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Intercalation of PM-19 into and in vitro Release of Anti-tumor Drug from Layered Double Hydroxide

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Chemical Research in Chinese Universities 2005年第4期21卷 492-495页

作者： WANGZhong-liang WANGEn-bo TIANShang-yi XIAOdong-rong GAOLei wangli XULin InstituteofPolyoxometalateChemistry FacultyofChemistry InstituteofGrassland SchoolofLifeSciencesNortheastNormalUniversityChangchun130024P.R.China

Recently,controlled release of drugs and gene delivery technology havereceived considerable attention due to their numerous advantages including prolonged duration ofaction of an active agent,improved efficacy,reduced toxicity and convenience compared to theconventional dosage *** this field typical systems are polymer delivery systems depending onthe hydrolysis-induced degradation,swelling and erosion of carriers' structures,mesoporous silicacarrier systems relying on capturing and releasing the CdS nanop-articles,and layered materialsrelease systems based on ion-exchange principle.

关键词： Hydrotalcite Layered double hydroxide Controlled release PM-19 Hybrid material

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Hydrothermal Synthesis and Crystal Structure of [(CH_3CH_2)_4N]_4[(La_(12)(OH)_(12)MoO_(29) )], A Novel Cluster Compound with a MoO_5 Hexahedron Center Surrounded by La-O Octahedron

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Chemical Research in Chinese Universities 2003年第2期19卷 132-134页

作者： HUChang-wen HUANGWei-tong ZHANGHong WANGXiu-li LIYang-guang DUANGLi-ying LANYang wangli WANGEn-bo InstituteofpolyoxometalateChemistry DepartmentofChemistryNortheastNormalUniversityChangchun130024P.R.China TonghuaHigherVocationalEducationInstitute Tonghua134001

A novel compound [(CH 3CH 2) 4N] 4[(La 12 (OH) 12 MoO 29 )] was synthesized by hydrothermal reaction. The single crystal X ray diffraction shows that the compound crystallized in the monoclinic space group C2/c ; a =2 5729(4) nm, b =1 4318(1) nm, c =2 1217(4) nm, β =111 56(1)°, V =6 8235(7) nm 3, Z =4, R =0 0751. The basic building blocks of the crystal structure included one MoO 5 hexahedron and twelve LaO 6 octahedra which shared a common edge to form a [(La 12 (OH) 12 MoO 29 )] 4- unit. These units were held together by the [(CH 3CH 2) 4N] + ions.

关键词： Hydrothermal synthesis Layer Lanthanum Triclinic system

Varying coefficient analysis for indeterminate species interactions with non-parametric estimation, exemplifying with a fig-fig wasp system

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Chinese Science Bulletin 2011年第24期56卷 2545-2552页

作者： SHI Lei WANG RuiWu ZHU LiXing ZEN WeiMing XU wangli ZHENG Qi Statistics and Mathematics School Yunnan University of Finance and Economics Kunming 650221 China Ecology Conservation and Environment Center (ECEC) State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoo-logy Chinese Academy of Sciences Kunming 650223 China Department of Mathematics Hong Kong Baptist University Hong Kong China Scientific and Technical Department Yunnan University of Nationalities Kunming 650031 China Statistics College RenMing University of China Beijing 100080 China

Research on species interactions has generally assumed that species have a fixed interaction and therefore linear or non-linear parametric regression models (e.g. exponential, logistic) have been widely used to describe the species interaction. However, these models that describe the relationship between interacting species as a specific functional response might not be appropriate for real biological communities, for instance, in a chaotic system, when the species relationship varies among different situations. To allow a more accurate description of the relationship, we developed a species correlation model with varying coefficient analysis, in which a non-parametric estimation is applied to identify, as a function of related factors, variation in the correlation coefficient. This was applied to a fig-fig wasp model system. When the effect of the factors on the relationship can be described with parameters, the new method reduces to traditional parametric correlation analysis. In this way, the new method is more general and flexible for empirical data analyses, but different by allowing investigation of whether a species interaction varies with respect to factors, and of the factors that maintain or change the species interaction. This method will have important applications in both theoretical and applied research (e.g. epidemiology, community management).

关键词：相互作用系数非参数估计混沌系统无花果物种非线性参数例证小蜂

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从领域到属性:亲环境行为测量的问题及建议

心理科学进展 2025年第1期33卷 163-175页

作者：张玥董艺佳蒋奖华北电力大学经济与管理学院北京102206 香港城市大学社会与行为科学系香港北京师范大学心理学部应用实验心理北京市重点实验室心理学国家级实验教学示范中心(北京师范大学)北京100875

已有研究开发了大量的亲环境行为测量工具,涉及量表、个体行为范式和群体博弈范式,其中大多数测量工具是基于行为领域设计,节约、出行、垃圾处理、消费和公域行为是5个最常被提及的领域。现有依据行为领域的亲环境行为测量方式存在标准... 详细信息

已有研究开发了大量的亲环境行为测量工具,涉及量表、个体行为范式和群体博弈范式,其中大多数测量工具是基于行为领域设计,节约、出行、垃圾处理、消费和公域行为是5个最常被提及的领域。现有依据行为领域的亲环境行为测量方式存在标准化程度低及测量结果推广性受限的问题,这主要是由于缺少对行为属性这一行为决定性特征的关注。未来研究应基于行为属性选用和开发标准化测量工具,并选取多种真实行为作为效标进行效度检验。

关键词：亲环境行为行为领域行为属性测量

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

Potassium ions and cyano group modified g-C3N4 for effective generation of H2O2 through two-electron oxygen reduction

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Science China Chemistry 2025年第1期 192-200页

作者： dongying Wang Shulan Pu Yongmin Chen Ke Lei Yujie Duan Linjiao Mao Xuhui Zeng Xi Luo Yuntao Zhang Yuqin dong Jin Zhong Zhang Yan Sun School of Mechanical Engineering Chengdu University Department of Chemistry and Biochemistry University of California

Potassium ions （K+） doped graphitic carbon nitride （g-C3N4） was prepared by a thermal etching method using potassium hydroxide （KOH） as an ion *** transform infrared spectroscopy （FTIR） and X-ray photoelectron spectroscopy （XPS）results showed that the generation of the cyano group was detected while introducing K+.Under simulated sunlight irradiation,the sample with a K+doping amount of 10%showed the highest hydrogen peroxide （H2O2） generation rate of2,140.2μmol *** apparent quantum yield （AQY） at 400 nm and the solar-to-chemical conversion （SCC） are 4.35%and1.23%,respectively.K+acted as a bridge between g-C3N4layers,which enhanced charge transfer ***,the cyano group enhanced the adsorption capacity of protons （H+） and promoted the yield of *** catalyst exhibited excellent photocatalytic stability based on four-cycle *** addition,a mechanism study showed that superoxide radicals （·O2-）were the most important active species in the reaction *** production of H2O2was achieved through consecutive single-electron *** study deepens the understanding of the oxygen reduction reaction process and opens up a new venue for improving H2O2generation.

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Novel method for the recognition of Jinnan cattle action using bottleneck attention enhanced two-stream neural network

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 203-210页

作者： wangli Hao Meng Han Kai Zhang Li Zhang Wangbao Hao Fuzhong Li Zhenyu Liu School of Software Shanxi Agricultural UniversityJinzhong 030801ShanxiChina Yuncheng National Jinnan Cattle Genetic Resources and Gene Protection Center Yongji 044500ShanxiChina Yongji Puzhou Old City Beimenwai Cattle Farm Yongji 044500ShanxiChina College of Engineering Shanxi Agricultural UniversityJinzhong 030801ShanxiChina

Effective and accurate action recognition is essential to the intelligent breeding of the Jinnan ***,there are still several challenges in the current Jinnan cattle action *** methods are based on manual characteristics and low recognition *** study is aimed at the efficient and accurate development of Jinnan cattle action recognition methods to overcome existing problems and support intelligent *** acquired data from the previous methods contain a lot of noise,which will cause individual cattle to have excessive behaviors due to *** the high labor costs,low efficiency,and low model accuracy of the above approaches,this study developed a bottleneck attention-enhanced two-stream(BATS)Jinnan cattle action recognition *** primarily comprises a Spatial Stream Subnetwork,a Temporal Stream Subnetwork,and a Bottleneck Attention *** can capture the spatial-channel dependencies in RGB and optical flow two branches respectively,so as to extract richer and more robust ***,the decision of the two branches can be fused to gain improved cattle action recognition *** with the traditional methods,the model proposed in this study has achieved state-of-the-art recognition performance,and the accuracy of motion recognition was 96.53%,which was 4.60%higher than other *** method significantly improves the efficiency and accuracy of behavior recognition and provides an important research foundation and direction for the development of higher-level behavior analysis models in the future development of smart animal husbandry.

关键词： Jinnan cattle action recognition bottleneck attention two-stream neural network

An NIR-Ⅱ-emissive Ru(Ⅱ) metallacycle for efficient and safe immunotherapy

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Science China Chemistry 2025年第01期 5-7页

作者： Chonglu Li Jianbo Zhan Biao dong Institute of Health Inspection and Testing Hubei Provincial Center for Disease Control and Prevention State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University

Immunotherapy, as a groundbreaking cancer treatment, has gained considerable attention for its utilization of the body’s immune system to combat tumors [1]. This therapy induces tumor cell apoptosis, triggering a sustained anti-tumor immune response and effectively preventing tumor recurrence and metastasis [2]. The fundamental principle lies in inducing tumor cell death through specific treatment modalities, leading to the release of a cascade of signaling molecules and antigens, thereby mobilizing the immune system to actively identify and attack tumor cells [3].

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