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Visualization analysis of research hotspots and trends on gastrointestinal tumor organoids

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2826-2841页

作者： gang wang Tao liu wen-Ting He School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Digestive System Tumor Prevention and Treatment and Translational Medicine Engineering Innovation Center of Lanzhou University Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Digestive System Tumor Translational Medicine Engineering Research Center of Gansu Province Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The Second Hospital&Clinical Medical School Lanzhou UniversityLanzhou 730030Gansu ProvinceChina

BACKGROUND Gastrointestinal tumor organoids serve as an effective model for simulating cancer in vitro and have been applied in basic biology and preclinical *** over a decade of development and increasing research achievements in this field,a systematic and comprehensive analysis of the research hotspots and future trends is *** To address this problem by employing bibliometric tools to explore the publication years,countries/regions,institutions,journals,authors,keywords,and references in this *** The literature was collected from Web of Science ***-6.2R4,a widely used bibliometric analysis software package,was used for institutional analysis and reference burst *** 1.6.19 was used for journal cocitation analysis,author co-authorship and co-citation ***‘online platform for bibliometric analysis(https://***/app)’was used to assess the total number of publications and the cooperation relationships between ***,we employed the bibliometric R software package(version R.4.3.1)in R-studio,for a comprehensive scientific analysis of the *** Our analysis included a total of 1466 publications,revealing a significant yearly increase in articles on the study of gastrointestinal tumor *** United States(n=393)and Helmholtz Association(n=93)have emerged as the leading countries and institutions,respectively,in this field,with Hans Clevers and Toshiro Sato being the most contributing *** most influential journal in this field is *** most impactful reference is"Long term expansion of epithelial organs from human colon,adenoma,adenocarcinoma,and Barrett's epithelium".Keywords analysis and citation burst analysis indicate that precision medicine,disease modeling,drug development and screening,and regenerative medicine are the most cutting-edge *** focal points were further detailed based on the *** This bibl

关键词： Gastrointestinal tumor organoids Bibliometric analysis Drug development and screening Model CiteSpace

Exploring a new path of green and efficient utilization of sinter return fine to produce composite pellets

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Journal of Iron and Steel Research International 2024年第7期31卷 1610-1622页

作者： Yan-biao Chen wen-guo liu Hao Guo Jing-song wang Qing-guo Xue Hai-bin Zuo State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China MCC Capital Engineering and Research Incorporation Limited Beijing 100176China

Efficient utilization of sinter return fine is an important measure to reduce cost,increase efficiency,save energy and reduce emission.A new path of green and efficient utilization of return fine was proposed to produce composite *** metallurgical properties of composite pellets under the condition of hydrogen-rich blast furnace were *** experimental results indicate that the coated concentrate was consolidated for the composite pellets through normal Fe_(2)O_(3) *** the surface of core return fine,the liquid phase formed due to its low-melting point,assimilated the adjacent concentrate,and then consolidated with the temperature *** with regular pellets,the com-pressive strength and reduction swelling index of composite pellets were decreased,but the reducibility index and softening-melting properties were *** addition,the reduction degradation index of composite pellets was sig-nificantly higher than that of ***,adding composite pellets was conducive to indirect reduction in blast furnace,reducing fuel ratio and improving production *** to the effect of the roasting system on the metallurgical properties,the roasting temperature and time were determined as 1250℃and 30 min,*** composite pellets can be produced under the traditional pelletizing process.

关键词： Sinter Return fine Composite pellet Roasting system Metallurgical property Hydrogen-rich blast furnace

A Correlation-Based Stochastic Model for Massive MIMO Channel

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China Communications 2024年第1期21卷 175-187页

作者： Yang liu gang Li Chengxiang wang National Mobile Communications Research Laboratory School of Information Science and EngineeringSoutheast UniversityNanjing 211189China School of Internet of Things Engineering Jiangnan UniversityWuxi 214122China Pervasive Communication Research Center Purple Mountain LaboratoriesNanjing 211111China

In this paper,the channel impulse response matrix(CIRM)can be expressed as a sum of couplings between the steering vectors at the base station(BS)and the eigenbases at the mobile station(MS).Nakagami distribution was used to describe the fading of the coupling between the steering vectors and the *** measurements were carried out to evaluate the performance of this proposed ***,the physical implications of this model were illustrated and the capacities are *** addition,the azimuthal power spectrum(APS)of several models was ***,the channel hardening effect was simulated and *** showed that the proposed model provides a better fit to the measured results than the other CBSM,i.e.,Weichselberger ***,the proposed model can provide better tradeoff between accuracy and complexity in channel *** CIRM model can be used for massive MIMO design in the future communication system design.

关键词： CBSM channel capacity channel hardening channel modeling massive MIMO

Online estimation and characteristic analysis of double nugget diameters during aluminum/steel resistance spot welding process

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Journal of Iron and Steel Research International 2024年第8期31卷 2053-2067页

作者： Kang Zhou wen-xiao Yu Bao-kai Ren gang wang School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China

Online estimation of the double nugget diameters was performed by means of a back propagation neural *** double nugget diameters were obtained using actual welding experiment and numerical simulation,according to different characteristics of aluminum nugget and steel *** input of the neural network was some key characteristic parameters extracted from dynamic power signal,which were peak point,knee point and their variation rate over time,as well as heat energy delivered into the welding *** architecture of the neural network was confirmed by confirming the number of neurons in hidden layer through a series of *** key parameters of the neural network were obtained by means of training 81 arrays of data ***,the neural network was used to test the remaining 20 arrays of verifying data set,and the results showed that both of the mean errors for the two nugget diameters were below 3%.In addition,corresponding analyses showed that the accuracy of two nugget diameters was higher than that of tensile-shear strength.

关键词： Resistance spot welding Aluminum Steel Double nugget Dynamic power signal.Neural network

Vibration attenuation performance of wind turbine tower using a prestressed tuned mass damper under seismic excitation

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 511-524页

作者： Lei Zhenbo liu gang wang Hui Hui Yi School of Civil Engineering Chongqing UniversityChongqing 400045China Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityMinistry of EducationChongqing 400045China

With the rapid development of large megawatt wind turbines,the operation environment of wind turbine towers(WTTs)has become increasingly *** particular,seismic excitation can create a resonance response and cause excessive vibration of the *** investigate the vibration attenuation performance of the WTT under seismic excitations,a novel passive vibration control device,called a prestressed tuned mass damper(PS-TMD),is presented in this ***,a mathematical model is established based on structural dynamics under seismic ***,the mathematical analytical expression of the dynamic coefficient is deduced,and the parameter design method is obtained by system tuning ***,based on a theoretical analysis and parameter design,the numerical results showed that the PS-TMD was able to effectively mitigate the resonance under the harmonic basal ***,the time-history analysis method is used to verify the effectiveness of the traditional pendulum tuned mass damper(PTMD)and the novel PS-TMD device,and the results indicate that the vibration attenuation performance of the PS-TMD is better than the *** addition,the PS-TMD avoids the nonlinear effect due to the large oscillation angle,and has the potential to dissipate hysteretic energy under seismic excitation.

关键词： wind turbine tower prestressed tuned mass damper vibration control seismic excitation numerical simulation

An interesting synergistic effect of heteronuclear dual-atom catalysts for hydrogen production:Offsetting or promoting

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Nano Research 2024年第6期17卷 5742-5752页

作者： Zhonghao wang Wei Tang Jialin liu gang Zhou School of Science Hubei University of TechnologyWuhan 430068China

To elucidate the synergistic effect of dual-atom catalysts(DACs)at the microscopic level,we propose and construct a prototype heteronuclear system,CuNi/TiO_(2),in which the two elements of a pair have significantly different d electron-donating abilities,as a piece in the *** density functional theory calculations,we investigate charge-dependent configurations of Cu-Ni dimers anchored on TiO_(2)by the mixing of individual constituent *** d electron-donating ability determines deposition sequence and position of transition metal atoms on oxides,establishing dimer pattern and metal-support *** interaction between Cu and Ni,beyond the coordination environment,predominately contributes to the synergistic effect.A complex adsorption-reduction behavior of H species on CuNi/TiO_(2)is *** reaction mechanism and catalytic activity of CuNi/TiO_(2)for hydrogen production are *** room temperature and high H coverages,CuNi/TiO_(2)shows better performance and efficiency than Ni1/TiO_(2).Our findings provide a new understanding of the synergistic effect on structure-activity relationships of supported dimers,which would be beneficial in the future design of various DACs or even atomically dispersed metal catalysts.

关键词： dual-atom catalysts heteronuclear/homonuclear dimers synergistic effect density functional theory hydrogen production

Comparison of Rotating Stall Warning by Different Methods for Variable Speed Configurations in a Contra-Rotating Compressor

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Journal of Thermal Science 2024年第4期33卷 1379-1393页

作者： XUE Fei wang Yan'gang liu Qian WU Tong liu Hanru School of Power and Energy Northwestern Polytechnical UniversityXi’an710072China

Stall in compressors can cause performance degradation and even lead to *** unacceptable consequences can be avoided by timely monitoring stall inception and taking effective *** paper focused on the rotating stall warning in a low-speed axial contra-rotating ***,the stall disturbance characteristics under different speed configurations were *** results showed that as the speed ratio(RR)increased,the stall disturbance propagation speed based on the rear rotor speed gradually ***,the standard deviation(SD)method,the cross-correlation(CC)method,and the discrete wavelet transform(DWT)method were employed to obtain the stall initiation moments of three different speed *** was found that the SD and CC methods did not achieve significant stall warning results in all three speed ***,the stall initiation moment obtained by the DWT method at RR=1.125 was one period after the stall had fully developed,which was ***,a stall warning method was developed in the present work based on the long short-term memory(LSTM)regression *** applying the LSTM model,the predicted stall initiation moments of three speed configurations were at the 557th,518th,and 333rd revolution,which were44,2,and 74 revolutions ahead of stall onset moments,***,in scenarios where a minor disturbance preceded the stall,the stall warning effect of the LSTM was greatly improved in comparison with the aforementioned three *** contrast,when the pressure fluctuation before the stall was relatively small,the differences between the stall initiation moments predicted by these four methods were not significant.

关键词： contra-rotating compressor stall disturbance stall initiation moment long short-term memory(LSTM) stall warning

In-situ synthesis of quantum dots in the nucleus of live cells

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National Science Review 2024年第3期11卷 172-182页

作者： Yusi Hu Zhi-gang wang Haohao Fu Chuanzheng Zhou wensheng Cai Xueguang Shao Shu-Lin liu Dai-wen Pang State Key Laboratory of Medicinal Chemical Biology Frontiers Science Centre for New Organic MatterTianjin Key Laboratory of Biosensing and Molecular Recognition Research Centre for Analytical Sciences College of Chemistry School of Medicine and Frontiers Science Centre for Cell Responses Nankai University Haihe Laboratory of Sustainable Chemical Transformations

The cell nucleus is the main site for the storage and replication of genetic material, and the synthesis of substances in the nucleus is rhythmic, regular and strictly regulated by physiological processes. However,whether exogenous substances, such as nanoparticles, can be synthesized in situ in the nucleus of live cells has not been reported. Here, we have achieved in-situ synthesis of CdSxSe1-xquantum dots（QDs） in the nucleus by regulation of the glutathione（GSH） metabolic pathway. High enrichment of GSH in the nucleus can be accomplished by the addition of GSH with the help of the Bcl-2 protein. Then, high-valence Se is reduced to low-valence Se by glutathione-reductase-catalyzed GSH, and interacts with the Cd precursor formed through Cd and thiol-rich proteins, eventually generating QDs in the nucleus. Our work contributes to a new understanding of the syntheses of substances in the cell nucleus and will pave the way for the development of advanced ‘supercells’.

关键词： glutathione live cell nucleus quantum dot intracellular synthesis

Effect of slow shot speed on externally solidified crystal,porosity and tensile property in a newly developed high-pressure die-cast Al-Si alloy

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China Foundry 2024年第1期21卷 11-19页

作者： wen-ning liu Wei Zhang Peng-yue wang Yi-xian liu Xiang-yi Jiao Ao-xiang Wan Cheng-gang wang Guo-dong Tong Shou-mei Xiong School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Tsinghua UniversityBeijing 100084Beijing China FAW Group Co. Ltd.Changchun 130013China China FAW Foundry Co. Ltd.Changchun 130013China

The effect of slow shot speed on externally solidified crystal(ESC),porosity and tensile property in a newly developed high-pressure die-cast Al-Si alloy was investigated by optical microscopy(OM),scanning electron microscopy(SEM)and laboratory computed tomography(CT).Results showed that the newly developed AlSi9MnMoV alloy exhibited improved mechanical properties when compared to the AlSi10MnMg *** AlSi9MnMoV alloy,which was designed with trace multicomponent additions,displays a notable grain refining effect in comparison to the AlSi10MnMg *** elements Ti,Zr,V,Nb,B promote heterogeneous nucleation and reduce the grain size of primaryα-*** a lower slow shot speed,the large ESCs are easier to form and gather,developing into the dendrite net and *** an increase in slow shot speed,the size and number of ESCs and porosities significantly *** addition,the distribution of ESCs is more dispersed and the net-shrinkage *** tensile property is greatly improved by adopting a higher slow shot *** ultimate tensile strength is enhanced from 260.31 MPa to 290.31 MPa(increased by 11.52%),and the elongation is enhanced from 3.72%to 6.34%(increased by 70.52%).

关键词： hypoeutectic Al-Si alloy high pressure die casting porosity externally solidified crystal tensile property