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Transactions of Nonferrous Metals Society of China 2022年第8期32卷 2494-2509页

作者： yue-hua SUN Ri-chu wang Chao-qun PENG Xiao-feng wang School of Materials Science and Engineering Anhui University of TechnologyMaanshan 243002China School of Materials Science and Engineering Central South UniversityChangsha 410083China

The microstructure observation,tensile test,electrochemical measurement,and corrosion morphology characterization were conducted to study the effect of Gd on the microstructure,mechanical properties,and corrosion behavior of as-homogenized Mg−8Li−3Al−2Zn−0.2Zr(LAZ832−0.2Zr)*** addition of trace Gd can improve the mechanical properties of as-homogenized LAZ832−0.2Zr alloy by refining the microstructure,reducing the content of AlLi softening phase,and forming Al_(2)Gd strengthening ***,the addition of trace Gd can weaken the microgalvanic corrosion between matrix phase and AlLi phase,inhibit the galvanic corrosion betweenα-Mg phase andβ-Li phase,and result in the formation of dense oxide film containing Gd_(2)O_(3),thereby improving the corrosion resistance of the *** the Gd content is 1.0 wt.%,the alloy shows the best comprehensive properties with the ultimate tensile strength of 189.8 MPa,elongation of 42.3%,and corrosion rate(determined by hydrogen evolution)of 0.86 mm·a^(−1).

关键词： Mg-Li alloy rare earth Gd microstructure mechanical properties corrosion behavior

Efficacy of multimodal cocktail periarticular injection with or without steroid in total knee arthroplasty

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Chinese Medical Journal 2013年第20期126卷 3851-3855页

作者： yue De-bo wang Bai-liang Liu Kun-peng Guo Wan-shou China Japan Friendship Hosp Dept Joint Surg Beijing 100029 Peoples R China China Japan Friendship Hosp Dept Anaesthesiol Beijing 100029 Peoples R China

Background Multimodal cocktail periarticular injection （MCPI） with a large volume of low concentration local anesthetics, adrenaline, and anti-inflammatory agents such as non-steroidal anti-inflammatory drug or steroids have shown good pain control and improvement in range of motion after surgery. This study compares the efficacy of pain control after total knee arthroplasty, using multimodal cocktail periarticular injection with steroid or without steroid.

关键词： periarticular injection total knee arthroplasty pain

Quantitatively mapping local quality of super-resolution microscopy by rolling Fourier ring correlation

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Light(Science & Applications) 2023年第12期12卷 2826-2844页

作者： Weisong Zhao Xiaoshuai Huang Jianyu Yang Liying Qu Guohua Qiu yue Zhao Xinwei wang Deer Su Xumin Ding Heng Mao Yaming Jiu Ying Hu Jiubin Tan Shiqun Zhao Leiting Pan Liangyi Chen Haoyu Li Innovation Photonics and Imaging Center School of Instrumentation Science and EngineeringHarbin Institute of TechnologyHarbinChina Key Laboratory of Ultra-Precision Intelligent Instrumentation of Ministry of Industry and Information Technology Harbin Institute of TechnologyHarbinChina Biomedical Engineering Department International Cancer InstitutePeking University Cancer Hospital and InstituteHealth Science CenterPeking UniversityBeijingChina The Key Laboratory of Weak-Light Nonlinear Photonics of Education Ministry School of Physics and TEDA Institute of Applied PhysicsFrontiers Science Center for Cell ResponsesNankai UniversityTianjinChina State Key Laboratory of Membrane Biology Beijing Key Laboratory of Cardiometabolic Molecular MedicineInstitute of Molecular MedicineNational Biomedical Imaging CenterSchool of Future TechnologyPeking UniversityBeijingChina Department of Control Science and Engineering Harbin Institute of TechnologyHarbinChina School of Mathematical Sciences Peking UniversityBeijingChina Unit of Cell Biology and Imaging Study of Pathogen Host Interaction The Center for MicrobesDevelopment and HealthKey Laboratory of Molecular Virology and ImmunologyShanghai Institute of Immunity and InfectionChinese Academy of SciencesShanghaiChina School of Life Science and Technology Harbin Institute of TechnologyHarbinChina PKU-IDG/McGovern Institute for Brain Research BeijingChina Beijing Academy of Artificial Intelligence BeijingChina Frontiers Science Center for Matter Behave in Space Environment Harbin Institute of TechnologyHarbinChina Key Laboratory of Micro-Systems and Micro-Structures Manufacturing of Ministry of Education Harbin Institute of TechnologyHarbinChina

In fluorescence microscopy,computational algorithms have been developed to suppress noise,enhance contrast,and even enable super-resolution(SR).However,the local quality of the images may vary on multiple scales,and these differences can lead to *** mapping methods fail to finely estimate the local quality,challenging to associate the SR scale ***,we develop a rolling Fourier ring correlation(rFRC)method to evaluate the reconstruction uncertainties down to SR *** visually pinpoint regions with low reliability,a filtered rFRC is combined with a modified resolution-scaled error map(RSM),offering a comprehensive and concise map for further *** demonstrate their performances on various SR imaging modalities,and the resulting quantitative maps enable better SR images integrated from different ***,we expect that our framework can become a routinely used tool for biologists in assessing their image datasets in general and inspire further advances in the rapidly developing field of computational imaging.

关键词： resolution local enable

Choroid plexus CCL2‒CCR2 signaling orchestrates macrophage recruitment and cerebrospinal fluid hypersecretion in hydrocephalus

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Acta Pharmaceutica Sinica B 2024年第10期14卷 4544-4559页

作者： Qiguang wang Fei Liu yue Li Huan Zhang Xin Qi Ke Wu Yi Zhang Shenglan You Wenke Liu Xuhui Hui Hanmei Li Lei Zhu Huile Gao Jian Cheng Department of Neurosurgery West China HospitalSichuan UniversityChengdu 610041China Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China Institute of Thoracic Oncology West China HospitalSichuan UniversityChengdu 610041China Institutes for Systems Genetics Frontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China Institute of Rare Diseases West China Hospital of Sichuan UniversityChengdu 610041China Research Core Facility of West China Hospital Sichuan UniversityChengdu 610041China Key Laboratory of Coarse Cereal Processing School of Food and Biological EngineeringChengdu UniversityChengdu 610106China

The choroid plexus(ChP)serves as the principal origin of cerebrospinal fluid(CSF).CSF hypersecretion due to ChP inflammation has emerged as an important pathogenesis of hydrocephalus ***,the precise mechanisms of ChP inflammation and the ensuing CSF hypersecretion in hydrocephalus remain *** the present study,we elucidate the critical role of macrophages in the pathogenesis of ChP ***,we identify the chemokine CCL2,released by ChP epithelial cells,recruits CCR2+monocytes to the ChP thereby inciting hydrocephalus *** accumulated ChP macrophages increase the inflammation in ChP epithelial cells through TNF-α/TNFR1/NF-κB signaling cascade,thereby leading to CSF ***,augmentation of ChP‒CCL2 using an adeno-associated viral approach(AAV)exacerbates macrophage recruitment,activation,and ventriculomegaly in rat PHH *** application of Bindarit,a specific CCL2 inhibitor,significantly inhibits ChP macrophage infiltration and activation and reduces CSF secretion ***,the administration of CCR2 antagonist(INCB 3284)reduces ChP macrophage accumulation and *** study not only unveils the ChP CCL2‒CCR2 signaling in the pathophysiology of hydrocephalus but also unveils Bindarit as a promising therapeutic choice for the management of posthemorrhagic hydrocephalus.

关键词： Hydrocephalus Macrophages CCL2 CCR2 Choroid plexus Epithelial cells Crosstalk Cerebrospinal fluid hypersecretion

Safety and immunogenicity of a recombinant COVID-19 vaccine(Sf9 cells)in healthy population aged 18 years or older:two single-center,randomised,double-blind,placebo-controlled,phase 1 and phase 2 trials

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2550-2560页

作者： Fan-yue Meng Fan Gao Si-yue Jia Xiang-Hong Wu Jing-Xin Li Xi-Ling Guo Jia-Lu Zhang Bo-Pei Cui Zhi-Ming Wu Ming-Wei Wei Zhi-Long Ma Hai-Lin Peng Hong-Xing Pan Lin Fan Jing Zhang Jiu-Qin Wan Zhong-Kui Zhu Xue-Wen wang Feng-Cai Zhu NHC Key Laboratory of Enteric Pathogenic Microbiology Jiangsu Provincial Center for Disease Control and PreventionNanjingChina China National Institute for Food and Drug Control BeijingChina Sheyang County Center for Disease Control and Prevention YanchengChina Jiangdu District Center for Disease Control and Prevention YangzhouChina Taizhou Center for Disease Control and Prevention TaizhouChina Jiangsu Taizhou Peopled Hospital TaizhouChina Shanghai Canming Medical Technology Co. LtdShanghaiChina

COVID-19 vaccines from multiple manufacturers are needed to cope with the problem of insufficient *** did two singlecenter,randomised,double-blind,placebo-controlled phase 1 and phase 2 trials to assess the safety,tolerability and immunogenicity of a recombinant COVID-19 vaccine(Sf9 cells)in healthy population aged 18 years or older in *** participants were enrolled,the ratio of candidate vaccine and placebo within each dose group was 3:1(phase 1)or 5:1(phase 2).From August 28,2020,168 participants were sequentially enrolled and randomly assigned to receive the low dose vaccine,high dose vaccine or placebo with the schedule of 0,28 days or 0,14,28 days in phase 1 *** November 18,2020,960 participants were randomly assigned to receive the low dose vaccine,high dose vaccine or placebo with the schedule of 0,21 days or 0;14,28 days in phase 2 *** most common solicited injection site adverse reaction within 7 days in both trials was *** most common solicited systematic adverse reactions within 7 days were fatigue,cough,sore throat,fever and *** antibodies and neutralising antibodies increased at 14 days,and peaked at 28 days(phase 1)or 30 days(phase 2)after the last dose *** GMTs of neutralising antibody against live SARS-CoV-2 at 28 days or 30 days after the last dose vaccination were highest in the adult high dose group(0,14,28 days),with 102.9(95%Cl 61.9-171.2)and 102.6(95%Cl 75.2-140.1)in phase 1 and phase 2 trials,*** T-cell response peaked at 14 days after the last dose vaccination in phase 1 *** vaccine is safe,and induced significant immune responses after three doses of vaccination.

关键词： fatigue phase double

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结合投影误差校正的快速SIFT图像拼接

光学精密工程 2017年第6期25卷 1645-1651页

作者：赵岩陈月王世刚吉林大学通信工程学院吉林长春130012

针对现有图像拼接方法实时性受限的问题,提出了一种通过对图像拼接中重叠区域部分图像特征检测和投影误差校正两部分相结合的快速图像拼接方法。首先,该方法特征检测范围仅集中在待拼接图像重叠区域的部分图像块,从中获取尺度不变特征变... 详细信息

针对现有图像拼接方法实时性受限的问题,提出了一种通过对图像拼接中重叠区域部分图像特征检测和投影误差校正两部分相结合的快速图像拼接方法。首先,该方法特征检测范围仅集中在待拼接图像重叠区域的部分图像块,从中获取尺度不变特征变换(SIFT)的特征点信息。然后,在特征匹配后应用投影误差校正方法,达到充分利用有限匹配点对计算出高精度投影变换矩阵的目的,避免了不必要的特征检测和匹配搜索,继而大大加快了图像拼接速度。最后,结合图像拼接的质量评价方法对图像拼接结果做出质量分析,以反映改进方法的性能。实验结果表明:对比文献所提出的快速图像拼接方法,本文方法在保证图像拼接质量的前提下显著降低了拼接时间;在所给的3组实验图像中,拼接速度平均提升了54%左右,证明了本文方法的可行性和有效性。

关键词：图像拼接尺度不变特征变换(SIFT) 投影误差校正质量评价

Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells

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Cellular & Molecular Immunology 2021年第2期18卷 440-451页

作者： Ke Rui yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun wang Liwei Lu Department of Laboratory Medicine Affiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Immunology Jiangsu Key Laboratory of Laboratory MedicineSchool of MedicineJiangsu UniversityZhenjiangChina Department of Rheumatology The First Affiliated Hospital and College of Clinical MedicineHenan University of Science and TechnologyLuoyangChina Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong Kong Center for Clinical Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Rheumatology The Second Affiliated Hospital of Dalian Medical UniversityLiaoningChina

Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal *** previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of *** this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO ***,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS ***,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in *** addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by *** together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases.

关键词： mesenchymal stem cells exosomes MDSCs Sjögren’s syndrome autoimmune diseases

Study of Indoor Location Algorithm Based on an Improved SVR Algorithm

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Study of Indoor Location Algorithm Based on an Improved SVR ...

Protective effects of nicotine on gamma-aminobutyricacid neurons and dopaminergic neurons in micewith Parkinson disease

2018中国信息通信大会(CICC2018)

作者： yue Jia xin wang Zhong Sichuan Film and Television University School of Electrical Engineering and Information Sichuan University

As the proliferation of mobile intelligent terminal and wireless network continues,the requirement for Location Based Services at the application level shows the most rapid and sizable growth *** at the small data sample processing in indoor position algorithm,SVR algorithm is used to structure the training model of received signal strength and position-fingerprint *** SVR algorithm has problems of low position accuracy and inefficient validity in the process of training ***,a modified SVR indoor position algorithm is *** algorithm takes RSS as the inputs and uses a SVR model,after being optimized by particle swarm optimization,to resolve position information in a real *** experiment results attest a relatively great improvement of position accuracy and speed in this modified SVR algorithm.

关键词： indoor positioning location fingerprint received signal strength wireless local network support vector regression particle swarm optimization

来源： cnki会议评论

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Frontiers of Medicine 2009年第3期3卷 330-335页

作者： Lei FU yue LI Dezheng GONG Dengqin YU Jin GONG Yanhui FENG Yan PENG Dongmei wang Hong XU Shengming YIN Yiping SUN Lab of Physiological Function College of Basic MedicineDalian Medical UniversityDalian 116044China Department of Physiology College of Basic MedicineDalian Medical UniversityDalian 116044China Department of Anatomy College of Basic MedicineDalian Medical UniversityDalian 116044China

This study aimed to investigate the protective effect of nicotine on dopaminergic neurons and its mechanisms in mice with Parkinson disease(PD)induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP).C57BL/6J mice were injected with MPTP for 8 days to establish a PD *** was given for 10 days in the nicotine therapeutic *** were examined behaviorally with the pole test and traction *** hydroxylase(TH)andγ-aminobutyric acid(GABA)were determined by using the immunocytochem-istry(ICC)*** ultrastructural changes of the caudate nucleus(CN)were observed under electron *** results showed that pretreatment with nicotine could improve the dyskinesia of PD mice ***,TH-positive(P<0.01)neurons and GABA-positive(P<0.05)neurons in the nicotine therapeutic group were signiﬁcantly more than those in the model *** ultrastructural injury of the nicotine therapeutic group was also *** has protective effects on theγ-aminobutyric acid neurons and dopaminergic neurons in the MPTP-treated mice.

关键词： Parkinson disease nicotine dopaminergic neuron gamma-aminobutyric acid neuron

The 8×10 GHz Receiver Optical Subassembly Based on Silica Hybrid Integration Technology for Data Center Interconnection

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Chinese Physics Letters 2017年第10期34卷 39-43页

作者： Chao-Yi Li Jun-Ming An Jiu-Qi wang Liang-Liang wang Jia-Shun Zhang Jian-Guang Li Yuan-Da Wu yue wang Xiao-Jie Yin Yong Li Fei Zhong State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences College of Material Science and Optoelectronic Technology University of Chinese Academy of Sciences Beijing 100049 College of Software Beihang University Beijing 100191 4Henan Shi Jia Photons Technology Co. Ltd Hebi 458030

An 8×10 GHz receiver optical sub-assembly （ROSA） consisting of an 8-channel arrayed waveguide grating （AWG） and an 8-channel PIN photodetector （PD） array is designed and fabricated based on silica hybrid integration technology. Multimode output waveguides in the silica AWG with 2% refractive index difference are used to obtain fiat-top spectra. The output waveguide facet is polished to 45° bevel to change the light propagation direction into the mesa-type PIN PD, which simplifies the packaging process. The experimentM results show that the single channel I dB bandwidth of AWG ranges from 2.12nm to 3.06nm, the ROSA responsivity ranges from 0.097 A/W to 0.158A/W, and the 3dB bandwidth is up to 11 GHz. It is promising to be applied in the eight-lane WDM transmission system in data center interconnection.

关键词： AWG GHz Receiver Optical Subassembly Based on Silica Hybrid Integration Technology for Data Center Interconnection The 8 PD