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Increased fatty acid synthase as a potential therapeutic target in multiple myeloma

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第6期9卷 441-447页

作者： Wei-qin wang Xiao-ying ZHAO Hai-yan wang yun liang Department of Hematology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Objective： To determine fatty acid synthase （FAS） expression in human multiple myeloma and verify its potential as a therapeutic target in multiple myeloma. Methods： FAS expression was determined by immunohistochemistry, reverse-transcription polymerase chain reaction （RT-PCR） and immunoblot analysis in bone marrow samples obtained from 27 patients with multiple myeloma （MM patients） and peripheral blood mononuclear cells （PBMCs） obtained from 12 healthy donors In parallel, additional analyses were performed on 2 human multiple myeloma cell lines, U266 and RPM18226. U266 cells were treated with cerulenin at various concentrations （5 to 320 μg/ml） for 24 h, and metabolic activity was measured by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide （MTT） assays. Apoptosis was evaluated by dual Annexin V/Pl （propidium iodide） labeling and flow cytometry （FCM） in U266 cells treated with 20 μg/ml cerulenin for 12 h or 24 h. Results： By immunohistochemistry, we found that 19 of 27 bone marrow samples obtained from MM patients expressed significantly high levels of FAS. Similarly, by RT-PCR, 22 of 27 bone marrow samples obtained from MM patients, U266 and RPM18226 showed FAS expression, whereas PBMC samples from 12 healthy donors did not express detectable level of FAS. FAS protein expression was confirmed by immunoblot analysis in 16 of 27 bone marrow samples obtained from MM patients, U266 and RPM18226 cell lines, and no FAS protein expression was detected in PBMC samples from 12 healthy donors. U266 cells were highly sensitive to cerulenin treatment, with a dosage-related effect on metabolic activity, as a measure for cell proliferation. U266 cells treated with 20 μg/ml cerulenin for 12 and 24 h also showed early sign of apoptosis with 56.9% and 69.3% Annexin V^＋/Pl cells, and late apoptotic and necrotic cells with 3.2% and 17.6% Annexin V^＋/Pl^＋ cells. Conclusion： Increased FAS expression existed in multiple myeloma samples and human myeloma cell lines. Cerulen

关键词： Fatty acid synthase (FAS) Cerulenin Apoptosis Multiple myeloma

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Relativistic Magnetosonic Solitary Wave in Magnetized Multi-Ion Plasma

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Communications in Theoretical Physics 2009年第6期51卷 1121-1124页

作者： wang yun-liang ZHOU Zhong-Xiang LU Yan-Zhen NI Xiao-Dong SHEN Jiang ZHANG Yu Department of Physics School of Applied Science University of Science and Technology Beijing Beijing 100083 China Department of Physics Harbin Institute of Technology Harbin 150001 China

In the presence of an applied uniform magnetic field Bo, the properties of 2-dimensional （2D） magnetosonic solitary waves of relativistic amplitude in the plasma containing electron, light ions He^＋, and heavy ions O＋ are presented. In the weakly relativistic limit, a Kadomtsev Petviashvili （KP） equation is derived by reductive perturbation method. We give the N-soliton solution of the KP equation and find dromion solutions of a potential of the physical field. The interaction law of the dromions is obtained, which shows there is no exchange of energy, momentum, and angular momentum before and after interaction of the dromions except for phase shifts.

关键词： magnetosonic solitary wave magnetized plasma weakly relativistic

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IoT Empowered Early Warning of Transmission Line Galloping Based on Integrated Optical Fiber Sensing and Weather Forecast Time Series Data

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Computers, Materials & Continua 2025年第1期82卷 1171-1192页

作者： Zhe Li yun liang Jinyu wang Yang Gao State Grid Henan Electric Power Company Electric Power Scientific Research Institute State Grid Henan Electric Power CompanyZhengzhou450052China

Iced transmission line galloping poses a significant threat to the safety and reliability of power systems,leading directly to line tripping,disconnections,and power *** early warning methods of iced transmission line galloping suffer from issues such as reliance on a single data source,neglect of irregular time series,and lack of attention-based closed-loop feedback,resulting in high rates of missed and false *** address these challenges,we propose an Internet of Things(IoT)empowered early warning method of transmission line galloping that integrates time series data from optical fiber sensing and weather ***,the method applies a primary adaptive weighted fusion to the IoT empowered optical fiber real-time sensing data and weather forecast data,followed by a secondary fusion based on a Back Propagation(BP)neural network,and uses the K-medoids algorithm for clustering the fused ***,an adaptive irregular time series perception adjustment module is introduced into the traditional Gated Recurrent Unit(GRU)network,and closed-loop feedback based on attentionmechanism is employed to update network parameters through gradient feedback of the loss function,enabling closed-loop training and time series data prediction of the GRU network ***,considering various types of prediction data and the duration of icing,an iced transmission line galloping risk coefficient is established,and warnings are categorized based on this ***,using an IoT-driven realistic dataset of iced transmission line galloping,the effectiveness of the proposed method is validated through multi-dimensional simulation scenarios.

关键词： Optical fiber sensing multi-source data fusion early warning of galloping time series data IoT adaptive weighted learning irregular time series perception closed-loop attention mechanism

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Relativistic degenerate effects of electrons and positrons on modulational instability of quantum ion acoustic waves in dense plasmas with two polarity ions

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Chinese Physics B 2015年第2期24卷 295-301页

作者：刘铁路王云良路彦珍 Department of Physics School of Mathematics and PhysicsUniversity of Science and Technology Beijing

The nonlinear propagation of quantum ion acoustic wave（QIAW） is investigated in a four-component plasma composed of warm classical positive ions and negative ions,as well as inertialess relativistically degenerate electrons and positrons.A nonlinear Schrodinger equation is derived by using the reductive perturbation method,which governs the dynamics of QIAW *** modulation instability analysis of QIAWs is considered based on the typical parameters of the white *** results exhibit that both in the weakly relativistic limit and in the ultrarelativistic limit,the modulational instability regions are sensitively dependent on the ratios of temperature and number density of negative ions to those of positive ions respectively,and on the relativistically degenerate effect as well.

关键词： quantum ion acoustic waves modulational instability relativistic degenerate

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Rockburst proneness criteria for rock materials:Review and new insights

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Journal of Central South University 2020年第10期27卷 2793-2821页

作者： GONG Feng-qiang wang yun-liang LUO Song School of Resources and Safety Engineering Central South UniversityChangsha 410083China School of Civil Engineering Southeast UniversityNanjing 211189China

To review the rockburst proneness(or tendency)criteria of rock materials and compare the judgment accuracy of them,twenty criteria were summarized,and their judgment accuracy was evaluated and compared based on the laboratory tests on fourteen types of *** study begins firstly by introducing the twenty rockburst proneness criteria,and their origins,definitions,calculation methods and grading standards were summarized in ***,to evaluate and compare the judgment accuracy of the twenty criteria,a series of laboratory tests were carried out on fourteen types of rocks,and the rockburst proneness judgment results of the twenty criteria for the fourteen types of rocks were obtained ***,to provide a unified basis for the judgment accuracy evaluation of above criteria,a classification standard(obtained according to the actual failure results and phenomena of rock specimen)of rockburst proneness in laboratory tests was *** judgment results of the twenty criteria were compared with the judgment results of this classification *** results show that the judgment results of the criterion based on residual elastic energy(REE)index are completely consistent with the actual rockburst proneness,and the other criteria have some inconsistent situations more or ***,the REE index is based on the linear energy storage law and defined in form of a difference value and considered the whole failure process,and these superior characteristics ensure its *** is believed that the criterion based on REE index is comparatively more accurate and scientific than other criteria,and it can be recommended to be applied to judge the rockburst proneness of rock materials.

关键词： deep rock rockburst rockburst proneness rockburst proneness criterion rock mechanics

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强激光与固体密度等离子体作用产生孤立阿秒脉冲的研究进展

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物理学报 2023年第5期72卷 162-177页

作者：王云良颜学庆北京科技大学数理学院北京100083 北京大学核物理与核技术国家重点实验室北京100871 北京怀柔激光加速创新中心北京101407 山西大学极端光学协同创新中心太原030006

强激光与固体密度等离子体作用产生的阿秒脉冲具有强度高、脉宽短等优势,因此吸引了很多研究者的注意.由于超快过程的泵浦探测技术需要的是一个孤立的阿秒脉冲,因此本文重点讨论了相对论强激光与固体密度等离子体作用产生孤立阿秒脉冲... 详细信息

强激光与固体密度等离子体作用产生的阿秒脉冲具有强度高、脉宽短等优势,因此吸引了很多研究者的注意.由于超快过程的泵浦探测技术需要的是一个孤立的阿秒脉冲,因此本文重点讨论了相对论强激光与固体密度等离子体作用产生孤立阿秒脉冲的几种物理机理.最近的几个代表性工作表明,强激光与固体密度等离子体作用还可以产生脉宽更短、强度更高的半周期阿秒脉冲.半周期孤立阿秒脉冲在对原子、固体中的电子进行超快的非对称操纵或探测等方面具有重要的应用,因此本文对半周期阿秒脉冲产生的理论机制、实验可行性、标定测量、及应用前景进行了深入的讨论.

关键词：强激光固体密度等离子体半周期阿秒脉冲孤立阿秒脉冲

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含多处损伤宽板螺接搭接件疲劳寿命研究

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工程力学 2017年第6期34卷 217-225页

作者：郁大照陈跃良王允良海军航空工程学院飞行器工程系烟台264001 海军航空工程学院青岛校区青岛266041

对含多处损伤(Multiple Side Damage,MSD)宽板搭接件做了等幅疲劳试验和断口分析,得到搭接件的疲劳寿命和孔边MSD裂纹的形成特点、裂纹前沿形状及扩展历程。结果表明,搭接件的疲劳破坏具有一定的隐蔽性,其疲劳寿命的绝大部分消耗在螺栓... 详细信息

对含多处损伤(Multiple Side Damage,MSD)宽板搭接件做了等幅疲劳试验和断口分析,得到搭接件的疲劳寿命和孔边MSD裂纹的形成特点、裂纹前沿形状及扩展历程。结果表明,搭接件的疲劳破坏具有一定的隐蔽性,其疲劳寿命的绝大部分消耗在螺栓头下裂纹扩展阶段,当孔间裂纹出现首次连通时,搭接件剩余寿命约为总寿命的0.7%~9.4%。基于有限元软件FRANC2D/L和裂纹扩展分析软件AFGROW,建立了考虑钉载、第二弯矩和孔间裂纹干涉等影响因素的含MSD宽板搭接件疲劳寿命计算模型,并对孔边多裂纹的扩展寿命进行了计算分析。计算结果与试验结果的对比表明,该文所建寿命计算模型具有一定的精度,能满足工程需要,计算结果和结论可作为该类结构损伤容限设计的参考依据。

关键词：螺接件多处损伤疲劳寿命裂纹扩展微动损伤

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鬼魂、精怪与玄异——论汉魏六朝小说中的亭传鬼怪观念

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北京社会科学 2018年第2期 82-94页

作者：王允亮郑州大学文学院郑州450001

亭是秦汉以来形成的基层职能单位,随着汉末六朝人口流动的加剧,它的旅途客舍功能日益重要。与家庭日常生活的封闭性空间相比,亭传空间具有陌生化、开放性等特点。在汉魏六朝鬼怪大兴的社会思潮下,作为凶杀、死亡事件高发地的亭传被附会... 详细信息

亭是秦汉以来形成的基层职能单位,随着汉末六朝人口流动的加剧,它的旅途客舍功能日益重要。与家庭日常生活的封闭性空间相比,亭传空间具有陌生化、开放性等特点。在汉魏六朝鬼怪大兴的社会思潮下,作为凶杀、死亡事件高发地的亭传被附会上众多的鬼怪故事。随着这些故事的广泛传播,亭传中充斥鬼魂、精怪兼具玄异的观念深入人心。在这一观念的生成过程中,文学起到了积极的推动作用,以其为切入点对这一现象深入追溯,便可触及到时人精神世界的独特之处,进而对它的形成进行有效的还原、阐释。

关键词：亭传鬼魂精怪玄异

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扬雄《剧秦美新》与汉代的王道观

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上海大学学报（社会科学版） 2017年第5期34卷 30-44页

作者：王允亮郑州大学文学院河南郑州450001

《文选》扬雄《剧秦美新》中"奋三为一",李善和五臣均释为于《尧典》、《舜典》外,新作帝典一篇,合三篇而为一,这种解释实为误解。"奋三为一"源于"王道通三"观念。"王道通三"是汉人王道观中的核心命题,它在贯通天人的基础上,强调屈民伸... 详细信息

《文选》扬雄《剧秦美新》中"奋三为一",李善和五臣均释为于《尧典》、《舜典》外,新作帝典一篇,合三篇而为一,这种解释实为误解。"奋三为一"源于"王道通三"观念。"王道通三"是汉人王道观中的核心命题,它在贯通天人的基础上,强调屈民伸君、屈君伸天,是与汉政治文化环境相应的原创理论。汉帝国不仅政治上超迈往古,思想上也涵括天人,具大一统特色。其王道观于思想领域集成众说,另辟新义,是时代精神的高度体现。

关键词：奋三为一古文《尚书》今文《尚书》王道通三

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汉廷政事与经典书写--论《史记·三王世家》的撰写及影响

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中山大学学报（社会科学版） 2023年第1期63卷 61-75页

作者：王允亮郑州大学文学院、中原文化资源与发展研究中心郑州450001

武帝分封三王是为了应对现实政治局面而施行的措施,其分封仪式乃汉廷礼制史上的大事件。今存之《史记·三王世家》为司马迁之原著,他秉着记录史实书写经典的心态,采用独特的方式记录下一朝宪政大典及文书运作。通过自己的独特行文,司马... 详细信息

武帝分封三王是为了应对现实政治局面而施行的措施,其分封仪式乃汉廷礼制史上的大事件。今存之《史记·三王世家》为司马迁之原著,他秉着记录史实书写经典的心态,采用独特的方式记录下一朝宪政大典及文书运作。通过自己的独特行文,司马迁让人感受到汉廷分封三王的严肃与隆重,彰显出此事在当日的巨大影响,这是历史书写对真实场景的有效还原。三王分封策书和记载此事的《三王世家》都成为经典文本流传后世,体现出政事与文学的互动关系,也是朝堂礼制与经典书写相互影响的代表。

关键词：《三王世家》分封三王经典书写文政互动

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