检索结果-南通市图书馆

Identification of deregulated miRNAs and their targets in hepatitis B virus-associated hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第38期18卷 5442-5453页

作者： Wen wang Lan-.luan Zhao Hao Ren zhong-tian Qi De-partment of Microbiology Shanghai Key Laboratory of Medi-cal Biodefense Second Military Medical University Shanghai200433 China Laboratory of Signal Transduction Eastem Hepa-tobiliary-Surgery Hospital Second Military Medical UniversityShanghai 200433 China

AIM： TO identify the differentially expressed miRNAs and their targets in hepatitis B virus （HBV）-associated hepatocellular carcinoma （HCC）. METHODS： Six hundred and sixty seven human miRNAs were quantitatively analyzed by Taqman lowdensity miRNA array （TLDA） in HBV-HCC tissues. Gene ontology （GO） and Kyoto Encyclopedia of Genes and Genomes （KEGG） pathway analyses were used to analyze the significant function and pathway of the differentially expressed miRNAs in HBV-HCC. TargetScan software was used to predict the targets of deregulated miRNAs. Western blotting and luciferase assay were performed to verify the targets of these ***： Ten up-regulated miRNAs （miR-217, miR- 518b, miR-517c, miR-520g, miR-519a, miR-522, miR- 518e, miR-525-3p, miR-512-3p, and miR-518a-3p） and 11 down-regulated miRNAs （miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275） were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. GO and KEGG pathway analysis revealed that ＂regulation of actin cytoskeleton＂ and ＂pathway in cancer＂ are most likely to play critical roles in HCC tumorigenesis. MiR- 519a and ribosomal protein S6 kinase polypeptide 3 （RPS6KA3） were predicted as the most significant can-didates by miRNA-mRNA network. In addition, cyclin D3 （CCND3） and clathrin heavy chain （CHC）, usually up-regulated in HCC tissues, were validated as the di- rect target of miR-138 and miR-199a-5p, respectively.

关键词： Hepatocellular carcinoma miR-138 miR- 199a-5p Cyclin D3 Clathrin heavy chain Bioinformatics Taqman array

Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanlong wang Pengyang wang Yali Liu Shanshan Qi Biao Shi Ying Zhao Xiaodan Zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of tianjin Haihe Laboratory of Sustainable Chemical Transformations Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Collaborative Innovation Center of Chemical Science and Engineering (tianjin)

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells （IPSCs）,which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid （5-MVA） was introduced as a strain buffer to release the residual strain of *** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb2+through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI2.85Br0.15perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI2.85Br0.15,resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI2.85Br0.15perovskite films and devices.

关键词： Inverted inorganic perovskite solar cells Flexible molecules Strain release Crystallization Energy barrier High PCE

Soil Organic Carbon Stocks of Citrus Orchards in Yongchun County Fujian Province China

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Pedosphere 2017年第5期27卷 985-990页

作者： wang Yixiang WENG Boqi tian Na zhong Zhenmei wang Mingkuang Institute of Agricultural Ecology Fujian Academy of Agricultural Sciences

Studies related to the quantitation and distribution of soil organic carbon （C） under different land use types can help to fill the knowledge gaps regarding estimation of the amount of C stored in soils at a global scale. Orchards are an important land use type in southern China; the total area （1.15 x 107 ha） of orchards in China comprises approximately 20.5% of the area of all orchards worldwide. We assessed soil organic C stocks （SOCS） in citrus orchards in Yongchun County （consisting of 22 towns）, Fujian Province, China in 1982 and 2010. The southeastern part of the county, an area featuring extensive citrus farming with a gently sloping landscape and low rates of water erosion, had the highest SOCS. In contrast, the lowest SCOS was observed in the northern part of the county, where steep hills with severe erosion problems are common and citrus orchards are sparsely distributed. From 1982 to 2010, the mean SOCS in citrus orchards increased from 22.1 to 41.7 Mg ha-1 which indicated that current management practices such as fertilization, irrigation, and cultivation enhanced soil C stocks. Further in-depth studies on the effects of these practices on C sequestration would be worthwhile and surveys of SOCS throughout Fujian Province are needed, to support efforts to mitigate global C emission.

关键词： carbon emission carbon pool carbon sequestration kriging land use type management practices

Probing the new strategy for the oral formulations of taxanes:changing the method with the situation

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2021年第9期19卷 656-665页

作者： wang He-Lin SUN Jin tian Chu-Tong HE zhong-Gui Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China

The first-generation taxanes(including paclitaxel and docetaxel)are widely used for the treatment of various cancers in clinical *** the past decade,a series of new-generation taxanes have been developed which are effective in the inhibition of tumor ***,intravenous(i.v.)infusion is still the only route of administration,and may result in serious adverse reactions with respect to the utilization of Cremophor EL or Tween-80 as ***,the dosing schedule is also ***,oral administration of taxanes is urgently needed to avoid the adverse reactionss and increase dosing *** this review,we first outlined the discovery and development of taxane-based anticancer ***,we summarized the research progress on the oral formulations of taxanes and proposed some thoughts on the future development of oral taxane formulations.

关键词： Taxanes Oral delivery Oral bioavailability Anti-tumor

Intra-beam scattering and beam lifetime in a candidate lattice of the soft X-ray diffraction-limited storage ring for the upgraded SSRF

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2021年第8期32卷 57-66页

作者： Xin-zhong Liu Shun-Qiang tian Xu Wu Meng wang Zhen-Tang Zhao Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China Shanghai University Shanghai 200444China

New-generation synchrotron light sources are being designed and operated worldwide to provide brighter radiation by reducing the beam emittance to X-ray diffraction ***-beam scattering(IBS)and Touschek scattering in such facilities are significant and require attention because of their ultra-low ***,cure strategies need to be carefully studied to obtain highquality photon *** the Shanghai Synchrotron Radiation Facility Upgrade(SSRF-U),a candidate lattice of the storage ring,reaching the soft X-ray diffraction limit,was designed and presented for the first time in this *** emittance growth and beam lifetime in the SSRF-U storage ring were studied using particle simulations for a series of different machine *** gains with RF frequencies of 100 MHz and 500 MHz were *** with a better filling pattern,a more suitable RF frequency was adopted in the *** variations in the equilibrium beam emittance with beam coupling and bunch-lengthening were identified using *** beam coupling and required bunch-lengthening for the SSRF-U storage ring were thus *** fitness of the beam energy in the SSRF-U was subsequently assessed using the obtained ***,the Touschek scattering and beam lifetime were calculated,and an acceptable total beam lifetime was obtained.

关键词： Diffraction-Limited Storage Ring(DLSR) Shanghai Synchrotron Radiation Facility Upgrade(SSRFU) Intra-Beam Scattering(IBS) Touschek scattering Beam lifetime

Nanofabrication of the gold scanning probe for the STM-SECM coupling system with nanoscale spatial resolution

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2017年第5期60卷 649-655页

作者： Fang-Fang wang Wei wang Xi He Lianhuan Han Jian-Zhang Zhou zhong-Qun tian Zhao-Wu tian Dongping Zhan State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen University Chemical Engineering and Environmental Engineering College of Chemistry Liaoning Shihua University

Scanning probe is the key issue for the electrochemical scanning probe techniques(EC-SPM) such as EC-scanning tunnel microscopy(STM), EC-atomic force microscopy(AFM) and scanning electrochemical microscopy(SECM), especially the insulative encapsulation of the nanoelectrode probe for both positioning and electrochemical feedbacks. To solve this problem,we develop a novel fabrication method of the gold nanoelectrodes: firstly, a micropipette with nanomter-sized orifice was prepared as the template by a laser puller; secondly, the inside wall of micropipette apex was blocked by compact and conic Au nano-piece through electroless plating; thirdly, the Au nano-piece was grown by bipolar electroplating and connected with a silver wire as a current collector. The fabricated Au nanoelectrode has very good voltammetric responses for the electrodic processes of both mass transfer and adsorption. The advantage lies in that it is well encapsulated by a thin glass sealing layer with a RG value lowered to 1.3, which makes it qualified in the SECM-STM coupling mode. On one hand, it can serve as STM tip for positioning which ensures the high spatial resolution; on the other hand, it is a high-quality nanoelectrode to explore the local chemical activity of the substrate. The nanofabrication method may promote the SPM techniques to obtain simultaneously the physical and chemical images with nanoscale spatial resolution, which opens a new approach to tip chemistry in electrochemical nanocatalysis and tip-enhanced spectroscopy.

关键词： scanning probe SECM bipolar nanoelectrode electrochemical imaging

Design of Low-cost Automobile Oil Level Sensor Detection Device 32

在线全文

学校读者我要写书评

暂无评论

Design of Low-cost Automobile Oil Level Sensor Detection Dev...

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

第32届中国控制与决策会议

作者： wang tian-he wang zhong-hua University of Jinan School of Electrical Engineering

ISBN: (数字)9781728158556

ISBN: (纸本)9781728158563

In today’s society with highly developed transportation, automobile transportation accounts for a large proportion, which has promoted the vigorous development of automobile manufacturing. The fuel tank level of an automobile is an important measured parameter in the driving process of the car, and the fuel quantity sensor is an indispensable part of the quantity measurement system. The importance of the quality inspection process at the factory is self-evident. At present, most of the vehicle oil quantity sensors use reed switch liquid level sensors, and most of the current factory detection of the sensors is manual way, which not only requires a lot of labor costs, but also have high missed detection rate. This article designs a low-cost automotive oil level sensor detection device, which uses MCU and constant current source circuit instead of the traditional manual instrument detection. It also has on-site display function and threshold storage function. At the same time, the device can automatically identify the sensor model and execute different detection procedure without manual settings when the sensor is connected. The test results show that this device greatly improves the detection efficiency and accuracy, and reduces the cost of testing.

关键词： Constant Current Source Reed Switch Oil Level Sensor MCU Resistance Detection

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min Song Lulu An Xiao Huang Qian Zhang Chenhao Zhang Tao Shen Shuang wang Deli wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Electrolytic reduction

Co-assembly of FeTPP@Fe_(3)O_(4) nanoparticles with photo-enhanced catalytic activity for synergistic tumor therapy

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2022年第10期15卷 9114-9124页

作者： tian tian Jianshuai Bao Jinghan wang Jiefei wang Yan Ge Zengyin Li Shanqing Gao zhongqi You Xiaoyan Yang Yong zhong Feng Bai Key Laboratory for Special Functional Materials of Ministry of Education National&Local Joint Engineering Research Center for High-efficiency Display and Lighting TechnologySchool of Materials Science and EngineeringCollaborative Innovation Center of Nano Functional Materials and ApplicationsHenan UniversityKaifeng 475004China Henan-Macquarie University Joint Centre for Biomedical Innovation School of Life SciencesHenan UniversityKaifeng 475004China

Chemodynamic therapy(CDT)offers a promising alternative to conventional cancer ***,the limited acidity and H_(2)O_(2) concentration in tumor microenvironment(TME)severely impair the anticancer effects of *** this study,we report a microemulsion-assisted coassembly method to prepare iron(III)tetraphenylporphyrin(FeTPP)and magnetic(Fe_(3)O_(4))nanocomposite material(FeTPP@Fe_(3)O_(4)),using photoactive FeTPP and Fe_(3)O_(4) nanocrystals as building *** selfassembling nature of FeTPP results in disordered aggregation and fluorescence quenching,leading to a high light-to-heat conversion ***,the photo-thermal effect enhances the catalytic decomposition of hydrogen peroxide(H_(2)O_(2))in the Fenton reaction on Fe_(3)O_(4) nanocrystals to generate highly toxic hydroxyl radicals(·OH)to destroy cancer *** cascade reaction produces a synergistic therapeutic effect between CDT and photothermal therapy(PTT),which significantly amplifies the therapeutic effect and enhances the treatment outcome of cancer *** highly efficient tumor catalytic therapy in vivo results confirmed that this nanomedicine treatment is an excellent biocompatible catalytic nanomedicine therapy achieved through a photo-enhanced Fenton reaction activity approach.

关键词： porphyrin photo-enhanced nanocatalyst synergistic therapy