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A Global Minimization Algorithm for Empirical Contact Potential Functions

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Chemical Research in Chinese Universities 2006年第2期22卷 248-250页

作者： wang yu-hong LI Wei Department of Molecular Biology College of Life Sciences Jilin University Changchun 130021 P. R. China

Global minimization algorithm is indispensable for solving protein folding problems based on thermodynamic hypothesis. A contact difference （CD） based on pseudo potential function, for simulating empirical contact potential functions and testing global minimization algorithm was proposed. The present article describes a conformational sampiing and global minimization algorithm, which is called WL, based on Monte Carlo simulation and simulated annealing. It can be used to locate CD＇s globe minimum and refold extended protein structures, as small as 0. 03 nm, from the native structures, back to ones with root mean square distance（RMSD）. These results demonstrate that the global minimization problems for empirical contact potential functions may be solvable.

关键词： Global minimization Contact potential function Simulated annealing Monte Carlo simulation

On the A-Dependence of the Okamoto-Nolen-Schiffer Anomaly

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Chinese Physics Letters 1996年第5期13卷 343-346页

作者： SHEN hong NING Ping-zhi CAI Chong-hai wang hong-yu Department of Physics Nankai UniversityTianjin 300071

A new version of the in-medium quark condensate is applied to study the Okamoto Nolen-Schiffer anomaly-The results show that the theoretical mass difference of mirror nuclei due to the neutron-proton mass diffei-ence ... 详细信息

关键词： Schiff mirror quark

Bioinformatics Assisted Gene Discovery and Annotation of Human Genome

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Chemical Research in Chinese Universities 2002年第4期18卷 491-494页

作者： wang Wei wang yu-hong Li Wei Biological Macromolecular Laboratory College of Life ScienceJilin UniversityChangchun 130023P.R.China

As the sequencing stage of human genome project is near the end, the work has begun for discovering novel genes from genome sequences and annotating their biological functions. Here are reviewed current major bioinformatics tools and technologies available for large scale gene discovery and annotation from human genome sequences. Some ideas about possible future development are also provided.

关键词： Bioinformatics Genomics Proteomics Database Annotation HGP

A Modified Projection Method for Linear Feasibility Problems

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International Journal of Automation and computing 2009年第4期6卷 401-405页

作者： Yi-Ju wang hong-yu Zhang School of Operations Research and Management Science Qufu Normal University Rizhao 276800 PRC

In this paper, we present a modified projection method for the linear feasibility problems （LFP）. Compared with the existing methods, the new method adopts a surrogate technique to obtain new iteration instead of the line search procedure with fixed stepsize. For the new method, we first show its global convergence under the condition that the solution set is nonempty, and then establish its linear convergence rate. Preliminary numerical experiments show that this method has good performance.

关键词： Linear feasibility problem (LFP) projection method global convergence convergence rate computational experiments

Assessment for Production and Operation Ability of Medium and Small-sized Enterprises Based on Neural Network

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Journal of China University of Mining and Technology 2006年第3期16卷 376-380页

作者： wang yu-hong XU Jun wang Guan ZENG Qi School of Remote Sensing Information Engineering Wuhan University Wuhan Hubei 430079 China School of Economy ＆ Management Henan Polytechnic University Jiaozuo Henan 454000 China School of Traffic and Transportation Southwest Jiaotong University Chengdu Sichuan 610031 China

In order to improve production and operation ability of medium and small-sized enterprises, an assessment-index system of production and operation ability was proposed, and a corresponding assessment model was established based on BP neural network. The conjunction weights of the neural network were continuously modified from output layer to input layer in the process of neural network training to reduce the errors between the anticipated and actual outputs. The results from an example show that this method is reliable and feasible. The production and operation abilitv of an enterorise with assessed result of 0.833 is fairly oowerful, and that with assessed result of 0.644 is average.

关键词： medium and small-sized enterprises production and operation ability BP neural network assessment

Simulation Study and Probe on UWB Wireless Communication in Underground Coal Mine

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Journal of China University of Mining and Technology 2006年第3期16卷 296-300页

作者： wang Yan-fen wang Zheng-gang yu hong-zhen School of lnformation and Electrical Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

From an analysis of the status of coal mine underground wireless communication, the application of UWB wireless communication system to underground coal mine is proposed. The basic composition of an UWB communication system and application in underground coal mines are introduced. The analyses show that, because of the transmission power being non-limitted in underground coal mines, the use of UWB in coal mines cannot only realize wireless access services of short distance high rate application for transmission of video monitoring signals, but also realize wireless access services of long distance low rate applications for mobile telephones in underground coal mines and parameters of working conditions monitoring, etc. It is emphasized on the simulation of a TH-PPM UWB communication system with traditional underground broadband model and ground CM1, CM3 model. It is shown that the traditional underground broadband model and ground CM1, CM3 models are not applicable to the UWB communication system in underground coal mines. It is necessary to conduct research on the propagation characteristics of UWB in coal mine tunnels, given the characteristics of the underground environment and to find the appropriate UWB model for underground coal mines.

关键词： ultra-wide band system simulation underground coal mine channel model characteristic of propagation.

A Generic and Dynamic Framework for Web Publishing of Bioinformatics Databases

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Chemical Research in Chinese Universities 2003年第1期19卷 44-48页

作者： SHI yu hua wang yu hong LI Tian yu LI Wei College of Life Science Jilin UniversityChangchun 130023P.R.China

The present paper covers a generic and dynamic framework for the web publishing of bioinformatics databases based upon a meta data design, Java Bean, Java Server Page(JSP), Extensible Markup Language(XML), Extensible Stylesheet Language(XSL) and Extensible Stylesheet Language Transformation(XSLT). In this framework, the content is stored in a configurable and structured XML format, dynamically generated from an Oracle Relational Database Management System(RDBMS). The presentation is dynamically generated by transforming the XML document into HTML through *** clean separation between content and presentation makes the web publishing more flexible; changing the presentation only needs a modification of the Extensive Stylesheet(XS).

关键词： Java Server Pages XML XSL Oracle Java Bioinformatics

Binding Mode of Insulin Receptor and Agonist Peptide

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Chemical Research in Chinese Universities 2006年第2期22卷 242-244页

作者： wang Song wang Li-ping SHAN Ya-ming wang yu-hong LI Wei SUN Chia-chung College of Life Science Jilin University Changchun 130012 P. R. China State Key Laboratory of Theoretical and Computational Chemistry Institute of Theoretical Chemistry Jilin University Changchun 130021 P. R. China

Insulin is a protein hormone secreted by pancreatic β cells. One of its main functions is to keep the balance of glucose inside the body by regulating the absorption and metabolism of glucose in the periphery tissue, as well as the production and storage of hepatic glycogen. The insulin receptor is a transmembrane glycoprotein in which two a subunits with a molecular weight of 135 kD and two,8 subunits with a molecular weight of 95 kD are joined by a disulfide bond to form a β-α-α-β structure. The extracellular a subunit, especially, its three domains near the N-terminal are partially responsible for signal transduction or ligand-binding, as indicated by the experiments. The extracellular α subunits are involved in binding the ligands. The experimental results indicate that the three domains of the N-terminal of the a subunits are the main determinative parts of the insulin receptor to bind the insulin or mimetic peptide. We employed the extracellular domain（ PDBID： 1IGR） of the insulin-like growth factor-1 receptor （IGF-1R） as the template to simulate and optimize the spatial structures of the three domains in the extracellular domain of the insulin receptor, which includes 468 residues. The work was accomplished by making use of the homology program in the Insight Ⅱ package on an Origin3800 server. The docking calculations of the insulin receptor obtained by homology with hexapeptides were carried out by means of the program Affinity. The analysis indicated that there were hydrogen bonding, and electrostatic and hydrophobic effects in the docking complex of the insulin receptor with hexapeptides. Moreover, we described the spatial orientation of a mimetic peptide with agonist activity in the docking complex. We obtained a rough model of binding of DLAPSQ or STIVYS with the insulin receptor, which provides the powerful theoretical support for designing the minimal insulin mimetic peptide with agonist activity, making it possible to develop oral small molecular hypo

关键词： Insulin Insulin receptor Mimetic peptide Homology Docking

Preparation of Anhydrous LnCl_3(Ln=Eu, Er, Lu) by Chemical Vapor Transport

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Journal of Rare Earths 2000年第2期18卷 152-154页

作者： wang Lin shan, LI Ying, wang yu hong (Department of Chemistry, Northeastern University, Shenyang 110006, China) Northeastern Univ Dept Chem Shenyang 110006 Peoples R China

Anhydrous lanthanide chlorides LnCl 3(Ln=Eu, Er, Lu) which are not easy to prepare in other ways were prepared by chemical vapor transport(CVT) method. Ln 2O 3 reacted with an excess of Al 2Cl 6 at 300 ℃ to produce LnCl 3. LnCl 3 reacted with Al 2Cl 6 at high temperature to form the gaseous complexes which decomposed at low temperature. LnCl 3 was then separated from other solids by controlling a proper temperature gradient. Residual Al 2Cl 6(g) was removed by the carrier of dry Cl 2 N 2 gases at 200 ℃. The yield rates are >90%, and the purity of products is >99 5%. The high purity of anhydrous lanthanide chlorides can be obtained by CVT method.

关键词： rare earths preparation chemical vapor transport