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A highly sensitive “turn-on” fluorescent probe for bovine serum albumin protein detection and quantification based on AIE-active distyrylanthracene derivative

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Science China Chemistry 2013年第9期56卷 1234-1238页

作者： wang zilong MA Ke XU Bin LI Xing TIAN WenJing State Key Laboratory of Supramolecular Structure and Materials Jilin University

A sulfonated 9,10-distyrylanthracene derivative with aggregation-induced emission (AIE) property is designed and synthesized. It shows a highly sensitive and selective fluorescence enhancement property for bovine serum albumin (BSA) protein detection and quantification. Analysis on the interaction between the probe molecule and BSA reveals the essential role of the hydrophobic cavities of the protein folding structure.

关键词： aggregation-induced emission fluorescent probe distyrylanthracene derivative

Magnetic properties enhancement of hot-deformed NdFeB magnets by two different methods of CeNdCu diffusion

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Journal of Rare Earths 2020年第12期38卷 1312-1316页

作者： Guibing Shi zilong wang Xinyuan Bai Wenlong Yan Yang Luo Dunbo Yu National Engineering Research Center for Rare Earth Materials GRINM Group Co.Ltd.Beijing 100088China GRIREM Advanced Materials Co. Ltd.Beijing 100088China General Research Institute for Nonferrous Metals Beijing 100088China

Two different ways were used to control the distribution of cerium for the enhancement of *** was by coating CeNdCu in the prepared magnet and annealing to make CeNdCu diffuse into the grain boundary to increase the coercivity,the other was by mixing CeNdCu with initial magnetic powders and then preparing the hot-deformed *** SEM-EDS result indicates that cerium diffuses more easily into the main phase by the mixing way,while cerium is mainly distributed in the grain boundary via the coating *** heat-treatment process may be one of the dominant influencing factors for the distribution of Ce,Multi-steps heat treatment in the mixing way,consisting of hot-pressing,hot-deforming and post heat process,easily introduces Ce into the main phase Nd2 Fe14B,which forms the Ce2 Fe14B shell resulting in the decrease of *** the coating way can ensure uniform dispersion of Ce in the grain boundary,which leads to the high coercivity.

关键词： Hot-deformed magnet Coating Mixing CeNdCu Rare earths

检验检测服务业经营绩效的关键影响因素研究——基于双循环视角

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河南科学 2024年第4期42卷 606-613页

作者：郭栋王子龙邱士雷章琪南京航空航天大学经济与管理学院南京211106 南京海关南京210001 南京邮电大学管理学院南京210003

利用多元线性回归模型,探究影响我国各地区检验检测服务业经营绩效的关键因素.选取机构营收额作为被解释变量,进出口贸易、第二产业发展、第三产业发展、受教育程度作为解释变量,进行我国整体分析和地区异质化分析.研究结果表明:产业结... 详细信息

利用多元线性回归模型,探究影响我国各地区检验检测服务业经营绩效的关键因素.选取机构营收额作为被解释变量,进出口贸易、第二产业发展、第三产业发展、受教育程度作为解释变量,进行我国整体分析和地区异质化分析.研究结果表明:产业结构优化是提升检验检测服务业经营绩效的决定因素,进出口贸易对检验检测服务业的发展具有显著的正向影响,但进出口贸易的正向作用明显小于产业结构的作用.人力资源错配是造成东部地区人力资本抑制检验检测服务业经营绩效的重要原因.

关键词：检验检测服务业产业结构双循环格局多元线性回归经营绩效

eALT-F:A New Non-Invasive Staging Method to Identify Medium to High-Risk Patients with HCC from Ultra-High HBV Viral Load Population—China,2010-2023

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China CDC weekly 2023年第49期5卷 1107-1114页

作者： Jiarui Zheng Xiaoxiao wang zilong wang Linxiang Huang Yandi Xie Suzhen Jiang Bo Feng Peking University People’s Hospital Peking University Hepatology InstituteBeijingChina Peking University People’s Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisBeijingChina

Background:The objective of this study was to examine the clinical characteristics of individuals with ultra-high hepatitis B virus(HBV)viral load and develop a novel staging method for chronic hepatitis B(CHB)that can more effectively identify patients with medium to high hepatocellular carcinoma(HCC)***:A total of 2,118 patients with HBV DNA>1×10^(7) IU/mL who visited Peking University People’s Hospital between January 2010 and March 2023 were enrolled *** data from the first visit were obtained and *** traditional phases and new‘eALT-F’stages were compared to evaluate the risk of ***:In the overall patients,more than onethird of the patients were under 30 years ***,a small proportion of older people(>60 years)also had ultra-high HBV viral load(4.3%).9.1%and 6.7%of individuals with ultra-high HBV viral load showed FIB-4>3.25 and aMAP≥50,*** the traditional stages of CHB,which are based on HBeAg and alanine aminotransferase(ALT)[the upper limit of normal(ULN)ALT level at 40 IU/L for both men and women],regardless of phase,a certain proportion of patients were at risk of developing HCC(4.1%,6.4%,25.0%,and 20.3%).However,in the new‘eALT-F’stages,which are based on HBeAg,ALT(the ULN of ALT level at 30 IU/L for men and 19 IU/L for women),and/or FIB-4 levels(>1.45),aMAP≥50 was only observed in chronic hepatitis patients with positive or negative HBeAg(6.4%and 22.1%,respectively).Conclusions:The‘eALT-F’staging method,based on HBeAg,ALT(males:the ULN of ALT was 30 IU/L,females:19 IU/L)and/or FIB-4 levels,was more effective in identifying medium to high-risk patients with HCC from patients with ultra-high HBV viral load than the traditional staging methods.

关键词： Patients Population Medium

Effects of grain boundary diffusion of PrCu alloy on microstructure and coercivity of hot deformed(Nd,Ce)-Fe-B magnets

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Journal of Rare Earths 2021年第8期39卷 986-992页

作者： Haijun Peng Dunbo Yu Xinyuan Bai Xiao Lin Yongjun Mao zilong wang Yang Luo National Engineering Research Center for Rare Earth Materials CRINM Group Co.Ltd.Beijing 100088China GRIREM Advanced Materials Co. Ltd.Beijing 100088China General Research Institute for Non/errous Metals Beijing 100088China

The technology of using high abundance rare earth element Ce in permanent magnets has attracted many *** this work,the magnetic properties and microstructures of hot deformed(Nd_(1-x)Ce_(x))_(13.8)Fe_(76.1)Co_(4)Ga_(0.5)B_(5.6) magnets and a selective magnet treated with PrCu grain boundary diffusion process(GBDP) were investigated *** is found that Ce is beneficial to improving the plastic deformation ability of NdFeB *** strongest c-axis orientation is achieved in the HD magnets with Ce concentration of x=0.3,resulting in good comprehensive magnetic properties of B_(r)=13.00 kGs,H_(cj)=10.12 kOe,(BH)_(max)=38.42 *** on that,the GBDP was implemented on the magnets with the best orientation using Pr_(68)Cu_(32) ribbons and the magnetic properties of B_(r)=12.87 kGs,H_(cj)=15.65 kOe,(BH)_(max)=37.48 MGOe were *** results of composition distribution and Curie temperature test of the GBDPed magnets illustrate that Pr diffuses into the(Nd,Ce)_(2)(Fe,Co)_(14)B grains to substitute Ce,which not only improves the Curie temperature of the grains,but also enhances the magnetic performance of the *** GBDP,the thermal stability of magnets has also been improved.

关键词： Nd-Ce-Fe-B GBDP Hot deformation Magnetic properties Microstructure Rare earths

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β3肾上腺素受体与冠心病的研究进展

中国分子心脏病学杂志 2024年第1期24卷 5933-5937页

作者：蔡家晟罗溶汪自龙复旦大学附属中山医院青浦分院上海201700

β肾上腺素受体(β-adrenergic receptor, β-AR)在冠心病病因研究中占据着重要位置,包括β1、β2和β3三个亚型,这些受体在机体广泛表达并具有多种生理功能。β3-AR可介导脂肪代谢相关反应,与脂代谢异常、胰岛素抵抗、糖尿病及高血压... 详细信息

β肾上腺素受体(β-adrenergic receptor, β-AR)在冠心病病因研究中占据着重要位置,包括β1、β2和β3三个亚型,这些受体在机体广泛表达并具有多种生理功能。β3-AR可介导脂肪代谢相关反应,与脂代谢异常、胰岛素抵抗、糖尿病及高血压等冠心病危险因素密切相关;另外,β3-AR激动对心肌梗死后心脏具有保护作用。本研究通过概述β3-AR分子结构特征、在心脏中的表达及生理功能,探讨β3-AR在冠心病发病中的潜在作用及其成为冠心病风险预测因子或治疗新靶点的潜力。

关键词： β3肾上腺素受体冠状动脉粥样硬化性心脏病心肌缺血再灌注损伤

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基于氧化石墨烯电化学传感器检测维C

农产品加工 2024年第10期 78-82,90页

作者：唐志永王子龙彭钢黄怡安徽科技学院食品工程学院安徽滁州233100

采用Hummer法制备氧化石墨烯(GO),再通过水热法合成石墨烯气凝胶(GAs),采用滴涂法将GAs附着在铟锡氧化物(ITO)电极表面,基于GAs材料构建维C电化学传感器。通过SEM对GAs材料的形貌进行表征,并利用CV和EIS对GAs材料的电化学性能进行表征,... 详细信息

采用Hummer法制备氧化石墨烯(GO),再通过水热法合成石墨烯气凝胶(GAs),采用滴涂法将GAs附着在铟锡氧化物(ITO)电极表面,基于GAs材料构建维C电化学传感器。通过SEM对GAs材料的形貌进行表征,并利用CV和EIS对GAs材料的电化学性能进行表征,并在最优条件下用DPV法对样品中的维C进行定量检测,获得检测线性范围为0.0005~15.0000 mmol/L,检测最低限为0.05μmol/L。

关键词：维C 石墨烯气凝胶电化学传感器

The regulation mechanism and heat transfer enhancement of composite mixed paraffin and copper foam phase change materials

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Science China(Technological Sciences) 2023年第8期66卷 2346-2360页

作者： YANG HanXue ZHANG GuanHua DOU BinLin CUI GuoMin YAN XiaoYu LU Wei wang zilong School of Energy and Power Engineering University of Shanghai for Science and TechnologyShanghai 200093China Environment and Sustainability Institute University of ExeterPenrynCornwall TR109FEUK

Phase change materials(PCMs)have remarkable energy storage capacity and promising applications in the field of thermal control of electronic *** problem of thermal property improvement and heat transfer of PCMs in metal-foam heatsinks is an important task for thermal management of electronic *** paraffin samples were prepared by mixing appropriate proportions of paraffin(mass)at various *** scanning calorimetry analysis revealed that the maximum enthalpy of 206.3 J/g is obtained by mixing 20%of 17°C liquid paraffin and 80%of 29℃ solid *** and cooling cycling tests revealed that mixed paraffin exhibits excellent thermal stability and that the regulation method marginally affects thermal ***,composites were prepared by embedding PCM into a copper foam by melt *** thermal conductivity of the composites increased to 4.35 W/(m K),corresponding to 20 times its original *** addition,density functional theory and experimental results were in good agreement,indicating that the regulation method is practical and effective.

关键词： phase change materials regulation mechanism temperature dependence thermal conductivity heat transfer enhancement

Coordination and order risk assessment of water and land resource system based on periphery and synergetics theories

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International Journal of Agricultural and Biological Engineering 2018年第3期11卷 146-153页

作者： Qiuxiang Jiang Zhimei Zhou zilong wang Qiang Fu Youzhu Zhao Tian wang School of Water Conservancy and Civil Engineering Northeast Agricultural UniversityHarbin150030China

Coordinated and orderly water and land resource system is vital to ensure the economic and social development of a *** production in Heilongjiang Province has increased consecutively every year since 2003,and numerous water and land resource-related problems have become increasingly prominent and have had significant adverse effects on social and economic development and stability in the *** this study,Heilongjiang Province and its 13 prefecture-level cities were selected as the study area,and the degrees of coordination of the social,economic and ecological subsystems were evaluated using periphery theory and the theory of *** ensure that the assessment was objective and accurate,weights were calculated using the projection pursuit technique,and similarity degrees were calculated using a modified(by introducing the chi-square distance)order of preference by similarity to ideal solution(TOPSIS)***,to reflect the variations in the overall degree of coordination in Heilongjiang Province,the risk level of the coordination of the water and land resource system was predicted through the year 2020 using a dynamic neural *** study provides a reference for establishing effective and balanced coordination between society and water and land resources.

关键词： water and land resources periphery theory coordination particle swarm optimization neural network