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Synthesis of A Novel Aluminosilicate with Bimodal Mesopore Distribution

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Chinese Chemical Letters 1997年第10期8卷 927-930页

作者： Yuan, ZY wang, jz Li, HX Chang, ZX NANKAI UNIV DEPT CHEMCATALYSIS LABTIANJIN 300071PEOPLES R CHINA SINOPEC FUSHUN RES INST PETR & PETROCHEMFUSHUN 113001PEOPLES R CHINA

A novel aluminosilicate with well-defined bimodal mesopore distribution has been synthesized directly, in which one mesopore is distributed at around 3.8nm and the other at 2.6nm.

关键词： MOLECULAR-SIEVES PHYSISORPTION

STRUCTURE OF 1-EPICRASSICAUDINE

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Chinese Chemical Letters 1995年第2期6卷 109-110页

作者： wang, FP Dai, XP wang, jz Zhang, R W China Univ Med Sci Sch Pharm Dept Chem Med Nat Prod Chengdu 610044 Peoples R China

A new C-19-diterpenoid alkaloid. 1-epicrassicaudine, was isolated from the roots of Aconitum hemslevanum Pritz var. pengshinese. Spectral methods demonstrated that it has the structure represented by (1) an 1-epimer o...

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SYNTHESIS OF MESOPOROUS CHROMIUM SILICATE

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Chinese Chemical Letters 1995年第12期6卷 1091-1094页

作者： Yuan, ZY Chen, TH wang, jz Li, HX Liu, SQ Nankai Univ Dept Chem Catalysis Lab Tianjin 300071 Peoples R China Nankai Univ Catalyst Plant Tianjin 300071 Peoples R China

A mesoporous chromium silicate molecular sieve with MCM-41 structure has beers prepared by direct hydrothermal synthesis; XRD; framework IR, ESR and DR-UV spectroscopies provided evidence of the presence of framework ...

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Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer brain and the possible mechanism

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中国病理生理杂志 2001年第8期 88-89页

作者： wang jz Tung YC wang YP Li XT Iqbal K GRUNDKE-IQBAL I Department of Pathophysiology Tongji Medical College HUST 13 HongKang RoadHubei Wuhan 430030 China Chemical Neuropathology Department NYS Institute for Basic Research1050 Forest Hill Road Staten Island New York NY10314 USA

Study on Alzheimer’s disease model

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中国病理生理杂志 2001年第8期 91-91页

作者： wang jz wang QB Li XT wang YP WEI ZL XIAO RH wang Q HAO TL wang XC LIU R Department of Pathophysiology Tongji Medical University Wuhan 430030 China

It is well known that the main brain lesion in Alzheimer's disease (AD) brain is neurofibrillary tangles (NFT) and senile plaques (SP). The amount of NFT is positively correlated with clinical degree of dementia in AD. It is also well studied that the major component of NFT is abnormally hyperphosphorylated microtubule associated protein tau that is caused by an imbalance of protein kinase and protein phosphatase (PP). To reconstitute a specific AD model based on the above hypothesis, we have injected separately calcium calmodulin dependent protein kinase (CaMKKII) activator, bradykinin and PP-2B inhibitor, cyclosporin A into rat hippocampus in the present study. The results showed that the injection of bradykinin caused learning and memory deficient in rats as well as Alzheimer-like tau phosphorylation, including Ser-262/356, Thr-231/235 and Ser-396/404. On the other hand, the injection of cyclosporin A induced the same phosphorylation sites as above except Ser-262/356, however, it did not mimic rat behavior abnormality as bradykinin injection did. The data suggested that activating of CaMKII and the phosphorylation of Ser-262/356 at tau might responsible for the lesion of learning and memory in our model rats. We also incubated PP-2A and PP-1 inhibitor, okadaic acid with human neuroblastoma cell line (SH-SY5Y), and found that (1) inhibition of above PPs induced Alzheimer-like phosphorylation and accumulation of neurofilaments, and Alzheimer-like microtubule disruption, (2) melatonin showed certain protection of the cell from okadaic acid toxicity. The data obtained from this study is significant in AD specific model study.

关键词： Study on Alzheimer s disease model

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睡眠过渡过程的外-内相互作用关联维数分析

中国组织工程研究与临床康复 2007年第13期11卷 2510-2513页

作者：高闯王建中黄坤魏薇华中师范大学物理科学与技术学院华中农业大学理学院湖北省武汉市430079

目的:探讨外-内相互作用下,认知任务与有害认知相互作用过程,并对比分析失眠者和正常人之间的相互作用过程差异。方法:实验于2005-10在中南民族大学脑认知实验室进行。选取华中师范大学和中南民族大学中在校大学生19人,其中睡眠良好者12... 详细信息

目的:探讨外-内相互作用下,认知任务与有害认知相互作用过程,并对比分析失眠者和正常人之间的相互作用过程差异。方法:实验于2005-10在中南民族大学脑认知实验室进行。选取华中师范大学和中南民族大学中在校大学生19人,其中睡眠良好者12人,失眠者7人。采用Tung实验模式,要求被试者在入睡过程中对目标刺激和非目标刺激进行鉴别反应,记录其睡眠过渡过程中的行为反应量。实验刺激物是由计算机控制的响度相近、频率不同的两种短音。两种声音中,一个是目标声,另一个为非目标声。结果:19人均进入结果分析。①失眠者的睡眠潜伏期均在30min以上。②获得睡眠过渡过程的归一化反应时间序列。对被试者的归一化反应时间序列进行相空间重构,分形结果显示:正常人存在三四个稳定的线性无标度区,失眠者存在1个稳定的线性无标度区。③影响正常被试者和失眠者睡眠过渡过程的独立变量并不相同,失眠者较多,一般大于6个,而正常被试者的较少,一般为两三个,少数存在4～6个的情况。结论:在过渡过程中,认知任务和有害认知相互作用,在无标度区内处于相对稳定。对于失眠者和正常人,稳定相互作用的区间数目及影响过渡过程的独立作用因素个数也并不相同。而每个无标度区都对应着一个脑资源占用状态,这就表明,正常人存在三四个脑资源占用不同的相互作用的稳定状态。而失眠者则只存在着一个相对稳定的相互作用稳定的状态。

关键词：睡眠外-内作用关联维度

Efficacy and Safety Recombinant Activated FactorⅦin Acute Intracerebral Hemorrhage Patients without Hemophilia:a Meta-Analysis

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Efficacy and Safety Recombinant Activated FactorⅦin Acute I...

Effect of Modification Treatment on Chloride Ions Permeability and Microstructure of Recycled Brick-mixed Aggregate Concrete

浙江省医学会创伤学分会成立大会暨2009年浙江省创伤学术年会

作者： Huang WD,Yuan ZH,Jiang JK,Pan J,Zhu JY,wang jz. Department of Emergency,the First Affiliated Hospital,College of Medicine, Zhejiang University,Hangzhou,China(310003)

Background:Hematoma growth is common in intracerebral hemorrhage(ICH) and is associated with the poor *** results were inconsistent in the trials that used recombinant activated factorⅦ(rFⅦa) to treat patients with ***:To evaluate the efficacy and safety of rFⅦa used as hemostatic agent in patients with ***:Medline,Scopus,the Cochrane Library,*** and Stroke Trials Directory were searched for placebo controlled trials of rFⅦa in patients without *** for dichotomous outcomes expressed as odds ratio(OR) with 95%confidence intervals(CI) and continuous outcomes as weighted mean difference(WMD).Fixed-effect model or random-effects model was used according to whether or not *** analyses were performed according to total dose of rFⅦa ***:Five randomized controlled trials - four spontaneous ICH(sICH) and one traumatic ICH(tICH) - were selected for *** the total 1402 subjects studied in the 5 trials,989patients(61 with tICH) received rFⅦa,413(36 with tICH) received *** rFⅦa can reduce the change of ICH volume,there was no significant difference in mortality(OR=0.86,95%CI[0.65,1.15]),scale of modified Rankin Scale(MRS)(grades 4 to 6)(OR=0.89,95%CI[0.48,1.39]) or extended Glasgow Outcome Scale(GOS-E)(grades 1 to 4)(OR= 0.91,95%CI[0.30,2.71]) between rFⅦa and *** was a significant increase of arterial thromboembolic adverse events (TAE) in rFⅦa group(OR=2.18,95%CI[1.13,4.19]).Besides the increase of incidence of DVT in tICH(OR=3.13,95%CI[0.35, 27.87]),similar results were observed in sICH and ***:Use of rFⅦa reduces the growth of the hematoma but does not improve survival or functional outcome after ICH;in addition,it increases the incidence of arterial *** any future study to confirm the clinical benefit of rFⅦa in ICH,thromboembolic risk should be carefully monitored.

关键词： intracerebral hemorrhage Recombinant Activated FactorⅦ randomized controlled trial meta-analysis thromboembolic adverse events

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 728-737页

作者：何子明申爱琴 wang Xiaobin WU Jinhua wang Lusheng School of Civil and Architectural Engineering Liaoning University of TechnologyJinzhou 121001China School of Highway Chang’an UniversityXi’an 710064China Department of Road and Bridge Engineering Liaoning Provincial College of Communica-tionsShenyang 110122China

The modification methods of pozzolan slurry combined with sodium silicate and silicon-based additive were respectively adopted to treat recycled coarse brick-mixed aggregate(RCBA)in this *** compressive strength and chloride permeability resistance of recycled aggregate concrete(RAC)before and after modification treatment were tested,and the microstructure of RAC was analyzed by mercury intrusion porosimetry(MIP)and scanning electron microscopy(SEM).The results show that the physical properties of RCBA strengthened by modification treatment are improved,and the compressive strength and chloride permeability resistance of treated RAC are also significantly *** modification treatment optimizes the pore size distribution of RAC,which increases the number of gel pores and transition pores,and decreases the number of capillary pores and macro *** surface fractal dimension shows a significant correlation with chloride diffusion coefficient,indicating that the variation of chloride permeability of treated RAC is consistent with the microstructure evolution.

关键词： recycled aggregate concrete modification treatment compressive strength chloride permeability resistance microstructure

Defense and anti-defense mechanisms of bacteria and bacteriophages

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 181-196页

作者： Xiaoqing wang Sebastian LEPTIHN School of Medicine Lishui UniversityLishui 323000China University of Edinburgh Medical School Biomedical SciencesCollege of Medicine&Veterinary MedicineThe University of EdinburghEdinburgh EH89JZUK HMU Health and Medical University Am Anger 64/73-99084 ErfurtGermany

In the post-antibiotic era,the overuse of antimicrobials has led to a massive increase in antimicrobial resistance,leaving medical doctors few or no treatment options to fight infections caused by *** use of bacteriophages is a promising alternative to treat infections,supplementing or possibly even replacing *** phages for therapy is possible,since these bacterial viruses can kill bacteria specifically,causing no harm to the normal ***,bacteria have developed a multitude of sophisticated and complex ways to resist infection by phages,including abortive infection and the clustered regularly interspersed short palindromic repeats(CRISPR)/CRISPR-associated(Cas)*** also can evolve and acquire new anti-defense strategies to continue *** in-depth exploration of both defense and anti-defense mechanisms would contribute to optimizing phage therapy,while we would also gain novel insights into the microbial *** this paper,we summarize recent research on bacterial phage resistance and phage anti-defense mechanisms,as well as collaborative win-win systems involving both virus and host.

关键词： Bacteriophage Phage resistance Abortive infection Phage therapy