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s-Nitroso-N-acetyl-L-cysteine ethyl ester(sNACET) and N-acetyl-L-cysteine ethyl ester(NACET)–Cysteine-based drug candidates with unique pharmacological profiles for oral use as NO, H_2s and GsH suppliers and as antioxidants: Results and overview

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Journal of Pharmaceutical Analysis 2018年第1期8卷 1-9页

作者： Dimitrios Tsikas Kathrin s.schwedhelm Andrzej surdacki Daniela Giustarini Ranieri Rossi Lea Kukoc-Modun George Kedia stefan ückert Institute of Toxicology Core Unit Proteomics Hannover Medical School second Department of Cardiology Jagiellonian University Medical College Department of Medicine Surgery and Neuroscience University of Siena Department of Life sciences Laboratory of Pharmacology and Toxicology University of Siena Department of Analytical Chemistry Faculty of Chemistry and Technology University of Split Department of Urology and Urological Oncology Hannover Medical School

s-Nitrosothiols or thionitrites with the general formula RsNO are formally composed of the nitrosyl cation(NOt) and a thiolate(Rsà), the base of the corresponding acids RsH. The smallest s-nitrosothiol is HsNO and derives from hydrogen sulfide(HsH, H_2s). The most common physiological s-nitrosothiols are derived from the amino acid L-cysteine(Cys sH). Thus, the simplest s-nitrosothiol is s-nitroso-L-cysteine(Cys sNO). Cys sNO is a spontaneous potent donor of nitric oxide(NO) which activates soluble guanylyl cyclase to form cyclic guanosine monophosphate(c GMP). This activation is associated with multiple biological actions that include relaxation of smooth muscle cells and inhibition of platelet *** NO, Cys sNO is a short-lived species and occurs physiologically at concentrations around 1 n M in human blood. Cys sNO can be formed from Cys sH and higher oxides of NO including nitrous acid(HONO)and its anhydride(N_2O_3). The most characteristic feature of RsNO is the s-transnitrosation reaction by which the NOtgroup is reversibly transferred to another thiolate. By this way numerous RsNO can be formed such as the low-molecular-mass s-nitroso-N-acetyl-L-cysteine(sNAC) and s-nitroso-glutathione(GsNO), and the high-molecular-mass s-nitrosol-L-cysteine hemoglobin(Hb Cys sNO) present in erythrocytes and s-nitrosol-L-cysteine albumin(Alb Cys sNO) present in plasma at concentrations of the order of 200 n M. All above mentioned RsNO exert NO-related biological activity, but they must be administered intravenously. This important drawback can be overcome by lipophilic charge-free ***, we prepared the ethyl ester of sNAC, the s-nitroso-N-acetyl-L-cysteine ethyl ester(sNACET), from synthetic N-acetyl-L-cysteine ethyl ester(NACET). Both NACET and sNACET have improved pharmacological features over N-acetyl-L-cysteine(NAC) and s-nitroso-N-acetyl-L-cysteine(sNAC), respectively,including higher oral bioavailability. sNACET exerts NO-related activities which can be

关键词： CGMP Nitric oxide s-Nitrosothiols Oxidative stress Pharmaceuticals

Comparing Ordinary Kriging and Regression Kriging for soil Properties in Contrasting Landscapes

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Pedosphere 2010年第5期20卷 594-606页

作者： Q.ZHU H.s.LIN Department of Crop and soil sciences 116 ASI BuildingThe Pennsylvania State UniversityUniversity ParkPA 16802(USA)

The accuracy between ordinary kriging and regression kriging was compared based on the combined consideration of sample size,spatial structure,and auxiliary variables(terrain indices and electromagnetic induction surveys) for a variety of soil properties in two contrasting landscapes(agricultural ***).When spatial structure could not be well captured by point-based observations(e.g.,when the ratio of sample spacing over correlation range was > 0.5),or when a strong relationship existed between target soil properties and auxiliary variables(e.g.,their R2 was > 0.6),regression kriging(RK) was more accurate for interpolating soil properties in both landscapes ***,ordinary kriging(OK) was *** depth and wetness condition did not appear to affect the selection of kriging for soil moisture interpolation,because they did not significantly change the ratio of sample spacing over correlation range and the relationship with the auxiliary *** of a smaller ratio of elevation change over total study area(E/A = 1.2) and multiple parent materials in the agricultural land,OK was generally more accurate in that *** contrast,a larger E/A ratio of 6.8 and a single parent material led to RK being preferable in the steep-sloped forested *** results from this study can be useful for selecting kriging for various soil properties and landscapes.

关键词： geostatistics soil moisture spatial interpolation spatial structure

A Robust Fractional Order Fuzzy P ＋ Fuzzy I ＋ Fuzzy D Controller for Nonlinear and Uncertain system

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International Journal of Automation and computing 2017年第4期14卷 474-488页

作者： Vineet Kumar K. P. s. Rana Jitendra Kumar Puneet Mishra sreejith s Nair Division of Instrumentation and Control Engineering Netaji Subhas Institute of Technology (NSIT) University of Delhi New Delhi 110078 India

In this paper, a robust fractional order fuzzy P ＋ fuzzy I ＋ fuzzy D （FOFP ＋ FOFI ＋ FOFD） controller is presented for a nonlinear and uncertain 2-1ink planar rigid manipulator. It is a nonlinear fuzzy controller with variable gains that makes it self- adjustable or adaptive in nature. The fractional order operators further make it more robust by providing additional degrees of freedom to the design engineer. The integer order counterpart, fuzzy P ＋ fuzzy I ＋ fuzzy D （FP ＋ FI ＋ FD） controller, for a comparative study, was realized by taking the integer value for the fractional order operators in FOFP ＋ FOFI ＋ FOFD controller. The performances of both the fuzzy controllers are evaluated for reference trajectory tracking and disturbance rejection with and without model uncertainty and measurement noise. Genetic algorithm was used to optimize the parameters of controller under study for minimum integral of absolute error. simulation results demonstrated that FOFP ＋ FOFI ＋ FOFD controller show much better performance as compared to its counterpart FP ＋ FI ＋ FD controller in servo as well as the regulatory problem and in model uncertainty and noisy environment FOFP ＋ FOFI ＋ FOFD controller demonstrated more robust behavior as compared to the FP ＋ FI ＋ FD controller. For the developed controller bounded-input and bounded-output stability conditions are also developed using small Gain Theorem.

关键词： Fuzzy P + fuzzy I + fuzzy D (FP + FI + FD) controller fractional order fuzzy P + fuzzy I + fuzzy D (FOFP + FOFI+ FOFD) controller fractional order operator robust control model uncertainty noise suppression.

Genetic divergence for growth and wood parameters in different clones of Dalbergia sissoo Roxb

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Journal of Forestry Research 2012年第2期23卷 285-288页

作者： Kumar A Bhatt A Ravichandran s Pande PK Dobhal s Forest Research Institute (Indian Council of Forestry Research and Education) Dehradun 248 195 Uttarakhand India Directorate of Rice Research Rajendra Nagar Hyderabad-500030 Andhra Pradesh India

The wood analysis for different parameters was carried out in a clonal seed orchard ofDalbergia sissoo Roxb. established during 1997 at Hoshiarpur, Punjab, India. Twelve clones with higher index value were subjected to Euclidean Cluster Analysis based on wood and growth parameters to group into seven clusters. Cluster I and II contained four and three clones, respectively, and remaining clusters bad just one clone each. Clone originated from Barielly, Uttar Pradesh of cluster VII was found to be the most divergent clone. Cluster II with three clones main- tained greater inter cluster distance with other clusters. The divergence analysis has confirmed that the clones planted in the clonal seed orchard are sufficiently divergent and seed harvested from the orchard would maintain high diversity.

关键词： Dalbergia sissoo Roxb. seed orchard wood and growthtraits genetic divergence hybridization

1960-2000年中国蒸发皿蒸发量的气候变化特征

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水科学进展 2007年第3期18卷 311-318页

作者：曾燕邱新法刘昌明潘敖大高苹中国科学院南京地理与湖泊研究所江苏南京210008 南京信息工程大学遥感学院江苏南京210044 中国科学院地理科学与资源研究所北京100101 江苏省气象科学研究所江苏南京210008

利用中国664个气象站1960-2000年20 cm口径蒸发皿资料,借助地理信息系统ArcGIs,分析了中国蒸发皿蒸发量的气候变化趋势。结果表明,就中国平均而言,1960-2000年中国蒸发皿蒸发量呈明显下降趋势,年蒸发皿蒸发量在20世纪80～90年代较60～7... 详细信息

利用中国664个气象站1960-2000年20 cm口径蒸发皿资料,借助地理信息系统ArcGIs,分析了中国蒸发皿蒸发量的气候变化趋势。结果表明,就中国平均而言,1960-2000年中国蒸发皿蒸发量呈明显下降趋势,年蒸发皿蒸发量在20世纪80～90年代较60～70年代下降了99.8 mm,下降幅度为5.8%;不同季节对照发现,蒸发皿蒸发量的下降主要表现在春季、夏季和冬季,秋季不明显;对蒸发皿蒸发量气候变化的空间分析表明,年蒸发皿蒸发量的下降主要表现在华东和中南地区;对蒸发皿蒸发量下降的原因分析表明,日照百分率下降从而导致太阳总辐射的下降可能是近年来蒸发皿蒸发量下降的主要原因。

关键词：气候变化地理信息系统蒸发皿蒸发量中国

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佛经词语研究现状综述

涪陵师范学院学报 2006年第4期22卷 59-61,109页

作者：江傲霜东北师范大学文学院

佛教产生于古印度,于西汉末年传入我国,东汉桓帝末年开始汉译佛经。近两千年的译经历史中,佛经的汉译对中土语言产生了巨大的影响。佛经语言与中土语言不同,与佛教原典语言也不同。它不但了补充了中土文献的语料,而且很多新词新义都能... 详细信息

佛教产生于古印度,于西汉末年传入我国,东汉桓帝末年开始汉译佛经。近两千年的译经历史中,佛经的汉译对中土语言产生了巨大的影响。佛经语言与中土语言不同,与佛教原典语言也不同。它不但了补充了中土文献的语料,而且很多新词新义都能在佛经文献中找到更早的例证。80年代以后,语言学界将研究重点转向佛经文献。综述近20年来佛经词语研究的现状,以期引起研究者对佛经词语研究的更多关注。

关键词：佛经词语综述

Maintenance with single agent bevacizumab fails to improve disease-control in metastatic colorectal cancer

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Hepatobiliary surgery and Nutrition 2018年第5期7卷 395-398页

作者： susana Roselló Ricard Borrás Andrés Cervantes CIBERONC Department of Medical OncologyBiomedical Research Institute INCLIVAUniversity of ValenciaValenciaSpain

The availability of biologicals,such as anti-EFGR and anti-VEGF antibodies in combination with chemotherapy(ChT),has improved prognosis of metastatic colorectal cancer(mCRC).However,the administration of drug combinations for a prolonged time implies an increased rate of toxicities,which is why some strategies to de-escalate treatment intensity have been studied.

关键词： colorectal metastatic cancer

Improved Dragonfly Optimizer for Intrusion Detection Using Deep Clustering CNN-PsO Classifier

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Computers, Materials & Continua 2022年第3期70卷 5949-5965页

作者： K.s.Bhuvaneshwari K.Venkatachalam s.Hubalovsky P.Trojovsky P.Prabu Department of Computer sceince and Engineering Karpagam College of EngineeringCoimbatore641032India Department of Computer science and Engineering CHRIST(Deemed to be University)Bangalore560074India Department of Applied Cybernetics Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Department of Mathematics Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Department of Computer sceince CHRIST(Deemed to be University)Bangalore560074India

With the rapid growth of internet based services and the data generated on these services are attracted by the attackers to intrude the networking services and *** on the characteristics of these intruders,many researchers attempted to aim to detect the intrusion with the help of automating ***,the large volume of data is generated and transferred through network,the security and performance are remained an ***(Intrusion Detection system)was developed to detect and prevent the intruders and secure the network *** performance and loss are still an issue because of the features space grows while detecting the *** this paper,deep clustering based CNN have been used to detect the intruders with the help of Meta heuristic algorithms for feature selection and *** proposed system includes three phases such as preprocessing,feature selection and *** the first phase,KDD dataset is preprocessed by using Binning normalization and Eigen-PCA based discretization *** second phase,feature selection is performed by using Information Gain based Dragonfly Optimizer(IGDFO).Finally,Deep clustering based Convolutional Neural Network(CCNN)classifier optimized with Particle swarm Optimization(PsO)identifies intrusion attacks *** clustering loss and network loss can be reduced with the optimization *** evaluate the proposed IDs model with the NsL-KDD dataset in terms of evaluation *** experimental results show that proposed system achieves better performance compared with the existing system in terms of accuracy,precision,recall,f-measure and false detection rate.

关键词： Intrusion detection system binning normalization deep clustering convolutional neural network information gain dragonfly optimizer

Nest site tenacity and mate fidelity in the Black-headed Gull(Chroicocephalus ridibundus)

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Avian Research 2021年第4期12卷 664-670页

作者： simon Piro Angela schmitz Ornés Vogelwarte Zoological Institute and MuseumUniversity of GreifswaldSoldmannstr.23GreifswaldGermany

Breeding philopatry is well known in the Black-headed Gull(Chroicocephalus ridibundus).Using a capture-markrecapture method,we studied if Black-headed Gulls show nest site tenacity and mate fidelity as well,and investigated if there are differences between a stable,and a newly established and fast-growing colony,as well as for differences between the center and edges of these colonies located in north-eastern *** found a high level of nest site tenacity in the center of the stable colony on B?hmke Island,and lower degrees of nest site tenacity at the edge of the same colony and in the newly established and fast-growing colony on Riether *** fidelity was very strong in all individuals which returned to their previous breeding place,regardless of the nest site location.

关键词： Black-headed Gull Croicocephalus ridibundus Mate fidelity Nest site tenacity Philopatry