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小肠镜检查技术在儿童小肠病变中的诊断及治疗价值

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中国实用儿科杂志 2018年第11期33卷 858-862页

作者：王玉环黄瑛复旦大学附属儿科医院消化科上海201102

小肠镜在成人小肠疾病中有很高的诊断和治疗价值,是一种安全有效的检查和治疗手段。但小肠镜在儿童中应用较少,目前小肠镜被用于儿童不明原因消化道出血、小肠息肉、克罗恩病、小肠狭窄、胆道狭窄等的诊断和治疗,该文介绍了小肠镜检查... 详细信息

小肠镜在成人小肠疾病中有很高的诊断和治疗价值,是一种安全有效的检查和治疗手段。但小肠镜在儿童中应用较少,目前小肠镜被用于儿童不明原因消化道出血、小肠息肉、克罗恩病、小肠狭窄、胆道狭窄等的诊断和治疗,该文介绍了小肠镜检查技术在儿童小肠疾病中的临床应用。

关键词：双气囊小肠镜单气囊小肠镜不明原因消化道出血小肠息肉克罗恩病儿童

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双列圆锥滚子轮毂轴承内圈挡边的设计改进

轴承 2005年第4期 4-5页

作者：邹德鹏王玉环瓦房店通用轴承有限公司辽宁瓦房店116300

双列圆锥滚子汽车轮毂轴承为双内圈无隔圈结构 ,通过分析内圈宽度对轴承轴向游隙的影响 ,探讨了在无内隔圈调整的情况下。

关键词：双列圆锥滚子轴承轮毂轴承内圈挡边宽度设计

新生代农民工参政行为影响因素分析——以江苏省为例

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安徽师范大学学报（社会科学版） 2013年第6期41卷 691-697页

作者：郑永兰王环宇南京农业大学公共管理学院南京210014

从发现新生代农民工参政行为的影响因素入手,分析得出新生代农民工参政行为影响因素的三层级清单,运用对数线性模型logit过程分析这些因素如何影响新生代农民工的参政行为,在此基础上对结果进行阐释,提出促进新生代农民工参政行为的对... 详细信息

从发现新生代农民工参政行为的影响因素入手,分析得出新生代农民工参政行为影响因素的三层级清单,运用对数线性模型logit过程分析这些因素如何影响新生代农民工的参政行为,在此基础上对结果进行阐释,提出促进新生代农民工参政行为的对策建议。

关键词：新生代农民工参政行为影响因素

1,3-双(2-(2,2-二氰乙烯基)苯氧基)-2-丙醇及其银(Ⅰ)配合物的合成、晶体结构及其荧光性质（英文）

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无机化学学报 2015年第2期31卷 353-360页

作者：张奇龙王焕宇胡鹏朱必学贵阳医学院化学教研室贵阳550004 贵州省大环化学及超分子化学重点实验室贵阳550025

用1,3-双(2-甲酰基苯氧基)-2-丙醇和丙二腈进行反应得到1,3-双(2-(2,2-二氰乙烯基)苯氧基)-2-丙醇配体L,然后将配体与Ag Sb F6进行配位反应,得到配合物[Ag LSb F6]n·n CHCl3(1),并用元素分析,FTIR和X-射线单晶衍射进行了表征。结果表明... 详细信息

用1,3-双(2-甲酰基苯氧基)-2-丙醇和丙二腈进行反应得到1,3-双(2-(2,2-二氰乙烯基)苯氧基)-2-丙醇配体L,然后将配体与Ag Sb F6进行配位反应,得到配合物[Ag LSb F6]n·n CHCl3(1),并用元素分析,FTIR和X-射线单晶衍射进行了表征。结果表明,配体L属于单斜晶系,空间群P21/n,晶体学参数:a=0.990 2(11)nm,b=2.181(2)nm,c=1.012 2(11)nm,β=109.374(10)°,V=2.062(4)nm3,Z=4,Dc=1.277 g·cm-3,Mr=396.40,μ=0.087 mm-1,F(000)=824,R1=0.064 2,w R2=0.117 4(I>2σ(I))。配合物1属于单斜晶系,空间群P21/n,晶体学参数:a=1.270 57(11)nm,b=1.456 44(13)nm,c=1.669 85(14)nm,β=105.643(3)°,V=2.975 6(4)nm 3,Z=4,Dc=1.918 g·cm-3,Mr=859.39,μ=1.907 mm-1,F(000)=1 664,R1=0.0417,w R2=0.1 032(I>2σ(I))。在配合物1中,配体L表现为四齿配体分别与4个银(Ⅰ)离子配位,同时,每一个银(Ⅰ)离子与4个相邻配体配位形成2D层状结构。同时,研究了配体和配合物的固体荧光性质。

关键词： 1,3-双(2-(2,2-二氰乙烯基)苯氧基)-2-丙醇晶体结构 Ag(Ⅰ)配合物荧光性质

Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai wang Yanbo Liang Chao wang yunhong Zhang Hong Liu yu Zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2025年第1期68卷 249-262页

作者： Jinliang wang Wenyong Zhou yu Xu Jianchun Duan Qiaoxia Zhou Guoqiang wang Leo Li Chunwei Xu Wenxian wang Shangli Cai Zhijie wang Jie wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for ancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers,the non-squamous and squamous subtypes（nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor（ICI）-based *** our inhouse training cohort（n=85）,the presence of the LRP1B deleterious mutation（LRP1B-del） was associated with longer and shorter progression-free survival（PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteraction<0.001).Multiplex immunofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+T cells in nsqNSCLCs（P=0.040） and sqNSCLCs（P=0.014）,*** the POPLAR/OAK cohort,nsqNSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel(hazard ratio（HR）=0.70,P=0.046),whereas this benefit was negligible in those without LRP1B-del（HR=1.05,P=0.64）.Conversely,sqNSCLCs without LRP1B-del benefited more from atezolizumab（HR=0.60,P=0.002） than those with LRP1B-del（HR=1.30,P=0.31）.Consistent results were observed in the in-house CHOICE-01 cohort,in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone(Pinteraction=0.008).This multi-cohort study delineates the antithetical impacts of LRP1B-del in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

关键词： non-squamous NSCLC squamous NSCLC LRP1B deleterious mutations predictive biomarker immune checkpoint inhibitor

Modeling and control of a rigid-flexible coupling robot for narrow space manipulations

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Science China Technological Sciences 2025年

作者： Kuangda CHEN huan ZHAO Jiexin ZHANG Mei FENG Yiwei wang Jinliang wang Han DING State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and Technology Key Laboratory of CNC Equipment Reliability Ministry of Education Jilin University School of Medical Equipment Science and Engineering Huazhong University of Science and Technology

Narrow space manipulations are crucial for equipment maintenance, as they eliminate the need for disassembly, thus reducing costs and increasing efficiency. Cable-driven flexible robots possess exceptional capabilities in maneuvering through narrow spaces, thanks to their interaction compliance and distal dexterity. However, their inherent low stiffness causes a decline in the location accuracy of the robot and could even lead to manipulation failure. To address this challenge, this paper proposes a novel type of rigid-flexible coupling robot, which increases the stiffness of the robot while ensuring the reachability within a narrow space. To achieve high-accuracy location in a narrow space, kinematic and control methods are proposed. Specifically,the robot forward kinematics are uniformly represented, and the closed-form inverse kinematics solution is derived. Furthermore, in cases where the robot?s structure fails to align with Pieper?s solution, a two-stage search strategy is utilized to solve the inverse kinematics, resulting in a high success rate of 99.1%. Based on the proposed kinematics, a rigid-dominated control method is then proposed to facilitate localization and pose alignment of target objects in narrow spaces. The practical comparative experiments show that the proposed robot has the capability of high accuracy control in narrow spaces.

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差异表达微RNA作为多囊卵巢综合征生物标志物的研究

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上海交通大学学报（医学版） 2021年第11期41卷 1429-1435页

作者：王昱欢丁奕岑蔡瑶雨康亚妮上海交通大学生物医学工程学院上海200240 上海交通大学医学院上海200025

目的·探索可作为多囊卵巢综合征(polycystic ovary syndrome,PCOS)生物标志物的微RNA (microRNA,miRNA)及其在PCOS发病机制中的生物学意义。方法·选取上海交通大学医学院附属仁济医院2019年1月—10月收治的5例PCOS患者为观察组,另选取... 详细信息

目的·探索可作为多囊卵巢综合征(polycystic ovary syndrome,PCOS)生物标志物的微RNA (microRNA,miRNA)及其在PCOS发病机制中的生物学意义。方法·选取上海交通大学医学院附属仁济医院2019年1月—10月收治的5例PCOS患者为观察组,另选取5例体检健康女性作为对照组。采集2组的颗粒细胞,用TRIzol法从中提取RNA,利用TruSeq Small RNA Library Prep试剂盒构建miRNA-seq文库,文库质检合格后用NextSeq500进行高通量测序,对测序结果进行生物信息学数据分析。采用RT-qPCR实验检验候选miRNA标志物是否存在差异表达。结果·分析获得颗粒细胞中20条差异表达miRNA (均P<0.05),其中miR-196a-5p、miR-10a-5p和miR-451a表达显著上调,miR-877-5p和miR-2355-5p表达显著下调,这些差异表达miRNA及其靶基因可能参与PCOS发生发展的转录调控机制。结论·差异表达miRNA具有作为PCOS生物标志物的潜能,并参与PCOS的发生发展。

关键词：微RNA 生物标志物多囊卵巢综合征基因表达靶基因

粒子激发X射线谱仪月夜生存装置的热设计和热仿真计算

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宇航学报 2014年第1期35卷 115-118页

作者：张家宇王焕玉崔兴柱彭文溪中国科学院高能研究所北京100049 中国科学院光电研究院北京100094

粒子激发X射线谱仪(APXS)安装在月面巡视器外部,为了适应月夜时段月面长时间的低温环境,设计了APXS专用的月夜生存装置来保证仪器长时间低温环境下的存储温度要求。该装置采用放射性同位素加热单元(RHU)作为热源,通过对APXS散热面持续... 详细信息

粒子激发X射线谱仪(APXS)安装在月面巡视器外部,为了适应月夜时段月面长时间的低温环境,设计了APXS专用的月夜生存装置来保证仪器长时间低温环境下的存储温度要求。该装置采用放射性同位素加热单元(RHU)作为热源,通过对APXS散热面持续不断的辐射加热,实现仪器的低温存储温度要求。由热仿真计算结果可知,月夜时段APXS的最低存储温度约为-103℃,计算结果高于其能够承受的最低存储温度,并且APXS热平衡试验校验了该热控设计的正确性。

关键词：粒子激发X射线谱仪月夜生存装置外热流存储温度热设计热仿真计算