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Light People:Professor Laura Na Liu

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Light(Science & Applications) 2024年第2期13卷 184-189页

作者： Hui wang Cun yu Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of Sciences130033ChangchunChina

Editorial The DNA nanotechnology outlines a new chapter in biological sciences,opening a new era of scientific and technological advancements.A pioneer of DNA nanotechnology,Professor Liu from the University of Stuttgart in Germany,our latest Light People,has been working at the interface,where nanophotonics meets biology and *** the path of scientific explorations.

关键词： chemistry. advancement pioneer

Relationship between expression of CD44v6 and nm23-H1 and tumor invasion and metastasis in hepatocellular carcinoma

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World Journal of Gastroenterology 1998年第5期4卷 49-51页

作者： XIAO Cheng Zhi, DAI Yi Min, yu Hong yu, wang Jian jun and NI Can Rong

AIM To detect the expression of CD44v6 mRNA and nm23-H1 mRNA in hepatocellular carcinoma (HCC) by in situ hybridization, and to evaluate the relationship between their expression and also relationship between their expressions and tumor invasion and *** CD44v6 cDNA probe was synthesized with PCR technique and the nm23-H1 cRNA probe by in vitro transcription. The expression of CD44v6 mRNA and nm23-H1 mRNA was detected by in situ *** In group with high invasion and metastasis potential, the positive rates of CD44v6 mRNA and nm23-H1 mRNA were 80% (8/10) and 40% (4/10), in group with poor invasion and metastasis potential, they were 21.7% (5/23) and 91.3% (21/23). There was a positive correlation between the expression of CD44v6 mRNA and tumor invasion and metastasis potential in HCC (P＜0.01), and a reverse correlation between the expression of nm23-H1 mRNA and tumor invasion and metastasis potential (P＜0.01) and a reverse correlation in the expression between CD44v6 mRNA and nm23-H1 mRNA in HCC (P＜0.01).CONCLUSION Detection of CD44v6 mRNA and nm23-H1 mRNA may be useful for tumor invasion and metastasis in ***44 is a cell surface transmembrane glycoprotein. As a kind of adhesive molecule, it participates in cell-cell and cell-matrix adhesion and interactions. Many studies revealed a correlation between high-level expression of CD44, especially CD44v and tumor invasion, metastasis and prognosis. The exon 6v containing isoforms may be an independent diagnostic parameter[1,2]. Some other studies, however, had different results[3,4]. Some researches showed a reverse correlation between the expression of nm23-H1 mRNA and tumor metastasis[5,6]. In order to evaluate the relationship between the expression of CD44v6 mRNA and nm23-H1 mRNA and tumor invasive and metastatic potential in HCC and to evaluate the relationship in the expression between CD44v6 mRNA and nm23-H1 mRNA, we detected their expression in HCC by in situ hybridiza

关键词： liver neoplasms carcinoma, hepatocellular neoplasm invasion neoplasm metastasis CD44v6 nm23 H1 RNA, messenger

Learning in games:a systematic review

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Science China(Information Sciences) 2024年第7期67卷 133-159页

作者： Rong-jun QIN Yang yu National Key Laboratory for Novel Software Technology Nanjing University Polixir Technologies

Game theory studies the mathematical models for self-interested individuals. Nash equilibrium is arguably the most central solution in game theory. While finding the Nash equilibrium in general is known as polynomial parity arguments on directed graphs(PPAD)-complete, learning in games provides an alternative to approximate Nash equilibrium, which iteratively updates the player's strategy through interactions with other players. Rules and models have been developed for learning in games, such as fictitious play and no-regret learning. Particularly, with recent advances in online learning and deep reinforcement learning,techniques from these fields greatly boost the breakthroughs in learning in games from theory to *** a result, we have witnessed many superhuman game AI systems. The techniques used in these systems evolve from conventional search and learning to purely reinforcement learning(RL)-style learning methods,gradually getting rid of the domain knowledge. In this article, we systematically review the above techniques,discuss the trend of basic learning rules towards a unified framework, and recap applications in large ***, we discuss some future directions and make the prospect of future game AI systems. We hope this article will give some insights into designing novel approaches.

关键词： non-cooperative games learning in games no-regret learning reinforcement learning superhuman AI

Geometry characteristics and wide temperature behavior of silicon-based GaN surface acoustic wave resonators with ultrahigh quality factor

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Science China(Information Sciences) 2024年第2期67卷 267-278页

作者： Guofang yu Renrong LIANG Haiming ZHAO Lei XIAO Jie CUI yue ZHAO Wenpu CUI Jing wang jun XU jun FU Tianling REN School of Integrated Circuits Tsinghua University Beijing National Research Center for Information Science Technology Tsinghua University

Surface acoustic wave(SAW) resonators with an ultrahigh Q-factor are designed and fabricated on silicon-based gallium nitride(GaN/Si). The temperature-dependent performance is characterized over a wide range, from 10 to 500 K. Finite element analysis is employed to guide the design of the SAW resonator from indications of the Rayleigh mode and weak propagation direction dependence of SAW in the c-plane of GaN/Si. The SAW resonator with 100 pairs of interdigital transducers(IDT), 100 pairs of grating reflectors(GR) for each side, aperture size of 80 μm, metallization ratio of 0.5, and electrode width of 500 nm resonates at 1.9133 GHz accordingly with an ultrahigh Q-factor of 7622 at room temperature, which contributes the fr× Qr, up to 14.583×1012Hz. A resonator operating over 10 to 500 K indicates an approximately linear decreasing temperature dependence above 280 K while being approximately constant below 40 K. The fitting to resonator characteristics using the modified Butterworth Van Dyke(m BVD) model reveals a reduction in both the electrode and mechanical losses while worsening the dielectric loss with cooling down.

关键词： GaN/Si SAW resonator ultrahigh Q-factor temperature-dependent performance mBVD losses

Enhanced Cooling Efficiency of Urban Trees on Hotter Summer Days in 70 Cities of China

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Advances in Atmospheric Sciences 2024年第11期41卷 2259-2275页

作者： Limei YANG jun GE Yipeng CAO yu LIU Xing LUO Shiyao wang Weidong GUO School of Atmospheric Sciences Nanjing UniversityNanjing 210023China Joint International Research Laboratory of Atmospheric and Earth System Sciences Nanjing UniversityNanjing 210023China Frontiers Science Center for Critical Earth Material Cycling Nanjing UniversityNanjing 210023China

Increasing the urban tree cover percentage(TCP) is widely recognized as an efficient way to mitigate the urban heat island effect. The cooling efficiency of urban trees can be either enhanced or attenuated on hotter days, depending on the physiological response of urban trees to rising ambient temperature. However, the response of urban trees' cooling efficiency to rising urban temperature remains poorly quantified for China's cities. In this study, we quantify the response of urban trees' cooling efficiency to rising urban temperature at noontime [~1330 LT(local time), LT=UTC+8] in 17summers(june, July, and August) from 2003–19 in 70 economically developed cities of China based on satellite observations. The results show that urban trees have stronger cooling efficiency with increasing temperature, suggesting additional cooling benefits provided by urban trees on hotter days. The enhanced cooling efficiency values of urban trees range from 0.002 to 0.055℃ %-1 per 1℃ increase in temperature across the selected cities, with larger values for the lowTCP-level cities. The response is also regulated by background temperature and precipitation, as the additional cooling benefit tends to be larger in warmer and wetter cities at the same TCP level. The positive response of urban trees' cooling efficiency to rising urban temperature is explained mainly by the stronger evapotranspiration of urban trees on hotter *** results have important implications for alleviating urban heat risk by utilizing urban trees, particularly considering that extreme hot days are becoming more frequent in cities under global warming.

关键词： urban trees cooling efficiency China's cities evapotranspiration summer hot days

Incremental Data Stream Classification with Adaptive Multi-Task Multi-View Learning

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Big Data Mining and Analytics 2024年第1期7卷 87-106页

作者： jun wang Maiwang Shi Xiao Zhang Yan Li yunsheng yuan Chengei Yang Dongxiao yu School of Computer Science and Technology Shandong UniversityQingdao 266237China School of Software Shandong UniversityJinan 250101China

With the enhancement of data collection capabilities,massive streaming data have been accumulated in numerous application ***,the issue of classifying data streams based on mobile sensors can be formalized as a multi-task multi-view learning problem with a specific task comprising multiple views with shared features collected from multiple *** incremental learning methods are often single-task single-view,which cannot learn shared representations between relevant tasks and *** adaptive multi-task multi-view incremental learning framework for data stream classification called MTMVIS is proposed to address the above challenges,utilizing the idea of multi-task multi-view ***,the attention mechanism is first used to align different sensor data of different *** addition,MTMVIS uses adaptive Fisher regularization from the perspective of multi-task multi-view learning to overcome catastrophic forgetting in incremental *** reveal that the proposed framework outperforms state-of-the-art methods based on the experiments on two different datasets with other baselines.

关键词： data stream classification mobile sensors multi-task multi-view learning incremental learning

A Novel Porcine Model of Septic Shock Induced by Acute Respiratory Distress Syndrome due to Methicillin-resistant Staphylococcus aureus

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Chinese Medical Journal 2017年第10期130卷 1226-1235页

作者： Shuo wang jun-yu wang Tao wang Chen-Chen Hang Rui Shao Chun-Sheng Li Department of Emergency Medicine Beijing Chao-Yang Hospital Capital Medical University Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation Beijing 100020 China

Background： Sepsis is one of the main canses of mortality in critically ill patients following progression to septic shock. To investigate the pathophysiologic changes of sepsis, we developed a novel porcine model of septic shock induced by acute respiratory distress syndrome （ARDS） due to methicillin-resistant Staphylococcus aureus （MRSA） pneumonia. Methods： Twenty-six male Landraces （Lvyuanweiye, Beijing, China） weighing 30 - 2 kg were divided into lbur groups： sham gronp （SH： n = 5）; cotton smoke inhalation group （SM; n = 6）; MRSA pneumonia group （MR; n = 6）; and septic shock group with cotton smoke inhalation ＋ MRSA pneumonia （SS; n = 9）. Extensive hemodynamics, oxygen dynamics, and lung function were monitored for 24 11 following the injury or until death. Tissues were collected, and histopathology evaluations were carried out. Results： Blood cultures from 6 of 9 animals in the SS group were positive for MRSA. Two hours following the injury, decreased mean arterial blood pressure （60 70 mmHg） and cardiac index （〈2 L-rain -＇m --） were observed in the animals in the SS group, while systemic vascular resistance index was increased. The hemodynamic characteristics of septic shock were only observed in the SS group but not significant in the other groups, The PO_JFiO2 in the SM and SS groups decreased to 300 and 100, respectively. In the SS group, extravascular lung water index increased to 20 ml/kg, whereas thoracopulmonary compliance decreased to 10 ml/H2O after injury. Deterioration of pulmonary function in the SS group was more serious than the SM and MR groups. Severe lung injury in the SS group was confinaaed by the histopathology evaluations. The lung injury confirmed by high-resolution thin-section computed tomography and histopathology in the SS group was more serious than those of other groups. Conclusions： In the present study, we developed a novel porcine model of septic shock induced by ARDS due to severe MRSA pneumonia with characteristic hyperdynamic

关键词： Acute Respiratory Distress Syndrome: Hemodynamic Methicillin-resistant Staphylococcus aureus: Oxygen Dynamic:Septic Shock

Annihilator Ideals of Indecomposable Modules of Finite-Dimensional Pointed Hopf Algebras of Rank One

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Algebra Colloquium 2024年第1期31卷 149-164页

作者： yu wang School of Mathematics and Physics Jiangsu University of Technology ChangzhouJiangsu 213001China

Let H be a finite-dimensional pointed Hopf algebra of rank one over an algebraically closed feld of characteristic *** describe all annihilator ideals of indecomposable H-modules by *** particular,we give the classification of all ideals of the finite-dimensional pointed rank one Hopf algebra of nilpotent type over the Klein 4-group.

关键词： indecomposable module annihilator ideal primitive central orthogonal idem-potent element

Electronic structure regulation and built-in electric field synergistically strengthen photocatalytic nitrogen fixation performance on Ti-BiOBr/TiO_(2)heterostructure

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Rare Metals 2024年第3期43卷 1125-1138页

作者： Ru-Qi Li yu-Jie Bian Chun-Ming Yang Li Guo Tao-Xia Ma Chuan-Tao wang Feng Fu Dan-jun wang College of Chemistry and Chemical Engineering Yan’an UniversityYan’an Key Laboratory of Green Catalysis and Quality Improvement and Utilization of Low Rank CoalYan’an716000China

At present,industrial synthetic ammonia was still obtained through the Hubble-Bosch process,with large energy *** is a research hotspot to realize green synthetic ammonia by using solar *** difficulty of photocatalytic ammonia synthesis was that the photo-excited electrons have not enough energy to active N≡*** this study,Ti was doped into BiOBr by one-step hydrothermal method,which was oxidized into TiO_(2)when the doping amount reaches the maximum,in situ forming Ti_(0.31)B_(0.69)OB/TiO_(2)*** from the synergistic effect of Ti doping and S-scheme heterojunction,the synthetic ammonia efficiency of Ti_(0.31)B_(0.69)OB/TiO_(2)-11.96 reached 1.643 mmol·g_(cat)^(-1)at mild conditions and without hole scavenger for up to 7 h,the efficiency of synthetic ammonia is 115 times,10.5 times and 3.3 times of that of BiOBr,Ti_(0.31)B_(0.69)OB and TiO_(2),***,DFT calculation confirms that Ti doping accurately refine the electronic structure of BiOBr,facilitate nitrogen adsorption activation and reduce hydrogenation reaction energy barrier,thus accelerating the reaction kinetics of photocatalytic nitrogen reduction(NRR),Meanwhile,constructing S-scheme heterojunction boosts the separation and transfer of photogenerated electron-hole pairs,improving the reduction ability of electrons in the conduction band of TiO_(2)and the oxidation ability of holes in the valence band of Ti_(0.31)B_(0.69)OB.

关键词： S-scheme heterostructure Electronic structure regulation Built-in electric field Synergistical stren4gthening Photocatalytic nitrogen fixation