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Dynamic response characteristics of muddy sandstone in pumped storage mine under action of high-stress dynamic disturbance

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Journal of Central South University 2024年第8期31卷 2736-2747页

作者： LIANG Bin wang Dong LUAN Heng-jie DONG Ling LIU Jian-kang wang chang-sheng State Key Laboratory of Mining Disaster Prevention and Control Co-Founded by Shandong Province and the Ministry of Science and Technology Shandong University of Science and TechnologyQingdao 266590China

During the construction and operation of the abandoned mine pumped storage power station,the underground space surrounding rock body faces the complex stress environment under the action of mining disturbance,frequent pumping,water storage and other dynamic *** stability of the abandoned mine surrounding rock body is the basis for guaranteeing the safety and effectiveness of water storage in the underground space of the abandoned *** considering the two main factors of different stress levels and disturbance amplitudes,the mechanical properties,damage characteristics and acoustic emission characteristics of the abandoned mine perimeter rock body under dynamic disturbance were investigated using a creep-disturbed dynamic impact loading *** experimental results show that:1)The stress level is considered to be the major contributing factor of the failure of muddy sandstone,followed by the amplitude of the disturbances;2)The time required for the destruction of muddy sandstone decreases with the increase of *** the stress level is 80%,the sandstone specimens have a decreasing number of cycles as the disturbance amplitude *** disturbance amplitude is sequentially increased from 4 MPa to 5,6,7,and 8 MPa,the number of cycles required for specimen destruction decreases significantly by 96.71%,99.13%,99.60%,and 99.93%,respectively;3)Disturbance amplitude and stress level have a significant effect on muddy sandstone damage and damage occurs only after a certain threshold is *** the increase of stress level and disturbance amplitude,the macroscopic damage of muddy sandstone is mainly conical,with obvious flake spalling and poor damage integrity;4)According to the time-dependent changes in AE energy and ringing counts,the acoustic emission activity during the failure process could be divided into three phases,namely,weakening period,smooth period,and surge period,corresponding to the compaction phase,elastic rise phase and p

关键词： abandoned mine pumped storage dynamic disturbance muddy sandstone acoustic emission

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DFT Studies on Hydrogen Overfall Mechanism for Catalyzed Hydroisomerization of Pentane

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Chinese Journal of Structural Chemistry 2007年第2期26卷 239-247页

作者： AI Chun-Zhi SUN Ren-An wang chang-sheng College of Chemistry and Chemical Engineering Liaoning Normal University Dalian 116029 China Dalian Institute of Chemical Physics The Chinese Academy of Sciences Dalian 116021 China

The mechanism and related reaction paths in the hydroisomerization of n-pentane were studied by DFT calculations at the B3LYP/6-311＋＋G^＊＊ level. Two possible transition states were theoretically predicted and verified by the vibration frequency analysis as well as the calculations of intrinsic reaction coordinates （IRC）. Furthermore, the related reaction barriers were evaluated by single point energy at the MP2/6-311＋＋G^＊＊ level with zero point vibration correction of DFT method. Thus, it is concluded that the isomerization might go through two pathways.

关键词： catalyzed isomerization of n-pentane hydrogen overfall mechanism i-pentane DFT

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Absorption and Fluorescence Emission Spectra of Molecules Containing Azo and/or Oxadiazole Units

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Chemical Research in Chinese Universities 2013年第4期29卷 776-781页

作者： wang chang-sheng YU Nan LIU Peng School of Chemistry and Chemical Engineering Liaoning Normal University Dalian 116029 P. R. China

The ground state structures of a series of organic molecules containing azo and/or oxadiazole units were obtained by means of density functional theory B3LYP/6-3IG（d） method. The first singlet excited state structures were optimized by virtue of singlet-excitation configuration interaction CIS/6-31G（d） method. The absorption and fluorescence emission spectra were then evaluated via the time-dependent density functional theory B3LYP and PBE1PBE methods with 6-31 l＋＋G（3df,2p） basis set. The calculation results show that compared with those of their parent molecules A-H, B-H, C-H, D-H, the absorption and emission wavelength values of all the derivatives show red shifts. The derivatives containing both the oxadiazole and methoxyl units are good candidates for longer absorption wavelength materials. The effects of azo, oxadiazole, and methoxyl units on the absorption and emission wavelength were discussed.

关键词： Azo Azobenzene Oxadiazole Absorption spectrum Fluorescence emission spectrum Excited state

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1例神经型布鲁氏菌病合并自身免疫性胶质纤维酸性蛋白星形细胞病患者抗感染治疗的药学监护

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抗感染药学 2024年第6期21卷 569-573页

作者：林辉国王昌盛广东三九脑科医院药剂科广州510510 广东药科大学附属第一医院药学部广州510062

目的:分析1例神经型布鲁氏菌病合并自身免疫性胶质纤维酸性蛋白星形细胞病(autoimmune glial fibrillary acidic protein astrocytopathy,GFAP-A)患者抗感染治疗的药学监护过程,为此类复杂、少见疾病患者的治疗提供参考。方法与结果:该... 详细信息

目的:分析1例神经型布鲁氏菌病合并自身免疫性胶质纤维酸性蛋白星形细胞病(autoimmune glial fibrillary acidic protein astrocytopathy,GFAP-A)患者抗感染治疗的药学监护过程,为此类复杂、少见疾病患者的治疗提供参考。方法与结果:该患者因“头晕、双下肢乏力4 d”来院就诊,入院后临床根据患者的症状、实验室检查和影像学检查结果初步诊断为结核性脑膜脑炎,而GFAP抗体检查提示患者还合并GFAP-A;在接受抗结核治疗10 d后,患者的症状和相关实验室指标均好转,遂准予出院;但出院第2天患者再次出现头痛、发热症状,追问病史发现患者长期从事羊肉加工工作,随即进行血清和脑脊液布鲁氏菌抗体检查,结果均为阳性,遂确诊出布鲁氏菌脑脊髓膜炎,临床药师会诊后建议予多西环素+利福平+头孢曲松治疗;11 d后,患者症状好转出院,临床药师建议出院治疗方案调整为多西环素+利福平+复方磺胺甲噁唑;4个多月后,患者脑部影像较前明显好转,脑脊液布鲁氏菌抗体检查结果呈阴性,头痛、肢体无力亦缓解,但血清布鲁氏菌抗体检查结果仍呈阳性。结论:神经型布鲁氏菌病属于较为复杂和严重的疾病,治疗上应足量、足疗程,临床药师的介入可以帮助医生制定出更优化的抗感染治疗方案,还可以在药学监护过程中监测患者的用药安全,以保障患者用药治疗的安全性和有效性。

关键词：神经型布鲁氏菌病自身免疫性胶质纤维酸性蛋白星形细胞病抗感染治疗药学监护

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神经外科Ⅰ类切口手术预防使用抗菌药物情况调查及术后颅内感染影响因素分析

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中国处方药 2024年第9期22卷 46-49页

作者：韩广信王昌盛广东药科大学附属第一医院广州510062

目的调查某院神经外科Ⅰ类切口手术预防使用抗菌药物情况及分析术后颅内感染影响因素,为制订某院Ⅰ类切口手术预防使用抗菌药物管理制度,采取临床干预,实施监控措施提供依据。方法抽调2023年1月~5月在某院神经外科接受Ⅰ类切口手术患者... 详细信息

目的调查某院神经外科Ⅰ类切口手术预防使用抗菌药物情况及分析术后颅内感染影响因素,为制订某院Ⅰ类切口手术预防使用抗菌药物管理制度,采取临床干预,实施监控措施提供依据。方法抽调2023年1月~5月在某院神经外科接受Ⅰ类切口手术患者的病例资料,共1276例,按统一方法及标准统计分析某院神经外科Ⅰ类切口手术预防用抗菌药物及术后颅内感染情况。结果1276例患者中,预防性使用抗菌药物的比例为96.6%(1232/1276);抗菌药物品种选择的合理率为51.1%(629/1232);给药时机的合理率为86.8%(1069/1232);术中应追加的合理率为23.4%(97/415);疗程≤24 h的比例为11.8%(145/1232);24 h48 h的比例为86.0%(1060/1232);术后颅内感染发生率为2.1%(27/1276);细菌培养的阳性率为40.7%(11/27);单因素分析结果显示:手术时间>4 h,术中出血量>750 ml,颅内置引流管时间>72 h是术后颅内感染的高危因素。结论某院神经外科Ⅰ类切口手术抗菌药物使用存在预防用药比例高,品种选择合理率低、疗程长、给药时机及术中应追加的合理率低等问题。建议某院根据国家围术期抗菌药物管理规范,对神经外科Ⅰ类切口手术患者进行术后颅内感染风险预测及分层,探索有效、可行的管理模式,提高神经外科Ⅰ类切口手术抗菌药物的合理应用水平。

关键词：神经外科 Ⅰ类切口抗菌药物颅内感染影响因素

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带支撑广义Maxwell粘弹性阻尼耗能结构风振响应分析

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计算力学学报 2024年第3期41卷 428-436页

作者：李创第杨雪峰李宇翔葛新广王昌盛广西科技大学土木建筑工程学院柳州545006 广西工学院土木建筑工程学院柳州545616 黄淮学院建筑工程学院驻马店463000

工程中粘弹性阻尼器的安装通过支撑与结构进行连接,但在安装粘弹性阻尼器的耗能结构随机响应分析中,为了简化计算过程,将支撑的刚度看作无穷大或者忽略支撑刚度的影响。实际上,对支撑刚度的影响加以考虑更能符合工程实际。针对考虑支撑... 详细信息

工程中粘弹性阻尼器的安装通过支撑与结构进行连接,但在安装粘弹性阻尼器的耗能结构随机响应分析中,为了简化计算过程,将支撑的刚度看作无穷大或者忽略支撑刚度的影响。实际上,对支撑刚度的影响加以考虑更能符合工程实际。针对考虑支撑刚度影响的粘弹性阻尼耗能结构风振响应分析过程复杂的问题,提出了一种求解考虑支撑影响的广义Maxwell粘弹性阻尼耗能结构基于Davenport谱风振响应的简明解析解法。在广义Maxwell粘弹性阻尼器微分型本构模型基础上,给出了考虑支撑刚度的粘弹性阻尼器等效本构关系。将粘弹性阻尼器等效本构关系与结构运动方程联立,采用复模态法将其解耦,获得结构风振响应的统一表达式。将耗能结构在Davenport风速谱下的系列响应功率谱密度函数分解为频域响应函数与Davenport功率谱密度函数的乘积形式,基于随机振动理论中谱矩的定义,对响应功率谱密度函数积分后获得无积分项的系列响应谱矩表达式。在算例中通过与虚拟激励法计算结果对比,验证了所提解法的准确性,并分析了支撑刚度在耗能系统中的影响。

关键词：支撑广义Maxwell模型粘弹性阻尼器 Davenport风速谱风振响应谱矩

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Culprit vessel only versus ＂one-week＂ staged percutaneous coronary intervention for multivessel disease in patients presenting with ST-segment elevation myocardial infarction

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Journal of Geriatric Cardiology 2015年第3期12卷 226-231页

作者： Li-Xiang MA Zhen-Hua LU Le wang Xin DU chang-sheng MA Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beo'ing China

Objective To explore the impact of a ＂one-week＂ staged muhivessel percutaneous coronary intervention （PCI） versus culprit-only PCI on deaths and major adverse cardiac events （MACE）. Methods We retrospectively analyzed 447 patients with multivessel disease who experienced a ST-segment elevation myocardial infarction （STEMI） within 12 h before undergoing PCI between July 26, 2008 and Septem- ber 25, 201 l. After completion of PCI in the infarct artery, 201 patients still in the hospital agreed to undergo PCI in non-infarct arteries with more than 70% stenosis for a ＂one-week＂ staged multivessel PCI. A total of 246 patients only received intervention for the culprit vessel. Follow-up ended on September 9, 2014. This study examined the differences in deaths from any cause （i.e., cardiac and noncardiac） and MACE between the two treatment groups. Results Compared to a culprit-only PCI treatment approach, the ＂one-week＂ staged multivessel PCI was strongly associated with greater benefits for 55-month all cause death [41 （16.7%） vs. 13 （6.5%）, P = 0.004] and MACE [82 （33.3%） vs. 40 （19.9%）, P = 0.002] rates. In addition, there were significant differences in the number of myocardial infarctions [43 （17.5%） vs. 20 （10.0%）, P = 0.023], coronary-artery bypass grafting [CABG; 20 （8.1%） vs. 6 （3.0%）, P = 0.021], and PCI [31 （12.6%） vs. 12 （6.0%）, P - 0.018]. Patients undergoing culprit-only PCI compared to ＂one-week＂ PCI had the same number of stent thrombosis events [7 （2.8%） vs. 3 （1.5%）, P - 0.522]. Conclusions Compared to a culprit-only PCI treatment approach, ＂one-week＂ staged multi-vessel PCI was a safe and effective selection for STEMI and multi-vessel PCL

关键词： ST-segment elevation myocardial infarction Percutaneous coronary intervention Multivessel revascularization

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Neurotoxicity of tetramethylammonium ion on larval and juvenile zebrafish:Effects on neurobehaviors and multiple biomarkers

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Journal of Environmental Sciences 2024年第9期143卷 138-147页

作者： Ruixin Zhang Rui wang Jiajun chang GDaniel sheng Daqiang Yin Key Laboratory of Yangtze River Water Environment Ministry of EducationCollege of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

Tetramethylammonium hydroxide(TMAH)is an important compound that utilized and released by the rapidly expanding semiconductor industry,which could hardly be removed by the conventional wastewater treatment *** a cholinergic agonist,the tetramethylammonium ion(TMA^(+))has been reported to induce toxicity to muscular and respiratory systems of mammals and human,however the toxicity on aquatic biota remains poorly *** investigated the neurotoxic effects of TMA^(+)exposure on zebrafish,based on neurobehavior tests and a series of *** inhibitions on the swimming distance of zebrafish larvae were observed when the exposure level exceeded 50 mg/L,and significant alterations on swimming path angles(straight and deflective movements)occurred even at 10 mg/*** tested neurobehavioral endpoints of zebrafish larvae were significantly positively correlated with reactive oxygen species(ROS)and malondialdehyde(MDA),significantly negatively related with the activities of antioxidant enzymes,but not significantly correlated with the level of acetylcholinesterase(AChE).Such relationship indicates that the observed neurotoxic effects on swimming behavior of zebrafish larvae is mainly driven by oxidative stress,rather than the alterations of *** the highest exposure concentration(200 mg/L),TMA^(+)evoked more severe toxicity on zebrafish juveniles,showing significantly stronger elevation on the MDA activity,and greater inhibitions on the activities of antioxidant enzymes and ACh E,suggesting juveniles were more susceptible to TMA^(+)exposure than larval zebrafish.

关键词： Tetramethylammonium Zebrafish Oxidative stress Acetylcholinesterase Neurobehavior

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Molecular Chaperone-Dependent Polymer Translocation through Nanopores: The Effects of Chaperone Concentration and Chaperone-Polymer Interaction

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Chinese Journal of Polymer Science 2024年第1期42卷 125-132,I0011页

作者： chang-sheng Zuo Kang wang Li-Zhen Sun Ting-Ting Sun Department of Physics Zhejiang University of Science and TechnologyHangzhou 310023China Department of Applied Physics Zhejiang University of TechnologyHangzhou 310014China

The polymer translocation through a nanopore from a donor space(or named cis side) to a receiver space(trans side) in the chaperone-induced crowded environment has attracted increasing attention in recent years due to its significance in biological systems and technological applications. In this work, we mainly focus on the effects of chaperone concentration and chaperone-polymer interaction on the polymer translocation. By assuming the polymer translocation to be a quasi-equilibrium process, the free energy F of the polymer can be estimated by Rosenbluth-Rosenbluth method and then the translocation time τ can be calculated by Fokker-Plank equation based on the obtained free energy landscape. Our calculation results show that the translocation time can be controlled by independently tuning the chaperone concentration and chaperone-polymer interaction at the cis side or the trans side. There exists a critical chaperone-polymer attraction ε~*=-0.2 at which the volume exclusion and interaction effects of the chaperone can balance each other. Additionally, we also find that at large chaperone-polymer attraction, the translocation time is mainly governed by the diffusion coefficient of the polymer.

关键词： Polymer translocation Rosenbluth-Rosenbluth method Fokker-Plank equation Free energy landscapes

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负载型金属催化剂在卤代硝基苯选择性加氢中的研究进展

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化学研究与应用 2024年第3期36卷 449-457页

作者：崔耀森钱利刚帅昌辉潘骏聂京王昌盛史明俞卫祥万东闯卢春山浙江友联化学工业有限公司浙江杭州314000 浙江工业大学化学工程学院浙江杭州310000

本文综述了近年来卤代硝基苯催化加氢制备卤代苯胺反应中,负载型金属催化剂的研究现状与进展。提高负载型金属催化剂的选择性和稳定性的主要方式包含调控金属粒子尺寸、制备双金属活性中心、改性催化剂载体、调变金属与载体之间的相互... 详细信息

本文综述了近年来卤代硝基苯催化加氢制备卤代苯胺反应中,负载型金属催化剂的研究现状与进展。提高负载型金属催化剂的选择性和稳定性的主要方式包含调控金属粒子尺寸、制备双金属活性中心、改性催化剂载体、调变金属与载体之间的相互作用、反应溶剂的选择以及添加脱卤抑制等,但催化剂的稳定性仍然是工业应用面临的最大难题之一。如何提高负载型金属催化剂的加氢稳定性和实现工业化应用是今后的研究方向。

关键词：卤代硝基苯催化加氢负载型金属催化剂稳定性

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