检索结果-南通市图书馆

Comprehensive metabolic profiling of dioxin-like compounds exposure in laying hens:Implications for toxicity assessment

引用

Journal of Environmental Sciences 2025年第2期148卷 107-115页

作者： Xiaoxu Hu Tong Xu Yangsheng Chen Qian Zhang Lijuan Tang Liping Zheng chu wang Pu wang Shujun Dong Ruiguo wang Su Zhang Qinghua Zhang Heidi Qunhui Xie Li Xu Bin Zhao State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Department of Cardiology Beijing HospitalNational Center of GerontologyBeijing 100730China School of Environment Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Hubei Key Laboratory of Industrial Fume and Dust Pollution Control School of Environment and HealthJianghan UniversityWuhan 430056China Institute of Quality Standards and Testing Technology for Agro-Products Chinese Academy of Agricultural SciencesBeijing 100081China

The evaluation of toxicity related to polychlorinated dibenzo-p-dioxins and furans(PCDD/Fs)and dioxin-like polychlorinated biphenyls(DL-PCBs)is crucial for a comprehensive risk assessment in real-world exposure *** study employed a controlled feeding experiment to investigate the metabolic effects of dioxin-like compounds(DLCs)on laying hens via feed *** enriched with two concentrations(1.17 and 5.13 pg toxic equivalents(TEQ)/g dry weight(dw))were administered over 14 days,followed by 28 days of clean *** analyses of blood samples revealed significant metabolic variations between PCDD/Fs and DL-PCBs exposed groups and controls,reflecting the induced metabolic *** changes were observed in sphingosine,palmitoleic acid,linoleate,linolenic acid,taurocholic acid,indole acrylic acid,and dibutyl phthalate levels,implying possible connections between PCDD/Fs and DL-PCBs toxic effects and energy-neuronal imbalances,along with lipid accumulation and anomalous amino acid metabolism,impacting taurine ***,we identified three differential endogenous metabolites—L-tryptophan,indole-3-acetaldehyde,and indole acrylic acid—as potential ligands for the aryl hydrocarbon receptor(AhR),suggesting their role inmediating PCDD/Fs and DL-PCBs *** comprehensive investigation provides novel insights into the metabolic alterations induced by PCDD/Fs and DL-PCBs in laying hens,thereby enhancing our ability to assess risks associated with their exposure in human populations.

关键词： Polychlorinated dibenzo-p-dioxins and furans Dioxin-like polychlorinated biphenyls Laying hens Metabolomic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Correcting on-chip distortion of control pulses with silicon spin qubits

引用

Chinese Physics B 2025年第1期34卷 265-271页

作者： Ming Ni Rong-Long Ma Zhen-Zhen Kong Ning chu Wei-Zhu Liao Sheng-Kai Zhu chu wang Gang Luo Di Liu Gang Cao Gui-Lei wang Hai-Ou Li Guo-Ping Guo CAS Key Laboratory of Quantum Information University of Science and Technology of China(USTC)Hefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Integrated Circuit Advanced Process Research and Development Center Institute of MicroelectronicsChinese Academy of Sciences(CAS)Beijing 100029China Hefei National Laboratory Hefei 230088China Beijing Superstring Academy of Memory Technology Beijing 100176China Origin Quantum Computing Company Limited Hefei 230026China

In semiconductor quantum dot systems,pulse distortion is a significant source of coherent errors,which impedes qubit characterization and ***,we demonstrate two calibration methods using a two-qubit system as the detector to correct distortion and calibrate the transfer function of the control *** methods are straightforward to implement,robust against noise,and applicable to a wide range of qubit *** two methods differ in correction accuracy and *** first,coarse predistortion(CPD)method,partially mitigates *** second,all predistortion(APD)method,measures the transfer function and significantly enhances exchange oscillation *** methods use exchange oscillation homogeneity as the metric and are suitable for any qubit driven by a diabatic *** believe these methods will enhance qubit characterization accuracy and operation quality in future applications.

关键词： quantum computation quantum dot pulse distortion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lifts of Non-Compact Convex Sets and Cone Factorizations

引用

Journal of Systems Science & Complexity 2020年第5期33卷 1632-1655页

作者： wang chu ZHI Lihong Beijing Jinghang Computation and Communication Research Institute Beijing 100074China KLMM Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

This paper generalizes the factorization theorem of Gouveia,Parrilo and Thomas to a broader class of convex *** a general convex set,the authors define a slack operator associated to the set and its polar according to whether the convex set is full dimensional,whether it is a translated cone and whether it contains *** authors strengthen the condition of a cone lift by requiring not only the convex set is the image of an affine slice of a given closed convex cone,but also its recession cone is the image of the linear slice of the closed convex *** authors show that the generalized lift of a convex set can also be characterized by the cone factorization of a properly defined slack operator.

关键词： Cone factorization convex set lift nonnegative rank polyhedron positive semidefinite rank recession cone

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

生态修复工程对排水沟细菌群落结构特征的影响

引用

中国农村水利水电 2025年第2期 50-59页

作者：王楚尤邱小琮尹娟倪成宁夏大学土木与水利工程学院宁夏银川750021 宁夏大学生命科学学院宁夏银川750021

细菌是水生态环境的重要组成部分,细菌群落结构会随着环境因子的变化而产生变化,同时也对水环境有着反作用。为探究生态修复工程对排水沟水体和沉积物微生物群落结构的影响,于2021年8月(工程实施前)、2021年12月、2022年5月及2022年7月... 详细信息

细菌是水生态环境的重要组成部分,细菌群落结构会随着环境因子的变化而产生变化,同时也对水环境有着反作用。为探究生态修复工程对排水沟水体和沉积物微生物群落结构的影响,于2021年8月(工程实施前)、2021年12月、2022年5月及2022年7月进行水体和沉积物样品采集调查,测定水体中8种理化因子(pH、电导率、盐度、总氮、COD_(Mn)、COD_(Cr)、总磷及F^(-))含量,通过16S rDNA高通量测序,分析第五排水沟水体及沉积物细菌群落结构特征,并探究其与水体理化因子间的响应关系。结果表明,生态修复工程实施后,水体电导率、盐度、总氮、总磷、COD_(Mn)及COD_(Cr)显著降低,水质得到改善。水体细菌物种多样性指数增加,群落丰度提高,均匀度提高,优势菌门、细菌群落结构组成存在显著变化,优势菌门Proteobacteria和Bacteroidetes等相对丰度增加,Cyanobacteria相对丰度减少。沉积物细菌优势菌门在生态修复工程实施前后无明显变化,为Proteobacteria、Bacteroidetes和Desulfobacterota,生态修复工程实施后Proteobacteria相对丰度增加,Bacteroidetes、Desulfobacterota相对丰度减少。沉积物细菌物种多样性和丰富度、均匀度高于水体,时空分布也存在较大差异。TP和F^(-)是水体细菌群落结构的主要影响因子,盐度、TP和COD_(Mn)是沉积物细菌群落结构的主要影响因子。

关键词：第五排水沟细菌群落结构环境因子

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

浅谈2024年诺贝尔化学奖——通过计算模拟和人工智能破译蛋白质结构的奥秘

引用

大学化学 2025年第1期40卷 75-81页

作者：王冯璋刘源王初北京大学化学与分子工程学院北京100871 北京大学前沿交叉学科研究院北大清华生命科学联合中心北京100871

蛋白质是生命活动的主要承担者和执行者,蛋白质的三维结构与其生物学功能息息相关。2024年诺贝尔化学奖的一半奖项授予了DeepMind公司的DemisHassabis博士和JohnJumper博士,以表彰他们在蛋白质结构预测领域的突破性贡献;另一半奖项则授... 详细信息

蛋白质是生命活动的主要承担者和执行者,蛋白质的三维结构与其生物学功能息息相关。2024年诺贝尔化学奖的一半奖项授予了DeepMind公司的DemisHassabis博士和JohnJumper博士,以表彰他们在蛋白质结构预测领域的突破性贡献;另一半奖项则授予了华盛顿大学的David Baker教授,以表彰他在蛋白质计算设计领域的系统性研究。本文简要回顾了蛋白质结构预测与设计这两个互逆问题研究历程的重点事件,并对它们的前沿应用进行了展望。

关键词：诺贝尔化学奖蛋白质折叠蛋白质结构预测蛋白质计算设计 Rosetta AlphaFold

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protein designer David Baker: I like doing things that seem like magic

引用

National Science Review 2020年第8期7卷 1410-1412页

作者： Weijie Zhao chu wang NSR Peking University

Search ‘de novo protein design’ on Google and you will find the name David Baker in all results of the first page. Professor David Baker at the University of Washington and other scientists are opening up a new world of fantastic proteins. Protein is the direct executor of most biological functions and its structure and function are fully determined by its primary sequence. Baker’s group developed the Rosetta software suite that enabled the computational prediction and design of protein structures. Being able to design proteins from scratch means being able to design executors for diverse purposes and benefit society in multiple ways. Recently, NSR interviewed Prof. Baker on this fast-developing field and his personal experiences.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Functional Proteomics Driven by Chemical and Computational Approaches

引用

Chinese Journal of Chemistry 2022年第5期40卷 628-634页

作者： Ying Chen Wei Qin chu wang College of Chemistry and Molecular Engineering Peking UniversityBeijing100871 China Peking-Tsinghua Center for Life Science Peking UniversityBeijing100871 China Beijing National Laboratory for Molecular Sciences Peking UniversityBeijing100871 China Synthetic and Functional Biomolecules Center Peking UniversityBeijing100871 China Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Peking UniversityBeijing100871 China

Functional proteomics is a powerful approach to globally investigate protein functions and their biological ***-based protein profiling(ABPP)has been widely applied to explore the activity and ligandability of proteins in complex biological ***,we summarized our efforts in developing chemical probes and chemical proteomic pipelines to identify protein targets of certain post-translational modifications(PTMs),covalent drugs,natural products and cellular ***,computer-aided proteomic strategies were developed to globally identify functional residues including hyper-reactive cysteines,active sites of selenoproteins and proximal anchors for protein activation.

关键词： Activity-based protein profiling Proteomics Protein modifications Protein design Target deconwolution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Global Optimization of Polynomials over Real Algebraic Sets

引用

Journal of Systems Science & Complexity 2019年第1期32卷 158-184页

作者： wang chu YANG Zhi-Hong ZHI Lihong Beijing Jinghang Computation and Communication Research Institute KLMM Academy of Mathematics and Systems Science Chinese Academy of Sciences University of Chinese Academy of Sciences

Let f, g_1, ···, g_s be polynomials in R[X_1, ···, X_n]. Based on topological properties of generalized critical values, the authors propose a method to compute the global in?mum f~? of f over an arbitrary given real algebraic set V = {x ∈ R^n| g_1(x) = 0, ···, g_s(x) = 0}, where V is not required to be compact or smooth. The authors also generalize this method to solve the problem of optimizing f over a basic closed semi-algebraic set S = {x ∈ R^n| g_1(x) ≥ 0, ···, g_s(x) ≥ 0}.

关键词： Polynomial optimization real algebraic set generalized critical value

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Blunt myocardial injury and gastrointestinal hemorrhage following Heimlich maneuver:A case report and literature review

引用

World Journal of Emergency Medicine 2022年第3期13卷 248-250页

作者： chu wang Zhen-zhou wang Tian-bing wang Trauma Medicine Center Peking University People's HospitalBeijing 100044China

Dear editor,In 1975,*** Heimlich introduced the Heimlich maneuver[2],which has become the initial treatment for emergency foreign-body airway *** is recommended by American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.[2]During thrusts,airway pressure increases,thereby expelling foreign bodies.

关键词： airway obstruction gastrointestinal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A quadruple helicene with a rubicene core: synthesis, structural analyses and properties

引用

Science China Chemistry 2021年第4期64卷 590-598页

作者： Qi Xu chu wang Dan Zheng Ying wang Xuebo Chen Di Sun Hua Jiang College of Chemistry Beijing Normal UniversityBeijing 100875China School of Chemistry and Chemical Engineering Shandong UniversityJinan 250100China

We report the synthesis of a quadruple helicene with a rubicene core R1 by a Scholl *** the 10 stereoisomers including 4 pairs of enantiomers and 2 meso isomers,only 2 pairs of enantiomers and 1 meso isomer have been *** sample structures were unambiguously determined by X-ray crystallography to be(P,P)_(6)-(P,P)_(5)/(M,M)_(6)-(M,M)_(5)-R1-A,which has a propeller-shaped structure,and(M,M)_(6)-(P,P)_(5)/(P,P)_(6)-(M,M)_(5)-R1-B and(M,P)_(6)-(P,M)_(5)-R1-C,which have saddle-shaped *** chiral resolutions of R1 were carried out by chiral HPLC,revealing two pairs of chiral stereoisomers(P,P)_(6)-(P,P)_(5)/(P,P)_(6)-(M,M)_(5),(M,M)_(6)-(P,P)_(5)/(M,M)_(6)-(M,M)_(5) as well as a meso isomer(M,P)_(6)-(P,M)_(5),which were further characterized by CD spectroscopy and time-dependent density functional theory(TD-DFT)***,the UV-vis absorption and emission spectra of these resolved stereoisomers and unresolved R1 were almost *** addition,the chemical oxidation of R1 led to the formation of radical cations and dications at room temperature.

关键词： quadruple helicene rubicene stereoisomer dynamic behaviors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：