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Role of ALDH2 in Hepatic Disorders: Gene Polymorphism and Disease Pathogenesis

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Journal of Clinical and Translational Hepatology 2021年第1期9卷 90-98页

作者： Qiaoling wang Binxia Chang Xiaoyan Li zhengsheng Zou Peking University 302 Clinical Medical SchoolBeijingChina Diagnosis and Treatment Center for Non-Infectious Liver Diseases Fifth Medical Center of Chinese PLA General HospitalBeijingChina Anhui Medical University HefeiAnhuiChina

Aldehyde dehydrogenase 2(ALDH2)is a key enzyme of alcohol metabolism and it is involved in the cellular mechanism of alcohol liver ***2 gene mutations exist in about 8%of the world’s population,with the incidence reaching 45%in East *** mutations will result in impairment of enzyme activity and accumulation of acetaldehyde,facilitating the progression of other liver diseases,including non-alcoholic fatty liver diseases,viral hepatitis and hepatocellular carcinoma,through adduct formation and inflammatory *** this review,we seek to summarize recent research progress on the correlation between ALDH2 gene polymorphism and multiple liver diseases,with an attempt to provide clues for better understanding of the disease mechanism and for strategy making.

关键词： Aldehyde dehydrogenase 2 Gene polymorphisms Alcoholic liver disease Non-alcoholic fatty liver disease Viral hepatitis Hepatocellular carcinoma

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人工智能参与养老服务的SWOT分析

循证护理 2022年第18期8卷 2497-2501页

作者：陈雪飞纪凯桑凌志王正盛陈任安徽医科大学安徽230032

通过建立SWOT分析模型,全面分析人工智能参与养老服务的内外部环境(优势、劣势、机遇和威胁),为人工智能参与养老服务提出发展战略和政策建议,完善智慧养老服务体系,促进智慧养老全面健康的发展。

关键词：人工智能养老服务智慧养老 SWOT分析

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图像去雾中深度学习数据增强方法

电光与控制 2024年第3期31卷 81-85页

作者：苏欣宇王涛诸葛杰王华英胡争胜张小磊李佩苏群董昭河北工程大学数理科学与工程学院河北邯郸056000 国家卫星气象中心北京100000 杭州佐格通信设备有限公司杭州310000 河北省计算光学成像与光电检测技术创新中心河北邯郸056000 河北省计算光学成像与智能感测国际联合研究中心河北邯郸056000

图像去雾是图像处理领域中非常重要的问题。深度学习可以有效提高图像清晰度,但训练过程中由于缺少相对应的真实雾匹配数据对,多采用合成雾作为数据集。现有合成雾多依赖于深度信息、大气散射系数等参数,针对由此作为数据集训练容易造... 详细信息

图像去雾是图像处理领域中非常重要的问题。深度学习可以有效提高图像清晰度,但训练过程中由于缺少相对应的真实雾匹配数据对,多采用合成雾作为数据集。现有合成雾多依赖于深度信息、大气散射系数等参数,针对由此作为数据集训练容易造成颜色失真和去雾不彻底的问题,提出基于循环生成对抗网络(CycleGAN)合成雾方法。通过该网络进行不匹配数据对训练学习有雾图像的特征,然后赋予清晰图片真实雾特征并与其自身构成匹配数据对,最后再用此类数据集进行去雾训练。结果表明,这些数据集可以有效解决颜色失真和去雾不彻底等问题。

关键词：图像去雾循环生成对抗网络图像模糊图像清晰度增强

Study on the Deformation Mechanism of a Soft Rock Tunnel

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Fluid Dynamics & Materials Processing 2022年第2期18卷 243-255页

作者： Jianhui Yang Kai Shen Shoudong Pan Shuren wang zhengsheng Zou School of Civil Engineering and Architecture Zhejiang University of Science and TechnologyHangzhou310023China China Railway 16 Bureau Group Co. Ltd.Beijing100018China School of Civil Engineering Henan Polytechnic UniversityJiaozuo454003China

The large deformation of soft rock tunnel is one of the key problems to be overcome in the tunnel construction *** the present study,the deformation mechanism of a representative tunnel and some related countermeasures are investigated using field tests and engineering geological *** to the scarce performances of methods based on other criteria such as small pipe spacing,anchor bolt length and steel frame spacing,a new support scheme is implemented and *** show that shear failure and bedding sliding are produced under high horizontal stress *** low strength of the surrounding rock results in the uneven convergence of both sides of the *** the aforementioned new support scheme,however,most of such problems can be mitigated leading to good stability properties and ensuing economic advantages.

关键词： Soft rock tunnel high stress deformation mechanism supporting countermeasure

Discovery of potent and selective c-Met inhibitor

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Discovery of potent and selective c-Met inhibitor

Water-level based discrete integrated dynamic control to regulate the flow for sewer-WWTP operation

2011年全国药物化学学术会议——药物的源头创新

作者： Fang Chen,~aJing Ai,~b Ying wang,~b zhengsheng Zhan,~a Yongcong Lu,~a Yi Chen,~b Jian ding,Meiyu Geng~b and Wenhu Duan~(*,a) a Department of Medicinal Chemistry,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,PR China bDivision of Anti-tumor Pharmacology,State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,PR China

＜正＞HGF/c-Met signaling pathway mediates a variety of important biological activities but deregulation of the pathway is closely associated with poor prognosis in a number of major human ***,c-Met has been considered as a good target for anti-cancer drug ***,we report the discovery of a series of triazolotriazine derivatives as selective

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Frontiers of Environmental Science & Engineering 2020年第3期14卷 103-111页

作者： zhengsheng Lu Moran wang Mingkai Zhang Ji Li Ying Xu Hanchang Shi Yanchen Liu Xia Huang State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China School of Environment and Civil Engineering Jiangnan UniversityWuxi 214122China Wuxi Water Group Co.Ltd. Wuxi 214031China

This study aims to propose a multi-point integrated real-time control method based on discrete dynamic water level variations,which can be realized only based on the programmable logic controller(PLC)system without using a complex mathematical model.A discretized water level control model was developed to conduct the real-time control based on *** combines the upstream pumping stations and the downstream influent pumping systems of wastewater treatment plant(WWTP).The discretized water level control method can regulate dynamic wastewater pumping flow of pumps following the dynamic water level variation in the sewer *** control method has been successfully applied in practical integrated operations of sewer-WWTP following the sensitive flow disturbances of the sewer *** operational results showed that the control method could provide a more stabilized regulate pumping flow for treatment process;it can also reduce the occurrence risk of combined sewer overflow(CSO)during heavy rainfall events by increasing transport capacity of pumping station and influent flow in WWTP,which takes full advantage of storage space in the sewer system.

关键词： Sewer system Integrated control Discrete control Water level

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建立我国发动机油台架试验的意义

合成润滑材料 2014年第1期41卷 26-28页

作者：杨国峰谢惊春冯振文王争胜李文华中国石油兰州润滑油研究开发中心兰州730060

台架试验是研制发动机油重要的评价手段。从必要性和重要性两个方面讲解了建立我国发动机润滑油台架试验的重要意义。

关键词：发动机油台架试验必要性重要性

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柴油机油滚子随动件磨损试验的建立

合成润滑材料 2014年第4期41卷 5-7页

作者：杨国峰谢惊春冯振文王争胜周建强中国石油兰州润滑油研究开发中心兰州730060

调配了一种能替代柴油机油滚子随动件磨损试验专用燃料的燃料。建立的柴油机油滚子随动件磨损试验具有良好的重复性和区分性,满足滚子随动件磨损试验的要求,可以用于评价柴油机油滚子随动件的磨损性能。

关键词：燃料柴油机油滚子随动件磨损试验方法

自噬相关蛋白ATG7在乳腺癌中的表达及其临床病理意义

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临床与实验病理学杂志 2024年第9期40卷 917-922页

作者：曲燕石亭亭王娟如罗军王志皓罗文武郭欠影赵敏吴正升安徽医科大学基础医学院病理学教研室合肥230032 安徽医科大学第一附属医院病理科合肥230022 合肥市第二人民医院病理科合肥230011

目的探讨ATG7(autophagy-related 7, ATG7)在乳腺癌中的表达及其对乳腺癌发生、发展的影响。方法采用免疫组化法检测乳腺癌组织中ATG7蛋白的表达,并分析其表达与乳腺癌临床病理特征的关系。使用shRNA干扰乳腺癌细胞MCF-7中ATG7的表达... 详细信息

目的探讨ATG7(autophagy-related 7, ATG7)在乳腺癌中的表达及其对乳腺癌发生、发展的影响。方法采用免疫组化法检测乳腺癌组织中ATG7蛋白的表达,并分析其表达与乳腺癌临床病理特征的关系。使用shRNA干扰乳腺癌细胞MCF-7中ATG7的表达。应用嘌呤霉素筛选稳转细胞系,并运用Western blot法检测转染效率。CCK-8和克隆形成实验检测敲低ATG7对细胞增殖能力的影响。裸鼠皮下成瘤实验检测敲低ATG7对体内成瘤能力的影响。结果免疫组化结果显示ATG7主要定位于乳腺癌细胞质,且其表达与肿瘤大小和Ki67显著相关(P<0.05)。ATG7-shRNA可显著干扰乳腺癌细胞MCF-7中ATG7的表达。CCK-8和克隆形成实验结果显示,与对照组相比,敲低ATG7可促进乳腺癌细胞增殖能力。裸鼠皮下成瘤实验结果显示,与对照组相比,敲低ATG7后小鼠成瘤能力明显升高。结论 ATG7表达可能抑制乳腺癌的增殖能力,可作为乳腺癌治疗的潜在靶点。

关键词：乳腺肿瘤自噬 ATG7 增殖