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Frontiers of Chemical Science and Engineering 2021年第6期15卷 1514-1523页

作者： Huaxin Qu jie Deng Bei wang Lezi Ouyang Yong Tang Kai Yu Lan-Lan Lou Shuangxi Liu Institute of New Catalytic Materials Science School of Materials Science and EngineeringNational Institute for Advanced MaterialsNankai UniversityTianjin300350China MOE Key Laboratory of Pollution Processes and Environmental Criteria and Tianjin Key Laboratory of Environmental Technology for Complex Transmedia Pollution College of Environmental Science and EngineeringNankai UniversityTianjin300350China MOE Key Laboratory of Advanced Energy Materials Chemistry Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin300072China

A base-free catalytic system for the aerobic oxidation of 5-hydroxymethyl-2-furfural was exploited by using Pt nanoparticles immobilized onto a thermoresponsive poly(acrylamide-co-acrylonitrile)-b-poly(N-vinylimidazole)block copolymer,with an upper critical solution temperature of about 45°*** Pt nanocatalysts were well-dispersed and highly active for the base-free oxidation of 5-hydroxymethyl-2-furfural by molecular oxygen in water,affording high yields of 2,5-furandicarboxylic acid(up to>99.9%).The imidazole groups in the block copolymer were conducive to the improvement of catalytic ***,the catalysts could be easily separated and recovered based on their thermosensitivity by cooling the reaction system below the upper critical solution *** stability and reusability were observed over these copolymer-immobilized catalysts with no obvious decrease in catalytic activity in the five consecutive cycles.

关键词： aerobic oxidation base-free 5-hydroxymethyl-2-furfural Pt nanoparticle thermoresponsive block copolymer

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基于页面Block的Web档案采集和存储

软件学报 2008年第2期19卷 275-290页

作者：宋杰王大玲鲍玉斌申德荣东北大学信息科学与工程学院辽宁沈阳100004

提出了基于页面Block对Web页面的采集和存储方式,并详细表述了该方法如何完成基于布局页面分区、Block主题的抽取、版本和差异的比较以及增量存储的方式.实现了一个Web归档原型系统,并对所提出的算法进行了详细的测试.理论和实验表明,... 详细信息

提出了基于页面Block对Web页面的采集和存储方式,并详细表述了该方法如何完成基于布局页面分区、Block主题的抽取、版本和差异的比较以及增量存储的方式.实现了一个Web归档原型系统,并对所提出的算法进行了详细的测试.理论和实验表明,所提出的基于页面Block的Web档案(Web archive)采集和存储方法能够很好地适应Web档案的管理方式,并对基于Web档案的查询、搜索、知识发现和数据挖掘等应用提供有利的数据资源.

关键词： Web档案页面分区页块

Sphingolipid metabolism, transport, and functions in plants:Recent progress and future perspectives

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Plant Communications 2021年第5期2卷 45-61页

作者： Ning-Jing Liu Li-Pan Hou Jing-Jing bao Ling-Jian wang Xiao-Ya Chen State Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences/Shanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesFenglin Road 300Shanghai 200032China University of Chinese Academy of Sciences Shanghai 200032China

Sphingolipids,which comprise membrane systems together with other lipids,are ubiquitous in cellular *** show a high degree of diversity across plant species and vary in their structures,properties,and *** from the development of lipidomic techniques,over 300 plant sphingolipids have been *** divided into free long-chain bases(LCBs),ceramides,glycosylceramides(GlcCers)and glycosyl inositol phosphoceramides(GIPCs),plant sphingolipids exhibit organized aggregation within lipid membranes to form raft domains with *** evidence has revealed that sphingolipids obey certain trafficking and distribution rules and confer unique properties to *** studies using sphingolipid biosynthetic mutants demonstrate that sphingolipids participate in plant developmental regulation,stimulus sensing,and stress ***,we present an updated metabolism/degradation map and summarize the structures of plant sphingolipids,review recent progress in understanding the functions of sphingolipids in plant development and stress responses,and review sphingolipid distribution and trafficking in plant *** also highlight some important challenges and issues that we may face during the process of studying sphingolipids.

关键词： sphingolipid metabolism membrane lateral heterogeneity vesicular and non-vesicular trafficking

Cesium-doped manganese-based Prussian blue analogue as a high-efficiency cathode material for potassium-ion batteries

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Journal of Energy Chemistry 2024年第12期99卷 120-127页

作者： jie wang Zeyu Yuan Jiaying Liao An Li Yifan Xu Haijie Qi Yuehua Man Yanqi Lv Xiaosi Zhou School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023JiangsuChina

Prussian blue analogues (PBAs) are regarded as promising cathode materials for potassium-ion batteries(PIBs) owing to their low cost and high reversible *** to other PBAs,potassium manganese hexacyanoferrate (KMnHCF) stands out for its superior capacity and operating ***,Jahn-Teller effect of Mn^(3+)and the structural collapse caused by potassium ion insertion/extraction still affect the structural stability and electrochemical performance of this ***,a green and efficient synthesis method is adopted to substitute potassium ions in KMnHCF with an appropriate amount of cesium ions to form a column ***-doped KMnHCF (Cs-KMnHCF) mitigates the irreversible structural damage caused by potassiation/depotassiation and the Jahn-Teller effect,thereby improving the cycling *** addition,it widens the lattice channels,reduces the diffusion barrier of potassium ions,and optimizes the diffusion *** rationally controlling the doping amount of Cs^(+),the obtained K_(1.71)Cs_(0.05)Mn[Fe(CN)_(6)]_(0.95·0.05)·0.88H_(2)O exhibits remarkable electrochemical performance,with an initial discharge capacity of 137.6 mA h g^(-1)at a current density of 20 mA g^(-1)and a capacity retention of 89.6%after 600 cycles at 200 mA g^(-1).More importantly,when assembled with a pitch-derived soft carbon anode,the full cell manifests excellent cycle stability and rate *** work is expected to provide a highly efficient cathode material for the practical application of PIBs.

关键词： Prussian blue analogue Cathode material Potassium-ion battery Ion exchange Column effect

Effect of reaction routes on the porosity and permeability of porous high entropy(Y0.2Yb0.2Sm0.2Nd0.2Eu0.2)B6 for transpiration cooling

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Journal of Materials Science & Technology 2020年第3期38卷 80-85页

作者： Heng Chen Zifan Zhao Huimin Xiang Fu-Zhi Dai jie Zhang Shaogang wang Jiachen Liu Yanchun Zhou Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education School of Materials Science and EngineeringTianjin UniversityTianjin 300072China Science and Technology on Advanced Functional Composite Laboratory Aerospace Research Institute of Materials&Processing TechnologyBeijing 100076China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Transpiration cooling technique is a reusable and high-efficiency thermal protection system(TPS),which is potential to improve the reusability and security of re-entry space *** low density,high permeability and high porosity are general requirements for porous media of transpiration cooling *** this work,a new porous high entropy metal hexaboride(Y0.2Yb0.2Sm0.2Nd0.2Eu0.2)B6 is designed and prepared by the in-situ reaction/partial sintering *** reaction routes are designed to synthesize(Y0.2Yb0.2Sm0.2Nd0.2Eu0.2)B6,including boron thermal reduction and borocarbon thermal *** as-prepared porous HE(Y0.2Yb0.2Sm0.2Nd0.2Eu0.2)B6 ceramics possess homogeneous microstructure and exhibit low density,high porosity,high compressive strength and high *** combination of these properties makes porous HE(Y0.2Yb0.2Sm0.2Nd0.2Eu0.2)B6 promising as a candidate porous media for various transpiration cooling applications.

关键词： High entropy ceramics (Y0.2Yb0.2Sm0.2Nd0.2Eu0.2)B6 Transpiration cooling Porous UHTCs In-situ reaction synthesis

Antitumor activity of aumolertinib, a third-generation EGFR tyrosine kinase inhibitor, in non-small-cell lung cancer harboring uncommon EGFR mutations

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Acta Pharmaceutica Sinica B 2023年第6期13卷 2613-2627页

作者： Chen Shi Cong Zhang Zhiwen Fu Jinmei Liu Yuanfeng Zhou bao Cheng Cong wang Shijun Li Yu Zhang Department of Pharmacy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Province Clinical Research Center for Precision Medicine for Critical Illness Wuhan 430022China Department of Preclinical Translational Science Shanghai Hansoh Biomedical Co.Ltd.Shanghai 201203China Department of Chemistry Shanghai Hansoh Biomedical Co.Ltd.Shanghai 201203China

Uncommon epidermal growth factor receptor(EGFR) mutations account for 10% 20% of all EGFR mutations in non-small-cell lung cancer(NSCLC). The uncommon EGFR-mutated NSCLC is associated with poor clinical outcomes and generally achieved unsatisfactory effects to the current therapies using standard EGFR-tyrosine kinase inhibitors(TKIs), including afatinib and osimertinib. Therefore, it is necessary to develop more novel EGFR-TKIs to treat uncommon EGFR-mutated *** is a third-generation EGFR-TKI approved in China for treating advanced NSCLC with common EGFR mutations. However, it remains unclear whether aumolertinib is effective in uncommon EGFR-mutated NSCLC. In this work, the in vitro anticancer activity of aumolertinib was investigated in engineered Ba/F3 cells and patient-derived cells bearing diverse uncommon EGFR mutations. Aumolertinib was shown to be more potent in inhibiting the viability of various uncommon EGFR-mutated cell lines than those with wild-type EGFR. And in vivo, aumolertinib could also significantly inhibit tumor growth in two mouse allograft models(V769-D770insASV and L861Q mutations) and a patientderived xenografts model(H773-V774insNPH mutation). Importantly, aumolertinib exerts responses against tumors in advanced NSCLC patients with uncommon EGFR mutations. These results suggest that aumolertinib has the potential as a promising therapeutic candidate for the treatment of uncommon EGFR-mutated NSCLC.

关键词： Aumolertinib Non-small cell lung cancer Oncology Uncommon EGFR mutations Exon 20 insertion EGFR tyrosine kinase inhibitor Targeted therapy Anti-tumor activity

CONTRIBUTION OF CHOLESTEROL MOIETIES ATTACHED ON MPEG-b-PCL-b-PLL TO THE CELL UPTAKE, ENDOSOMAL ESCAPE AND GENE KNOCKDOWN OF THE MICELLEPLEXES OF siRNA

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Chinese Journal of Polymer Science 2013年第6期31卷 912-923页

作者： Ruo-gu Qi Su-hong Wu Yu wang jie Chen Zhi-gang Xie Yu-bin Huang 景遐斌 State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences

To further enhance the transfection efficiency of a micelleplex system based on monomethoxy poly（ethylene glycol）-block-poly（e-caprolactone）-block-poly（L-lysine）（MPEG-b-PCL-b-PLL）, cholesterol （Chol） moieties are attached to the e-termini of PLL segments to obtain MPEG-b-PCL-b-PLL/Chol. The structure and morphology of the copolymer are studied by IH-NMR, TEM and DLS （dynamic light scattering）. The cytotoxicity, cell uptake, endosomal release and mRNA knockdown are studied by MTT （3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide） assay, flow cytometry, CLSM （confocal laser scanning microscopy） and RT-PCR （real-time polymerase chain reaction）. The results show that compared to their precursor MPEG-b-PCL-b-PLL, the cholesterol-grafted copolymer shows significantly lower toxicity, more rapid cellular endocytosis and endosome escape, and consequently displays enhanced siRNA transfection efficiency even at a lower N/P ratio. These improvements are ascribed to enhanced interaction of the cholesterol moieties with both cellular membrane and endosomal membrane. Moreover, effect of the PLL block length is examined. The final conclusion is that long enough PLL segments and incorporation of proper fraction of cholesterol onto the PLL segments benefit the enhancement of siRNA transfection efficiency.

关键词： Amphiphilic copolymer Cholesterol Endosome escape Micelleplex siRNA delivery.

Preparation,physicochemical and structural characterizations,and bioactivities of polysaccharides from Corbicula fluminea industrial distillate

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Food Bioscience 2022年第3期47卷 928-937页

作者： Jing-Kun Yan Chun wang Yun-Bo Yu Zi-Wei wang Xu Chen jie Zhu Lin Li Key Laboratory of Healthy Food Development and Nutrition Regulation of China National Light Industry School of Chemical Engineering and Energy TechnologyDongguan University of TechnologyDongguan523808China School of Food & Biological Engineering Jiangsu UniversityZhenjiang212013China

Corbicula fluminea distillate(CFD),as an industrial sub-product of the steaming process of ***,is rich in polysaccharides,proteins,and amino acids and has important developmental *** this study,therefore,three water-soluble polysaccharides(CFDPs:CFDP-D,CFDP-U,and CFDP-T)were extracted and separated from CFD through direct ethanol precipitation,ultrasound-assisted extraction,and three-phase partitioning(TPP),*** demonstrated that the three extraction methods had important influences on extraction yields,chemical compositions,molecular weights,monosaccharide and amino acid constituents,structural characteristics,and microstructures as well as biological activities of ***,CFDP-T had higher yield(60.92%±3.58%),carbohydrate content(91.05%±1.22%),and uronic acid content(8.55%±0.18%)and lower protein content(7.15%±0.15%)than CFDP-D and *** three CFDPs were acidic proteoheteroglycans combined through O-glycosidic bonds and had high molecular weights of 1.93–2.41×10^(7) Da and the same monosaccharide and amino acid compositions but different *** with CFDP-D and CFDP-U,CFDP-T exhibited more excellent free radical scavenging and stimulating(1.57±0.03μM,500μg/mL)activities on RAW264.7 macrophages in ***,our findings suggested that CFDP-T obtained from CFD by TPP had the potential to be a functional food ingredient in food industry.

关键词： Corbicula fluminea Industrial sub-product Polysaccharide Extraction methods Physicochemical characteristics Biological activity

Heterostructure:application of absorption-catalytic center in lithium-sulfur batteries

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Rare Metals 2024年第4期43卷 1461-1487页

作者： Fei wang Chun-Man Yang Yong-Qi wang Dan You Wen-Hao Yang Rong-Wei Huang Ji-Yue Hou Qian wang Ying-jie Zhang Ying wang Yue-Jing Zeng Yi-Yong Zhang Xue Li National Local Joint Engineering Research Center for Lithium-Ion Batteries and Materials Preparation Technology Key Laboratory of Advanced Batteries Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming650093China College of Electrical Information Engineering Panzhihua UniversityPanzhihua617000China State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Centre of Chemistry for Energy MaterialsState-Province Joint Engineering Laboratory of Power Source Technology for New Energy VehicleEngineering Research Center of Electrochemical TechnologyMinistry of EducationCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China

Due to the high theoretical specific capacity(1675 mAh·g^(-1)),low cost,and high safety of the sulfur cathodes,they are expected to be one of the most promising rivals for a new generation of energy storage ***,the shuttle effect,low conductivity of sulfur and its discharge products,volume expansion,and other factors hinder the commercialization of lithium-sulfur batteries(LSBs).The development of sulfur-fixing materials and the design of multifunctional materials to enhance the electrochemical performance of LSBs have been the main research priorities in recent *** of the advantages of high conductivity,built-in electric field,and good synergism,more and more researchers have employed heterostructure into sulfur-fixing materials to enhance the catalytic and absorption ability for *** this review,the principle of heterostructure and the mechanism of enhancing the performance of lithium-sulfur batteries are *** applications of heterostructure in cathode and interlayer of LSBs in the latest years are ***,the cutting-edge troubles and possibilities of heterostructures in LSBs are briefly presented.

关键词： Lithium-sulfur batteries(LSBs) Heterostructure Built-in electric field Catalytic Absorption

In utero delivery of mRNA to the heart,diaphragm and muscle with lipid nanoparticles

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Bioactive Materials 2023年第7期25卷 387-398页

作者： Kewa Gao jie Li Hengyue Song Hesong Han Yongheng wang Boyan Yin Diana L.Farmer Niren Murthy Aijun wang Department of Surgery School of MedicineUniversity of CaliforniaDavisSacramentoCA95817United States Department of Bioengineering University of CaliforniaBerkeleyCA94704United States Institute for Pediatric Regenerative Medicine Shriners Hospitals for ChildrenSacramentoCA95817United States Department of Biomedical Engineering University of CaliforniaDavisCA95616United States Department of Burns and Plastic Surgery The Third Xiangya Hospital of Central South UniversityHunan410013China

Nanoparticle-based drug delivery systems have the potential to revolutionize medicine,but their low vascular permeability and rapid clearance by phagocytic cells have limited their medical *** delivered at the in utero stage can overcome these key limitations due to the high rate of angiogenesis and cell division in fetal tissue and the under-developed immune ***,very little is known about nanoparticle drug delivery at the fetal stage of *** this report,using Ai9 CRE reporter mice,we demonstrate that lipid nanoparticle(LNP)mRNA complexes can deliver mRNA in utero,and can access and transfect major organs,such as the heart,the liver,kidneys,lungs and the gastrointestinal tract with remarkable efficiency and low *** addition,at 4 weeks after birth,we demonstrate that 50.99±5.05%,36.62±3.42%and 23.7±3.21%of myofiber in the diaphragm,heart and skeletal muscle,respectively,were ***,we show here that Cas9 mRNA and sgRNA complexed to LNPs were able to edit the fetal organs in *** experiments demonstrate the possibility of non-viral delivery of mRNA to organs outside of the liver in utero,which provides a promising strategy for treating a wide variety of devastating diseases before birth.

关键词： In utero mRNA delivery Nanoparticles Gene editing CRISPR/Cas9