长势强,单果质量230～260g,果实红色,颜色鲜艳,果面光滑美观,硬度大,耐贮运,货架期达18d(天)以上。露地栽培每667m2产量4000kg左右,大棚栽培每667m2产量10000kg以上,适合大棚和露地栽培。

关键词：番茄东农714 一代杂种

The synthesis of PROTAC molecule and new target KAT6A identification of CDK9 inhibitor i CDK9

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Chinese Chemical Letters 2023年第4期34卷 216-221页

作者： Mingtao ao Jun Wu Yin Cao Yaohui He Yuxiang Zhang Xiang Gao Yuhua xue Meijuan Fang Zhen Wu Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology School of Pharmaceutical SciencesXiamen UniversityXiamen 361102China School of Pharmacy Hubei Engineering Research Center of Traditional Chinese Medicine of South Hubei ProvinceHubei University of Science and TechnologyXianning 437100China

Cyclin-dependent kinases(CDKs) have become potential targets for treating various diseases, especially cancer. Compound i CDK9 is an excellent and selective CDK9 inhibitor, but its major limitation is the potential toxicity and poor understanding of the underlying mechanism. The PROTAC(proteolysis targeting chimera) degraders of bioactive molecules can significantly induce in vitro and in vivo degradation of their target protein with high selectivity and effectively reduce the dose-limiting toxicity of small molecule drugs. Therefore, we designed and synthesized the bifunctional PROTAC molecules of i CDK9, being used for identifying its previously unknown target and revealing the underlying pharmacological *** PROTAC bifunctional molecule CD-5 could selectively and significantly degrade CDK9 with low cell toxicity. Therefore, we selected CD-5 as a chemical prober in the SILAC quantitative proteomic analysis, which disclosed that CD-5 could enormously lessen the lysine acetyltransferase KAT6A. Furthermore,KAT6A degradation induced by CD-5 repressed the levels of H3K14Ac and H3K23Ac. Lastly, the streptavidin immunoprecipitation(IP) assay confirmed a direct interaction between KAT6A and i CDK9. Collectively, our results uncover that KAT6A is a potential non-kinase target of i CDK9. Notably, this study also demonstrates that the PROTAC-SILAC strategy is an alternative approach for cellular target identification of bioactive molecules.

关键词： PROTAC SILAC iCDK9 KAT6A Target identification

Zero-shot Fine-grained Classification by Deep Feature Learning with Semantics

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International Journal of Automation and computing 2019年第5期16卷 563-574页

作者： ao-xue Li Ke-Xin Zhang Li-Wei wang The Key Laboratory of Machine Perception (MOE) School of Electronics Engineering and Computer SciencePeking University

Fine-grained image classification, which aims to distinguish images with subtle distinctions, is a challenging task for two main reasons: lack of sufficient training data for every class and difficulty in learning discriminative features for representation. In this paper, to address the two issues, we propose a two-phase framework for recognizing images from unseen fine-grained classes, i.e., zeroshot fine-grained classification. In the first feature learning phase, we finetune deep convolutional neural networks using hierarchical semantic structure among fine-grained classes to extract discriminative deep visual features. Meanwhile, a domain adaptation structure is induced into deep convolutional neural networks to avoid domain shift from training data to test data. In the second label inference phase, a semantic directed graph is constructed over attributes of fine-grained classes. Based on this graph, we develop a label propagation algorithm to infer the labels of images in the unseen classes. Experimental results on two benchmark datasets demonstrate that our model outperforms the state-of-the-art zero-shot learning models. In addition, the features obtained by our feature learning model also yield significant gains when they are used by other zero-shot learning models, which shows the flexility of our model in zero-shot finegrained classification.

关键词： Fine-grained image classification zero-shot learning deep feature learning domain adaptation semantic graph

Independent prognostic value of the congestion and renal index in patients with acute heart failure

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Journal of Geriatric Cardiology 2023年第7期20卷 516-526页

作者： Run-Qing JI Bin wang Jin-Guo ZHANG Shu-Hong SU Li LI Qin YU Xian-YanJIANG Xin FU xue-Hua FANG Xiao-Wen MA ao-Xi TIAN Jing LI National Clinical Research Center for Cardiovascular Diseases NHC Key Laboratory of Clinical Research for Cardiovascular MedicationsState Key Laboratory of Cardiovascular DiseaseFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNational Center for Cardiovascular DiseasesBeijingChina Fuwai Hospital Chinese Academy of Medical SciencesShenzhenChina Department of Cardiology Affiliated Hospital of Jining Medical UniversityJiningChina Department of Cardiology Xinxiang Central HospitalXinxiangChina Department of Cardiology Shanxi Fenyang HospitalFenyangChina Department of Cardiology Affiliated Zhongshan Hospital of Dalian UniversityDalianChina Heart Center Qingdao Fuwai Cardiovascular HospitalQingdaoChina Department of Cardiology the First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Cardiology Beijing Liangxiang HospitalBeijingChina Department of Cardiology Qinyang People’s HospitalQinyangChina

BACKGROUND Clinical outcomes are poor if patients with acute heart failure(AHF)are discharged with residual congestion in the presence of renal ***,there is no single indication to reflect the combined effects of the two related pathophysiological ***,therefore,proposed an indicator,congestion and renal index(CRI),and examined the associations between the CRI and one-year outcomes and the incremental prognostic value of CRI compared with the established scoring systems in a multicenter prospective cohort of *** We enrolled AHF patients and calculated the ratio of thoracic fluid content index divided by estimated glomerular filtration rate before discharge,as *** we examined the associations between CRI and one-year *** A total of 944 patients were included in the analysis(mean age 63.3±13.8 years,39.3%women).Compared with patients with CRI≤0.59 mL/min per kΩ,those with CRI>0.59 mL/min per kΩhad higher risks of cardiovascular death or HF hospitalization(HR=1.56[1.13-2.15])and all-cause death or all-cause hospitalization(HR=1.33[1.01-1.74]).CRI had an incremental prognostic value compared with the established scoring *** In patients with AHF,CRI is independently associated with the risk of death or hospitalization within one year,and improves the risk stratification of the established risk models.

关键词： patients acute index

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青蛙七中异黄酮类成分质量控制研究

药物分析杂志 2024年第8期44卷 1310-1319页

作者：何姬刘妍如段金廒唐志书宋忠兴赵艳婷游雪莲张德柱杨国伟陕西中医药大学陕西中药资源产业化省部共建协同创新中心咸阳712083 南京中医药大学江苏省中药资源产业化过程协同创新中心江苏省方剂高技术研究重点实验室南京210023 中国中医科学院北京100700 陕西盘龙药业集团股份有限公司商洛711400 山西省检验检测中心(山西省标准计量技术研究院) 太原030002

目的:依据对青蛙七主要成分的表征结果,建立青蛙七薄层色谱(TLC)定性鉴别方法及一测多评(QAMS)的含量测定方法。方法:首先,采用超高效液相色谱-四极杆-飞行时间质谱联用(UPLC-Q TOF MS/MS)技术对青蛙七的主要成分进行表征,使用ACQUITY U... 详细信息

目的:依据对青蛙七主要成分的表征结果,建立青蛙七薄层色谱(TLC)定性鉴别方法及一测多评(QAMS)的含量测定方法。方法:首先,采用超高效液相色谱-四极杆-飞行时间质谱联用(UPLC-Q TOF MS/MS)技术对青蛙七的主要成分进行表征,使用ACQUITY UPLC^(Ⓡ)BEH C_(18)(100 mm×2.1 mm,1.7μm)色谱柱,以0.1%甲酸水溶液(A)-乙腈溶液(B)为流动相进行梯度洗脱,正离子模式下采集信息;其次,通过TLC建立定性鉴别方法;最后,建立QAMS方法,采用Agilent 5 TC-C_(18)(250 mm×4.6 mm,5μm)色谱柱,流动相为0.05%磷酸水(A)-乙腈(B),梯度洗脱,以鸢尾黄素为内参物,建立其与鸢尾苷及野鸢尾黄素的相对校正因子,并通过校正因子计算3个异黄酮类成分的含量。同时与外标法(ESM)进行比较,以验证QAMS法的准确性和可行性。结果:UPLC-Q TOF MS共表征出青蛙七中5个含量较高的异黄酮类成分(鸢尾苷、鸢尾甲苷B、鸢尾黄素、野鸢尾黄素、鸢尾黄酮A)。建立了鸢尾苷、鸢尾甲苷B、鸢尾黄素、野鸢尾黄素4个成分的TLC鉴别法。在一定的浓度范围内,鸢尾苷、鸢尾黄素、野鸢尾黄素3个成分线性关系良好(r﹥0.999),平均加样回收率为97.7%~100.8%,RSD为1.1%~2.9%,鸢尾苷、野鸢尾黄素的相对校正因子分别为1.1145、0.8270,在不同试验条件下重现性良好(RSD<5%);采用QAMS法测定的10个不同产地青蛙七中3个成分含量与ESM的实测值之间无显著性差异。结论:以表征的青蛙七药材的成分为基础,选择含量较高且稳定的成分建立的TLC和QAMS方法简便、稳定,可用于青蛙七药材定性定量分析及质量评价。

关键词：青蛙七超高效液相色谱-四极杆-飞行时间质谱联用鸢尾苷鸢尾甲苷B 鸢尾黄素野鸢尾黄素薄层色谱一测多评法

芍药苷对人外周血T淋巴细胞CD25、CD69及NF-κB表达的影响

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中国中西医结合皮肤性病学杂志 2013年第6期12卷 349-352页

作者：张蕴颖杜恺王傲雪齐晓怡涂彩霞辽宁省大连医科大学附属第二医院大连116027

目的研究芍药苷对人外周血T淋巴细胞CD25、CD69及NF-κB表达的影响。方法分离健康人外周血T淋巴细胞,抗人CD3单克隆抗体及抗人CD28单克隆抗体共刺激T淋巴细胞活化,加入不同浓度的芍药苷,流式细胞术检测T淋巴细胞CD25、CD69及NF-κB的表... 详细信息

目的研究芍药苷对人外周血T淋巴细胞CD25、CD69及NF-κB表达的影响。方法分离健康人外周血T淋巴细胞,抗人CD3单克隆抗体及抗人CD28单克隆抗体共刺激T淋巴细胞活化,加入不同浓度的芍药苷,流式细胞术检测T淋巴细胞CD25、CD69及NF-κB的表达。结果 50μmol/L芍药苷对活化的T淋巴细胞CD25的表达有抑制作用(P<0.05),100,200μmol/L芍药苷对活化的T淋巴细胞CD25的表达有明显抑制作用(P<0.01);100,200μmol/L芍药苷对活化的T淋巴细胞CD69的表达有明显抑制作用(P<0.01);25,50,100,200μmol/L芍药苷对活化的T淋巴细胞NF-κB的表达有明显抑制作用(P<0.01)。结论芍药苷可呈浓度依赖性抑制T淋巴细胞CD25、CD69及NF-κB的表达。

关键词：芍药苷 T淋巴细胞 CD25 CD69 NF—KB

Synthesis of 3D ordered macroporous indium tin oxide using polymer colloidal crystal template

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Science China(Technological Sciences) 2006年第5期49卷 537-546页

作者： ZHANG xue'ao MAN Yahui wang Jianfang LIU Changli WU Wenjian College of Aerospace and Materials Engineering National University of Defense Technology Changsha 410073 China College of Aerospace and Materials Engineering National University of Defense Technology Changsha 410073 China College of Aerospace and Materials Engineering National University of Defense Technology Changsha 410073 China College of Aerospace and Materials Engineering National University of Defense Technology Changsha 410073 China College of Aerospace and Materials Engineering National University of Defense Technology Changsha 410073 China

Three-dimensional (3D) ordered macroporous indium tin oxide (ITO) is pre- pared using a polymer colloidal crystal template that is formed by self-assembly of the monodisperse poly(methyl methacrylate) (PMMA) microspheres. The morphologies and BET surface area of the macroporous material is examined by scanning electron micro- scope, transmission electron microscopy and N2 adsorption/desorption. Results indicate that the macroporous material has highly ordered arrays of the uniform pores replicated from the PMMA colloidal crystal template when the polymer colloidal crystal template is removed by calcinations at 500℃. The pore diameter (about 450 nm) of macroporous ITO slightly shrank to the PMMA microspheres. The BET surface area and pore volume of the macroporous material are 389 m2·g-1 and 0.36 cm3·g-1, respectively. Moreover, the macroporous ITO, containing 5 mol% Sn and after annealing under vacuum, shows the minimum resistivity of ρ = 8.2×10-3 Ω· cm. The conductive mechanism of macroporous ITO is discussed, and it is believed that the oxygen vacancies are the major factor for excellent electrical properties.

关键词： template synthesis, polymer colloidal crystal, indium tin oxide, three-dimensional order, macroporous material.

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液相超声法制备金属及化合物量子点研究进展

激光与红外 2024年第7期54卷 1007-1015页

作者：张泰玮胡坤李国彬夏溢坪杨奥李学铭唐利斌杨培志云南师范大学能源与环境科学学院可再生能源材料先进技术与制备教育部重点实验室云南昆明650500 昆明物理研究所云南昆明650223 云南省先进光电材料与器件重点实验室云南昆明650223

量子点(Quantum Dots,QDs)的电子结构及光学性质等与传统材料显著不同,由于其独特的尺寸效应和表面效应而受到广泛关注,除金属硫化物量子点外,其他含金属元素的量子点有Ⅴ族金属单质、Ⅱ-Ⅵ族量子点、Ⅳ-Ⅵ族量子点及碳化物量子点等。... 详细信息

量子点(Quantum Dots,QDs)的电子结构及光学性质等与传统材料显著不同,由于其独特的尺寸效应和表面效应而受到广泛关注,除金属硫化物量子点外,其他含金属元素的量子点有Ⅴ族金属单质、Ⅱ-Ⅵ族量子点、Ⅳ-Ⅵ族量子点及碳化物量子点等。液相超声法是一种制备量子点的重要手段,具有操作简单、反应速度快、产率高和粒径可控性好等优势。量子点具有可调控的光学性质、高量子效率和荧光亮度、优越的电子输运性能、良好的化学稳定性和生物兼容性等良好的特性,使其在光电子学、光催化和生物医学等领域得到了深入的研究。本文综述了超声法制备不同金属及金属化合物量子点的研究进展,并对其应用进行了归纳和总结。最后,对超声法制备金属单质及金属化合物量子点进行了展望。

关键词：量子点超声法尺寸效应金属单质金属化合物