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Exploring the molecular mechanisms and potential therapeutic strategies of ferroptosis in ovarian cancer

BIOCELL 2024年第3期48卷 379-386页

作者： LIsHA MA wanqi s.ao WEILI ZHU Department of Gynecology Jiaxing University Master Degree Cultivation BaseZhejiang Chinese Medical UniversityJiaxingChina Department of Gynecology Jiaxing University Affiliated Women and Children’s HospitalJiaxingChina

The morbidity rate of ovarian cancer,a malignant tumour in gynaecological tumours,is rising,and it is considered to be the most lethal *** majority of patients are typically diagnosed during the advanced stages of the illness due to the elusive characteristics of ovarian cancer and an absence of highly sensitive and speciﬁc diagnostic *** excision of the lesions,along with chemotherapy,is the conventional treatment for ovarian cancer;however,resistance to platinum-based chemotherapeutic drugs and molecular targeted therapies frequently *** the survival rate and prognosis of patients with end-stage or recurring ovarian cancer requires the identiﬁcation of new therapeutic targets due to the absence of efﬁcient medications,and this has emerged as a highly demanding *** have demonstrated that ferroptosis effectively hinders the proliferation of ovarian cancer and induces the demise of malignant *** is composed of the cystine/glutamate antiporter system(the system Xc-)and glutathione peroxidase 4(GPX4).solute carrier family 7 member 11(sLC7A11)and solute carrier family 3 member 2(sLC3A2)play crucial roles in the regulation of ferroptosis by facilitating the uptake of cystine into cells and the efﬂux of glutamate out of cells,*** cells,GPX4 is the exclusive enzyme employed for reducing liposomal peroxide through glutathione peroxidase *** occurrence of ferroptosis in ovarian cancer is strongly associated with three main pathways,namely,the GPX4-glutathione(GsH)protective pathway,the ferroptosis suppressor protein 1(FsP1)-coenzyme Q10(CoQ10)protective pathway,and the guanosine 5'-triphosphate cyclohydrolase I(GCH1)protective *** ovarian cancer cells,the postsynaptic density-95,discs-large,zona occludens 1(PDZ)-binding motif-angiopoietin-like 4-nicotinamide adenine dinucleotide phosphate oxidases 2(TAZ-ANGPTL4-NOX2)pathway can be regulated by Yes-associated protein(YAP)/TAZ,a downstream

关键词： Ovarian cancer Ferroptosis Therapy

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The characteristics of driver lane-changing behaviour in congested road environments

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Transportation safety and Environment 2024年第3期6卷 96-110页

作者： wanqi Wang Guozhu Cheng school of Traffic and Transportation Northeast Forestry UniversityHarbin 150040HeilongjiangChina

Lane-changing behaviour is one of the complex|driving *** lane-changing behaviour of drivers may exacerbate congestion,however driver behavioural characteristics are difficult to accurately acquire and quantify,and thus tend to be simplified or ignored in existing lane-changing *** this paper,the Bik-means clustering algorithm is used to analyse the urban road congestion state discrimination ***,simulated driving tests were conducted for different traffic congestion *** the force feedback system and infrared camera,the data of driver lane-changing behaviours at different traffic congestion levels are obtained separately,and the definitions of the start and end points of a vehicle changing lanes are ***,statistical analysis and discussion of key feature parameters including driver lane-changing behaviour data and visual data under different levels of traffic congestion were *** is found that the average lane-change intention times in each congestion state are 2 s,4 s,6 s and 7 s,while the turn-signal duration and the number of rear-view mirror observations have similar patterns of change to the data on lane-changing intention ***,drivers’pupil diameters become smaller during the lane-changing intention phase,and then relatively enlarge during lane-changing;the range of pupil variation is roughly 3.5 mm to 4 *** frequency of observing the vehicle in front of the target lane increased as the level of congestion increased,and the frequency of observation in the driver’s mirrors while changing lanes approximately doubled compared to driving straight ahead,and this ratio increased as the level of congestion increased.

关键词： road congestion lane-changing behaviour Bik-means clustering algorithm characterization study

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Efficient piezo-assisted near-infrared-light-driven Cr(Ⅵ)reduction over Bi_(2)s_(3) nanowires transformed from ultrathin Bi_(2)WO_(6) nanosheets

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Rare Metals 2024年第9期43卷 4333-4343页

作者： Qiang Zhang Yuan-Hao Cheng Wei Liu Hui-Nan Che Yan-Hui ao Key Laboratory of Integrated Regulation and Resource Development On shallow Lakes Ministry of EducationCollege of EnvironmentHohai UniversityNanjing 210098China

The utilization of piezo-photocatalytic technol ogy for environmental remediation under full spectrum solar light is promising but still ***,one dimensional Bi_(2)s_(3)nanowires,which can utilize both mechanical energy and near-infrared(NIR)light to remov hexavalent chromium(Cr(Ⅵ))efficiently,were synthe sized by a restrained growth *** reaction rat constants of Cr(Ⅵ)reduction in piezo-photocatalyti process under NIR(800–2500 nm)reached 0.334 min^(-1)which were 3.2 and 12.4 times as that of single piezo and photocatalytic *** formation of polarized electri fields and one-dimensional structure allow ultrafast sepa ration of charge carriers,thereby promoting the catalyti ***,due to the strong penetrability o NIR light,the piezo-photocatalysis performance in turbid solutions under NIR light(0.188 min^(-1))was even com parable to that under visible light(0.186 min^(-1)).Thi study provides a new concept on the development of piezo photocatalytic technology for environmental remediation by utilization of NIR light and natural mechanical energy.

关键词： Piezo-photocatalysis NIR light Bi_(2)s_(3)nanowires Cr(Ⅵ)

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Copper isotope constraints on the origins of basaltic and andesitic magmas in the Tengchong volcanic field,sE Tibet

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Geoscience Frontiers 2024年第4期15卷 290-303页

作者： Yuan-Ru Qu sheng-ao Liu state Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesBeijing 100083China

The Tengchong volcano field(TVF),situated at the southeastern margin of the Tibetan Plateau,holds crucial information regarding Cenozoic volcanic activities and geotectonic evolution of the sE *** provide new constraints on petrogenesis and evolution of the Tengchong volcanism,here we conducted copper(Cu)elemental and isotopic analyses on a suite of samples that document the evolution from basalts to andesites in the *** basalts are Cu-depleted(29.7-36.9 ppm)and have higherδ65Cu val-ues(0.19‰-0.40‰,mean=0.31‰±0.05‰;n=11)than those of mid-ocean ridge basalts(MORBs,~0.09‰)and the mantle(~0.06‰)as well as the majority of island arc *** with the low Cu/Zr ratios,these characteristics are interpreted to reflect the fractionation of isotopically light sulfides in the s-saturated systems during magma ascent,rather than source heterogeneity induced by recycled materials and redox *** with the basalts,the andesites have slightly lower Cu contents(14.4-29.4 ppm)and lighter Cu isotopic compositions(mean=-0.14‰±0.06‰;n=13).These differences cannot be attributed to progressive sulfide fractionation of basaltic magmas but require the assimilation of lower crustal materials with lowδ65Cu values during evolution of the andesitic *** results collectively suggest that Cu isotopes can provide valuable insights into magma origin and evolution.

关键词： Copper isotopes sulfide segregation Magmatic differentiation Tengchong volcanic field

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strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period

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signal Transduction and Targeted Therapy 2024年第1期9卷 19-35页

作者： Danyi ao Xuemei He Jian Liu Li Xu state Key Laboratory of Biotherapy West China HospitalSichuan University610041 SichuanPeople’s Republic of China

The spread of severe acute respiratory syndrome coronavirus 2(sARs-CoV-2)has resulted in significant casualties and put immense strain on public health systems worldwide,leading to economic recession and social *** response,various prevention and control strategies have been implemented globally,including vaccine and drug development and the promotion of preventive *** these strategies has effectively curbed the transmission of the virus,reduced infection rates,and gradually restored normal social and economic ***,the mutations of sARs-CoV-2 have led to inevitable infections and reinfections,and the number of deaths continues to ***,there is still a need to improve existing prevention and control strategies,mainly focusing on developing novel vaccines and drugs,expediting medical authorization processes,and keeping epidemic *** measures are crucial to combat the Coronavirus disease(COVID-19)pandemic and achieve sustained,long-term prevention,management,and disease ***,we summarized the characteristics of existing COVID-19 vaccines and drugs and suggested potential future directions for their ***,we discussed the COVID-19-related policies implemented over the past years and presented some strategies for the future.

关键词： prevention sustained approval

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strategies of selective electroreduction of aqueous nitrate to N_(2) in chloride-free system:A critical review

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Green Energy & Environment 2024年第2期9卷 198-216页

作者： Fukuan Li Weizhe Zhang Peng Zhang ao Gong Kexun Li College of Environmental science and Engineering Nankai UniversityTianjin300350China MOE Key Laboratory of Pollution Processes and Environmental Criteria Tianjin Key Laboratory of Environmental Remediation and Pollution ControlTianjin Key Laboratory of Environmental Technology for Complex Trans-Media PollutionNankai UniversityTianjin300350China

Electroreduction of nitrate has been gaining wide attention in recent years owing to it's beneficial for converting nitrate into benign N_(2) from the perspective of electrocatalytic denitrification or into value-added ammonia from the perspective of electrocatalytic NH_(3) *** reason of the undesired formation of ammonia is dominant during electroreduction of nitrate-containing wastewater,chloride has been widely used to improve N_(2) ***,selective electroreduction of nitrate to N2 gas in chloride-containing system poses several *** this review,we focus on the key strategies for efficiently enhancing N_(2) selectivity of electroreduction of nitrate in chloride-free system,including optimal selection of elements,combining an active metal catalyst with another metal,manipulating the crystalline morphology and facet orientation,constructing core–shell structure catalysts,*** summarizing the strategies,four possible reaction pathways of electro-reduction of nitrate to N_(2) are ***,this review attempts to provide practical strategies for enhancing N2 selectivity without the aid of electrochlorination and highlight directions for future research for designing appropriate electrocatalyst for final electrocatalytic denitrifi-cation.

关键词： Nitrate Chloride Electroreduction selectivity Nitrogen

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La sabiduría detrás del Gran Canal

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今日中国（西文版） 2024年第3期 29-31页

作者： HE YUN'ao 不详

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Flavor mixing and solution structures in Dyson–schwinger equations for a two-flavor system

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Communications in Theoretical Physics 2024年第10期76卷 64-77页

作者： Xue-ao Chao Yu-xin Liu Department of Physics and state Key Laboratory of Nuclear Physics and Technology Peking University Collaborative Innovation Center of Quantum Matter Center for High Energy Physics Peking University

We solved the Dyson–schwinger(Ds) equations for a two-flavor system with symmetry to study its flavor mixing effects. Initially, we employed the point interaction model and bare vertex approximation to reveal the structure of the solutions. Using the point interaction model, the Ds equations can be solved analytically, and we found that these solutions can be classified into three groups, each forming an ellipse. These solutions exhibit sO(2) symmetry, while the original sU(2)symmetry at the Lagrangian level is dynamically broken to sO(2), corresponding to the emergence of flavor mixing effects. However, this flavor mixing effect does not manifest in the final physical *** utilizing the system's sO(2) symmetry, we can diagonalize the propagators of the Ds equations,eliminating the flavor mixing effect but causing the originally degenerate masses at the Lagrangian level to split. These mass eigenstates have identical quantum numbers but different masses. If we can correspond these to quark particles of different generations, we can explain why the three generations of quarks have different masses and obtain the corresponding quark mass spectrum. Finally, we provide the corresponding numerical results using a more realistic interaction model.

关键词： dynamic symmetry breaking Dyson-schwinger equation flavor change mass splitting

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Therapeutic potential of targeting protein tyrosine phosphatases in liver diseases

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Acta Pharmaceutica sinica B 2024年第8期14卷 3295-3311页

作者： ao Wang Yi Zhang Xinting Lv Guang Liang Department of Pharmacy and Institute of Inflammation Zhejiang Provincial Affiliated People’s HospitalHangzhou Medical CollegeHangzhou 310014China Key Laboratory of Natural Medicines of the Changbai Mountain Ministry of EducationYanbian UniversityYanji 133002China Chemical Biology Research Center School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035China

Protein tyrosine phosphorylation is a post-translational modification that regulates protein structure to modulate demic organisms’homeostasis and *** physiological process is regulated by two enzyme families,protein tyrosine kinases(PTKs)and protein tyrosine phosphatases(PTPs).As an important regulator of protein function,PTPs are indispensable for maintaining cell intrinsic physiology in different systems,as well as liver physiological and pathological *** of PTPs has been implicated in multiple liver-related diseases,including chronic liver diseases(CLDs),hepatocellular carcinoma(HCC),and liver injury,and several PTPs are being studied as drug therapeutic ***,given the regulatory role of PTPs in diverse liver diseases,a collated review of their function and mechanism is ***,based on the current research status of targeted therapy,we emphasize the inclusion of several PTP members that are clinically significant in the development and progression of liver *** an emerging breakthrough direction in the treatment of liver diseases,this review summarizes the research status of PTP-targeting compounds in liver diseases to illustrate their potential in clinical ***,this review aims to support the development of novel PTP-based treatment pathways for liver diseases.

关键词： Tyrosine phosphorylation PTPs signal transduction CLDs HCC Allosteric inhibitor PROTACs Drug development

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study on the properties of solar cell under bias condition by using impedance spectroscopy

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Optoelectronics Letters 2024年第9期20卷 518-522页

作者： XIao Wenbo LI ao XIao Bangzhi Key Laboratory of Nondestructive Test Ministry of EducationNanchang Hangkong UniversityNanchang 330063China science and Technology College Nanchang Hangkong UniversityGongqingcheng 332020China school of Engineering and Construction Nanchang UniversityNanchang 330031China

This paper investigates the properties of silicon cells(sI)and perovskite solar cells(PsC)under bias condition by using impedance *** parallel resistances R_(p) of sI and PsC are found to decrease with increasing bias,but the capacitance C_(p) shows the opposite *** Rp with C_(p),bias has a greater impact on the C_(p) of both cells.

关键词： spectroscopy impedance condition

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