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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 194-203页

作者： wang Zhen LI Huajian HUANG Fali YANG Zhiqiang wen Jiaxin SHI Henan Railway Engineering Research Institute China Academy of Railway Science Corporation LimitedBeijing 100081China State Key Laboratory for Track Technology of High-Speed Railway Beijing 100081China

In order to achieve the large-scale application of manufactured sand in railway high-strength concrete structure,a series of high-strength manufactured sand concrete(HMC)are prepared by taking the manufactured sand lithology(tuff,limestone,basalt,granite),stone powder content(0,5%,10%,15%)and concrete strength grade(C60,C80,C100)as *** evolution of mechanical properties of HMC and the correlation between cubic compressive strength and other mechanical properties are *** to river sand,manufactured sand enhances the cubic compressive strength,axial compressive strength and elastic modulus of concrete,while its potential microcracks weaken the flexural strength and splitting tensile strength of *** powder content displays both positive and negative effects on mechanical properties of HMC,and the stone powder content is suggested to be less than 10%.The empirical formulas between cubic compressive strength and other mechanical properties are proposed.

关键词： manufactured sand concrete railway mechanical property lithology stone powder content

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang wen-Hui Wei Shu-Hui Fan Li Chen Jie wang xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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超级钢热轧带肋线材工业试验与生产

钢铁 2005年第10期40卷 52-54,83页

作者：赵德文王晓文王国栋孙建伦任玉辉轧制技术及连轧自动化国家重点实验室(东北大学) 辽宁沈阳110004 鞍山钢铁集团公司技术中心辽宁鞍山114021 鞍山钢铁集团公司线材厂辽宁鞍山 114021

对成品直径为φ6～φ10 mm的Q235钢热轧带肋超级钢线材进行了研究.经成分微调,采用碳的质量分数为0.21%～0.25%,硅的质量分数为0.3%～0.4%,锰的质量分数为0.7%～0.8%的钢坯及合理的控轧控冷工艺制度,使屈服强度提高到415～460 MPa,抗拉... 详细信息

对成品直径为φ6～φ10 mm的Q235钢热轧带肋超级钢线材进行了研究.经成分微调,采用碳的质量分数为0.21%～0.25%,硅的质量分数为0.3%～0.4%,锰的质量分数为0.7%～0.8%的钢坯及合理的控轧控冷工艺制度,使屈服强度提高到415～460 MPa,抗拉强度与屈服强度比值大于1.2,线材产品的晶粒尺寸达到5 μm,金相组织为珠光体加铁素体.经8次控轧控冷工业试验已在国内成功轧制上述超级钢线材3100 t.

关键词：超级钢带肋线材成分微调晶粒细化工业试验与生产

氮硅添加对高寒草甸垂穗披碱草叶片全氮含量及净光合速率的影响

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植物生态学报 2016年第12期40卷 1238-1244页

作者：司晓林王文银高小刚徐当会兰州大学生命科学学院草地农业生态系统国家重点实验室兰州730000

该文以青藏高原高寒草甸优势种垂穗披碱草(Elymus nutans)为研究对象,探究不同水平氮肥与硅肥混合添加后对其叶片全氮含量和净光合速率的影响,以期对高寒草甸牧场施肥提供一定的理论依据。研究发现:氮、硅单独添加时,均可提高垂穗披碱... 详细信息

该文以青藏高原高寒草甸优势种垂穗披碱草(Elymus nutans)为研究对象,探究不同水平氮肥与硅肥混合添加后对其叶片全氮含量和净光合速率的影响,以期对高寒草甸牧场施肥提供一定的理论依据。研究发现:氮、硅单独添加时,均可提高垂穗披碱草叶片全氮含量以及净光合速率;氮、硅配施处理对叶片全氮含量和净光合速率均存在显著的交互作用;低(N1)、中(N2)、高(N3)3种不同浓度的氮肥处理下,低硅(Si1)添加对垂穗披碱草叶片全氮含量以及净光合速率没有显著的促进作用,而添加中浓度硅肥(Si2)可显著提高垂穗披碱草叶片全氮含量;低、中浓度施氮水平下,中浓度硅肥可显著促进垂穗披碱草光合作用;叶片全氮含量和净光合速率最大平均值均出现在中浓度氮、硅肥配施下,与不施肥相比分别提高了119.99%和85.70%;就该试验而言,施加氮肥的同时,适当添加一些硅肥能够更好地提高垂穗披碱草叶片全氮含量和净光合速率,且硅的添加量为8 g·m–2时效果较好。

关键词：垂穗披碱草氮硅配施交互作用叶片全氮含量净光合速率

波浪作用下饱和砂质海床土体与管线相互作用规律研究

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岩土力学 2018年第7期39卷 2499-2508,2554页

作者：王小雯张建民李焯芬清华大学水沙科学与水利水电工程国家重点实验室北京100084 清华大学岩土工程研究所北京100084

针对波浪引起的饱和砂质海床土体和管线相互作用问题,将Biot动力固结理论与笔者课题组提出的砂土液化变形弹塑性本构模型相耦合,较为合理地再现了简谐波浪作用下较浅饱和砂质海床中管线周围可液化海床土体的超静孔隙水压力瞬态累积变化... 详细信息

针对波浪引起的饱和砂质海床土体和管线相互作用问题,将Biot动力固结理论与笔者课题组提出的砂土液化变形弹塑性本构模型相耦合,较为合理地再现了简谐波浪作用下较浅饱和砂质海床中管线周围可液化海床土体的超静孔隙水压力瞬态累积变化规律与液化过程。数值计算结果与Sumer等的试验规律一致。结果表明:由于管线的存在,改变了饱和砂质海床液化区域的空间分布。液化首先由管线下部土体开始产生,随着波浪荷载的持续作用,液化区域沿着管线外壁向上演化;同时海床表层土体产生液化并向深层发展,最终管线周围土体都发生液化,这是导致空管上浮的主要原因。当饱和砂质海床中存在管线时,管线附近海床土体液化深度明显变深。超静孔压累积和渗透力变化的耦合作用是导致饱和砂质海床土体产生液化的原因。与将海床土体视为饱和弹性多孔介质相比,可考虑液化全过程的弹塑性动力分析能更为合理地揭示实际波浪作用下饱和砂质海床土体的渗流场和应力场的瞬态时空演变规律。

关键词：波浪饱和砂质海床管线液化弹塑性动力分析

Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： xiao wang Jia Zeng Donglin Gan Kun Ling Mingfang He Jianshu Li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei wang Yuewei Bi Min Li Jiazhi Chen Zhuyong wang Huantao wen Ming Zhou Minjie Luo wangming Zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

“丝绸之路经济带”沿线国家贸易与能源效率关系研究——基于DEA模型与贸易引力模型的实证研究

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兰州大学学报（社会科学版） 2015年第4期43卷 7-15页

作者：汪晓文马晓锦倪鲲鹏兰州大学经济学院甘肃兰州730000

"丝绸之路经济带"是中国成为全球大国、重构特定区域内国际秩序的政治战略。区域经济合作是实现途径,能源是重要支柱。文章利用中国与经济带沿线10个贸易伙伴国的面板数据,运用DEA模型测算能源效率,并引入改进的贸易引力模型探索分析经... 详细信息

"丝绸之路经济带"是中国成为全球大国、重构特定区域内国际秩序的政治战略。区域经济合作是实现途径,能源是重要支柱。文章利用中国与经济带沿线10个贸易伙伴国的面板数据,运用DEA模型测算能源效率,并引入改进的贸易引力模型探索分析经济规模、能源效率、地理距离、国际合作组织等因素对双边贸易的影响。研究表明,对于经济带沿线国家而言,经济规模对双边贸易具有正向影响,而能源效率、地理距离与双边贸易呈现负相关关系。同时,文章通过分析中国与经济带沿线国家的对外贸易商品结构,对实证结果做出了进一步的阐释,尝试对制定长期经贸合作与区域发展相关政策提供借鉴和参考。

关键词：丝绸之路经济带能源效率引力模型对外贸易商品结构

Polarization-encoded neural networks with simplified grating patch

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Science China Technological Sciences 2025年

作者： Chengyan ZHONG Xiang wang Lingfei LI Yuanchi CUI Lei xiao Dawei SONG Junxiong GUO wen HUANG Yufeng GUO Yu LIU College of Integrated Circuit Science and Engineering Nanjing University of Posts and Telecommunications National and Local Joint Engineering Laboratory of RF Integration and Micro-Assembly Technology College of Integrated Circuits Hangzhou Global Scientific and Technological Innovation Centre Zhejiang University Nanjing Mumusili Technology Co. LTD School of Integrated Circuits Tsinghua University Institute of Advanced Study School of Electronic Information and Electrical Engineering Chengdu University State Key Laboratory of Electronic Thin Films and Integrated Devices School of Integrated Circuit Science and EngineeringUniversity of Electronic Science and Technology of China

Optical neural networks (ONNs) offer a promising solution for high-performance, energy-efficient artificial intelligence hardware by leveraging the parallelism and speed of light. However, the large-scale implementation of ONNs remains challenging due to the bulky footprint and complex control of optical synapses. In this work, we propose and simulate a plasmonic polarized synaptic architecture that overcomes the diffraction limit and enables ultra-compact ONNs. By tuning the polarization state of incident light, the optical transmittance through each plasmonic unit can be dynamically adjusted to represent a synaptic weight. Our plasmonic structures, with features as small as 40 nm, operate well below this limit in the visible spectrum (400–750 nm). Compared with diffraction and interference-based circuit designs, our proposed method achieves a substantial reduction in synaptic density by factors of 150000-fold and 1500-fold, respectively. Furthermore, we successfully demonstrate a proof-of-concept plasmonic ONN applied to the Canadian Institute for Advanced Research—10classes (CIFAR-10) dataset using a Visual Geometry Group network with 16 layers (VGG16) model. After training for 80epochs, the network achieves an accuracy of 93%. The polarization-tunable plasmonics paves the way towards scalable ONNs for next-generation artificial intelligence (AI) accelerators and smart sensors.

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结节性硬化症患儿的临床、视频脑电图与影像学特征

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实用儿科临床杂志 2011年第7期26卷 524-526页

作者：孙岩王晓雯新疆维吾尔自治区人民医院儿科乌鲁木齐830001

目的分析结节性硬化症(TSC)患儿的临床、视频脑电图(VEEG)和影像学特征。方法对2000年6月-2010年6月在新疆维吾尔自治区人民医院儿科诊断为TSC患儿的临床资料,包括性别、年龄、民族构成、癫发作形式、皮肤损害情况和眼底情况等,以及头颅... 详细信息

目的分析结节性硬化症(TSC)患儿的临床、视频脑电图(VEEG)和影像学特征。方法对2000年6月-2010年6月在新疆维吾尔自治区人民医院儿科诊断为TSC患儿的临床资料,包括性别、年龄、民族构成、癫发作形式、皮肤损害情况和眼底情况等,以及头颅CT/MR I资料和VEEG。结果 41例TSC患儿中癫发作36例,癫的发生率为88.71%(36/41例),局限性发作为癫主要发作形式。VEEG异常者占77.78%(91/117例次),同一例患儿可见多种异常。TSC患儿头颅CT检查均有异常,均可见侧脑室外侧壁室管膜下结节状高密度影;23例TSC患儿头颅MR I异常,同一例患儿病变可以累及多个脑叶,并且病变范围较头颅CT更为广泛,头颅CT/MR I异常部位与VEEG的异常部位不完全相符。患儿眼底均未发现异常。结论 TSC患儿诊断主要依靠皮肤损害和头颅影像学检查,头颅CT/MR I检查对该病有诊断意义,但与VEEG的异常部位不完全相符,从经济学角度上认为行头颅CT检查更有价值。癫发作主要类型为局限性发作。

关键词：结节性硬化症临床视频脑电图计算机断层扫描术磁共振成像