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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China life Sciences 2025年第1期 300-302页

作者： Ze-Min lin Mai Xiang Wen-hui Wei Shu-hui Fan li Chen jie wang Xiao-Qian yang chun-Hao yang Shi-Jun He jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Asymptotic state estimation for linear systems with sensor and actuator faults

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Science China(Information Sciences) 2019年第11期62卷 106-120页

作者： chun-Hua XIE hui yang Dianhui wang Zhe li School of Electrical and Automation Engineering East China Jiaotong University Key Laboratory of Advanced Control & Optimization of jiangxi Province Department of Computer Science and Information Technology La Trobe University College of Electrical and Information Engineering Hunan University

This paper investigates the asymptotic state estimation problem for linear systems with sensor and actuator faults, where the faults are modeled via multiple modes. For the case of sensor faults, we first introduce a new notion of detectability, i.e., detectability of system against sensor faults. The notion helps to address the question of whether it is possible to asymptotically estimate the system state by using the control input and system output, irrespective of which mode the system is in and what values the fault signals are.A necessary and sufficient condition for the system to be detectable against sensor faults is given, and then two switched observers are proposed for asymptotic state estimation with the help of maximin strategy. For the system with ? fault modes, we provide the explicit form of the switched observer, which is based on a bank of ?(?+1)/2 Luenberger-like or sliding-mode observers. Furthermore, extensions to the case of sensor and actuator faults are further studied. Finally, a simulation example of a reduced-order aircraft system is provided to show the effectiveness of the proposed approaches.

关键词： asymptotic state estimation observer linear systems sensor faults actuator faults

The column density structure of Orion A depicted by N-PDF

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Research in Astronomy and Astrophysics 2020年第4期20卷 139-155页

作者： Yue-hui Ma Hong-Chi wang Chong li ji yang Purple Mountain Observatory and Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210033China University of Chinese Academy of Sciences Beijing 100049China School of Astronomy and Space Science University of Science and Technology of ChinaAnhui 230026China

We have conducted a large-field simultaneous survey of 12 CO,13 CO and C18O J=1-0 emission toward the Orion A giant molecular cloud(GMC)with a sky coverage of4.4 deg2 using the Purple Mountain Observatory(PMO)-13.7 m millimeter-wavelength *** use the probability distribution function of the column density(N-PDF)to investigate the distribution of molecular hydrogen in the Orion A *** H2 column density,derived from the 13CO emission,of the GMC is dominated by a log-normal distribution in the range from4×1021 to1.5×1023 cm-2 with excesses both at the low-density and high-density *** excess of the low-density end is possibly caused by an extended and low-temperature(10 K)component with velocities in the range of 5-8 km *** with the northern sub-regions,the southern sub-regions of the Orion A GMC contain less gas with column density in NH2>1.25×1022 *** dispersions of the N-PDFs of the sub-regions are found to correlate with the evolutionary stages of the clouds across the Orion A *** structure hierarchy of Orion A GMC is explored with the DENDROGRAM algorithm,and it is found that the GMC is composed of two *** structures except one in the tree have virial parameters less than 2,indicating self-gravity is important on the spatial scales from0.3 to4 *** power-laws and departures from lognormal distributions are found at the high-density end of N-PDFs for active star-forming regions,the N-PDFs of structures in the Orion A GMC are predominantly lognormal on scales from R0.4 to 4 pc.

关键词： ISM:clouds ISM:individual objects(Orion A) ISM:structure stars:formation surveys turbulence

生物材料促进角膜碱烧伤修复的作用机制和应用途径

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中国组织工程研究 2025年第10期29卷 2162-2170页

作者：肖辉李冬妍汲婧王丽珍北京航空航天大学生物与医学工程学院生物力学与力生物学教育部重点实验室北京市生物医学工程高精尖创新中心北京市100083

背景:在角膜碱烧伤治疗中,传统治疗方法存在多种局限,尤其在控制炎症、预防新生血管形成和抑制角膜瘢痕化方面表现不佳。天然材料、合成材料或复合材料为治疗提供了多元化的选择,然而生物材料促进角膜碱烧伤修复的相关机制尚未形成系统... 详细信息

背景:在角膜碱烧伤治疗中,传统治疗方法存在多种局限,尤其在控制炎症、预防新生血管形成和抑制角膜瘢痕化方面表现不佳。天然材料、合成材料或复合材料为治疗提供了多元化的选择,然而生物材料促进角膜碱烧伤修复的相关机制尚未形成系统深入的认识。目的:对目前生物材料促进角膜碱烧伤修复的国内外研究进行梳理,综述生物材料修复角膜碱烧伤的机制及其应用途径。方法:第一作者以“角膜,碱烧伤,羊膜,透明质酸,胶原,壳聚糖,高分子材料”“Amniotic membrane,Hyaluronic acid,Collagen,Chitosan,Polymer,Cornea,Alkali burn”为关键词在Pub Med、Web of Science、中国知网和万方文献数据库内检索,根据纳入标准和排除标准,最终纳入符合要求的76篇文献进行综述。结果与结论:(1)在角膜碱烧伤修复领域,羊膜、透明质酸、胶原、壳聚糖和可降解高分子材料等生物材料被广泛研究和应用,这些生物材料各有其特点和优缺点,在不同方面都有所突出。(2)首先,羊膜因含丰富的生物活性因子而被认为是最有前景的生物材料之一,其生物相容性良好,并且能够调节角膜炎症反应,但是存在供体短缺和易感染疾病的问题。(3)透明质酸具有良好的保湿性和生物相容性,并且能够提高角膜细胞的生存率和增加角膜透明度。(4)胶原具有良好的生物相容性和支架结构,能够促进角膜细胞的黏附和增殖,促进角膜组织结构的重建。(5)壳聚糖具有良好的生物相容性和可降解性,可作为载体用于药物递送和细胞移植。(6)可降解高分子材料具有较好的降解可控性,可为角膜碱烧伤的修复提供良好的支持和递送平台,但其稳定性和生物相容性仍需进一步研究。(7)综合来看,目前还没有一种生物材料能够完全解决角膜碱烧伤的修复问题,每种生物材料都有其特定的适用场景和局限性。(8)未来的研究方向应该是通过进一步改进生物材料的性能和结构,探索更有效的组合应用方式,以及深入了解生物材料与角膜组织的相互作用机制,以提高角膜碱烧伤的治疗效果和患者的生活质量。

关键词：角膜碱烧伤生物材料修复机制羊膜透明质酸壳聚糖高分子材料综述

Influence of Deformation Degree and Cooling Rate on Microstructure and Phase Transformation Temperature of B1500HS Steel

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Acta Metallurgica Sinica(English Letters) 2018年第1期31卷 33-47页

作者： hui-Ping li Rui jiang lian-Fang He hui yang Cheng wang chun-Zhi Zhang School of Materials Science and Engineering Shandong University of Science and Technology

To study the effects of the deformation degree and cooling rate on the microstructure and phase transformation temperature for the B 1500HS steel, the samples were heated at 900 ℃ for 5 min, compressed by 10, 20, 30 and 40% at the strain rate of 0.1 s^-1, and then cooled down at the rates of 50, 40, 25, 20 and 15 ℃/s by the thermo-mechanical simulator, respectively. The start and finish temperatures of the phase transformation were determined by the tangent method, and the volume fraction of the phase transformation was ascertained by the level principle according to the dilatometric curves. The volume fraction of the retained austenite was determined by X-ray diffraction. The results show that the volume fraction of the bainite rises with an increase in the deformation degree as the cooling rate is lower than the critical rate. At the same cooling rate, the phase transformation temperature rises with an increase in the deformation degree, and the sizes of both the martensite and bainite phases reduce due to the austenite grain refinement induced by the deformation. The volume fraction of the retained austenite reduces as the deformation degree increases. The critical cooling rate of the undeformed samples is approximately 25 ℃/s and the critical cooling rate rises as the deformation degree increases.

关键词： Deformation Cooling rate Microstructure Phase transformation temperature

An amplitude-preserved adaptive focused beam seismic migration method

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Petroleum Science 2015年第3期12卷 417-427页

作者： ji-Dong yang jian-Ping Huang Xin wang Zhen-chun li School of Geoscience China University of PetroleumQingdao

Gaussian beam migration （GBM） is an effec- tive and robust depth seismic imaging method, which overcomes the disadvantage of Kirchhoff migration in imaging multiple arrivals and has no steep-dip limitation of one-way wave equation migration. However, its imaging quality depends on the initial beam parameters, which can make the beam width increase and wave-front spread with the propagation of the central ray, resulting in poor migration accuracy at depth, especially for exploration areas with complex geological structures. To address this problem, we present an adaptive focused beam method for shot-domain prestack depth migration. Using the infor- mation of the input smooth velocity field, we first derive an adaptive focused parameter, which makes a seismic beam focused along the whole central ray to enhance the wave- field construction accuracy in both the shallow and deep regions. Then we introduce this parameter into the GBM, which not only improves imaging quality of deep reflectors but also makes the shallow small-scale geological struc- tures well-defined. As well, using the amplitude-preserved extrapolation operator and deconvolution imaging condi- tion, the concept of amplitude-preserved imaging has been included in our method. Typical numerical examples and the field data processing results demonstrate the validity and adaptability of our method.

关键词： Keywords Gaussian beam Adaptive focused beam Amplitude-preserved migration Depth imaging

Triggering mechanism and dynamic process of water-rock flow in Nanfen waste dump in 2010

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Journal of Mountain Science 2021年第10期18卷 2565-2579页

作者： CAO chun-hui FENG ji-li TAO Zhi-gang State Key Laboratory for Deep Geomechanics and Underground Engineering China University of Mining and Technology BeijingBeijing 100083China School of Mechanics and Civil Engineering China University of Mining and Technology BeijingBeijing 100083China

Water-rock flow is a kind of debris flow with more coarse particles and low viscosity, which occurs in many areas of the world. In this work, the water-rock flow that occurred on May 24, 2010, at Nanfen’s open-pit mine of China was investigated by combining field investigation, meteorological and hydrological survey with numerical simulation to understand its triggering mechanism and dynamic process. The field data shows that the short-term high-intensity rainfall is the most direct inducement to trigger water-rock flow in the waste dump. The loose shallow gravel soil and the V-shaped valley with a certain slope provide the necessary conditions of the occurrence of water-rock flow in the waste dump. Moreover, the possibility criterion of water-rock flow is presented by analyzing the historical rainfall data. In addition, the smoothed particle hydrodynamics(SPH) method was employed to simulate the waterrock flow under the conditions of Newtonian fluid with uniform distribution of water and coarse-grained materials. The simulating results show that the flow distance, velocity, shape, and deposition profile of water-rock flow are in good agreement with the field observation. The present work is beneficial to the risk assessment and mitigation design of water-rock flow disaster in the waste dump.

关键词： Water-rock flow Waste dump Triggering mechanism Smoothed particle hydrodynamics Rainfall intensity

Thermopressure Coupling Effect Mimicking Natural Graphite Formation to Enhance the Storage K-Ion Performance of Carbonaceous Heterostructures

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Research 2023年第4期2023卷 379-389页

作者： Tianyi ji Xiaoxu liu hui wang Yunli Shi yang li Man Zhang Junqi li hui liu Ze Xiang Shen Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic Materials School of Material Science and EngineeringShaanxi University of Science and TechnologyXi’an 710021ShaanxiChina Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore

Borrowing from natural mechanisms for material design can lead to functional mimicry and *** by graphite formation,a thermopressure coupling strategy under micropressure(<400 Pa)is applied to prepare carbon anodes.A t... 详细信息

Borrowing from natural mechanisms for material design can lead to functional mimicry and *** by graphite formation,a thermopressure coupling strategy under micropressure(lied to prepare carbon anodes.A thermopressure response is discovered based on the cellulose ***,homologous graphene quantum dot/hard carbon(GQD/HC)heterostructures are *** 181.4 Pa and 1,200°C,the product shows a capacity of 310 mAh g^(−1),while the capacity of the direct carbonization product is only 120 mAh g^(−1).Prominently,the GQD/HC heterostructure displays marked mechanical strength and *** experimental and theoretical results illustrate the ion and electron transfer,coordination environment,and electronic states in the GQD/HC heterostructure and elaborate on the origin of the enhanced *** thermopressure coupling under micropressure mimics graphite formation,but the heterostructure has better properties than traditional carbon ***,micropressure injects new vitality into material research.

关键词： coupling Coupling Carbon

Strain-controlled fatigue characteristics of a cast Mg-Nd-Zn under peak-aged and over-aged conditions

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Rare Metals 2023年第7期42卷 2381-2389页

作者： Zhen-Ming li ji-chun Dai Bao-liang liu hui Zou ji-Peng Pan Institute of Sci-technology Strategy Jiangxi Academy of SciencesNanchang330096China Zhejiang jinfei Kaida Wheel Co. LtdJinhua321000China Research Institute(R&D Center) Shanghai JuneBang Technology CorporationShanghai200032China National Engineering Research Center of light Alloy Net Forming Shanghai200240China National Engineering Research Center of light Alloy Net Forming Shanghai Jiao Tong UniversityShanghai200240China

Strain-controlled fatigue characteristics of peakaged and over-aged Mg_(96.47)Nd_(2.9)Zn_(0.21)magnesium alloys containing 0.42Zr,including stress response,strain resistance,hysteresis loops,strain-life and corresponding lowcycle fatigue life prediction model,were *** the peak-aged state(T61:540℃×8 h+200℃×14 h),the alloy shows higher cyclic stress response,but lower ductility than the alloy in the over-aged state(T6_(2):540℃×8 h+200℃×400 h).The yield strength and ultimate tensile strength of the alloy under T6_(1)-and T6_(2)-treated conditions are *** with T6_(1)-treated alloy,the steady stress amplitude occurred in T6_(2)-treated alloy is due to higher ductility and more homogenous *** T6_(1)state,the fatigue cracks in the alloy first initiate along the cracked persistent slip bands and then propagate in the trans-granular mode,while in the T6_(2)state,the fatigue cracks initiate along grain boundaries and then propagate in the inter-granular mode.

关键词： Mg-Nd-Zn alloy Strain-controlled fatigue Peak-aged and over-aged conditions Hysteresis energy