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Characteristics of super drought in Southwest China and the associated compounding effect of multiscalar anomalies

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Science China Earth Sciences 2024年第7期67卷 2084-2102页

作者： Lin wang Wen CHEN Gang HAUNG Ting wang Qiulin wang Xiaoyun SU zixuan REN Chakrit CHOTAMONSAK Atsamon LIMSAKUL Kritanai TORSRI CAS Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Heavy Rain and Drought-Flood Disasters in Plateau and Basin Key Laboratory of Sichuan Province Chengdu 610072China Department of Atmospheric Science Yunnan UniversityKunming 650500China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Carbon Neutrality Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Hangzhou Meteorological Bureau Hangzhou 310051China Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Department of Geography Faculty of Social SciencesChiang Mai UniversityChiang Mai 50200Thailand Environmental Science Research Center Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Climate Change and Environmental Research Center TechnopolisKlong 5Klong LuangPathumthani 12120Thailand Hydro-Informatics Innovation Division Hydro-Informatics InstituteMinistry of Higher EducationScienceResearch and InnovationBangkok 10900Thailand

In recent decades,Southwest China(SWC)has suffered from frequent super droughts,leading to severe economic losses and ecological *** study investigates the characteristics of super droughts in SWC during 1961-2022,reveals the compounding effect of multiscalar anomalies,and explores the plausible atmospheric circulation mechanisms *** nature of super drought is a compound drought caused by the superposition of extreme drought events across multiple time *** contrasting the typical drought cases in 2006 and 2022,the decisive role of multiscalar drought compounding is *** on the Comprehensive Multiscalar Index(CMI),multiple super drought events in SWC were identified to be temporally clustered during *** them,the decadal background of enhanced evaporation and precipitation deficit at long time scales is a necessary condition for shaping the overall pattern of super droughts,while the precipitation and evaporation anomalies at short time scales trigger the outbreak of super droughts,determining the exact timing of *** events include August-September 2006,November 2009 to May 2010,July-October 2011,April-May 2012,January-April 2013,*** results suggest that the contribution of superposed precipitation anomalies to super drought is 2.4 times that of *** regards the circulation mechanisms affecting multiscalar precipitation,the anomalous spatial patterns at short-term and long-term scales are similar,featuring the cyclonic circulation over the South China Sea and the northeasterly wind anomalies together with the subsidence center over *** 2006-2014,the possible causes for the cross-seasonal persistent precipitation reduction in SWC are the extreme negative phase of the Pacific Decadal Oscillation(PDO)in the North Pacific as well as the pronounced warming of the warm pool in the western *** key dynamic processes are outlined as *** the one hand,the negative PDO p

关键词： Super drought Multiscalar Compounding effect Mechanism analysis Southwest China

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抗拔锚杆在超高挡土墙中的加筋作用研究

岩土工程技术 2024年第2期38卷 156-162页

作者：徐书平汪紫璇柯芊芊陈律涂耀程杰林武汉轻工大学土木工程与建筑学院湖北武汉430023 武汉正洪岩土工程有限公司湖北武汉430000 武汉鑫地岩土工程技术有限公司湖北武汉430040

通过在超高挡土墙中安装水平抗拔锚杆和抗滑块,从而降低挡土墙的截面积。这种加筋方式可以有效地减轻主动土压力。当布置不同形式的抗拔锚杆和抗滑块时,墙后土体应力分布产生大幅的影响,对其水平应力和水平位移进行了数值分析。根据某... 详细信息

通过在超高挡土墙中安装水平抗拔锚杆和抗滑块,从而降低挡土墙的截面积。这种加筋方式可以有效地减轻主动土压力。当布置不同形式的抗拔锚杆和抗滑块时,墙后土体应力分布产生大幅的影响,对其水平应力和水平位移进行了数值分析。根据某工程实际情况,计算得出挡土墙背部土体在不同工况下的水平方向应力和位移大小,以验证其安全性,达到减少土体压力的目的。结果表明,在超高挡土墙中,采用3层抗拔锚杆和每层抗拔锚杆上安装2个抗滑块的加筋方式,对挡土墙墙后土体的预加固,增加墙后土体的自身稳定性,削减墙后土体对挡墙的土压力,可以获得最佳的加筋效果。

关键词：挡土墙抗拔锚杆抗滑块预加固数值模拟

Experimental investigation on a small-scale ORC system with a pump driven by internal multi-potential

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Science China(Technological Sciences) 2021年第8期64卷 1599-1610页

作者： wang zixuan wang LiWei ZHOU Lei DU Shuai XU ShengZhi Institute of Refrigeration and Cryogenics Key Laboratory for Power Machinery and Engineering of M.O.E.Shanghai Jiao Tong UniversityShanghai200240China Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering MechanicsTsinghua UniversityBeijing100084China

In this study,a novel organic Rankine cycle(ORC)based on a pump driven by internal multi-potential,i.e.,gravity-assisted thermally driven pump(GTP),is *** newly proposed cycle consists of a GTP,a condenser,an expander,and an *** GTP component is composed of three top-down organized units,and it drives the transport of liquid from the low-pressure condenser to the high-pressure evaporator by thermal energy and *** a component substitutes the conventional electricity-driven ***,the modified scroll expander of the ORC-GTP system is experimentally studied,and the results show that the best conversion efficiency from shaft work to electricity and the best isentropic efficiency are 82.0%and 84.2%,*** experimental setup of the ORC-GTP power system is built for low-grade thermal energy *** is tested under the average evaporator outlet temperature of 96.4℃,106.1℃,and 108.8℃at the ambient temperature of around 25℃.The highest shaft work is achieved at 96.4℃evaporator outlet temperature,and the largest ratio of time lasting for power generation is 100%.Since the ORC-GTP system has much less sensible heat loss of the evaporator,the highest average thermal efficiency of the ORC-GTP reaches 3.57%,which is increased by 71.74%compared with the pumpless ORC system in the literature.

关键词： small-scale power system organic Rankine cycle gravity-assisted thermally driven pump scroll expander internal multi-potential

Identification of two pIgR-like molecules in teleost fish with opposite roles in mucosal immunity against bacterial infection

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Water Biology and Security 2023年第4期2卷 101-115页

作者： Haoyue Xu zixuan wang Zhenyu Huang Xiaoyun Chen Ruiqi Lin Yongyao Yu Zhen Xu Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture Institute of HydrobiologyChinese Academy of SciencesWuhan430072China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing100049China Department of Aquatic Animal Medicine College of FisheriesHuazhong Agricultural UniversityWuhan430070China

Polymeric immunoglobulin(Ig)receptor-like(pIgRL)molecules have been identified in teleost ***,compared to functional studies of their related genes(e.g.,mammalian CD300 family)in eliminating pathogen invasion while preserving homeostasis,the roles of pIgRL in teleost fish remain *** this study,we demonstrated that a pair of pIgRL molecules in zebrafish,pIgRL3.5 and pIgRL4.2,were highly expressed in the intestine and immune ***,we constructed an Edwardsiella piscicida infection model,which induced strong inflammatory responses in the zebrafish ***,pIgRL3.5 and pIgRL4.2 exhibited opposite inducible expression patterns in response to bacterial infection,suggesting that they perform different *** importantly,by conducting overexpression and knockdown experiments,our findings demonstrated that zebrafish pIgRL3.5 played a protective role in host defense against *** infection by inhibiting excessive inflammatory *** contrast,pIgRL4.2 facilitated pathogen growth and dissemination in zebrafish ***,our findings are the first to demonstrate that a pair of pIgRL molecules in teleost fish play opposite roles in mucosal immune response to bacterial ***,our results provide crucial insights into the conserved role of pIgRL molecules in immune regulatory functions throughout vertebrate evolution.

关键词： pIgR-like Mucosal immunity Edwardsiella piscicida Inflammatory response Zebrafish

窄带LED无创光疗对糖尿病足真皮成纤维细胞增殖及分泌功能的影响

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中国激光医学杂志 2024年第2期33卷 61-66,116,117页

作者：王子萱祝闽辉王颖王贺冉冀全博赵洪友褚万立顾瑛邱海霞解放军医学院北京市100853 中国人民解放军总医院第一医学中心激光医学科中国人民解放军总医院第四医学中心烧伤整形医学部中国人民解放军总医院第二医学中心老年医学研究所中国人民解放军总医院第四医学中心骨科医学部北京理工大学医学技术学院

目的研究窄带发光二极管(light emitting diode,LED)无创光疗对糖尿病足真皮成纤维细胞(diabetic foot dermal fibroblasts,DFFs)增殖和分泌功能的影响。方法将糖尿病足溃疡患者的足部皮肤标本使用酶消化法原代分离培养获得DFFs,采用细... 详细信息

目的研究窄带发光二极管(light emitting diode,LED)无创光疗对糖尿病足真皮成纤维细胞(diabetic foot dermal fibroblasts,DFFs)增殖和分泌功能的影响。方法将糖尿病足溃疡患者的足部皮肤标本使用酶消化法原代分离培养获得DFFs,采用细胞免疫荧光实验进行成纤维细胞鉴定。以DFFs为研究对象,实验分为两部分:(1)窄带LED对DFFs细胞增殖情况的影响。细胞增殖实验分为3组,分别为非光疗组(A组)即仅接种细胞但不进行LED光照;光疗组(B组),采用波长630 nm,带宽16 nm,功率密度10 mW/cm^(2)的LED光分别照射60 s、100 s、500 s、1000 s、2000 s和2500 s。空白对照组(C组)即不接种细胞也不进行LED光照。各组处理后24 h检测细胞吸光度计算各组细胞活力以评估增殖情况。(2)窄带LED对DFFs细胞因子分泌的影响。实验分为光疗组和非光疗组两组,优选促进DFFs增殖作用最强的光剂量作为光疗组的光剂量;非光疗组不进行光照,两组干预后12 h,比较两组DFFs分泌转化生子因子-β1(transforming growth factor-beta 1,TGF-β1)、基质金属蛋白酶抑制剂1(matrix metalloproteinase inhibitor 1,TIMP1)和血管生成素(angiopoietin 1,Ang1)的差异。结果(1)细胞免疫荧光鉴定发现酶消化法分离培养的原代DFFs中成纤维细胞纯度接近100%。(2)窄带LED照射DFFs细胞后细胞增殖情况。光疗组(B组)的细胞增殖随照射时间的增加先升高达到最大值后开始降低。光疗组(B组)中以波长630nm,功率密度10 mW/cm^(2)的LED照射500 s和1000 s时能够促进原代培养的DFFs的增殖,与非光疗组(A组)比较差异具有统计学意义(P0.05)。结论窄带LED无创光疗可以促进DFFs增殖,并增加与成纤维细胞增殖相关的因子TGF-β1、血管生成相关的因子Ang1的分泌。

关键词：窄带LED 无创光疗糖尿病足真皮成纤维细胞细胞因子

Innovation leading development:a glimpse into three-dimensional bioprinting in Israel

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Bio-Design and Manufacturing 2024年第3期7卷 358-382页

作者： Lujing Gao zixuan Liu Daniel Dikovsky Jiqian wang Deqing Mei Lihi Adler-Abramovich Ehud Gazit Kai Tao State Key Laboratory of Heavy Oil Processing and Centre for Bioengineering and Biotechnology College of Chemistry and Chemical EngineeringChina University of Petroleum(East China)Qingdao 266580China Future Science Research Institute Hangzhou Global Scientific and Technological Innovation CentreHangzhou 311200China Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials Hangzhou 311200China Redefine Meat Ltd. Rehovot 7670110Israel State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310058China Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310058China Department of Oral Biology The Maurice and Gabriela Goldschleger School of Dental MedicineFaculty of Medical&Health SciencesTel Aviv UniversityTel Aviv 6997801Israel The Center for Nanoscience and Nanotechnology Tel Aviv UniversityTel Aviv 6997801Israel Department of Materials Science and Engineering Iby and Aladar FleischmanTel Aviv UniversityTel Aviv 6997801Israel The Shmunis School of Biomedicine and Cancer Research George S.Wise Faculty of Life SciencesTel Aviv UniversityTel Aviv 6997801Israel

Three-dimensional(3D)printing has attracted increasing research interest as an emerging manufacturing technology for devel-oping sophisticated and exquisite architecture through hierarchical *** has also been employed in various advanced industrial *** development of intelligent biomedical engineering has raised the requirements for 3D printing,such as flexible manufacturing processes and technologies,biocompatible constituents,and alternative ***,state-of-the-art 3D printing mainly involves inorganics or polymers and generally focuses on traditional industrial fields,thus severely limiting applications demanding biocompatibility and *** this regard,peptide architectonics,which are self-assembled by programmed amino acid sequences that can be flexibly functionalized,have shown promising potential as bioinspired inks for 3D ***,the combination of 3D printing and peptide self-assembly poten-tially opens up an alternative avenue of 3D bioprinting for diverse advanced ***,a small but innovative nation,has significantly contributed to 3D bioprinting in terms of scientific studies,marketization,and peptide architectonics,including modulations and applications,and ranks as a leading area in the 3D bioprinting *** review summarizes the recent progress in 3D bioprinting in Israel,focusing on scientific studies on printable components,soft devices,and tissue *** paper further delves into the manufacture of industrial products,such as artificial meats and bioinspired supramolecular architectures,and the mechanisms,physicochemical properties,and applications of peptide ***,Israel contributes significantly to the field of 3D bioprinting and should thus be appropriately recognized.

关键词： Israel 3D bioprinting Biomanufacturing Peptide self-assembly Integration of industry,education and research

Degradation properties of fulvic acid and its microbially driven mechanism from a partial nitritation bioreactor through multi-spectral and bioinformatic analysis

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Journal of Environmental Sciences 2024年第1期135卷 318-331页

作者： Quanhao Dou Li Zhang Tingjun Dong zixuan Song Xuepeng Fan Yongzhen Peng Xiayan wang Jiachun Yang National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology Key Laboratory of Beijing for Water Quality Science and Water Environment Recovery EngineeringBeijing University of TechnologyBeijing 100124China Department of Chemistry and Biology Center of Excellence for Environmental Safety and Biological EffectsBeijing Key Laboratory for Green Catalysis and SeparationBeijing University of TechnologyBeijing 100124China Environmental Protection Development Group Co. Ltd.Shandong 250101China

This study employed multispectral techniques to evaluate fulvic acid(FA)compositional characteristic and elucidate its biodegradation mechanisms during partial nitritation(PN)*** showed that FA removal efficiency(FRE)decreased from 90.22 to 23.11%when FA concentrations in the reactor were increased from 0 to 162.30 mg/L,and that molecular size,degree of aromatization and humification of the effluent FA macromolecules all increased after *** population analysis indicated that the proliferation of the Comamonas,OLB12 and Thauera exhibit high FA utilization capacity in lower concentrations(<50.59 mg/L),promoting the degradation and removal of macromolecular *** addition,the sustained increase in external FA may decrease the abundance of above functional microorganisms,resulting in a rapid drop in ***,from the genetic perspective,the elevated FA levels restricted carbohydrate(ko00620,ko00010 and ko00020)and nitrogen(HAO,AMO,NIR and NOR)metabolism-related pathways,thereby impeding FA removal and total nitrogen loss associated with N_(2)O emissions.

关键词： Partial nitritation Fulvic acid 3DEEM-PARAFAC UV/Vis Microbially driven mechanism

Creating a semi-opened micro-cavity ovary through sacrificial microspheres as an in vitro model for discovering the potential effect of ovarian toxic agents

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Bioactive Materials 2023年第8期26卷 216-230页

作者： Min Ye Yiran Shan Bingchuan Lu Hao Luo Binhan Li Yanmei Zhang zixuan wang Yuzhi Guo Liliang Ouyang Jin Gu Zhuo Xiong Ting Zhang Biomanufacturing Center Department of Mechanical EngineeringTsinghua UniversityBeijing100084China Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing Beijing100084China Biomanufacturing and Engineering Living Systems Innovation International Talents Base(111 Base)Beijing100084China MOE Key Laboratory of Bioinformatics BNRIST Bioinformatics DivisionDepartment of AutomationTsinghua UniversityBeijing100084China

The bio-engineered ovary is an essential technology for treating female *** the development of relevant in vitro models could be a critical step in a drug ***,we develop a semi-opened culturing system(SOCS)strategy that maintains a 3D structure of follicles during the *** on the SOCS,we further developed micro-cavity ovary(MCO)with mouse follicles by the microsphere-templated technique,where sacrificial gelatin microspheres were mixed with photo-crosslinkable gelatin methacryloyl(GelMA)to engineer a micro-cavity niche for follicle *** semi-opened MCO could support the follicle growing to the antral stage,secreting hormones,and ovulating cumulus-oocyte complex out of the MCO without extra *** MCO-ovulated oocyte exhibits a highly similar transcriptome to the in vivo counterpart(correlation of 0.97)and can be ***,we found that a high ROS level could affect the cumulus expansion,which may result in anovulation *** damage could be rescued by melatonin,but the end of cumulus expansion was 3h earlier than anticipation,validating that MCO has the potential for investigating ovarian toxic agents in *** provide a novel approach for building an in vitro ovarian model to recapitulate ovarian functions and test chemical toxicity,suggesting it has the potential for clinical research in the future.

关键词： Bio-engineered ovary SOCS Semi-opened MCO Ovarian model Drug study

A High-Contrast Autolysosome Probe for Detecting Interaction between Autophagosomes and Autolysosomes in Mitophagy

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Chinese Journal of Chemistry 2024年第8期42卷 858-866页

作者： Weihua wang Chu Han Shengjie Xie Zisong Cong zixuan Yang Yuxin Feng Limin Xiang Heng Song College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei430072 China

Comprehensive Summary,Autophagy is a multi-step cell metabolism process in which cells remove damaged and unwanted *** autophagy,autophagosomes fuse with lysosomes to form *** membrane components are recycled from autolysosomes through the autophagosomal components recycling(ACR),while lysosomal components circulate on the autolysosomal surface through the autophagic lysosome reformation(ALR)*** contain components from autophagosomes and ***,whether there is a fusion between autolysosome and autophagosome or lysosome at the organelle level remains *** this study,a pH and viscosity dual-controlled mitochondria-targeting fluorescent probe Mito-Q was designed based on an asymmetric norcyanine to achieve the high-contrast imaging of mitochondria-containing ***-Q not only effectively detected mitochondrial viscosity changes and mitophagy with high sensitivity,but more importantly,the fusion of mitochondria-containing autolysosomes and autophagosomes(FMAA)was observed during autophagy by the real-time confocal imaging of HeLa cells.

关键词： Mitophagy Autolysosomes Bioimaging Biosensors Fluorescence imaging