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重庆大气中多环芳香类物质气粒分配模型预测

中国环境科学 2024年第2期44卷 629-637页

作者：王子倩郝炜伟董玲池陈静赵鑫泉田密重庆大学环境与生态学院重庆400044

本研究以典型半挥发性有机物,多环芳烃(PAHs)及含氧PAHs(OPAHs)为研究对象,基于对重庆典型城区冬季大气样品的采集与分析,探讨不同类型多环芳香类化合物的气粒分配特征及其模型预测.结果表明,OPAHs较同环数PAHs更倾向于分配至颗粒相.PAH... 详细信息

本研究以典型半挥发性有机物,多环芳烃(PAHs)及含氧PAHs(OPAHs)为研究对象,基于对重庆典型城区冬季大气样品的采集与分析,探讨不同类型多环芳香类化合物的气粒分配特征及其模型预测.结果表明,OPAHs较同环数PAHs更倾向于分配至颗粒相.PAHs的温度经验模型可较好地模拟其气粒分配行为,但已有模型对OPAHs气粒分配的预测效果均不理想.本研究借鉴PAHs温度经验模型建立方法,利用前期监测数据分别基于温度和相对湿度(RH)建立了预测OPAHs气粒分配的两种经验模型.预测值落入合理偏差区域内的百分数(67.57%及88.74%)及均方根误差(1.05及0.65)分析均表明,相较于前期模型(百分数:52.25%、4.95%、61.26%,均方根误差:1.26、2.21、1.16),基于RH的经验模型可较好地预测OPAHs的气粒分配行为.可见,与PAHs不同,RH对OPAHs气粒分配的影响不可忽略.

关键词：含氧多环芳烃气粒分配预测模型相对湿度

基于工艺与装备视角分析中药制剂质量的关键影响因素

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中国中药杂志 2024年第6期49卷 1699-1704页

作者：万鑫浩舒清霞王子千杨东印杨明王学成伍振峰江西中医药大学现代中药制剂教育部重点实验室江西南昌330004 江西省药品检验检测研究院江西南昌330004 江西省药品检查员中心江西南昌330004

中药制剂的质量直接关乎患者的安全,在其诸多的影响因素中以制剂的工艺环节及相应关键设备较为突出,是中药制剂质量的关键影响因素。为了更好地提高中药制剂质量,该文围绕中药制剂制造过程中各工艺环节及相应关键设备存在的问题进行总... 详细信息

中药制剂的质量直接关乎患者的安全,在其诸多的影响因素中以制剂的工艺环节及相应关键设备较为突出,是中药制剂质量的关键影响因素。为了更好地提高中药制剂质量,该文围绕中药制剂制造过程中各工艺环节及相应关键设备存在的问题进行总结分析,并建立以安全性和有效性为前提,结合药物自身性质、制备工艺、制剂特征的药品关键质量属性评价体系,为以质量提升为目标的工艺与设备改进提供依据。

关键词：药品质量中药制剂工艺环节关键装备关键质量属性

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数字中药药剂学的现状与发展趋势分析

中国中药杂志 2024年第2期49卷 285-293页

作者：伍振峰杨书洁杨怡琴王子千艾灵朱根华朱卫丰江西中医药大学现代中药制剂教育部重点实验室江西中医药大学中药制药技术协同创新研究院江西省药品检查员中心

21世纪是一个高度信息化的时代,中药药剂学也在向着数字化、信息化方向发展,以信息技术为核心的人工智能、大数据等新技术正在渗透到药品研发、制造、评价以及应用等各个环节,促进各环节相交互,提高了中药制剂品质和效益,为人民群众提... 详细信息

21世纪是一个高度信息化的时代,中药药剂学也在向着数字化、信息化方向发展,以信息技术为核心的人工智能、大数据等新技术正在渗透到药品研发、制造、评价以及应用等各个环节,促进各环节相交互,提高了中药制剂品质和效益,为人民群众提供更优质的健康服务。人工智能、大数据、云计算等新兴技术与中药药剂产业的深度融合将创新中药制药技术,加速中药药剂学的研发和产业化进程,为世界科技提供更前沿的技术支持,带动中药产业的效益,促进经济社会发展。参考近年来我国中药药剂学发展研究的相关进展,该文在此基础上探讨数字中药药剂学当前的研究现状和未来发展趋势,为后续中药药剂学相关方面的研究提供参考。

关键词：数字化中药药剂学药物研发制药过程质量控制研究进展

基于“辨状论质”理论对中药炮制火候的科学内涵研究

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中国中药杂志 2024年第5期49卷 1196-1205页

作者：曹萱张雨恬伍振峰徐柳风王子千曾慧敏杨明江西中医药大学现代中药制剂教育部重点实验室江西南昌330004 江西中医药大学附属医院江西南昌330004 江西省药品检查员中心江西南昌330000

中药炮制是中国医药遗产的组成部分,是中药前处理工艺中的重要环节,炮制过程中“火候”对中药的品质和药效有直接影响。但药材炮制过程中存在火候判断模糊,全凭人工经验把控火候终点;炮制机制不明确;炮制品质量不稳定;炮制标准不统一等... 详细信息

中药炮制是中国医药遗产的组成部分,是中药前处理工艺中的重要环节,炮制过程中“火候”对中药的品质和药效有直接影响。但药材炮制过程中存在火候判断模糊,全凭人工经验把控火候终点;炮制机制不明确;炮制品质量不稳定;炮制标准不统一等系列问题。中药炮制的火候控制程度体现在中药的外观性状和内在质量,而“辨状论质”理论是对中药的“形、色、味、成分”的综合判断,与中药炮制过程火候的调控相联系,针对这些问题,该文提出解决思路,一是文献挖掘,对传统文献、药工经验采集整理,深刻揭示炮制火候意图和方法演变;二是遵循古法、探究原理、创新炮制工艺技术;三是建立相关标准作业程序(SOP),量化火力火候,为制定规范的中药炮制工艺标准提供理论基础;同时为提高炮制产品品质,增加中药临床使用的安全性和有效性提供依据。

关键词：中药炮制火候火力辨状论质炮制机制干馏法

离散元法(DEM)在中药固体制剂制造过程中的应用

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中国中药杂志 2024年第12期49卷 3152-3159页

作者：吴一峰王子千万鑫浩胡恢权杨怡琴艾兵杨明伍振峰江西中医药大学现代中药制剂教育部重点实验室江西省中药绿色制造技术创新中心江西省药品检查员中心经典名方现代中药创制全国重点实验室

近年来，数值模拟越来越多地应用于新药研发和生产过程中，离散元法(DEM)是数值模拟方法中的一种重要方法，也是非连续介质模拟的有效手段。参考近年来DEM和中药固体制剂发展研究的相关进展，该文将对DEM在中药固体制剂制造过程中的应... 详细信息

近年来，数值模拟越来越多地应用于新药研发和生产过程中，离散元法(DEM)是数值模拟方法中的一种重要方法，也是非连续介质模拟的有效手段。参考近年来DEM和中药固体制剂发展研究的相关进展，该文将对DEM在中药固体制剂制造过程中的应用进行总结分析，并在此基础上探讨其在中药固体制剂中应用存在的挑战，以期为推动中药制剂高质量制造提供新方法新思路。

关键词：数值模拟离散元法中药固体制剂制造过程

Micro segment analysis of supercritical methane thermal-hydraulic performance and pseudo-boiling in a PCHE straight channel

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Petroleum Science 2024年第2期21卷 1275-1289页

作者： qian Li zi-Jie Lin Liu Yang Yue wang Yue Li Wei-Hua Cai Laboratory of Thermo-Fluid Science and Nuclear Engineering Northeast Electric Power UniversityJilin132000JilinChina School of Energy and Power Engineering Northeast Electric Power UniversityJilin132000JilinChina

The printed circuit heat exchanger(PCHE) is receiving wide attention as a new kind of compact heat exchanger and is considered as a promising vaporizer in the LNG process. In this paper, a PCHE straight channel in the length of 500 mm is established, with a semicircular cross section in a diameter of 1.2 mm.Numerical simulation is employed to investigate the flow and heat transfer performance of supercritical methane in the channel. The pseudo-boiling theory is adopted and the liquid-like, two-phase-like, and vapor-like regimes are divided for supercritical methane to analyze the heat transfer and flow features.The results are presented in micro segment to show the local convective heat transfer coefficient and pressure drop. It shows that the convective heat transfer coefficient in segments along the channel has a significant peak feature near the pseudo-critical point and a heat transfer deterioration when the average fluid temperature in the segment is higher than the pseudo-critical point. The reason is explained with the generation of vapor-like film near the channel wall that the peak feature related to a nucleateboiling-like state and heat transfer deterioration related to a film-boiling-like state. The effects of parameters, including mass flow rate, pressure, and wall heat flux on flow and heat transfer were analyzed.In calculating of the averaged heat transfer coefficient of the whole channel, the traditional method shows significant deviation and the micro segment weighted average method is adopted. The pressure drop can mainly be affected by the mass flux and pressure and little affected by the wall heat flux. The peak of the convective heat transfer coefficient can only form at high mass flux, low wall heat flux, and near critical pressure, in which condition the nucleate-boiling-like state is easier to appear. Moreover,heat transfer deterioration will always appear, since the supercritical flow will finally develop into a filmboiling-like state. So heat transfer deterioration should be taken serious

关键词： Printed circuit heat exchanger Vaporization Supercritical methane Pseudo-boiling Micro segment analysis

Ferritinophagy: A new idea for liver diseases regulated by ferroptosis

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 160-170页

作者： zi-Bing qian Jun-Feng Li Wan-Yuan Xiong Xiao-Rong Mao The First Clinical Medical College of Lanzhou University Lanzhou 730000China Institute of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000China Department of Infectious Disease The First Hospital of Lanzhou UniversityLanzhou 730000China

Background:The discovery of regulatory cell death has led to a breakthrough in the therapeutic field.Various forms of cell death,such as necrosis,apoptosis,pyroptosis,autophagy,and ferroptosis,play an important role in the development of liver diseases.In general,more than one form of cell death pathways is responsible for the disease state.Therefore,it is particularly important to study the regulation and interaction of various cell death forms in liver diseases.Data sources:We performed a PubMed search up to November 2022 with the following keywords:ferritinophagy,ferroptosis,and liver disease.We also used terms such as signal path,inducer,and inhibitor to supplement the query results.Results:This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regulation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver diseases.Conclusions:Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.

关键词： Ferritinophagy Ferroptosis Liver disease

A generalization of Banach's lemma and its applications to perturbations of bounded linear operators

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 363-369页

作者： wang zi DING Jiu wang Yu-wen School of Mathematics Sciences Harbin Normal UniversityHarbin 150025China School of Mathematics and Natural Sciences The University of Southern MississippiHattiesburg MS 39406-5043USA Academic Committee Harbin Institute of PetroleumHarbin 150027China

Let X be a Banach space and let P:X→X be a bounded linear operator.Using an algebraic inequality on the spectrum of P,we give a new sufficient condition that guarantees the existence of(I-P)^(-1) as a bounded linear operator on X,and a bound on its spectral radius is also obtained.This generalizes the classic Banach lemma.We apply the result to the perturbation analysis of general bounded linear operators on X with commutative perturbations.

关键词： Banach lemma spectral radius generalized inverse perturbation analysis

Efficacy and safety of perioperative therapy for locally resectable gastric cancer:A network meta-analysis of randomized clinical trials

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1046-1058页

作者： zi-Yu Kuang qian-Hui Sun Lu-Chang Cao Xin-Yi Ma Jia-Xi wang Ke-Xin Liu Jie Li Graduate College Beijing University of Traditional Chinese MedicineBeijing 100029China Oncology Department Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China

BACKGROUND Gastric cancer(GC)is the fifth most commonly diagnosed malignancy worldwide,with over 1 million new cases per year,and the third leading cause of cancer-related death.AIM To determine the optimal perioperative treatment regimen for patients with locally resectable GC.METHODS A comprehensive literature search was conducted,focusing on phase II/III randomized controlled trials(RCTs)assessing perioperative chemotherapy and chemoradiotherapy in treating locally resectable GC.The R0 resection rate,overall survival(OS),disease-free survival(DFS),and incidence of grade 3 or higher nonsurgical severe adverse events(SAEs)associated with various perioperative regimens were analyzed.A Bayesian network meta-analysis was performed to compare treatment regimens and rank their efficacy.RESULTS Thirty RCTs involving 8346 patients were included in this study.Neoadjuvant XELOX plus neoadjuvant radiotherapy and neoadjuvant CF were found to significantly improve the R0 resection rate compared with surgery alone,and the former had the highest probability of being the most effective option in this context.Neoadjuvant plus adjuvant FLOT was associated with the highest probability of being the best regimen for improving OS.Owing to limited data,no definitive ranking could be determined for DFS.Considering nonsurgical SAEs,FLO has emerged as the safest treatment regimen.CONCLUSION This study provides valuable insights for clinicians when selecting perioperative treatment regimens for patients with locally resectable GC.Further studies are required to validate these findings.

关键词： Gastric cancer Perioperative treatment Network meta-analysis Efficacy and safety