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测绘通报 2024年第S2期 246-250页

作者：徐朋祥李晓龙王春友方亮北京首钢国际工程技术有限公司北京100043

本文提出了一种适用于大体量高精度数据拼接方法。通过生产总结,将大体量数据分区域或线路纳入不同群集,再对群集内和群集间进行有效约束控制,提高拼接精度和效率,使整体点云精度保持一致,相对精度高且满足工程测量的大比例绘图方向应用。

关键词：站式扫描点云分层拼接方法整体点云精度

基于集成机器学习构建胰十二指肠术后胰瘘风险预测模型及其验证

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中华外科杂志 2024年第10期62卷 929-937页

作者：程诗博赵传兵吴遒勾善淼熊炯炘杨明王春友吴河水殷涛华中科技大学同济医学院附属协和医院胰腺外科武汉430022

目的构建并验证预测胰十二指肠切除术后患者发生临床相关术后胰瘘(CR-POPF)的集成机器学习模型。方法本研究为预测模型研究。回顾性收集2020年6月至2023年5月在华中科技大学同济医学院附属协和医院胰腺外科接受胰十二指肠切除术的421例... 详细信息

目的构建并验证预测胰十二指肠切除术后患者发生临床相关术后胰瘘(CR-POPF)的集成机器学习模型。方法本研究为预测模型研究。回顾性收集2020年6月至2023年5月在华中科技大学同济医学院附属协和医院胰腺外科接受胰十二指肠切除术的421例患者的临床资料。其中男性241例(57.2%),女性180例(42.8%),年龄(59.7±11.0)岁(范围:12~85岁)。通过分层随机抽样法将研究对象按照3∶1的比例分为训练集(315例)和测试集(106例)。使用递归特征消除算法对特征进行筛选,运用9种机器学习算法分别建模,挑选拟合能力较优的三组模型,通过Stacking算法进行模型融合构建集成模型。通过多种指标评估模型性能,并使用Shapley Additive Explanations(SHAP)方法对最优模型进行可解释性分析。根据替代胰瘘风险评分系统(a-FRS)的预测概率(P)将测试集患者分为不同风险组,对a-FRS评分进行验证并比较其与所建模型的预测效能。结果421例患者中,发生CR-POPF 84例(20.0%)。在测试集中,Stacking集成模型表现最佳,其受试者工作特征曲线的曲线下面积(AUC)为0.823,准确率为0.83,F1分数为0.63,Brier得分为0.097。SHAP总结图显示,影响胰十二指肠切除术后发生CR-POPF的前9位因素依次为胰管直径、CT值比值、术后血清淀粉酶、IL-6水平、体重指数、手术时间、术前术后白蛋白差值、降钙素原及IL-10。各个因素对胰十二指肠切除术后CR-POPF发生的影响均呈现出复杂的非线性关系。当胰管直径150 U/L、IL-6水平>280 ng/L、手术时间>350 min、白蛋白降低超过10 g/L时,发生CR-POPF的风险增加。a-FRS在测试集中的AUC为0.668,预测效能低于Stacking集成机器学习模型。结论本研究构建的Stacking集成机器学习模型能够预测胰十二指肠切除术后CR-POPF的发生,有潜力成为胰十二指肠切除术后个性化诊疗的有效工具。

关键词：胰十二指肠切除术手术后并发症临床相关胰瘘预测模型机器学习集成学习

Research on Energy Consumption Evaluation Combined with Endogenous Pollutants of China Based on Entropy-Topsis

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Chinese Journal of Population,Resources and Environment 2011年第4期9卷 71-76页

作者： Zhao Ao Wu chunyou wang Enxu School of Management Dalian University of Technology Dalian Liaoning 116023 China

The traditional evaluation of energy consumption mostly introduces pollutants as a negative economic output into evaluating model,ignoring the configuration relationship among the energy input,pollutants as well as economic *** paper considers the overall process of energy consumption and constructs an evaluation indication system of energy consumption level combined with endogenous pollutants based on entropytopsis method,then makes empirical *** results show that China's energy consumption level presents a fluctuant rise in the premise of *** consumption level depends on the relationship among energy input,pollutants and economic *** raise of energy consumption level should not increase economic output and reduce pollutant emission at the expense of ***,the whole paper puts forward the countermeasures to improve the overall level of energy consumption.

关键词： entropy-topsis pollutants energy consumption

Expression of Toll-like Receptor 2/4 on Alveolar Macrophage in the Model of Total Hepatic Ischemia/Reperfusion Injury in Mice

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The Chinese-German Journal of Clinical Oncology 2006年第4期5卷 298-300页

作者： GU Yuanting WU Heshui XU Jianbo wang Lin TIAN Yuan wang chunyou Department of General Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Surgery the First Affiliated Hospital Zhengzhou University Zhengzhou 450052 China Department of Pediatrics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

Objective： To explore the expression and meaning of Toll-like receptor 2/4 in alveolar macrophage during the process of total hepatic ischemia in mice. Methods： BALB/c mice were used in a model of total hepatic ischemia/reperfusion. Alveolar Macrophage were collected at the time point of lh, 6h and 12h by the means of bronchoalveolar lavage （BAL）, and its TLR2/4 mRNA and protein were detected with Flow Cytometry and Real-time PCR. The level of TNF in BAL fluid were measured. The concentration of MPO, the ratio of wet/dry and lung histological scores were used to assess the degrees of lung injuries. Results： At the three time points of hepatic ischemia reperfusion, the expression of TLR2/4 protein of and mRNA were up-regulated and the level of TLR2 was on the rise continually. TLR4 at the time of 6 h reached the peak value （P〈0.01）. The level of TNF-2 in BAL fluid reached the highest point at the time of 6 h （P〈0.01）. The ratio of wet/dry rose continually during hepatic ischemia reperfusion. After 1 h, the level of MPO increased rapidly. Then it reached the peak value during the period of 6 h to 12 h. Conclusion： TLR2/4 on the mice of alveolar macrophage were activated in the process of hepatic ischemia/reperfusion and involved in the injury of lung.

关键词： Toll-like receptors liver hepatic ischemia reperfusion injury of lungs, alveolar macrophage

The relationship between activation of TLR4 and partial hepatic ischemia/reperfusion injury in mice

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Hepatobiliary & Pancreatic Diseases International 2006年第1期5卷 101-104页

作者： Lin wang JianBo Xu HeShui Wu JinXiang Zhang JinHui Zhang Yuan Tian chunyou wang Department of Pediatrics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China. whs1898@***

BACKGROUND: Toil-like receptors (TLRs) are a group of evolutionarily conserved pattern recognition receptors involved in the activation of the immune system in response to various pathogens. In this study, we elucidated the relationship between activation of TLR4 and liver injury in partial hepatic ischemia/reperfusion (I/R) injury in mice. METHODS: BALB/c mice were used in a model of partial hepatic I/R injury, and the changes of TLR4 gene expression in ischemic liver lobes were detected with real-time polymerase chain reaction (RT-PCR). The levels of plasma ALT and endotoxin in the portal vein were measured. TLR4-deficient mice (C3H/Hej) and wild type mice (C3H/Heouj) were used in a model of I/R injury; liver function impairment and the level of serum TNF-α were observed. RESULTS: After one hour ischemia, the expression of TLR4 mRNA increased at the 1st, 3rd hour of reperfusion, indicating the value of △Ct(1st hour: 1.21±0.87vs. 5.85±1.07, t=13.72, P<0.01; 3rd hour: 0.85±0.92vs. 6.11±1.24, t=16.33, P<0.01). No endotoxemia developed in every group of mice. At the 3rd hour of reperfusion, the level of serum TNF-α was significantly higher than that of sham group (Hej: 152±43 pg/ml vs. 18±10pg/ml, t=5.26, P<0.01; Heouj: 249±52pg/ml vs. 25±13 pg/ml, t=7.24, P<0.01). At the 1st, 3rd hour reperfusion, the level of plasmid ALT in Hej mice was lower than that in Heouj mice (1st hour 662±106 U/Lvs. 1216±174 U/L, t=4.21, P<0.01; 3rd hour 1145±132U/L vs. 29584±187 U/L, t=13.72, P<0.01). The level of serum TNF-αwas lower than that in Heouj mice (1524.43 U/L vs. 2494±52 U/L, t=3.94, P<0.01) at the 3rd hour reperfusion. CONCLUSION: TLR4 activation causes partial hepatic I/R injury through release of TNF-α.

关键词： liver reperfusion injury toll-like receptor endotoxin

急性坏死性胰腺炎治疗的历史与现状:百年探索二十年突破

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中华外科杂志 2020年第1期58卷 9-12页

作者：王春友华中科技大学同济医学院附属协和医院胰腺病研究所武汉430022

一百多年来,围绕急性坏死性胰腺炎的手术和非手术治疗、早期手术还是后期手术进行了艰苦的探索,每一次治疗理念的变革、技术的进步和疗效的突破,均是在实践中总结和逐步完善的。长期临床实践和基础研究,逐步阐明了急性坏死性胰腺炎"两... 详细信息

一百多年来,围绕急性坏死性胰腺炎的手术和非手术治疗、早期手术还是后期手术进行了艰苦的探索,每一次治疗理念的变革、技术的进步和疗效的突破,均是在实践中总结和逐步完善的。长期临床实践和基础研究,逐步阐明了急性坏死性胰腺炎"两个死亡高峰"的病理生理过程,不断提高早期多器官功能衰竭的防治水平。深化对急性坏死性胰腺炎局部并发症病理转归多样性的认识,划时代改变了坏死性胰腺炎后期的治疗模式,逐步形成了现代综合治疗体系。即在疾病早期,以预防和控制多器官功能衰竭为主轴;在后期阶段,探索最佳手术时机及手术方法为主轴。实施微创与开放相结合的外科干预模式,努力探索和提高针对胰腺坏死组织延期一次性手术清除的成功率。目前,我国不少大中心的坏死性胰腺炎的治疗水平已处于世界前沿,通过中华医学会外科学分会胰腺外科学组对《急性胰腺炎诊治指南(2014)》的巡讲推广及大量的学术交流,我国基层医院急性坏死性胰腺炎治疗水平也在不断提高。因此有理由相信,我国急性坏死性胰腺炎诊疗水平实现再突破的那一天将不再遥远。

关键词：胰腺炎,急性坏死性治疗

急性坏死性胰腺炎的外科干预:时机比技术更重要

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中华消化外科杂志 2020年第4期19卷 366-369页

作者：王春友华中科技大学同济医学院附属协和医院胰腺外科武汉430022

目前,围绕急性坏死性胰腺炎的手术和非手术治疗、早期手术还是后期手术、微创干预还是开放手术等问题,仍在探索中不断取得进步并逐步形成共识。进一步探索清除胰腺坏死组织最佳手术时机及手术技术、实施微创与开放相结合的外科干预策略... 详细信息

目前,围绕急性坏死性胰腺炎的手术和非手术治疗、早期手术还是后期手术、微创干预还是开放手术等问题,仍在探索中不断取得进步并逐步形成共识。进一步探索清除胰腺坏死组织最佳手术时机及手术技术、实施微创与开放相结合的外科干预策略、提高针对胰腺坏死组织延期一次性手术清除的成功率,是降低急性坏死性胰腺炎后期病死率的关键。近20年来,对急性坏死性胰腺炎局部并发症病理转归多样性认识的深化,划时代改变了急性坏死性胰腺炎后期的治疗模式。从20世纪末的早期开腹手术引流减压到计划性多次手术清创,再到延期一次性手术,以及近年来探索实施的创伤递进式手术策略,随着治疗理念的变革,逐步实现了疗效的突破。相较于坏死组织的清除技术,手术时机的选择对治疗成功更具重要意义。根据现有针对急性坏死性胰腺炎循证医学研究结果,鉴于急性坏死性胰腺炎病情的复杂性、个体间的差异性、以及有限的多中心研究结果,目前尚不能确定外科技术对改善预后的优势;而手术时机的正确把握,对提高急性坏死性胰腺炎手术治疗效果的地位不容置疑。笔者回顾性分析其团队收治的1000余例外科治疗急性坏死性胰腺炎患者的临床资料,探讨针对急性坏死性胰腺炎后期局部并发症外科干预时机及技术对改善预后的临床意义。

关键词：胰腺炎,急性坏死性外科手术时机手术技术预后

Detection of K-ras Gene Point Mutation＇s Style in Human Pancreatic Cancer Cell Line PANC-1 by PCR-SSP

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The Chinese-German Journal of Clinical Oncology 2006年第1期5卷 45-48页

作者： wang Wei wang chunyou DONG Jihua ZHAO Gang CHEN Xiong ZHANG Min Department of Pancreas Surgery Center Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Central Laboratory Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Otolaryngology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

Objective： To detect the style of K-ras gene point mutation in human pancreatic cancer cell line PANC-1 and decide the bp sequence of Ras target position interfered by RNA. Methods： Three kinds of special sequence primers （SSP） for polymerase chain reaction （PCR） with regard to the mutation styles （OAT, COT and GOT） at codon 12 of K-ras were used to study the human pancreatic cancer cell line PANC-1. The amplification products were studied with polyacrylamine gel electrophoresis to detect the style of point mutation. Results： The style of K-ras gene point mutation at codon 12 was OAT in human pancreatic cancer cell line. Conclusion： PCR-SSP is rapid, convenient and high specific. The results provide a basis for further gene therapy by RNA interference for pancreatic cancer.

关键词： pancreatic cancer K-ras gene point mutation polymerase chain reaction

提高对重症急性胰腺炎多脏器功能障碍的认识及防治水平

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中国实用外科杂志 2006年第5期26卷 328-330页

作者：王春友华中科技大学同济医学院附属协和医院胰腺外科中心湖北武汉430022

重症急性胰腺炎（SAP）是一种特殊类型的外科急腹症。因其病情凶险，进展迅速，临床表现出明显的个体差异，病情转归复杂多变，而倍受外科临床和学术界关注。近20年来，随着对SAP发病机制研究的深入和临床救治技术水平的提高，其疗效亦... 详细信息

重症急性胰腺炎（SAP）是一种特殊类型的外科急腹症。因其病情凶险，进展迅速，临床表现出明显的个体差异，病情转归复杂多变，而倍受外科临床和学术界关注。近20年来，随着对SAP发病机制研究的深入和临床救治技术水平的提高，其疗效亦有了明显改善，但总体病死率仍在10％以上。SAP病人死亡主要有两个高峰：其一是SAP发病的早期，即全身炎症反应综合征期（SIRS期），致死的主要原因是速发性多器官功能障碍（MODS），如急性呼吸窘迫综合征（ARDS）、急性肾功能衰竭（ARF）等，占SAP死亡病例的半数以上；其二是全身感染期和残余感染期，

关键词：重症急性胰腺炎多脏器功能障碍急性呼吸窘迫综合征全身炎症反应综合征发病机制研究多器官功能障碍急性肾功能衰竭临床表现病情转归

再谈坏死性胰腺炎手术干预方式和时机的个体化

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中华外科杂志 2019年第10期57卷 721-724页

作者：殷涛王春友华中科技大学同济医学院附属协和医院胰腺外科武汉430022

坏死性胰腺炎病变复杂、临床转归多样,治疗抉择困难。坏死性胰腺炎局部并发症的病理及病灶转归在不同患者、发病不同阶段表现出极大的多样性和个体化差异。因此,在临床上区分并发症的类型并实施个体化治疗,对进一步提高坏死性胰腺炎的... 详细信息

坏死性胰腺炎病变复杂、临床转归多样,治疗抉择困难。坏死性胰腺炎局部并发症的病理及病灶转归在不同患者、发病不同阶段表现出极大的多样性和个体化差异。因此,在临床上区分并发症的类型并实施个体化治疗,对进一步提高坏死性胰腺炎的治疗效果极为重要。当前针对坏死性胰腺炎后期的局部并发症可以选择微创和开腹等多种治疗方式,其基本处理原则为彻底清除感染坏死组织和通畅引流。根据患者的具体情况辩证实施微创和(或)开腹手术,不能片面应用某一种手术方式去处理所有患者的病情。临床实践证明,针对坏死性胰腺炎的局部并发症,手术时机的选择对治疗成败更具重要意义,只要手术时机得当,任何干预方式均能达到良好的效果,避免过度强调清创方式而忽视了手术时机对预后的影响。

关键词：胰腺炎,急性坏死性外科手术,微创性开腹手术个体化治疗干预时机