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LncRNA PCAT6 promotes progression and metastasis of colonic neuroendocrine carcinoma via MAPK pathway

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 163-178页

作者： Fei wang Hai-Feng Mu Chun wang Yue Tang Ming-Yuan Si jing Peng Department of General Surgery Nanjing Tongren HospitalNanjing 211100Jiangsu ProvinceChina Department of Pathology Nanjing Tongren HospitalNanjing 211100Jiangsu ProvinceChina

BACKGROUND Colonic neuroendocrine carcinomas(NECs)are highly malignant and invasive with poor *** noncoding RNAs(LncRNAs)participate in the tumorigenesis and metastasis of multiple cancers AIM To detect the roles and mechanisms of lncRNA prostate cancer associated transcript 6(PCAT6)in the progression of colonic *** Human NEC and adjacent normal samples were collected for immunohistochemistry staining of CgA and real-time quantitative polymerase chain reaction(RT-qPCR)of PCAT6 mRNA *** xenograft tumor model and lung metastasis model were established in nude *** lung tissues were stained by hematoxylin and eosin to assess pulmonary *** expression of epithelial-mesenchymal transition(EMT)-related markers and pathway-related genes was measured by RT-qPCR and western ***56 expression was assessed by immunofluorescence *** biological functions of PCAT6 were examined by cell counting kit-8,colony formation assays,Transwell assays and wound healing *** interaction between PCAT6 and its potential downstream target was verified by luciferase reporter *** LncRNA PCAT6 was upregulated in human NEC samples and LCC-18 cells,and its high expression was positively correlated with poor prognosis in patients with colonic ***,the expression of PCAT6 was positively associated with the proliferation,migration,invasion,and EMT of LCC-18 ***,PCAT6 facilitated tumor growth,lung metastasis and EMT in ***,PCAT6 promoted the activation of MAPK to enhance the EMT in colonic NEC by targeting *** In conclusion,lncRNA PCAT6 accelerates the process of colonic NEC by activating ERK/p38 MAPK signaling through targeting *** results might provide useful information for exploring the potential therapeutic targets in colonic NEC.

关键词： Colonic neuroendocrine carcinoma lncRNA PCAT6 Metastasis Epithelial-mesenchymal transition MAPK ceRNA

Research progress in methods of acquisition, structure elucidation, and quality control of Chinese herbal polysaccharides

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Chinese Journal of Natural Medicines 2025年第02期23卷 143-157页

作者： Tingting wang Baojie Zhu jing Zhao Shaoping Li Joint Laboratory of Chinese Herbal Glycoengineering and Testing Technology University of Macau & National Glycoengineering Research Center State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Macao Centre for Testing of Chinese Medicine University of Macau

The therapeutic efficacy of traditional Chinese medicine has been widely acknowledged due to its extensive history of clinical effectiveness. However, the precise active components underlying each prescription remain incompletely understood. Polysaccharides, as a major constituent of water decoctions —the most common preparation method for Chinese medicinals—may provide a crucial avenue for deepening our understanding of the efficacy principles of Chinese medicine and establishing a framework for its modern development. The structural complexity and diversity of Chinese herbal polysaccharides present significant challenges in their separation and analysis compared to small molecules. This paper aims to explore the potential of Chinese herbal polysaccharides efficiently by briefly summarizing recent advancements in polysaccharide chemical research, focusing on methods of acquisition, structure elucidation, and quality control.

关键词： Chinese medicine Extraction and purification Polysaccharide Quality control Structural analysis

Adaptive Mitigation Control for Wideband Oscillations of Offshore Wind Farms With MMC-HVDC System

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CSEE Journal of Power and Energy Systems 2025年第1期11卷 208-216页

作者： Yiming Rao jing Lyu Yifan wang Xu Cai The Key Laboratory of Control of Power Transmission and Conversion Ministry of EducationShanghai Jiao Tong UniversityShanghai200240China Science and Technology Research Institute China Three Gorges CorporationBeijing101199China

With offshore becoming the main battlefield of wind power generation,modular multilevel converter-based high-voltage DC(MMC-HVDC)transmission technology has become an ideal solution for offshore wind power integration and received rapid ***,wideband oscillation events have seriously threatened stable operation of power *** far,existing oscillation mitigation methods are usually designed for specific oscillation cases and are not capable of mitigating wideband *** order to mitigate various oscillations adaptively,this article proposes an adaptive wideband oscillation mitigation control for MMC-HVDC system connected to offshore wind *** wideband impedance models of the wind farm side MMC(WFMMC)and offshore wind farm composed of permanent-magnetic synchronous generator-based wind turbine generators(PMSG-WTGs)are derived,respectively,which are verified by measured impedances from time-domain ***,a wideband oscillation mechanism is revealed by impedance-frequency *** this basis,an adaptive wide band oscillation mitigation control is proposed,and its working principle as well as implementation process are *** studies of a sub-/super-synchronous oscillation(SSO)event and a high-frequency oscillation(HFO)event of an offshore wind farm with MMC-HVDC system are carried out to verify effectiveness of the proposed adaptive wideband oscillation mitigation control.

关键词： Adaptive mitigation control MMC-HVDC offshore wind farm wideband oscillation.

Effective stress dissipation by multi-dimensional architecture engineering for ultrafast and ultralong sodium storage

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Journal of Energy Chemistry 2025年第2期101卷 619-629页

作者： Man Zhang jing Zhu Qianqian Li Fenghua Zheng Sijiang Hu Youguo Huang Hongqiang wang Xing Ou Qichang Pan Qingyu Li Guangxi Key Laboratory of Low Carbon Energy Materials School of Chemistry and Pharmaceutical Sciences Guangxi Normal University School of Metallurgy and Environment Central South University

Stress accumulation is a key factor leading to sodium storage performance deterioration for NiSe2-based ***,inhibiting the concentrated local stress during the sodiataion/desodiation process is crucial for acquiring stable NiSe2-based materials for sodium-ion batteries（SIBs）,Herein,a stress dissipation strategy driven by architecture engineering is proposed,which can achieve ultrafast and ultralong sodium storage *** from the conventional sphere-like or rod-like architecture,the three-dimensional（3D） flower-like NiSe2@C composite is delicately designed and assembled with onedimensional nanorods and carbon *** importantly,the fundamental mechanism of improved structure stability is unveiled by simulations and experimental results *** demonstrates that this designed multidimensional flower-like architecture with dispersed nanorods can balance the structural mismatch,avoid concentrated local strain,and relax the internal stress,mainly induced by the unavoidable volume variation during the repeated conversion ***,it can provide more Na+-storage sites and multi-directional migration pathways,leading to a fast Na+-migration channel with boosted reaction *** expected,it delivers superior rate performance(441 mA h g-1at 5.0 A g-1) and long cycling stability(563 mA h g-1at 1.0 A g-1over 1000 cycles) for *** work provides useful insights for designing high-performance conversion-based anode materials for SIBs.

关键词： Conversion-based anodes Multi-dimensional architecture Sodium-ion batteries Stress dissipation Structure engineering

Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan Ling wang jing Ren Chenguang Zheng Jiajia Yang Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： jing Yao Yuan Li Xi Liu Wenping Liang Yu Li Liyong Wu Zhe wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

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A Novel Harmonic State-space Modelling Method on the Modular Multilevel Matrix Converter and Coupling Analysis

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CSEE Journal of Power and Energy Systems 2025年第1期11卷 78-90页

作者： jing Li Boyang Zhao Shenquan Liu Jie Li Xiuli wang Xifan wang Shaanxi Key Laboratory of Smart Grid in Xi'an Jiaotong University School of Electrical EngineeringXi'an Jiaotong UniversityXi'an710049China School of Electric Power Engineering South China University of TechnologyGuangzhou510641China

The fractional frequency transmission system is an emerging technology for long-distance wind power integration,and the modular multilevel matrix converter(M3C)is the keen *** the M3C directly connects two ac grids with different frequencies,the external and internal harmonics have complex coupling relationships with a unique dual-fundamental-frequency spectrum,which has not been properly investigated due to a lack of an effective *** address this issue,a novel harmonic state-space method is proposed to achieve comprehensive modelling of the harmonic dynamics of the *** on the principle of two-dimensional Fourier transform,the decomposition of the dual-fundamental-frequency harmonics is realized,and the multiplicative coupling between time-domain variables is modelled through double-layer convolution on the frequency ***,the general expression of the proposed method is provided,which highlights a modularized matrix with easy scalability to meet different truncation ***,the HSS model of M3C considering the close-loop control is established,based on which a panoramic harmonic coupling relationship between the system-and the low-frequency side is ***,the M3C model and harmonic coupling relationship are validated by simulation tests conducted in MATLAB/Simulink environment.

关键词： Harmonic state-space harmonic transmission modular multilevel matrix converter.Harmonic state-space harmonic transmission modular multilevel matrix converter

Clinical significance of Ki-67 in patients with lung adenocarcinoma in situ complicated by type 2 diabetes

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World Journal of Diabetes 2025年第2期16卷 114-122页

作者： Ke Chen Ge wang jing-Cheng Hu Ying-Yi Zhou Hai-Tao Ma Department of Thoracic Surgery The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Endocrine The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND The increasing number of type 2 diabetes mellitus(T2DM)patients leads to higher rates of morbidity and mortality related to lung *** To investigate the utility of the proliferating cell nuclear antigen Ki-67 in patients with lung adenocarcinoma in situ(AIS)complicated by *** One hundred patients with AIS and T2DM(group A),100 patients with AIS alone(group B),and 60 patients with benign lung lesions(group C)admitted to the Department of Thoracic Surgery and Endocrinology of the First Affiliated Hospital of Soochow University from November 2021 to December 2022 were ***-67 expression was compared among the *** Group A had significantly higher levels of fasting plasma glucose(FPG),total cholesterol(TC),total triglyceride,low-density lipoprotein cholesterol,glycosylated hemoglobin(HbA1c),and insulin than groups B and C(P<0.01).Meanwhile,group B had higher insulin levels than group C(P<0.01).Group A exhibited a significantly higher average Ki-67 positivity rate than group B(P<0.01).The Ki-67 positivity rate in group A was 86.87%,while the positivity rate in group B was 77%.Ki-67 was positively correlated with FPG(P<0.01)and HbA1c levels(P<0.01).Ki-67,FBG,insulin,HbA1c,high-density lipoprotein cholesterol and TC were independent factors for patients with AIS complicated by *** K et ***67 in patients with AIS complicated by T2DM WJD https://*** 2 February 15,2025 Volume 16 Issue 2 CONCLUSION Ki-67 expression was higher in patients with AIS complicated by T2DM than in patients with AIS ***,detecting the Ki-67 level might assist in the diagnosis of AIS in patients with T2DM.

关键词： Ki-67 Type 2 diabetes mellitus Lung adenocarcinoma in situ Immunohistochemistry Prognostic marker

Mapping the landscape of gastric cancer immunotherapy:Bibliometric insights into advances and hotspots

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 349-370页

作者： Zhen Yuan jing-Hang wang Hao Cui Shu-Yuan wang Bo Wei Jian-Xin Cui School of Medicine Nankai UniversityTianjin 300071China Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND Immunotherapy has surfaced as a promising therapeutic modality for gastric cancer(GC).A comprehensive review of advancements,current status,and research trends in GC immunotherapy is essential to inform future investigative *** To delineate the trends,advancements,and focal points in immunotherapy for *** We performed a bibliometric analysis of 2906 articles in English concerning GC immunotherapy published from 2000 to December 20,2023,indexed in the Web of Science Core *** analysis and visualization were facilitated by CiteSpace(6.1.6R),VOSviewer v.1.6.17,and GraphPad Prism *** There has been an increase in the annual publication rate of GC immunotherapy *** leads in publication volume,while the United States demonstrates the highest citation *** University is notable for its citation frequency and publication ***-citation analysis and keyword frequency revealed and highlighted a focus on GC prognosis,the tumor microenvironment(TME),and integrative immunotherapy with targeted *** research areas include gastroesophageal junction cancer,adoptive immunotherapy,and the role of Treg cell in *** GC immunotherapy research is an expanding field attracting considerable scientific *** the clinical adoption of immunotherapy in GC,the primary goals are to enhance treatment efficacy and patient *** hematological malignancies,GC's solid TME presents distinct immunological challenges that may attenuate the cytotoxic effects of immune cells on cancer *** instance,although CAR-T therapy is effective in hematological malignancies,it has underperformed in GC *** research is centered on overcoming immunosuppression within the TME,with a focus on combinations of targeted therapy,adoptive immunotherapy,Treg cell dynamics,and precise prognosis prediction in ***,immunotherapy's role in treating gastroesophageal junctio

关键词： Bibliometrics Gastric cancer Immunotherapy Immune checkpoint inhibitor Tumor microenvironment