检索结果-南通市图书馆

Integration of serum pharmacochemistry with network pharmacology to reveal the potential mechanism of Yangqing Chenfei formula(养清尘肺方) for the treatment of silicosis

引用

Journal of Traditional Chinese Medicine 2024年第4期44卷 784-793页

作者： HU Yuanyuan LIU Xinguang ZHAO Peng WU Jinyan YAN Xinhua HOU Runsu wang xiangcheng YANG Fan TIAN Xinrong LI Jiansheng Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 200032China Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan and Education Ministry of P.R.China.Zhengzhou 450046China Henan Key Laboratory of Chinese Medicine for Respiratory Disease Henan University of Chinese MedicineZhengzhou 450046China

OBJECTIVE:To explore the mechanisms of Yangqing Chenfei formula(养清尘肺方,YCF)in the treatment of silicosis through a comprehensive strategy consisting of serum pharmacochemistry,network pharmacology analysis,and in vitro ***:An ultrahigh-performance liquid chromatography-tandem mass spectrometry method was used to confirm the active components in YCF-medicated ***,we obtained targets for active components and genes for silicosis from multiple ***,a protein-protein interaction network was constructed,and Kyoto Encyclopedia of Genes and Genomes pathway and biological process analyses were conducted to elucidate the mechanisms of YCF for the treatment of ***,we validated the important components and mechanisms in ***:Altogether,19 active components were identified from rat serum after YCF *** identified 724 targets for 19 components,which were mainly related to inflammation[phosphatidy linositol 3 kinase/protein kinase B,forkhead box O,hypoxia inducible factor,and T-cell receptor signaling pathway,nitric oxide biosynthetic process],fibrotic processes[vascular endothelial growth factor signaling pathway,extracellular signal regulated kinase(ERK)1 and ERK2 cascade,smooth muscle cell proliferation],and apoptosis(negative regulation of apoptotic process).In addition,218 genes for silicosis were identified and were mainly associated with the inflammatory response and immune process[cytokine-cytokine receptor interaction,tumor necrosis factor alpha(TNF-α),toll-like receptor,and nucleotide binding oligomerization domain-like receptor signaling pathway].Taking an intersection of active component targets and silicosis genes,we obtained 61 common genes that were mainly related to the inflammatory response and apoptosis,such as the phosphatidylinositol-3-kinase/protein kinase B signaling pathway,mitogen activated protein kinases signaling pathway,TNF signaling pathway,toll-like receptor signaling pathway,b

关键词： silicosis network treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新型PET/CT显像剂在原发性肝癌诊断中的作用

引用

分子影像学杂志 2024年第2期47卷 212-215页

作者：牛瑞龙王相成王雪梅内蒙古医科大学第一临床医学院内蒙古呼和浩特010050 内蒙古医科大学附属医院核医学科内蒙古呼和浩特010050 深圳市人民医院核医学科广东深圳518020 内蒙古自治区分子影像学重点实验室内蒙古呼和浩特010050

原发性肝癌早期发病隐匿、诊断困难,大部分肝癌患者在确诊时已处于肝癌中晚期,治疗后易复发且生存率低。近期研究发现,肝癌的发生发展并非由上皮细胞或间质细胞单方面作用所决定,而是由两者交互作用所形成的肿瘤微环境来决定。肿瘤微环... 详细信息

原发性肝癌早期发病隐匿、诊断困难,大部分肝癌患者在确诊时已处于肝癌中晚期,治疗后易复发且生存率低。近期研究发现,肝癌的发生发展并非由上皮细胞或间质细胞单方面作用所决定,而是由两者交互作用所形成的肿瘤微环境来决定。肿瘤微环境主要由肿瘤相关成纤维细胞构成,其通过分泌各种细胞因子、蛋白酶类等对肿瘤细胞产生重要的调控作用,成纤维细胞活化蛋白是肿瘤微环境产物之一,成纤维细胞活化蛋白过表达与肿瘤的生长、侵袭及转移有一定关联。放射性核素标记成纤维活化蛋白抑制剂(68Ga-FAPI)作为一种新型PET/CT显像剂,已在多种恶性肿瘤中表现出良好的敏感性及特异性,特别是在原发性肝癌中,因肝脏本底摄取较低,在早期原发性肝癌的诊断、原发性肝癌的分期、肝脏结节良恶性的鉴别都表现出更高的敏感性及特异性。本文主要通过阐述新型PET/CT显像剂68Ga-FAPI在早期原发性肝癌的诊断中、原发性肝癌的分期、原发性肝癌治疗后复发及肝结节良恶性的鉴别中的研究进展,以期对临床原发性肝癌诊治有所裨益。

关键词：成纤维活化蛋白抑制剂原发性肝癌 PET/CT 核素

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gamma knife treatment for refractory epilepsy in seizure focus localized by positron emission tomography/CT

引用

Neural Regeneration Research 2012年第36期7卷 2937-2943页

作者： Xia Bai Xuemei wang Hongwei wang Shigang Zhao Xiaodong Han Linjun Hao xiangcheng wang Department of Nuclear Medicine Affiliated Hospital of Inner Mongolia Medical College Department of Gamma Knife Center Affiliated Hospital of Inner Mongolia Medical College Department of Neurology Affiliated Hospital of Inner Mongolia Medical College Department of MRI Center Affiliated Hospital of Inner Mongolia Medical College Department of Emergency Medical Center Affiliated Hospital of Inner Mongolia Medical College

A total of 80 patients with refractory epilepsy were recruited from the Inner Mongolia Medical College Affiliated Hospital. The loci of 60% of the patients could be positioned using a combined positron emission tomography/CT imaging modality. Hyper- and hypometabolism foci were examined as part of this study. Patients who had abnormal metabolism in positron emission tomography/CT imaging were divided into intermittent-phase group and the seizure-phase group. The intermittent-phase group was further divided into a single-focus group and a multiple-foci group according to the number of seizure foci detected by imaging. Following gamma knife treatment, seizure frequency was significantly lower in the intermittent-phase group and the seizure-phase group. Wieser＇s classification reached Grade I or II in nearly 40% of patients. Seizure frequency was significantly lower following treatment, but Wieser＇s classification score was significantly higher in the seizure-phase group compared with the intermittent-phase group. Seizure frequency was significantly lower following treatment in the single-focus group, but Wieser＇s classification score was significantly higher in the single-focus group as compared with the multiple-foci group.

关键词： epilepsy seizure positron emission tomography/CT gamma knife radiosurgery metabolism 18F-fluorodeoxyglucose neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

保金尘肺方对矽肺大鼠肺纤维化及肺组织Akt/Gsk-3β通路的影响

引用

中华中医药杂志 2024年第2期39卷 897-902页

作者：侯润苏闫鑫华杨帆王相成田鑫荣赵鹏李建生河南中医药大学呼吸疾病中医药防治省部共建协同创新中心河南省中医药防治呼吸病重点实验室郑州450046 河南中医药大学第一附属医院郑州450046

目的:探讨保金尘肺方对矽肺大鼠纤维化的干预效果及对蛋白激酶B(Akt)/糖原合酶激酶-3β(Gsk-3β)通路的影响。方法:将48只SD大鼠随机分为空白组、模型组、汉方己甲素组和保金尘肺组,每组12只。采用一次性气管内注入三氧化硅(SiO2)混悬... 详细信息

目的:探讨保金尘肺方对矽肺大鼠纤维化的干预效果及对蛋白激酶B(Akt)/糖原合酶激酶-3β(Gsk-3β)通路的影响。方法:将48只SD大鼠随机分为空白组、模型组、汉方己甲素组和保金尘肺组,每组12只。采用一次性气管内注入三氧化硅(SiO2)混悬液方法制备矽肺大鼠模型,于造模后第15—28天进行相应的药物灌胃治疗。治疗结束后测定大鼠肺功能,包括肺活量(VC)、潮气量(TV)、呼吸暂停(PAU)和用力最大吸气流速(PIF),观察肺组织病理形态并进行纤维化评分,检测肺组织Col-Ⅰ、Col-Ⅲ表达,羟脯氨酸(HYP)含量,N-钙黏蛋白(N-cadherin)、E-钙黏蛋白(E-cadherin)以及Akt/Gsk-3β通路相关mRNA、蛋白水平。结果:与空白组比较,模型组大鼠肺组织结构破坏严重且可见纤维结节,PAU显著延长(P<0.01),纤维化评分、肺组织HYP含量、Col-Ⅰ和Col-Ⅲ蛋白表达、α-SMA mRNA、转化生长因子-β1(TGF-β1)mRNA、N-cadherin蛋白、p-Akt蛋白、p-Gsk-3β蛋白表达均显著升高(P<0.01,P<0.05),VC、TV、PIF、E-cadherin蛋白及mRNA均显著下降(P<0.01,P<0.05)。与模型组比较,保金尘肺组和汉防己甲素组大鼠肺组织纤维化评分、HYP含量、Col-Ⅰ表达、N-cadherin蛋白、p-Gsk-3β蛋白均显著下降(P<0.01,P<0.05),E-cadherin蛋白表达显著升高(P<0.01),保金尘肺组Col-Ⅲ表达、PAU、α-SMA和TGF-β1 mRNA、p-Akt蛋白降低(P<0.05,P<0.01)。与汉防己甲素组比较,保金尘肺组TV、E-cadherin蛋白表达显著升高(P<0.05,P<0.01),Col-Ⅲ表达显著降低(P<0.05)。结论:保金尘肺方可通过抑制上皮-间质转化改善矽肺大鼠纤维化,其机制可能与调控Akt/Gsk-3β信号通路有关。

关键词：矽肺保金尘肺方二氧化硅上皮-间质转化蛋白激酶B/糖原合酶激酶-3β通路机制肺纤维化肺功能

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental study on spectral responses of offshore oil slick

引用

Chinese Science Bulletin 2008年第24期53卷 3937-3941页

作者： LU YingCheng TIAN QingJiu wang JingJing wang xiangcheng QI XiaoPing International Institute for Earth System Science Nanjing University Nanjing 210093 China Center for Earth Observation and Digital Earth Chinese Academy of Sciences Beijing 100086 China PetroChina Exploration and Development Research Institute Beijing 100083 China

Using the seawater taken from Liaodong Bay and crude oil taken from Liaohe Oilfield,a laboratory experiment was designed to study the change of reflectance spectrum of artificial offshore oil slick with its thickness and to identify the spectrum ranges suitable for quantifying the thickness of the oil *** the experiment,crude oil was continuously dropped into the seawater to generate artificial oil slick with different *** every drop of crude oil was added,reflectance spectrum of the oil slick was measured with a high resolution spectroradiometer(ASD FieldSpec Pro FR).The influence of oil slick thickness on its reflectance spectrum was explored through statistical *** results show that the reflectance of oil slick changes marginally with oil slick thickness and higher than that of seawater in infrared band from 1150 to 2500 *** spectrum range can be practically used to distinguish oil slick from *** the spectrum range from 400 to 1150 nm,the reflectance of oil slick decreases with its *** negative power function is the best-fit function expressing the relationship between the reflectance and *** spectral characteristics of oil slick are very distinct at 550 and 645 *** are the best wavelengths for monitoring the existence of offshore oil slick and estimating its thickness.

关键词：遥感技术反射比海上飘油光谱学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Galerkin-based quasi-smooth manifold element(QSME)method for anisotropic heat conduction problems in composites with complex geometry

引用

Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 137-154页

作者： Pan wang xiangcheng HAN Weibin WEN Baolin wang Jun LIANG School of Civil Engineering Central South UniversityChangsha 410083China Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China School of Science Harbin Institute of TechnologyShenzhen 518055Guangdong ProvinceChina

The accurate and efficient analysis of anisotropic heat conduction problems in complex composites is crucial for structural design and performance evaluation. Traditional numerical methods, such as the finite element method(FEM), often face a trade-off between calculation accuracy and efficiency. In this paper, we propose a quasi-smooth manifold element(QSME) method to address this challenge, and provide the accurate and efficient analysis of two-dimensional(2D) anisotropic heat conduction problems in composites with complex geometry. The QSME approach achieves high calculation precision by a high-order local approximation that ensures the first-order derivative *** results demonstrate that the QSME method is robust and stable, offering both high accuracy and efficiency in the heat conduction analysis. With the same degrees of freedom(DOFs), the QSME method can achieve at least an order of magnitude higher calculation accuracy than the traditional FEM. Additionally, under the same level of calculation error, the QSME method requires 10 times fewer DOFs than the traditional FEM. The versatility of the proposed QSME method extends beyond anisotropic heat conduction problems in complex composites. The proposed QSME method can also be applied to other problems, including fluid flows, mechanical analyses, and other multi-field coupled problems, providing accurate and efficient numerical simulations.

关键词： anisotropic heat conduction quasi-smooth manifold element(QSME) composite with complex geometry numerical simulation finite element method(FEM)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Living Donor Liver Transplantation for End-stage Liver Disease

引用

器官移植内科学杂志 2008年第3期3卷 129-133页

作者： Xuehao wang Feng Zhang xiangcheng Li Lianbao Kong Beicheng Sun Guoqiang Li Feng Cheng Ling Lv Liver Transplantation Center First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

Objective To investigate the value of preoperative assessment for donors and recipients and explore the optimization model of operation for living donor liver transplantation (LDLT). Methods The clinical data of 95 patients who underwent LDLT from January 1995 to October 2007 in our center was retrospectively analyzed. In the 92 recipients with benign end-stage liver diseases, 45 patients suffered from Wilson disease and the other 3 patients from malignant hepatic carcinoma. Results Thirty-one patients received the right lobe without middle hepatic vein (MHV) and 3 patients received the right lobe with MHV, 51 patients received the left lobe with MHV and 10 patients received the left lobe or left lateral lobe without MHV. All the donors recovered successfully after operation. The recipients with benign end-stage liver diseases were followed up for 1 to 86 months, and the 1-, 3-, 5-year accumulative survival rate was 89% (82 cases), 78% (71 cases) and 73% (67 cases) respectively. The 1-, 3-, 5-year survival rate in patients with Wilson disease was 92% (42 cases), 89% (40 cases) and 76% (34 cases) respectively. For the 3 patients with malignant hepatic carcinoma, 2 died and 1 was still survival. Copper metabolism recovered to be normal both in donors and recipients after operation. Conclusion The establishment of an assessment system for the safety of donors is the basic of LDLT. The key issue to elevate recipient survival rate is to choose an optimal operation method. LDLT is an effective treatment of Wilson disease.

关键词：活体肝移植末期肝病治疗方法临床分析

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

体制观念、构成模式与运作机制探析

引用

经济与管理 2010年第1期24卷 15-20页

作者：王向成山东财政学院学报编辑部山东济南250014

体制观念是由组织模式、所有制、运作机制和核算方式等诸项要素构成的组合体。不同体制具有不同的运作机制和运作效率。体制改革的目标选择是由体制机制及其效率要求产生和决定的。衡量体制机制效率的主要因素是资产经营效果。自负盈亏... 详细信息

体制观念是由组织模式、所有制、运作机制和核算方式等诸项要素构成的组合体。不同体制具有不同的运作机制和运作效率。体制改革的目标选择是由体制机制及其效率要求产生和决定的。衡量体制机制效率的主要因素是资产经营效果。自负盈亏机制是资产经营和核算的基本规律。财产所有制制度和国民经济核算方式都要适合资产经营和自负盈亏机制的规律要求。要改革计划方式,把制定发展计划的主要依据建立在科学国民经济核算方式的基础上。

关键词：体制机制资产经营自负盈亏利润国民经济核算

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

农业价值经济范式与现代化探讨

引用

经济动态与评论 2017年第1期 160-173页

作者：王向成山东财经大学期刊编辑部

农业现代化不仅指农业传统产业技术条件的改造和创新,而且还要求具有现代化的生产效率和价值经济的运作范式。农业价值经济范式是农业与市场经济和城市经济一体化的中间必经路径。应当逐步建立起农业价值经济的自生运作机制和良性循环... 详细信息

农业现代化不仅指农业传统产业技术条件的改造和创新,而且还要求具有现代化的生产效率和价值经济的运作范式。农业价值经济范式是农业与市场经济和城市经济一体化的中间必经路径。应当逐步建立起农业价值经济的自生运作机制和良性循环发展机制,培育独立农业经济实体,实现农业经济的政企分开。在农业资源配给方式上引入竞争机制以提高土地使用效率。在分清土地保障和发展两个基本功能的基础上,转变农村低保方式,给农业与资本结合的条件和机会。通过实现人地分离的法治化、常规化,实现土地规模化经营这一农业现代化的必要条件。

关键词：农业现代化土地细碎化价值范式低保方式农业实体

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

财务风险会影响财务审计重要性阈值吗?

引用

中国审计评论 2020年第2期 90-99页

作者：王向成南京审计大学政府审计学院

基于现代风险导向审计理论分析被审计单位财务风险与审计人员设置的财务审计重要性阈值的关系,并以2016—2018年沪深两市A股上市公司为样本,检验了财务风险对财务审计重要性阈值的影响,研究结果表明,面对财务风险较高的公司,审计人员通... 详细信息

基于现代风险导向审计理论分析被审计单位财务风险与审计人员设置的财务审计重要性阈值的关系,并以2016—2018年沪深两市A股上市公司为样本,检验了财务风险对财务审计重要性阈值的影响,研究结果表明,面对财务风险较高的公司,审计人员通常设置较低的财务审计重要性阈值,揭示了财务风险对审计行为的影响及审计判断谨慎性的内在要求。研究结果对审计实践具有一定的启示意义,对监督部门完善相关制度、优化监督行为也有一定的参考价值。

关键词：财务风险财务审计重要性阈值 Z-score 审计判断现代风险导向审计

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：