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Hawthorn Extract Alleviates Atherosclerosis through Regulating Inflammation and Apoptosis Related Factors: An Experimental Study

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Chinese Journal of Integrative Medicine 2019年第2期25卷 108-115页

作者： wang song-zi WU Min CHEN Ke-ji LIU Yue SUN Jing SUN Zhuo MA He LIU Long-tao Department of Cardiovascular Diseases Xiyuan HospitalChina Academy of Chinese Medical Sciences Department of Cardiovascular Diseases Guang'an men HospitalChina Academy of Chinese Medical Sciences

Objective: To determine the effects of hawthorn extract on serum lipid levels, pathological changes in aortic atherosclerosis plaque, inflammatory factors, and apoptosis-related protein and mRNA expression in apolipoprotein E gene knockout(ApoE^(-/-)) mice. Methods: Thirty-six ApoE^(-/-) mice were fed with a high-fat diet starting at the age of 8 weeks. Mice were randomly divided into 3 groups by a random number table including model group, hawthorn extract group, and simvastatin group, 12 mice in each group. Twelve 8-week-old C57BL/6 mice were fed a basic diet and served as control. The mice in the control and model groups were administered 0.2 mL saline daily, the mice in the hawthorn extract and simvastatin groups were administered with 50 mg/kg hawthorn extract or 5 mg/kg simvastatin daily for 16 weeks. After 16 weeks, plasma lipids including total cholesterol(TC), triglyceride(TG), low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) were determined by an enzymatic assay. Aortic atherosclerotic lesions were observed by light microscopy, scanning and transmission electron microscopy, respectively. Plasma levels of monocyte chemoattractant protein-1(MCP-1), interleukin-1β(IL-1β), adiponectin(APN), and hypersensitive C-reactive protein(hs-CRP) were measured by enzyme-linked immunosorbent assay(ELISA). Protein and mRNA expressions of Bax and Bcl-2 in the aorta were assessed by Western blotting and quantitative real-time polymerase chain reaction(qR T-PCR), respectively. Results: Compared to the control group, the plasma levels of TC, TG and LDL-C were significantly increased and HDL-C were significantly decreased in the model group(P<0.01). Compared to the model group, treatment with hawthorn extract significantly decreased the plasma levels of TC, TG, and LDL-C and increased the plasma level of HDL-C in ApoE^(-/-)mice(P<0.01). The levels of MCP-1, IL-1β, and hs-CRP in the model group were significantly increased and APN was si

关键词： hawthorn extract atherosclerosis unstable plaque inflammation factors apoptosis-related protein

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： song He Li Li Sai wang Shao-Jiang wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

控制开发规划中的城市设计导则编制研究——以无锡市太湖新城市民中心东侧地块城市设计为例

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现代城市研究 2010年第10期25卷 40-47页

作者：汪滋淞同济大学建筑与城市规划学院建筑系

城市设计导则是城市设计项目的核心内容,是城市设计参与城市建设管理的重要途径。它把对未来城市空间的美好预期与日常的规划管理联系起来,其质量直接影响城市空间的品质。文章从释义、本质与作用、编制与表达等方面对城市设计导则进行... 详细信息

城市设计导则是城市设计项目的核心内容,是城市设计参与城市建设管理的重要途径。它把对未来城市空间的美好预期与日常的规划管理联系起来,其质量直接影响城市空间的品质。文章从释义、本质与作用、编制与表达等方面对城市设计导则进行研究与论述,并结合无锡城市设计项目导则编制的归纳研究,总结城市设计导则的特性与要素,以期为促进我国城市设计的实践提供有益参考。

关键词：城市设计城市设计导则控制关联

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基于加热炉多场耦合传热的板坯加热均匀性

东北大学学报（自然科学版） 2019年第10期40卷 1413-1418页

作者：齐凤升王子松李宝宽东北大学冶金学院

针对某钢厂步进式加热炉建立了炉内燃烧、烟气流动、烟气和钢坯传热的全耦合三维模型,采用动网格方法模拟钢坯运动.重点分析了炉内烟气与钢坯耦合传热、钢坯温度均匀性及不同垫块结构(一字型垫块、千岛式垫块、错位梁)时钢坯温度的分布... 详细信息

针对某钢厂步进式加热炉建立了炉内燃烧、烟气流动、烟气和钢坯传热的全耦合三维模型,采用动网格方法模拟钢坯运动.重点分析了炉内烟气与钢坯耦合传热、钢坯温度均匀性及不同垫块结构(一字型垫块、千岛式垫块、错位梁)时钢坯温度的分布规律.研究结果表明:所提加热炉数学模型能够准确描述炉内燃烧、湍流和传热过程;垫块结构对钢坯温度分布具有决定性影响,千岛式垫块、错位梁分别能减少40%和50%的黑印温差.该数学模型解决了步进梁、钢坯、垫块和水管立柱等复杂结构的钢坯运动问题和加热炉与钢坯的共轭传热问题.

关键词：步进式加热炉炉内燃烧耦合传热黑印数学模型

Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： zi Ye Runqing Liu Hangxing wang Aizhen Zuo Cen Jin Nan wang Huiqi Sun Luqian Feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

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倒置液滴法的非球面微小透镜制作及实验研究

激光与红外 2018年第11期48卷 1416-1422页

作者：王松子简伟明王翔中国科学技术大学精密机械与精密仪器系安徽合肥230026

非球面透镜具有优良的光学性能,为了实现利用液滴法制作非球面微小透镜,基于流体动力学二相流原理,利用COMSOL建立了层流液滴的流动模型,计算了不同体积下正置和倒置液滴内部的流动速度和压力分布及其稳态下的面形;结合实验考察了不同... 详细信息

非球面透镜具有优良的光学性能,为了实现利用液滴法制作非球面微小透镜,基于流体动力学二相流原理,利用COMSOL建立了层流液滴的流动模型,计算了不同体积下正置和倒置液滴内部的流动速度和压力分布及其稳态下的面形;结合实验考察了不同体积力作用对光固化液滴所得透镜面形轮廓非球面系数K及几何参数的影响。结果表明,计算与实验具有很好一致性,正置液滴透镜为K> 0的扁椭球面,倒置液滴透镜的K值均为负值,且液滴体积越大越趋于双曲面;同时,倒置液滴透镜不仅具有更小的顶点曲率半径和底径,相近体积下(V=1. 6,2. 4μL)倒置液滴透镜聚焦光斑RMS值比正置液滴透镜的RMS值分别减小36%和45%;较大体积所得透镜具有更清晰的边缘和成像质量。因此,利用倒置液滴制作的非球面透镜具有更小的焦斑和优良的成像性能。

关键词：非球面微小透镜倒置液滴流体动力学

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min song Lulu An Xiao Huang Qian Zhang Chenhao Zhang Tao Shen Shuang wang Deli wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Synergistic effect Intermetallics Single atomic sites Oxygen reduction reaction Hydrogen evolution reaction

Electrochemical conversion of methane to bridge the gap in the artificial carbon cycle

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Journal of Energy Chemistry 2025年第1期100卷 286-308页

作者： Yuhao Peng Yuefeng song Ihar Razanau Juanxiu Xiao Wei Xiao Di Hu Guoxiong wang College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power Sources Wuhan University State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Dalian Institute of Chemical Physics Chinese Academy of Sciences Laboratory of Physical-Chemical Technologies SSPA Scientific and Practical Materials Research Centre of NAS of Belarus State Key Laboratory of Marine Resources Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University Department of Chemical and Environmental Engineering University of Nottingham Ningbo China

Methane, an abundant one-carbon（C1） resource, is extensively used in the industrial production of vital fuels and value-added chemicals. However, current industrial methane conversion technologies are energy-and carbon-intensive, mainly due to the high activation energy required to break the inert C–H bond, low selectivity, and problematic side reactions, including CO2emissions and coke deposition. Electrochemical conversion of methane（ECM） using intermittent renewable energy offers an attractive solution, due to its modular reactor design and operational flexibility across a broad spectrum of temperatures and pressures. This review emphasizes conversion pathways of methane in various reaction systems, highlighting the significance and advantages of ECM in facilitating a sustainable artificial carbon cycle. This work provides a comprehensive overview of conventional methane activation mechanisms and delineates the complete pathways of methane conversion in electrolysis contexts. Based on surface/interface chemistry, this work systematically analyzes proposed reaction pathways and corresponding strategies to enhance ECM efficiency towards various target products, including syngas, hydrocarbons, oxygenates, and advanced carbon materials. The discussion also encompasses opportunities and challenges for the ECM process, including insights into ECM pathways, rational electrocatalyst design, establishment of benchmarking protocols, electrolyte engineering, enhancement of CH4conversion rates, and minimization of CO2emission.

关键词： Activation energy

All-optical neuromorphic devices: materials, working mechanism,and applications

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Science China Chemistry 2025年

作者： song wang Hao Chen Hui Huang College of Materials Science and Opto-Electronic Technology Center of Materials Science and Optoelectronics Engineering CAS Center for Excellence in Topological Quantum Computation CAS Key Laboratory of Vacuum Physics University of Chinese Academy of Sciences College of Chemistry and Molecular Engineering Peking University

Traditional von Neumann computing, with physical separation of memory and processing units, cannot satisfy the development of artificial intelligence and cloud computing. Neuromorphic computing, inspired by the human brain, has drawn much ***-optical neuromorphic (AON) devices employ optical signals as information carriers and leverage the neuromorphic functions to implement fast operation speed, low energy consumption, and high bandwidth of neuromorphic computing. Here, we discuss the recent progress in AON devices, including materials, device performance, working mechanisms, and applications. Moreover,the advantages and limitations of AON are presented and discussed. Finally, the perspective of AON devices points out the future research direction of neuromorphic computing.

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