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On island landscape pattern of forests in Helan Mountain and its cause of formation

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Science China(Technological Sciences) 2006年第Z1期49卷 45-53页

作者： DENG hongbing wang Yingming ZHANG Qiaoxian YAN Yan State Key Lab of Systems Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China State Key Lab of Systems Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China State Key Lab of Systems Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China State Key Lab of Systems Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Based on the spatial information techniques such as RS, GIS, and GPS, the forest landscape patterns in the Helan Mountain, western China, were studied. The Landsat 5 TM data were used to classify the forest landscapes through RS digital cartography, and then, the landscape characteristics and landscape pattern were analyzed quantificationally. Furthermore, through spatial data collection and spatial analysis of the main disturbances in this area, the cause of landscape formation was studied. The results showed that the total 1177 forest landscape patches could be classified into 21 landscape types, and the forest landscape in the Helan Mountain was island pattern, which was encircled by deserta as matrix. The values of landscape diversity index and landscape fragmentation index were 2.61 and 0.43, respectively. In this area, the landscape pattern was clearly formed and continuously changed in response to geological processes, climate, activities of organisms, forest fire, desertification, human activities and so on. This landscape pattern had an obviously negative effect on the stability and ecosystem services of forests. So, scientific landscape planning and protection should be adopted to improve the sustainability of forest management in this area.

关键词： landscape pattern, island landscape of forest, disturbance, Helan Mountain.

Thermal Stability and Electrochemical Properties of Separators for Lithium-ion Batteries

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Journal of Wuhan University of Technology(Materials Science) 2023年第6期38卷 1231-1241页

作者： YI Guangyuan XU Caiyun LIU Wan QU Deyu wang hongbing TANG Haolin State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Department of Chemistry Wuhan University of TechnologyWuhan 430070China Wuhan Huiqiang New Energy Materials Technology Co. LtdWuhan 430070China

The mechanical properties,contact angle,thermomechanical and electrochemical properties of PE,PVDF,and ceramic separators were *** experimental results show that the PE separator has the largest porosity,the PVDF separator has the best mechanical properties,wettability,and heat *** kinds of separators were assembled into lithium-ion batteries for electrochemical *** them,the PE separator has the best rate performance,and the ceramic separator has poor performance in charge-discharge *** the same time,the PE and ceramic separators were tested with different amounts of electrolytes at room temperature and a high temperature,and it is found that the capacity of the PE separator is higher at room temperature,while the performance of the ceramic separator is better at a high *** amount of electrolyte also has a certain influence on its electrochemical performance.

关键词： lithium-ion battery separator tensile strength electrochemical performance

Insights into CYP2B6-mediated drug–drug interactions

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Acta Pharmaceutica Sinica B 2016年第5期6卷 413-425页

作者： William D.Hedrich Hazem E.Hassan hongbing wang Department of Pharmaceutical Sciences University of Maryland School of Pharmacy

Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug metabolism than was previously *** discovery of multiple important substrates of CYP2B6 as well as polymorphic differences has sparked increasing interest in the genetic and xenobiotic factors contributing to the expression and function of the *** expression of CYP2B6 is regulated primarily by the xenobiotic receptors constitutive androstane receptor(CAR) and pregnane X receptor(PXR) in the *** addition to CYP2B6,these receptors also mediate the inductive expression of CYP3A4,and a number of important phase II enzymes and drug ***2B6 has been demonstrated to play a role in the metabolism of 2%–10% of clinically used drugs including widely used antineoplastic agents cyclophosphamide and ifosfamide,anesthetics propofol and ketamine,synthetic opioids pethidine and methadone,and the antiretrovirals nevirapine and efavirenz,among *** inter-individual variability in the expression and function of the human CYP2B6 gene exists and can result in altered clinical outcomes in patients receiving treatment with CYP2B6-substrate *** variances arise from a number of sources including genetic polymorphism,and xenobiotic *** this review,we will provide an overview of the key players in CYP2B6 expression and function and highlight recent advances made in assessing clinical ramifications of important CYP2B6-mediated drug–drug interactions.

关键词： CYP2B6 CAR PXR Polymorphism Drug–drug interaction Cyclophosphamide Efavirenz

In-Situ HP-STM and Operando EC-STM Studies of Heterogeneous Catalysis at Interfaces

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Chinese Journal of Structural Chemistry 2022年第10期41卷 29-44页

作者： Lei Xie Chaoqin Huang Zhaofeng Liang hongbing wang Zheng Jiang Fei Song Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201000China University of Chinese Academy of Sciences Bejing 101000China

Heterogeneous catalysis taking place at solid interfaces plays a crucial role not only in industrial chemical production, energy conversion but also in fundamental research. The dynamic evolution of surface morphology and composition requires full understanding especially under realistic reaction conditions. To this end, conventional scanning tunneling microscopy(STM) has been integrated with high pressure cell and electrochemical cell, forming high pressure(HP) STM and electrochemical(EC) STM for the in-situ/operando characterization at solid-gas and solid-liquid interfaces with atomic resolution, respectively. In this review, we attempt to give a brief introduction to the development and working principle of these two techniques and subsequently summarize several representative progresses in recent days. The dynamic changes in active sites, surface reconstruction, absorbates alteration and products formation are directly characterized in a combination with other surface sensitive technologies. The correlation between surface structures and catalytic performance as well as the underlying mechanism can thus be unraveled, which provides insights into the rational design and optimization of catalysts.

关键词： HP-STM EC-STM heterogeneous catalysis in-situ operando interfaces

Function of Ca^(2+)-/calmodulin-dependent protein kinase Ⅳ in Ca^(2+)-stimulated neuronal signaling and behavior

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Science China(Life Sciences) 2015年第1期58卷 6-13页

作者： SONG ZiXiang CHEN Qi DING Qi ZHENG Fei LI ChengWei XU LePing wang hongbing Department of Adolescent Psychiatry and Behavioral Therapy Heping Hospital Changzhou Department of Physiology Michigan State University Department of Biochemistry and Molecular Biology Michigan State University College of Life Science and Agronomy Zhoukou Normal University Neuroscience Program Michigan State University

The activity of Ca2+/calmodulin-dependent protein kinase IV(Ca MKIV) is sensitive to activity-dependent changes in the level of intracellular Ca2+.Following neuronal stimulation,the activation of Ca MKIV may trigger synaptic modifications and transcriptional responses,both of which are involved in regulating cognitive and emotional ***,we used Ca MKIV knockout(KO) neurons and mice to examine the function of Ca MKIV in Ca2+-stimulated intracellular signaling and animal behavior,*** NMDA receptor activation or membrane depolarization,the up-regulation of CREB(c AMP responsive element binding protein) and its target gene Bdnf(brain-derived neurotrophic factor) was intact in cortical neurons obtained from Ca MKIV KO *** MKIV KO mice displayed severe impairment in contextual fear memory but normal locomotor activity and anxiety level in the contextual training *** Ca MKIV KO mice showed normal memory in the standard passive avoidance task,they were defective in learning the temporal dissociative passive avoidance *** indicated by the light/dark test and marble-burying test data,Ca MKIV KO mice showed less anxiety and normal *** the voluntary wheel-running test,Ca MKIV KO mice showed normal running time and distance but higher maximal running *** results demonstrate the function of Ca MKIV in regulating different forms of fear memory,anxiety,and certain aspect of motor function.

关键词： animal behavior calmodulin CREB ERK1/2 intracellular signaling learning and memory

Clinical Efficacy and Safety Analysis of Tigecycline in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Combined with Multidrug-Resistant Acinetobacter baumannii Infection

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Journal of Clinical and Nursing Research 2024年第5期8卷 194-199页

作者： hongbing wang Nantong RICH Hospital Nantong 226000Jiangsu ProvinceChina

Objective:To study the clinical efficacy and safety of tigecycline in the treatment of acute exacerbation of chronic obstructive pulmonary disease(COPD)combined with multidrug-resistant Acinetobacter baumannii ***:113 patients with acute exacerbation of COPD combined with multidrug-resistant Acinetobacter baumannii infection were recruited between January 2021 and January 2023,and given tigecycline *** total effective rate,lung function indexes,related biochemical index levels,and the incidence rate of adverse reactions were observed after the ***:After the treatment,100 patients were cured,1 case with apparent effect,2 cases were effective,10 cases were ineffective,and the total effective rate was 91.15%.The post-treatment CRP(21.22±3.35 mg/L),PCT(3.18±1.11 ng/L),CRE(76.36±9.24μmol/L),and ALT(37.76±6.99 U/L)were significantly improved as compared to the pre-treatment(P<0.05).After treatment,10 cases of vomiting(8.85%),13 cases of nausea(11.50%),4 cases of diarrhea(3.53%),1 case of abdominal pain(0.88%),and 2 cases of allergy(1.77%)were observed in 113 ***:Tigecycline therapy for patients with acute exacerbation of COPD combined with multidrug-resistant Acinetobacter baumannii infection not only has significant therapeutic efficacy but also has a high degree of safety.

关键词： Tigecycline Chronic obstructive pulmonary disease Acute exacerbation Multidrug-resistant Acinetobacter baumannii infection

Facile synthesis of nanosized spinel high entropy oxide (FeCoNiCrMn)_(3)O_(4) for efficient oxygen evolution reaction

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Journal of Materiomics 2024年第4期10卷 919-927页

作者： Bomin Feng Jun Chen Yifei Yang Mao Yang hongbing wang Changyin Zhong Xiaochong Zhao Yunxi Yao Institute of Materials China Academy of Engineering PhysicsJiangyou621908China

The sluggish reaction kinetics of oxygen evolution reaction(OER)and the high price of noble metal catalysts hinder the wide application of water electrolysis for hydrogen ***-entropy oxides(HEOs)with multi-components and high entropy stabilized structures have attracted great research interests due to their efficient and durable performance in electrolytic water splitting ***,the development of efficient HEO electrocatalysts are often hindered by the limited surface exposed active sites because high temperature is usually required to form a high entropy stabilized ***,a flaky high-entropy oxide with a spinel structure,(FeCoNiCrMn)_(3)O_(4),was synthesized by using the sacrificial layered carbon template in situ prepared by the volatile reaction between ammonium sulfate and molten ***-resolution TEM results show the as-prepared(FeCoNiCrMn)_(3)O_(4) flakes are composed of nanosized HEO *** nanosized(FeCoNiCrMn)_(3)O_(4) HEO electrocatalysts exhibit excellent OER activity,with an overpotential of 239 mV at 10 mA/cm^(2) and a Tafel slope of 52.4 mV/*** electrocatalyst has excellent *** at a high current density of 100 mA/cm^(2),the activity remains unchanged during the stability test for 24 *** results here shed a new light in the design and fabrication of highly efficient HEO electrocatalysts.

关键词： High entropy oxides Oxygen evolution reaction Spinel oxide Millard reaction Electrocatalyst

Carbon Dioxide Captured from Flue Gas by Modified Ca-based Sorbents in Fixed-bed Reactor at High Temperature

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Chinese Journal of Chemical Engineering 2013年第2期21卷 199-204页

作者： YANG Lei YU hongbing wang Shengqiang wang Haowen ZHOU Qibin College of Environmental Science and Engineering Nankai University Tianjin 300071 China

Four kinds of Ca-based sorbents were prepared by calcination and hydration reactions using different precursors： calcium hydroxide, calcium carbonate, calcium acetate monohydrate and calcium oxide. The CO2 absorption capacity of those sorbents was investigated in a fixed-bed reactor in the temperature range of 350-650 ℃. It was found that all of those sorbents showed higher capacity for CO2 absorption when the operating temperature higher than 450 ℃. The CaAc2-CaO sorbent showed the highest CO2 absorption capacity of 299 mg.g-1. The mor- phology of those sorbents was examined by scanning electron microscope （SEM）, and the changes of composition before and after carbonation were also determined by X-ray diffraction （XRD）. Results indicated that those sorbents have the similar chemical compositions and crystalline phases before carbonation reaction [mainly Ca（OH）2], and CaCO3 is the main component after carbonation reaction. The SEM morphology shows clearly that the sorbent pores were filled with reaction products after carbonation reaction, and became much denser than before. The N2 adsorption-desorption isotherms indicated that the CaAc2-CaO and CaCO3-CaO sorbents have higher specific surface area. lar2er oore volume and anoropriate pore size distribution than that of CaO-CaO and Ca（OH）2-CaO.

关键词： CO2 capture carbonation reaction fixed-bed reactor multicycle reaction

Oxazaphosphorine bioactivation and detoxification: the role of xenobiotic receptors

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Acta Pharmaceutica Sinica B 2012年第2期2卷 107-117页

作者： Duan wang hongbing wang Department of Pharmaceutical Sciences School of PharmacyUniversity of MarylandBaltimoreUSA

Oxazaphosphorines,with the most representative members including cyclophosphamide,ifosfamide,and trofosfamide,constitute a class of alkylating agents that have a broad spectrum of anticancer activity against many malignant ailments including both solid tumors such as breast cancer and hematological malignancies such as leukemia and *** oxazaphosphorines are prodrugs that require hepatic cytochrome P450 enzymes to generate active alkylating moieties before manifesting their chemotherapeutic ***,oxazaphosphorines can also be transformed into non-therapeutic byproducts by various drug-metabolizing ***,oxazaphosphorines are often administered in combination with other chemotherapeutics in adjuvant *** such,the therapeutic efficacy,off-target toxicity,and unintentional drug–drug interactions of oxazaphosphorines have been long-lasting clinical concerns and heightened focuses of scientific *** evidence suggests that xenobiotic receptors may play important roles in regulating the metabolism and clearance of *** as modulators of xenobiotic receptors can affect the therapeutic efficacy,cytotoxicity,and pharmacokinetics of coadministered oxazaphosphorines,providing a new molecular mechanism of drug–drug ***,we review current advances regarding the influence of xenobiotic receptors,particularly,the constitutive androstane receptor,the pregnane X receptor and the aryl hydrocarbon receptor,on the bioactivation and detoxification of oxazaphosphorines,with a focus on cyclophosphamide and ifosfamide.

关键词： Oxazaphosphorine Cyclophosphamide Ifosfamide CAR PXR CYP2B6