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Preparation and Evaluation of MPEG-PCL Polymeric Nanoparticles Against Gastric Cancer

Journal of Wuhan University of Technology(Materials Science) 2020年第6期35卷 1162-1168页

作者： LIU Xia LI Juncan HUANG Long YANG Jin wang yaowen YANG Mengjia TANG Mingxiu QIU Tong School of Chemistry Chemical Engineering and Life SciencesWuhan University of technologyWuhan 430070China China Tobacco Hubei Industrial Co. LtdWuhan 430000China College of Chemical and Environmental Engineering Hubei University for NationalitiesEnshi 445000China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Biomedical Materials and Engineering Research Center of Hubei Province Wuhan University of TechnologyWuhan 430070China

This paper provides a new treatment for gastric cancer with a new OMT delivery *** synthesized MPEG-PCL,an amphiphilic polymer,to construct a nanoparticle encapsulated OMT by pH gradient method,and then examined the nanodrug’s therapeutic *** integral analytical method was used to characterize the structure of *** single factor method and orthogonal test were utilized to investigate the optimum preparation *** morphology and average size of the OMT-NPs were analyzed by transmission electron microscopy and ***-8 assay and confocal fluorescent microscope were used to study the inhibitory effect on SGC-7901 gastric cancer *** average size of nanoparticles was 95.86±1.54 *** maximum encapsulation efficiency of OMT was 46.84±4.37%,while the drug loading content was 8.89±1.09%.The cumulative release of nanoparticles was 73.07±1.5%,inspected through dynamic dialysis in *** with free OMT,OMT-NPs showed enhanced cytotoxic effects in SGC-7901 *** nanoparticles could efficiently deliver the OMT into the cancer cells and release *** OMT delivery system prepared in this paper provides a potential platform for the treatment of gastric cancer..

关键词： MPEG-PCL nanoparticles oxymatrine gastric cancer

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Is it cost-effective to treat sudden sensorineural hearing loss patients repetitively?

Is it cost-effective to treat sudden sensorineural hearing l...

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2016年浙江省医学会耳鼻咽喉头颈外科学学术年会

作者： wang yaowen Zhang Litao Tang Shixiong ningbo first hospital

Aim:To investigate if the retreatment of sudden sensorineural hearing loss(SSNHL)is cost-effective Methods:54 hospitalized patients with SSNHL were retrospectively *** undertook 2 or 3 courses of treatments at an interval about 2 *** information was collected,pure-tone tests were taken before and after each course of treatment,average pure thresholds(PTA)and effective rates were *** 15.0 was used to ***:54 patients undertook two courses of *** PTAs were 93.91±20.39dB(before the first course),77.08±23.25dB(after the first course),71.90±17.53dB(before the second course)and 68.84±17.70dB(after the second course).The effective rates were 16.67%(after the first course),3 1.48%(before the second course),and 42.59%(after the second course).9 of 54 patients undertook three courses of *** effective rates were44.44%(after the first course),66.67%(before the second course),77.78%(after the second course),and 88.89%(before and after the third course).Conclusion:A second course of treatment to SSNHL was not cost-effective,but we could give the patient a second course of treatment according to the patient’s will and economic *** was no need for the third course of treatment.

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Removal of fibrolipoma in orbit and ethmoid sinus by transnasal endoscopic surgery

Removal of fibrolipoma in orbit and ethmoid sinus by transna...

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2016年浙江省医学会耳鼻咽喉头颈外科学学术年会

作者： wang yaowen zhang litao zhang weimin chen xing ningbo first hospital

Background:Fibrolipoma is a kind of variant *** it is rare in orbital and ethmoid *** common surgical approach of orbital lipomas and their variants is *** aim of this study was to report a rare case of fibrolipoma in orbital and ehmoid sinus,which was removed by by transnasal endoscopic *** presentation:A young male presented with consistent pain of his right eye,exophthalmos,and difficulty to see things near *** patient’s right eye was swollen and eyeball was protruded,conjunctiva was congested,the inward movement of right eyeball was limited,intraocular pressure in the right was much higher than the left,but light reflex and eyesight was *** computer tomography showed cystic mass in orbital and *** endoscopic surgery was carried out under general anesthesia to remove the *** diagnosis was *** recurrence was seen in two ***:To remove orbital fibrolipoma,especially when the lipoma on medial side of medial rectus,transnasal endoscope surgery is a good choice.

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Application of noninvasive mechanical ventilation on acute respiratory failure after kidney transplantation

Application of noninvasive mechanical ventilation on acute r...

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2012中国器官移植大会

作者： Jinguo wang,Na wang,yaowen Fu Urology Center,The First Hospital of Jilin University

【Objectives】Acute respiratory failure is a common and severe complication after renal transplantation,which positively relate to the long term survival of recipients and renal ***,we evaluate the clinical value and influence factors of noninvasive mechanical ventilation(NIV) in the patients with acute respiratory failure(ARF) after renal transplantation.【Methods】According to the symptoms and signs which combined with the【Results】of examination,6 patients with pneumonia(4/6) or acute left heart failure(2/6) after renal transplantation were

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Mental disorders of the patients after renal transplantation

Mental disorders of the patients after renal transplantation

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2012中国器官移植大会

作者： Jinguo wang,Na wang,yaowen Fu Urology Center,The First Hospital of Jilin University

【Objectives】To improve recognition for prevention and treatment of mental disorders in patients after kidney transplantation.【Methods】339 cases received kidney transplantation from 2007 to 2011 inour *** of the recipients were administrated with 3 dose of methylprednisolone intravenous injection(day 0,day 1 and day 2;500mg/day).All the patients received triple immunosuppression therapy,including calcineurin inhibitor(CNI),mycophenolate mofetil(MMF) and prednisone (Pred).31 cases of them developed mental disorders after kidney *** clinical data of glucose,cholesterol and

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血管源性搏动性耳鸣的研究进展

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中华耳科学杂志 2022年第4期20卷 631-635页

作者：吕莎王耀文宁波市第一医院耳鼻咽喉头颈外科宁波315000 宁波大学宁波315000

血管源性搏动性耳鸣(Pulsatile tinnitus,PT)的病理生理与头颈部血流动力学改变有关。乙状窦病变、岩骨段颈内动脉病变、颅内硬脑膜动静脉瘘等不同血管解剖改变所致的PT其耳鸣特点不同,并且伴随症状亦不同。这使我们在诊治疾病时有迹可... 详细信息

血管源性搏动性耳鸣(Pulsatile tinnitus,PT)的病理生理与头颈部血流动力学改变有关。乙状窦病变、岩骨段颈内动脉病变、颅内硬脑膜动静脉瘘等不同血管解剖改变所致的PT其耳鸣特点不同,并且伴随症状亦不同。这使我们在诊治疾病时有迹可循,并通过影像学检查明确病变的血管。找到结构异常血管后,通过手术纠正血管解剖异常,可使PT缓解,甚至消失。

关键词：搏动性耳鸣血管结构异常病因诊疗策略疗效

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改进的语义分割模型及其应用

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计算机工程与应用 2024年第2期60卷 337-343页

作者：王耀文程军圣杨宇湖南大学机械与运载工程学院长沙410082

训练语义分割网络模型需要较为繁琐的人工标注作为训练标签,同时语义分割模型在构建和运行过程中也存在超参数较难确定以及模型过于庞大等问题。为解决这类问题,提出了一种基于标注框生成热点图的标签生成方法,简化了语义分割训练标签... 详细信息

训练语义分割网络模型需要较为繁琐的人工标注作为训练标签,同时语义分割模型在构建和运行过程中也存在超参数较难确定以及模型过于庞大等问题。为解决这类问题,提出了一种基于标注框生成热点图的标签生成方法,简化了语义分割训练标签的人工标注过程。以及在可微分神经网络结构搜索方法的基础上提出了一种对硬件要求更低的神经网络结构搜索方法,并基于此种方法改进了特征金字塔结构,构建了一个改进的语义分割模型,并在安全帽与口罩检测数据集上进行了试验。与U-Net、FPN等模型比较,新的模型在参数量、计算速度以及精确度上都更有优势。

关键词：语义分割模型神经网络结构搜索特征金字塔结构安全帽与口罩检测

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wholly otoendoscopical removal of a petrous apex cholesteatoma through supralabyrinthine approach

wholly otoendoscopical removal of a petrous apex cholesteato...

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2019年浙江省医学会耳鼻咽喉头颈外科学学术大会

作者： yaowen wang Qiuhang Zhang Shixiong Tang Weimin Zhang Xudong Chen Peng Cheng Cihao Hu Ningbo first hospital Xuanwu hospital Capital medical university

Objective:To evaluate the feasiblity of wholly otoendoscopic removal of petrous apex cholesteatoma through supralabyrinthine ***:The patient was placed on the supine position,the intubation was under general *** disinfecion and the placement of towel,incision of posterior auricle sulcus was made. the otoendoscope was *** ethmoid region of mastoid and posterior superior spine of external auditory canal,drills were used to remove the lateral wall of the matoid cavity and superior tympanic *** the triangle area above horizontal part of facial nerve,anterior to the superior semicircular canal,under the dura of the middle cranial fossa and posterior to the geniculate ganglion,removed the bone of this area,then we can find the cholesteatome was deeply inside,it adhered to the dura and spreaded to the internal auditory *** was used to remove the cholesteatoma *** surgical cavity was irrigated with levofloxacin and packed with ***:The petrous apex cholesteatoma was removed thouroughly throuth the superlabyrinthine *** there no damage to the patient’ s hearing and facial nerve function,the bleeding was ***:wholly otoendoscopic removal of cholesteatoma through supralabyrinthine approach is an effective and safe way to cure the petrous apex cholesteatoma.

关键词： cholesteatoma petrous apex otoendoscope supralabyrinthine approach

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等离子弧焊接穿孔行为的声信号传感

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机械工程学报 2001年第1期37卷 53-56页

作者：王耀文陈强孙振国孙久文王海燕清华大学机械工程系北京100084

使用高精度传声器采集穿孔型等离子弧焊接过程中的声音信号 ,围绕焊接过程中出现的“小孔效应” ,开展了等离子弧焊接熔透的声音信号传感方法的研究。结果表明 ,焊接过程中的声音信号在熔池的过渡阶段产生了剧烈的低频振动 ,与熔池的振... 详细信息

使用高精度传声器采集穿孔型等离子弧焊接过程中的声音信号 ,围绕焊接过程中出现的“小孔效应” ,开展了等离子弧焊接熔透的声音信号传感方法的研究。结果表明 ,焊接过程中的声音信号在熔池的过渡阶段产生了剧烈的低频振动 ,与熔池的振动有关 ,说明声音信号的低频段分量中包含有熔池穿孔状态的信息。频域分析表明 ,声音信号的低频段分量 (0～ 10 0Hz) ,在熔池处于不同阶段时有明显的变化 ,熔池处于过渡阶段时其值大 ,穿孔后小 ,未穿孔时居中。据此 ,设计出了声音信号的A算法 ,用于识别焊接过程中熔池的穿孔状态 ,该算法可靠性较高。

关键词：等离子弧焊声音信号传感小孔效应

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专题文献著者群评价——一种“标准化”方法的探讨

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图书情报工作 2007年第4期51卷 97-99页

作者：王耀文刘永胜太原科技大学经济管理学院太原030024 太原理工大学图书馆太原030024

指出在人文社会科学研究领域,对学术文献著者学术成就的评价多以发文的数量为主,而对文献的质量评价没有一定标准,提出考察文献著者群的数量指标和质量指标相结合的评价体系,论述被引量作为质量指标的特殊作用,介绍“标准化”计量方法... 详细信息

指出在人文社会科学研究领域,对学术文献著者学术成就的评价多以发文的数量为主,而对文献的质量评价没有一定标准,提出考察文献著者群的数量指标和质量指标相结合的评价体系,论述被引量作为质量指标的特殊作用,介绍“标准化”计量方法的含义和计算过程,并以“数字图书馆”专题文献为例,对103位核心著者进行评价排序,筛选出15位最有影响力的著者。

关键词：专题文献著者群 “标准化”方法

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