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Liquid droplet movement on horizontal surface with gradient surface energy

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Science China(Technological Sciences) 2006年第6期49卷 733-741页

作者： LIAO Qiang wang hong zhu Xun LI Mingwei Institute of Engineering Thermophysics Chongqing University Chongqing 400044 China Institute of Engineering Thermophysics Chongqing University Chongqing 400044 China Institute of Engineering Thermophysics Chongqing University Chongqing 400044 China Institute of Engineering Thermophysics Chongqing University Chongqing 400044 China

A surface with gradient surface energy was fabricated on a silicon wafer by using the chemical vapor deposition (CVD) technology with the dodecyltrichlorosilane (C12H25Cl3Si) vapor which was adsorbed chemically on the surface of the silicon wafer to form a self-assemble monolayer (ASM); thus a gradient profile of wettability. The microscopic contours of the gradient surface were measured with Seiko SPA400 atom force microscope (AFM). And the surface wettability profile was characterized by the sessile drop method, measuring the contact angle of fine water droplets that lay on the gradient surface, to represent the distribution of the surface energy on the surface. Using a high-speed video imaging system, the motion of water droplet on the horizontal gradient surface was visualized; the transient velocity was measured under ambient condition. The experimental results show that the liquid droplets can be driven to move from hydrophobic side to hydrophilic side on the horizontal gradient surface; the velocity of droplet can reach up to 40 mm/s. In addition, the motion of the water droplet can be generally divided into two stages: an acceleration stage; a deceleration stage. The droplet presents a squirming movement on the surface with a lower peak velocity; a larger extent of deceleration motion. And the static advancing contact angle of the droplet is obviously larger than the dynamic advancing contact angle on the gradient energy surface.

关键词： chemical vapor deposition, surface with gradient surface energy, contact angle profile, droplet motion.

浅水湖泊沉积物生源要素与浮游藻类和沉水植物的关系

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水生态学杂志 2024年第4期45卷 19-27页

作者：刘佳豪李艳申东方乔瑞婷王洪铸大连海洋大学水产与生命学院辽宁大连116023 中国科学院水生生物研究所淡水生态与生物技术国家重点实验室湖北武汉430072 中国科学院大学北京100049

为探究长江中下游浅水湖泊沉积物碳、氮、磷等生源要素的含量及其对浮游藻类和沉水植物的影响,以长江中下游11个浅水湖泊为研究对象,分析2003-2020年夏季沉积物总氮(TN_(Sed))、总磷(TP_(Sed))和有机碳(TOC_(Sed))含量与浮游藻类和沉水... 详细信息

为探究长江中下游浅水湖泊沉积物碳、氮、磷等生源要素的含量及其对浮游藻类和沉水植物的影响,以长江中下游11个浅水湖泊为研究对象,分析2003-2020年夏季沉积物总氮(TN_(Sed))、总磷(TP_(Sed))和有机碳(TOC_(Sed))含量与浮游藻类和沉水植物的关系。结果表明:(1)在长江中下游湖泊中,TP_(Sed)在藻型湖泊中最高,为(0.71±0.21)g/kg,草型湖泊中最低,为(0.52±0.13)g/kg。TN_(Sed)和TOC_(Sed)则在草型湖泊中最高,分别为(4.64±3.57)g/kg和(55.89±50.28)g/kg,中间态湖泊最低,分别为TN_(Sed)(1.86±1.26)g/kg,TOC_(Sed)(20.00±12.13)g/kg。(2)回归分析结果显示,夏季浮游藻类Chl-a含量在TP_(Sed)较高的湖泊中更高(P=0.01),沉水植物生物量(BMac)则在TP_(Sed)较低的湖泊中更高(P=0.03),而TN_(Sed)和TOC_(Sed)与Chl-a和BMac的回归关系不显著(P>0.17)。(3)长江中下游湖泊夏季沉水植物消失的沉积物总磷阈值约为0.87~0.98 g/kg。在长江中下游湖泊的沉积物中,磷含量对浮游藻类和沉水植物生物量的预测力比碳、氮含量更高,进一步研究二者定量关系后可为评价水生态系统沉积物污染状况及确定水生植被修复的沉积物条件需求提供科学依据。

关键词：长江中下游湖泊沉积物生源要素沉水植物浮游藻类

Development of Non-Quenched Prehardened Steel for Large Section Plastic Mould

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Journal of Iron and Steel Research International 2009年第2期16卷 61-67页

作者： LUO Yi WU Xiao-chun MIN Yong-an zhu zhu wang hong-bin School of Material Science and Engineering Shanghai University Shanghai 200072 China

In order to meet the demand of prehardened steel for large section plastic mould and save energy, a nonquenched prehardened （NQP） steel is developed. The temperature field of a large block is researched by finite element method simulation and 9 test steels are designed in the laboratory. Their microstructures and hardness are investigated when they are air cooled and control cooled at cooling rate similar to the simulation. The result shows that the hardness uniformity through section is closely correlated to bainitic hardenability for the NQP steel, and the hardness of one test steel （0.27C-1.95Mn-1.04Cr-0.45Mo-0.1V） fluctuates between HRC 40 and 43 under both cooling conditions. The test steel has better machinability compared with C45 steel, and the NQP steel is produced successfully in the factory based on the laboratory results. Its microstructure is bainite, and it is distributed uniformly through the size of 460 mm×800 mm×3 200 mm.

关键词： NQP steel large section plastic mould temperature estimation chemical composition microstructure machinability

Macrophage senescence in health and diseases

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1508-1524页

作者： Longling wang Wenxiang hong hong zhu Qiaojun He Bo Yang Jiajia wang Qinjie Weng Center for Drug Safety Evaluation and Research Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Nanhu Brain-Computer Interface Institute Hangzhou 311100China Taizhou Institute of Zhejiang University Taizhou 318000China The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310009China

Macrophage senescence,manifested by the special form of durable cell cycle arrest and chronic low-grade inflammation like senescence-associated secretory phenotype,has long been consid-ered *** senescence of macrophages may lead to maladaptation,immune dysfunction,and finally the development of age-related diseases,infections,autoimmune diseases,and ***,it is a ubiquitous,multi-factorial,and dynamic complex phenomenon that also plays roles in remodeled processes,including wound repair and *** this review,we summarize some general molecular changes and several specific biomarkers during macrophage senescence,which may bring new sight to recognize senescent macrophages in different ***,we take an in-depth look at the functional changes in senescent macrophages,including metabolism,autophagy,polarization,phagocytosis,antigen presentation,and infiltration or ***,some degenerations and diseases associated with senescent macrophages as well as the mechanisms or relevant genetic regulations of senescent macrophages are integrated,not only emphasizing the possibility of regulating macrophage senescence to benefit age-associated diseases but also has an implication on the finding of potential tar-gets ordrugs clinically.

关键词： Macrophages Senescence Molecular changes Functional alterations Aging tissues Age-associated diseases Drug treatment Genetic regulation

Assessments and diagnoses of aquatic ecosystem integrity based on integrity requirements of ecosystem service targets

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Water Biology and Security 2024年第1期3卷 1-10页

作者： hong-zhu wang Institute of Hydrobiology Chinese Academy of SciencesWuhan430072China

This paper critically reviews the progress in ecosystem integrity(health)assessment of inland waters and provides future directions for *** biotic integrity assessments mainly use multimetric indices and predictive models to evaluate overall health status;the criteria largely rely on pristine reference sites,but such an approach is not applicable to unique natural waters and irreversibly modified *** diagnostic assessments are still in the exploratory stage and can only diagnose possible stressor types and wide-ranges of their intensities through empirical models linking stressors and *** chemical integrity assessments mainly use criteria determined by small-scale ecotoxicity tests,rather than quantitative relationships developed between chemical factors and biotic effects in real ecosystems,thus potentially under or overestimating pollutant *** physical integrity assessments focus on overall habitat quality,rather than quantitative habitat requirements,and thus cannot provide quantitative support for ecological restoration and *** hydrological integrity(environment flow)assessments largely depend on quantitative relationships between hydrological regimes with a few species and single groups,rather than with whole communities,and fail to comprehensively diagnose hydrological causes of biotic resource *** the future,integrity assessments need to be based on ecosystem integrity requirements of ecosystem service targets:first,there is a need to build quantitative relationships between biotic integrity and ecosystem services,assess requirements of community structure and function for service goals,and establish biotic integrity assessment methods;second,we must build quantitative relationships between biotic integrity and abiotic integrity in real ecosystems,assess chemical,physical,and hydrological integrity requirements of biotic needs,and establish diagnostic assessment methods.

关键词： Ecosystem integrity Ecosystem health Inland waters Compliance assessment Diagnostic assessment Ecosystem service-based assessment

Characterization of Nutrients,Heavy Metals,Petroleum and Their Impact on Phytoplankton in Laizhou Bay:Implications for Environmental Management and Monitoring

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Journal of Ocean University of China 2024年第3期23卷 822-834页

作者： wang Kai ZHAO Linlin zhu Yugui YANG Liqiang wang Yunfeng hong Xuguang College of Marine Life Science Ocean University of ChinaQingdao 266003China First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China College of Fisheries Ocean University of ChinaQingdao 266003China Institute of Oceanology Chinese Academy of SciencesQingdao 266071China Southern Marine Science and Engineering Guangdong Laboratory Guangzhou 511458China

The Laizhou Bay(LB)represents a substantial ecological area that is vulnerable to human activities and confronts diverse environmental *** study provides a comprehensive characterization of nutrients,petroleum,heavy metals,and phytoplankton community structure across seven distinct areas in *** results indicate relatively high concentrations of NO_(2)-N,SiO_(4)-Si,and NO_(3)-N in the Southwest Laizhou Bay(SWLB)and Huanghe River Estuary(HRE).In contrast,the East Laizhou bay(ELB)and the North of Huanghe River Estuary(NHRE)exhibit the highest concentrations of heavy metals(As,Cr and Hg).The areas with high phytoplankton density and community diversity are mainly located in the *** adjusting for basic environmental factors,phytoplankton density and Margalef richness index D are significantly associated with nutrients(NO_(3)-N,NO_(2)-N,NH_(4)-N,SiO_(4)-Si),and heavy metal(Cr)*** highlight that,in addition to Xiaoqinghe River,nutrients brought by the Mihe River in the SWLB and heavy metal(Cr)pollution in the ELB resulting from industrial and mining activities along the coast significantly influence phytoplankton growth and community ***,it is recommended that more monitoring and management efforts be focused on these regions in the future.

关键词： Huanghe River Estuary Laizhou Bay nutrients heavy metals phytoplankton biodiversity

AZGP1P2/UBA1/RBM15 Cascade Mediates the Fate Determinations of Prostate Cancer Stem Cells and Promotes Therapeutic Effect of Docetaxel in Castration-Resistant Prostate Cancer via TPM1 m6A Modification

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Research 2024年第3期6卷 151-167页

作者： hong wang Jj Liu Xiaojun zhu Bin Yang Zuping He Xudong Yao Department of Urology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghaiChina Urologic Cancer Institute School of MedicineTongji UniversityShanghaiChina. Department of Urology Surgery The Affiliated Hospital of Inner Mongolia Medical UniversityHohhotChina. The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province School of MedicineHunan Normal UniversityThe Engineering Research Center of Reproduction and Translational Medicine of Hunan ProvinceChangshaChina Shanghai Key Laboratory of Reproductive Medicine Shanghai Jiao Tong University School of MedicineShanghaiChina.

Prostate cancer(PCa)is a common malignant tumor with high morbidity and mortality *** prostate cancer stem cell(PCSC)model provides novel insights into the pathogenesis of PCa and its therapeutic ***,the roles and molecular mechanisms of specific genes in mediating fate decisions of PCSCs and carcinogenesis of PCa remain to be *** this study,we have explored the expression,function,and mechanism of AZGP1P2,a pseudogene of AZGP1,in regulating the stemness and apoptosis of PCSCs and treatment resistance of docetaxel in castration-resistant prostate cancer(CRPC).We revealed that AZGP1P2 was downregulated in CRPC cell lines and PCSCs,while it was positively associated with progression-free *** of the AZGP1P2 enhanced the sensitivity of docetaxel treatment in CRPCs via inhibiting their *** pull-down associated with mass spectrometry analysis,co-immunoprecipitation assay,and RNA immunoprecipitation assay demonstrated that AZGP1P2 could bind to UBA1 and RBM15 as a“writer”of methyltransferase to form a ***1,an E1 ubiquitin-activating enzyme,contributed to RBM15 protein degradation via ubiquitination *** RNA immunoprecipitation assay displayed that RBM15 controlled the mRNA decay of TPM1 in m6A ***,a xenograft mouse model and patient-derived organoids showed that the therapeutic effect of docetaxel in CRPC was increased by AZGP1P2 in ***,these results imply that AZGP1P2 mediates the stemness and apoptosis of PCSCs and promotes docetaxel therapeutic effect by suppressing tumor growth and metastasis via UBA1/RBM15-mediated TPM1 mRNA decay in CRPC.

关键词： Prostate TPM1 m6A

High-throughput calculations combining machine learning to investigate the corrosion properties of binary Mg alloys

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Journal of Magnesium and Alloys 2024年第4期12卷 1406-1418页

作者： Yaowei wang Tian Xie Qingli Tang Mingxu wang Tao Ying hong zhu Xiaoqin Zeng University of Michigan-Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong University200240ShanghaiChina State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai200240China

Magnesium(Mg)alloys have shown great prospects as both structural and biomedical materials,while poor corrosion resistance limits their further *** this work,to avoid the time-consuming and laborious experiment trial,a high-throughput computational strategy based on first-principles calculations is designed for screening corrosion-resistant binary Mg alloy with intermetallics,from both the thermodynamic and kinetic *** stable binary Mg intermetallics with low equilibrium potential difference with respect to the Mg matrix are firstly ***,the hydrogen adsorption energies on the surfaces of these Mg intermetallics are calculated,and the corrosion exchange current density is further calculated by a hydrogen evolution reaction(HER)kinetic *** intermetallics,e.g.Y_(3)Mg,Y_(2)Mg and La_(5)Mg,are identified to be promising intermetallics which might effectively hinder the cathodic ***,machine learning(ML)models are developed to predict Mg intermetallics with proper hydrogen adsorption energy employing work function(W_(f))and weighted first ionization energy(WFIE).The generalization of the ML models is tested on five new binary Mg intermetallics with the average root mean square error(RMSE)of 0.11 *** study not only predicts some promising binary Mg intermetallics which may suppress the galvanic corrosion,but also provides a high-throughput screening strategy and ML models for the design of corrosion-resistant alloy,which can be extended to ternary Mg alloys or other alloy systems.

关键词： Mg intermetallics Corrosion property High-throughput Density functional theory Machine learning

Gut flora in multiple sclerosis:implications for pathogenesis and treatment

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Neural Regeneration Research 2024年第7期19卷 1480-1488页

作者： Weiwei Zhang Ying wang Mingqin zhu Kangding Liu hong-Liang Zhang Department of Neurology the First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Department of Life Sciences National Natural Science Foundation of ChinaBeijingChina

Multiple sclerosis is an inflammatory disorder chara cterized by inflammation,demyelination,and neurodegeneration in the central nervous *** current first-line therapies can help manage symptoms and slow down disease progression,there is no cure for multiple *** gut-brain axis refers to complex communications between the gut flo ra and the immune,nervous,and endocrine systems,which bridges the functions of the gut and the *** in the gut flora,termed dys biosis,can lead to systemic inflammation,leaky gut syndrome,and increased susceptibility to *** pathogenesis of multiple sclerosis involves a combination of genetic and environmental factors,and gut flora may play a pivotal role in regulating immune responses related to multiple scle *** develop more effective therapies for multiple scle rosis,we should further uncover the disease processes involved in multiple sclerosis and gain a better understanding of the gut-brain *** review provides an overview of the role of the gut flora in multiple scle rosis.

关键词： gut flora gut-brain axis multiple sclerosis pathogenesis treatment