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Protein & Cell 2024年第6期15卷 403-418页

作者： Song xue Yuru Han Fan Wu Qiao wang Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS) Shanghai Institute of Infectious Disease and BiosecurityShanghai Frontiers Science Center of Pathogenic Microorganisms and InfectionSchool of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China

Intensive selection pressure constrains the evolutionary trajectory of SARS-CoV-2 genomes and results in various novel variants with distinct mutation *** mutations,particularly those within the receptor binding domain(RBD)of SARS-CoV-2 spike(S)protein,lead to the functional alteration in both receptor engagement and monoclonal antibody(mAb)***,we review the data of the RBD point mutations possessed by major SARS-CoV-2 variants and discuss their individual effects on ACE2 affinity and immune *** single amino acid substitutions within RBD epitopes crucial for the antibody evasion capacity may conversely weaken ACE2 binding ***,this weakened effect could be largely compensated by specific epistatic mutations,such as N501Y,thus maintaining the overall ACE2 affinity for the spike protein of all major *** predominant direction of SARS-CoV-2 evolution lies neither in promoting ACE2 affinity nor evading mAb neutralization but in maintaining a delicate balance between these two ***,this review interprets how RBD mutations efficiently resist antibody neutralization and meanwhile how the affinity between ACE2 and spike protein is maintained,emphasizing the significance of comprehensive assessment of spike mutations.

关键词： ACE2 affinity maintained

A stable implicit nodal integration-based particle finite element method(N-PFEM)for modelling saturated soil dynamics

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2172-2183页

作者： Liang wang xue Zhang Jingjing Meng Qinghua Lei Department of Earth Sciences ETH ZürichZürich8092Switzerland Department of Civil Engineering and Industrial Design University of LiverpoolLiverpoolL693BXUK Department of Civil Environmental and Natural Resources EngineeringLuleåUniversity of TechnologyLuleå97187Sweden Department of Earth Sciences Uppsala UniversityUppsala75105Sweden

In this study,we present a novel nodal integration-based particle finite element method(N-PFEM)designed for the dynamic analysis of saturated *** approach incorporates the nodal integration technique into a generalised Hellinger-Reissner(HR)variational principle,creating an implicit PFEM *** mitigate the volumetric locking issue in low-order elements,we employ a node-based strain smoothing *** discretising field variables at the centre of smoothing cells,we achieve nodal integration over cells,eliminating the need for sophisticated mapping operations after re-meshing in the *** express the discretised governing equations as a min-max optimisation problem,which is further reformulated as a standard second-order cone programming(SOCP)***,pore water pressure,and displacements are simultaneously determined using the advanced primal-dual interior point ***,our numerical model offers improved accuracy for stresses and pore water pressure compared to the displacement-based PFEM *** experiments demonstrate that the N-PFEM efficiently captures both transient and long-term hydro-mechanical behaviour of saturated soils with high accuracy,obviating the need for stabilisation or regularisation techniques commonly employed in other nodal integration-based PFEM *** work holds significant implications for the development of robust and accurate numerical tools for studying saturated soil dynamics.

关键词： Particle finite element method Nodal integration Dynamic saturated media Second-order cone programming(SOCP)

Two Stages Segmentation Algorithm of Breast Tumor in DCE-MRI Based on Multi-Scale Feature and Boundary Attention Mechanism

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Computers, Materials & Continua 2024年第7期80卷 1543-1561页

作者： Bing Li Liangyu wang Xia Liu Hongbin Fan Bo wang Shoudi tong School of Automation Harbin University of Science and TechnologyHarbin150080China Heilongjiang Provincial Key Laboratory of Complex Intelligent System and Integration Harbin150080China School of Computer Engineering Technology Guangdong Institute of Science and TechnologyZhuhai519090China

Nuclearmagnetic resonance imaging of breasts often presents complex *** tumors exhibit varying sizes,uneven intensity,and indistinct *** characteristics can lead to challenges such as low accuracy and incorrect segmentation during tumor ***,we propose a two-stage breast tumor segmentation method leveraging multi-scale features and boundary attention ***,the breast region of interest is extracted to isolate the breast area from surrounding tissues and ***,we devise a fusion network incorporatingmulti-scale features and boundary attentionmechanisms for breast tumor *** incorporate multi-scale parallel dilated convolution modules into the network,enhancing its capability to segment tumors of various sizes through multi-scale convolution and novel fusion ***,attention and boundary detection modules are included to augment the network’s capacity to locate tumors by capturing nonlocal dependencies in both spatial and channel ***,a hybrid loss function with boundary weight is employed to address sample class imbalance issues and enhance the network’s boundary maintenance capability through additional *** was evaluated using breast data from 207 patients at RuijinHospital,resulting in a 6.64%increase in Dice similarity coefficient compared to the *** results demonstrate the superiority of the method over other segmentation techniques,with fewer model parameters.

关键词： Dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) breast tumor segmentation multi-scale dilated convolution boundary attention the hybrid loss function with boundary weight

A study on the impact of heritage protection on urban carbon emissions

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Science China(Technological Sciences) 2024年第9期67卷 2675-2692页

作者： wang Fang xue PengCheng wang ShunYi LIU YunHuai River Basin Habitats Research Center College of Architecture and Landscape ArchitecturePeking UniversityBeijing 100871China Shanxi Key Laboratory of Watershed Built Environment with Locality(Peking University) Peking UniversityBeijing 100871China College of Urban and Environmental Sciences Peking UniversityBeijing 100871China School of Computer Science Peking UniversityBeijing 100871China

A major goal of current international urban development and construction is to lower carbon *** exist between the preservation of historic cities and the development of low-carbon cities;however,the relationship between preservation of historic cities and carbon emissions remains *** study focuses on the cities in the“Yellow-Canal-Yangtze”watershed community,which includes the Yellow River Basin,Yangtze River Basin,and the Grand Canal region,and aims to verify the differences in CO_(2) emissions(CE)between historic and non-historic cities through multiple comparisons after ***,Ridge Regression was used to determine the impact and dimensions of the relevant variables associated with the preservation of historic cities on *** with national development goals,this study predicts changes in the CE of historic city preservation under different *** study found significant differences between historic and non-historic cities,as the total CE of historic cities is 2.42 times higher than that of non-historic *** dimension with the largest difference was the CE related to transportation,with aviation emissions of historic cities reaching 15.22 times higher than that of non-historic *** the preservation of historic cities has led to an overall increase in the CE,there is significant potential for CE reduction in land use,transportation infrastructure,and tourism development related to historic city *** the future,historic cities can contribute to China's carbon neutrality and the United Nation's development goals through the creation of larger historical preservation areas,more convenient public transportation,and more vibrant tourism.

关键词： CO_(2) emissions urban planning cultural heritage historic city “Yellow-Canal-Yangtze”watershed community

Multi-scale detector optimized for small target

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Optoelectronics Letters 2024年第4期20卷 243-248页

作者： ZHU Yongchang YANG Sen tong Jigang wang Zenghui School of Electrical Engineering and Automation Tianjin University of TechnologyTianjin 300384China Center of Artificial Intelligence and Data Science University of South AfricaFlorida 1709South Africa Department of Electrical Engineering University of South AfricaFlorida 1709South Africa

The effectiveness of deep learning networks in detecting small objects is limited,thereby posing challenges in addressing practical object detection *** this research,we propose a small object detection model that operates at multiple *** model incorporates a multi-level bidirectional pyramid structure,which integrates deep and shallow networks to simultaneously preserve intricate local details and augment global ***,a dedicated multi-scale detection head is integrated into the model,specifically designed to capture crucial information pertaining to small *** comprehensive experimentation,we have achieved promising results,wherein our proposed model exhibits a mean average precision(mAP)that surpasses that of the well-established you only look once version 7(YOLOv7)model by 1.1%.These findings validate the improved performance of our model in both conventional and small object detection scenarios.

关键词： networks details thereby

Recent advances in Ir/Ru-based perovskite electrocatalysts for oxygen evolution reaction

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Rare Metals 2024年第7期43卷 2891-2912页

作者： Zhi-Qi Jiang Cheng-Zhen Fan Jun-Yu Pan Li Shao Hao Chen Erum Pervaiz Yan Dong tong-Zhou wang xue-Rong Zheng Ji-Hong Li Yi-Da Deng School of Materials Science and Engineering Hainan UniversityHaikou570228Chin Department of Chemical Engineering School of Chemical and Materials Engineering(SCME)National University of Sciences&Technology(NUST)Islamabad 44000Pakistan Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071Chin

Oxygen evolution reaction(OER)is a kinetically harsh four-electron anode reaction that requires a large overpotential to provide current and is of great importance in renewable electrochemical ***/Rubased perovskite oxides hold great significance for application as OER electrocatalysts,due to that their multimetal-oxide forms can reduce the use of noble metals,and their compositional tunability can modulate the electronic structure and optimize OER ***,high operating potentials and corrosive environments pose a serious challenge to the development of durable Ir-based and Ru-based perovskite *** efforts have been dedicated to improving the Ir/Ru-based perovskite activity to enhance the efficiency;however,progress in improving the durability of Ir/Ru-based perovskite electrocatalysts has been rather *** this review,the recent research progress of Ir/Ru-based perovskites is reviewed from the perspective of heteroatom doping,structural modulation,and formation of *** dissolution mechanism studies of Ir/Ru and experimental attempts to improve the durability of Ir/Ru-based perovskite electrocatalysts are *** and outlooks for further developing Ru-and Irbased perovskite oxygen electrocatalysts are also presented.

关键词： Oxygen evolution reaction Ir/Ru-based perovskites Stability Electrocatalysts

Dynamic Location Method for Shallow Ocean Bottom Nodes Using the Levenberg-Marquart Algorithm

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Journal of Ocean University of China 2024年第4期23卷 953-960页

作者： tong Siyou LI Junjie XU Xiugang FANG Yunfen wang Zhongcheng Key Laboratory of Submarine Geosciences and Prospecting Techniques MOEOcean University of ChinaQingdao 266100China Laboratory for Marine Mineral Resources Qingdao Marine Science and Technology CenterQingdao 266237China R&D Center of BGP CNPCZhuozhou 072751China Insitute of Shengli Oilfield SINOPECDongying 257022China

Ocean bottom node(OBN)data acquisition is the main development direction of marine seismic exploration;it is widely promoted,especially in shallow sea ***,the OBN receivers may move several times because they are easily affected by tides,currents,and other factors in the shallow sea environment during long-term *** uncorrected,then the imaging quality of subsequent processing will be *** conventional secondary positioning does not consider the case of multiple movements of the receivers,and the accuracy of secondary positioning is *** first arrival wave of OBN seismic data in shallow ocean mainly comprises refracted *** this study,a nonlinear model is established in accordance with the propagation mechanism of a refracted wave and its relationship with the time interval curve to realize the accurate location of multiple receiver *** addition,the Levenberg-Marquart algorithm is used to reduce the influence of the first arrival pickup error and to automatically detect the receiver movements,identifying the accurate dynamic relocation of the *** simulation and field data show that the proposed method can realize the dynamic location of multiple receiver movements,thereby improving the accuracy of seismic imaging and achieving high practical value.

关键词： OBN dynamic location method Levenberg-Marquart algorithm seismic exploration of shallow sea

Coordinated Robust PID-based Damping Control of Permanent Magnet Synchronous Generators for Low-frequency Oscillations Considering Power System Operational Uncertainties

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1042-1051页

作者： Rehan Sadiq Zhen wang Chi Yung Chung Deqiang Gan Cunzhi tong College of Electrical Engineering Zhejiang UniversityHangzhou 310058China The Hong Kong Polytechnic University Hong KongChina State Grid Zhejiang Electric Power Company Hangzhou 310007China

In recent years, with the growth of wind energy resources,the capability of wind farms to damp low-frequency oscillations(LFOs) has provided a notable advantage for the stabilityenhancement of the modern power grid. Meanwhile, owingto variations in the power system operating point (OP), thedamping characteristics of LFOs may be affected adversely. Inthis respect, this paper presents a coordinated robust proportional-integral-derivative (PID) based damping control approachfor permanent magnet synchronous generators (PMSGs)to effectively stabilize LFOs, while considering power system operationaluncertainties in the form of a polytopic model constructedby linearizing the power system under a given set ofOPs. The proposed approach works by modulating the DC-linkvoltage control loop of the grid-side converter (GSC) via a supplementaryPID controller, which is synthesized by transformingthe design problem into H-infinity static output feedback(SOF) control methodology. The solution of H-infinity SOF controlproblem involves satisfying linear matrix inequality (LMI)constraints based on the parameter-dependent Lyapunov functionto ensure asymptotic stability such that the minimal H-infinityperformance objective is simultaneously accomplished forthe entire polytope. The coordinated damping controllers forthe multiple wind farms are then designed sequentially by usingthe proposed approach. Eigenvalue analysis confirms the improveddamping characteristics of the closed-loop system forseveral representative OPs. Afterward, the simulation results, includingthe performance comparison with existing approaches,validate the higher robustness of the proposed approach for awide range of operating scenarios.

关键词： Permanent magnet synchronous generator(PMSG) low-frequency oscillation(LFO) proportional-integralderivative(PID) robust control H-infinity static output feed-back control linear matrix inequality(LMI)

Effect of Fe Addition on Dehydrogenation Performance of Methylcyclohexance over Pt/Al_(2)O_(3)

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 12-18页

作者： tong Fengya Tian Hao wang Hao Miao Changxi Song Lei Shanghai Research Institute of Petrochemical Technology SINOPEC Shanghai201208

Catalysts with varying Fe contents were prepared using a sequential impregnation method to investigate the effects of Fe addition on the physicochemical properties of Pt/Al_(2)O_(3) and their performance in methylcyclohexane(MCH)*** results demonstrated that the addition of Fe to Pt/Al_(2)O_(3) enhanced the electron density of Pt and improved catalytic activity,while exhibiting negligible influence on the catalytic selectivity for *** the Fe content was 0.057%,the catalyst exhibited the highest MCH consumption rate,which was approximately two times higher than that of the catalyst without ***,the incorporation of Fe inhibited the formation of coke and reduced the quantity of coke deposits on the catalyst,thereby improving its catalytic ***,Fe shows promise as a prospective secondary element for Pt/Al_(2)O_(3) to enhance the MCH dehydrogenation performance.

关键词： methylcyclohexane dehydrogenation hydrogen storage deactivation Fe addition

Exercise-with-melatonin therapy improves sleep disorder and motor dysfunction in a rat model of ischemic stroke

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Neural Regeneration Research 2024年第6期19卷 1336-1343页

作者： Haitao Zhao tong Zhang Haojie Zhang Yunlei wang Lingna Cheng School of Rehabilitation Medicine Capital Medical UniversityBeijingChina Department of Neurological Rehabilitation Beijing Bo’ai HospitalChina Rehabilitation Research CenterBeijingChina School of Rehabilitation Medicine University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina Laboratory of Brain Injury Repair and Rehabilitation China Rehabilitation Science InstituteBeijingChina

Exercise-with-melatonin therapy has complementary and synergistic effects on spinal cord injury and Alzheimer's disease,but its effect on stroke is still poorly *** this study,we established a rat model of ischemic stroke by occluding the middle cerebral artery for 60 *** treated the rats with exercise and melatonin therapy for 7 consecutive *** showed that exercise-with-melatonin therapy significantly prolonged sleep duration in the model rats,increased delta power values,and regularized delta power ***,exercise-with-melatonin therapy improved coordination,endurance,and grip strength,as well as learning and memory *** the same time,it led to higher hippocampal CA1 neuron activity and postsynaptic density thickness and lower expression of glutamate receptor 2 than did exercise or melatonin therapy *** findings suggest that exercise-withmelatonin therapy can alleviate sleep disorder and motor dysfunction by increasing glutamate receptor 2 protein expression and regulating hippocampal CA1 synaptic plasticity.

关键词： exercise glutamate receptor 2 hippocampus ischemic stroke learning melatonin memory sleep disorder synaptic plasticity