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A Bird’s Eye View of Quantitative Proteome of Tumor Tissues from Lung Cancer Patients by a High Precision Mass Spectrometry Method

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Chemical Research in Chinese Universities 2024年第1期40卷 136-144页

作者： DU Xiaohui LI Encheng wang qi YOU Xin Lung Cancer Transitional Medicine Center The Second Affiliated Hospital of Dalian Medical UniversityDalian116023P.R.China Department of Scientific Research Center The Second Affiliated Hospital of Dalian Medical UniversityDalian116023P.R.China Department of Respiratory Medicine The Second Affiliated Hospital of Dalian Medical UniversityDalian116023P.R.China

Lung cancer produces a high incidence of malignant tumors.There have been many studies on lung cancer using mass spectrometry(MS)technologies.However,most studies have focused on humoral samples.In this work,26 pairs of tissue samples(tumor vs.para-tumor)from patients with lung cancer were analyzed using liquid chromatography-tandem MS(LC-MS/MS)with data-independent acquisition mode.In total,3152 proteins were quantified from tissue samples with high confidence,including 189 up-regulated and 522 down-regulated proteins(tumor vs.para-tumor).In addition,79 and 690 proteins were identified only in para-cancerous samples and cancerous samples,respectively.The results from bio-informatics tools indicated that altered proteins like PEBP1,HRG and LYZ could be ideal reservoirs for screening the potential biomarkers for lung cancer.It is believed these tissue-specific proteomics results will assist in the studies of lung cancer.

关键词： Lung cancer Proteome Data-independent aquisition

Differences in vascular endothelial function and serum proteome between obese people with phlegm-dampness constitution and balanced constitution

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Journal of Traditional Chinese Medicine 2024年第1期44卷 188-196页

作者： ZHU Linghui SUN Ziwei GUAN Yuanyuan LIU Meiyi ZHENG Yi YU Ruoxi wang qi LI Lingru School of Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China National Institute of TCM Constitution and Preventive Medicine Beijing University of Chinese MedicineBeijing 100029China

OBJECTIVE:To evaluate the extent of vascular endothelial dysfunction and preliminary identify serum protein biomarkers associated with obese individuals at risk for cardiovascular disease(CVD).METHODS:Fifteen obese volunteers with the phlegmdampness constitution or balanced constitution were recruited for this study respectively.The clinical baseline data was collected,and the vascular endothelial function was evaluated using the EndoPAT?.Blood samples were collected for the serum proteome analysis.The differences in the serum protein expression levels between the two groups were detected and the protein interaction network analysis,correlation analysis,receiver operating characteristic(ROC)curve analysis,and random forest model investigation were conducted.RESULTS:There were no statistical differences found in the baseline data.For vascular endothelial function,the reactive hyperemia index(RHI)of the phlegm-dampness constitution obese group was significantly lower than that of the balanced constitution obese group(1.46±0.30 vs 2.82±0.78,P<0.0001),indicating vascular endothelial dysfunction.There are 66 differentially expressed serum proteins between the two groups.apolipoprotein A2(Apo A2),angiotensin-converting enzyme 2(ACE-2),interleukin-33(IL-33),and forkhead box P3(FoxP3)showed significant differences and area under curve values of their ROC curves were greater than 0.7 and correlated significantly with RHI.CONCLUSION:Vascular endothelial dysfunction was present in the phlegm-dampness constitution obese group.Thus,alterations in the expression levels of key serum proteins,including Apo A2,ACE-2,IL-33,and Fox P3 could serve as potential biomarkers in the obese population at risk of CVD.

关键词： obesity phlegm-dampness constitution vascular endothelial function proteome reactive hyperemia index

Trench gate GaN IGBT with controlled hole injection efficiency

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The Journal of China Universities of Posts and Telecommunications 2024年第2期31卷 10-16页

作者： Huang Yi Li Yueyue Gao Sheng wang qi Liu Bin Han Genquan School of Optoelectronic Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China School of Electronic Science and Engineering Nanjing UniversityNanjing 210008China School of Microelectronics Xidian UniversityXi’an 710126China

In this paper,a novel trench gate gallium nitride(GaN)insulated gate bipolar transistor(GaN IGBT),in which the collector is divided into multiple regions to control the hole injection efficiency,is designed and theoretically studied.The incorporation of a P+/P-multi-region alternating structure in the collector region mitigates hole injection within the collector region.When the device is in forward conduction,the conductivity modulation effect results in a reduced storage of carriers in the drift region.As a result,the number of carriers requiring extraction during device turn-off is minimized,leading to a faster turn-off speed.The results illustrate that the GaN IGBT with controlled hole injection efficiency(CEH GaN IGBT)exhibits markedly enhanced performance compared to conventional GaN IGBT,showing a remarkable 42.2%reduction in turn-off time and a notable 28.5%decrease in turn-off loss.

关键词： gallium nitride insulated gate bipolar transistor(GaN IGBT) hole injection trench gate turn-off loss

A Fibonacci View on the Galois NFSR Used in Trivium

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Journal of Systems Science & Complexity 2024年第3期37卷 1326-1350页

作者： wang Hongyu ZHENG Qunxiong qi Wenfeng PLA Strategic Support Force Information Engineering University Zhengzhou 450001China

Trivium is an international standard of lightweight stream ciphers(ISO/IEC 29192-3:2012).In this paper,the Trivium-like NFSRs,a class of Galois NFSRs generalized from the Galois NFSR of Trivium,are studied from the perspective of Fibonacci NFSRs.It is shown that an n-stage Trivium-like NFSR cannot be equivalent to an n-stage Fibonacci NFSR,which is proved by showing the existence of“collision initial states”.As an intermediate conclusion,a necessary and sufficient condition for a kind of linear degeneracy of a Trivium-like NFSR is obtained from the persepective of interleaved sequences.Moreover,the smallest stage number of a Fibonacci NFSR that can generate all the output sequences of an n-stage Trivium-like NFSR is shown to be greater than n-7 and this value is no less than 371=287+min{93,84,111}specifically for the 288-stage Galois NFSR used in Trivium.These results contradict the existence of a equivalent Fibonacci model of Trivium NFSR of small stage,which implies that Trivium algorithm possesses a fair degree of immunity against“structure attack”.

关键词： Fibonacci NFSR galois NFSR interleaved sequence linear degeneracy trivium

Adaptive fault-tolerant control for non-minimum phase hypersonic vehicles based on adaptive dynamic programming

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Chinese Journal of Aeronautics 2024年第3期37卷 290-311页

作者： Le wang Ruiyun qi Bin JIANG State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China

In this paper,a novel adaptive Fault-Tolerant Control(FTC)strategy is proposed for non-minimum phase Hypersonic Vehicles(HSVs)that are affected by actuator faults and parameter uncertainties.The strategy is based on the output redefinition method and Adaptive Dynamic Programming(ADP).The intelligent FTC scheme consists of two main parts:a basic fault-tolerant and stable controller and an ADP-based supplementary controller.In the basic FTC part,an output redefinition approach is designed to make zero-dynamics stable with respect to the new output.Then,Ideal Internal Dynamic(IID)is obtained using an optimal bounded inversion approach,and a tracking controller is designed for the new output to realize output tracking of the nonminimum phase HSV system.For the ADP-based compensation control part,an ActionDependent Heuristic Dynamic Programming(ADHDP)adopting an actor-critic learning structure is utilized to further optimize the tracking performance of the HSV control system.Finally,simulation results are provided to verify the effectiveness and efficiency of the proposed FTC algorithm.

关键词： Hypersonic vehicle Fault-tolerant control Non-minimum phase system Adaptive control Nonlinear control Adaptive dynamic programming

Chaotic Map-Based Authentication and Key Agreement Protocol with Low-Latency for Metasystem

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Computers, Materials & Continua 2024年第3期78卷 4471-4488页

作者： Guojun wang qi Liu School of Electronics&Information Engineering Nanjing University of Information Science&TechnologyNanjing210044China Yancheng Polytechnic College Yancheng224000China Jiangsu Province Engineering Research Center of Advanced Computing and Intelligent Services School of SoftwareNanjing University of Information Science and TechnologyNanjingChina

With the rapid advancement in exploring perceptual interactions and digital twins,metaverse technology has emerged to transcend the constraints of space-time and reality,facilitating remote AI-based collaboration.In this dynamic metasystem environment,frequent information exchanges necessitate robust security measures,with Authentication and Key Agreement(AKA)serving as the primary line of defense to ensure communication security.However,traditional AKA protocols fall short in meeting the low-latency requirements essential for synchronous interactions within the metaverse.To address this challenge and enable nearly latency-free interactions,a novel low-latency AKA protocol based on chaotic maps is proposed.This protocol not only ensures mutual authentication of entities within the metasystem but also generates secure session keys.The security of these session keys is rigorously validated through formal proofs,formal verification,and informal proofs.When confronted with the Dolev-Yao(DY)threat model,the session keys are formally demonstrated to be secure under the Real-or-Random(ROR)model.The proposed protocol is further validated through simulations conducted using VMware workstation compiled in HLPSL language and C language.The simulation results affirm the protocol’s effectiveness in resisting well-known attacks while achieving the desired low latency for optimal metaverse interactions.

关键词： Metasystem authentication and key agreement chaotic map secure communication

Single-particle spectroscopies of p-wave and d-wave interacting Bose gases in normal phase

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Communications in Theoretical Physics 2024年第5期76卷 140-147页

作者： Zeqing wang Ran qi Department of Physics Renmin University of ChinaBeijing 100872China

Motivated by experiments with interacting quantum gases across high partial wave resonance,we investigate the thermodynamic properties and single-particle spectra of Bose gases in normal phase for different interaction strengths for both p-and d-wave interactions.The equation of state,contact density,momentum distributions and self-energies of single-particle Green’s functions are obtained in the spirit of ladder diagram approximations.The radio-frequency(RF)spectrum,as an important experimental approach for detecting Feshbach molecules or the interaction effect,is calculated at different temperatures.A reversed temperature dependence on the Bose–Einstein condensation side and Bardeen–Cooper–Schrieffer side is identified for both p-and d-wave interactions.An estimate for the signal of RF spectra under typical experimental conditions is also provided.

关键词： quantum gases ultracold atom high partial wave RF spectra

Extensive prediction of drug response in mutation-subtype-specific LUAD with machine learning approach

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Oncology Research 2024年第2期32卷 409-419页

作者： KEGANG JIA YAWEI wang qi CAO YOUYU wang Department of Thoracic Surgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduChina School of Medicine University of Electronic Science and Technology of ChinaChengduChina Department of Assisted Reproductive Medicine Sichuan Provincial Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengduChina

Lung cancer is the most prevalent cancer diagnosis and the leading cause of cancer death worldwide.Therapeutic failure in lung cancer(LUAD)is heavily influenced by drug resistance.This challenge stems from the diverse cell populations within the tumor,each having unique genetic,epigenetic,and phenotypic profiles.Such variations lead to varied therapeutic responses,thereby contributing to tumor relapse and disease progression.Methods:The Genomics of Drug Sensitivity in Cancer(GDSC)database was used in this investigation to obtain the mRNA expression dataset,genomic mutation profile,and drug sensitivity information of NSCLS.Machine Learning(ML)methods,including Random Forest(RF),Artificial Neurol Network(ANN),and Support Vector Machine(SVM),were used to predict the response status of each compound based on the mRNA and mutation characteristics determined using statistical methods.The most suitable method for each drug was proposed by comparing the prediction accuracy of different ML methods,and the selected mRNA and mutation characteristics were identified as molecular features for the drug-responsive cancer subtype.Finally,the prognostic influence of molecular features on the mutational subtype of LUAD in publicly available datasets.Results:Our analyses yielded 1,564 gene features and 45 mutational features for 46 drugs.Applying the ML approach to predict the drug response for each medication revealed an upstanding performance for SVM in predicting Afuresertib drug response(area under the curve[AUC]0.875)using CIT,GAS2L3,STAG3L3,ATP2B4-mut,and IL15RA-mut as molecular features.Furthermore,the ANN algorithm using 9 mRNA characteristics demonstrated the highest prediction performance(AUC 0.780)in Gefitinib with CCL23-mut.Conclusion:This work extensively investigated the mRNA and mutation signatures associated with drug response in LUAD using a machine-learning approach and proposed a priority algorithm to predict drug response for different drugs.

关键词： Lung adenocarcinoma Drug resistance Machine learning Molecular features Personalized treatment

Characterization of a smog chamber for studying formation of gas-phase products and secondary organic aerosol

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Journal of Environmental Sciences 2024年第2期136卷 570-582页

作者： qi Yuan Zhuozhi Zhang Meng wang Kin Fai Ho Tao wang Shuncheng Lee Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina School of Public Health and Primary Care The Chinese University of Hong KongShatinHong KongChina

Smog chambers provide a potent approach to explore the secondary organic aerosol formation under varied conditions.This study describes the construction and characterization of a new smog chamber facility for studying the formation mechanisms of gas-phase products and secondary organic aerosol from the photooxidation of volatile organic compounds.The chamber is a 5.4 m^(3) Fluorinated Ethylene Propylene(FEP)Teflon reactor with the potential to perform photooxidation experiments at controlled temperature and relative humidity.Detailed characterizations were conducted for evaluation of stability of environmental parameters,mixing time,background contamination,light intensity,and wall losses of gases and particles.The photolysis rate of NO_(2)(J_(NO2))ranged from(1.02-3.32)×10^(-3)sec^(-1),comparable to the average J_(NO2)in ambient environment.The wall loss rates for NO,NO_(2),and O_(3)were 0.47×10^(-4),0.37×10^(-4),and 1.17×10^(-4)min^(-1),while wall loss of toluene was obsoletely found in a 6 hr test.The particle number wall loss rates are(0.01-2.46)×10^(-3)min^(-1)for 40-350 nm with an average lifetime of more than one day.A series of toluene photooxidation experiments were carried out in absence of NO_xunder dry conditions.The results of the simulation experiments demonstrated that the chamber is well designed to simulate photolysis progress in the atmosphere.

关键词： Smog chamber Gas-phase oxidation Chamber characterization Chemical mechanism