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The Changing Trends of HIV/AIDS in An Ethnic Minority Region of China: Modeling the Epidemic in Liangshan Prefecture, Sichuan Province

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Biomedical and Environmental Sciences 2013年第7期26卷 562-570页

作者： LIU Shou wang Qi Xing NAN Lei WU Chun Lin wang zhao fen BAI Zhen Zhong LIU Li CAI Peng QIN Si LUAN Rong Sheng Department of Epidemiology West China School of Public Health Sichuan University Department of Epidemiology Medical College of Qinghai University Center for Disease Control and Prevention of Liangshan Prefecture Chengdu Cancer Hospital Research Center for High Altitude Medicine Medical College of Qinghai University Center for Disease Control and Prevention of Sichuan Province

Objective This study was to investigate the HIV current situation in Liangshan prefecture, in order to predict prevalence and transmission trends. Methods Region-specific population, behavior, serosurveillence, and policy/program data （from 1995 to 2020） were gathered from various local and national organizations and applied to the Asian Epidemic Model （AEM） and used to derive estimates of future HIV prevalence, epidemic trends, and outcomes of intervention strategies. Results The AEM projections for 2020 included increased number of people living with HIV （PLHIV; to 136 617）, increased HIV prevalence （2.51%）, and 8037 deaths from acquired immunodeficiency syndrome （AIDS） in this region. However, the overall HIV incidence rate （per 10 000） was projected to decline from 27 in 2015 to 22 in 2020, largely due to a predicted decrease in HIV infection rate （per 10 000） from 658 in 2013 to 621 in 2020 among intravenous drug users. In contrast, the cases of HIV infection per i0 000 was projected to increase from 420 in 2010 to 503 in 2020 among men who have sex with men, and from 8 in 2010 to 15 in 2020 among the general population. The predominant risk factor for HIV transmission over the next decade in Liangshan was casual sex. Community-based outreach strategies to reduce injected drug use and casual sex, and to promote condom use, were predicted as effective interventions to decrease HIV transmission. Conclusion Implementation of a comprehensive public health program, with targeting to the region-specific at-risk populations, will help to mitigate HIV/AIDS spread in Liangshan.

关键词： HIV/AIDS Asian epidemic model High-risk population Liangshan Prefecture

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TIME RESOLVED SPECTRA OF Eu(MBA)_3 PHEN COMPLEXES

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Chinese Chemical Letters 1993年第2期4卷 183-186页

作者： Lin Pei JIN Ming zhao wang Rui fen wang Department of Chemistry,Beijing Normal University,Beijing,100875Jian Xin CHEN Guang Zhi XU Institute of Chemistry,Academia Sinica,Beijing,100080

Time-resolved fluorescence spectra of europium methylbenzoates (MBA)with 1,10-phenanthroline(phen)have been measured at room *** each of the europium chelates,where the ligand triple states lie above the ~5D_1 level of Eu^(3-),the spectra providc evidence that the Eu^(3-) ~5D_0 state is populated by nonradiative energy transfer from the higher-lying ~5D_1,*** relaxation time for energy decay from ~5D_1 state is measured in the microcrystals to bc of the order of a few *** is suggested that the ligand C=0 and C=C stretching vibrations and Eu-O vibrations,chclate ring and benzene ring vibrations make important contributions to the relaxation *** ~5D\-1—~5D\-0 relaxation time of Eu- (p-MBA)_3phen is shorter than those of Eu(m-MBA)_3phen and Eu(o-MBA)_3phen since nonradiative degradation to ~5D_0 from ~5D_1 appears to be more strongly influenced by the E_u^(3+)sites in the former.

关键词： MBA TIME RESOLVED SPECTRA OF Eu PHEN COMPLEXES

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结核分枝杆菌耐药特征及新型抗结核药物研究进展

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国际药学研究杂志 2017年第7期44卷 663-668页

作者：申秀丽王兆芬青海大学医学院公共卫生系西宁810008

近年来耐药结核病流行呈日益严重趋势,已成为严重威胁人类健康的重大公共卫生和社会问题。及早发现并应用规范药物治疗对控制其蔓延意义重大。本文对常用抗结核药物耐药现状、耐药机制和新型抗结核药物进行了总结,以期为结核病的预防及... 详细信息

近年来耐药结核病流行呈日益严重趋势,已成为严重威胁人类健康的重大公共卫生和社会问题。及早发现并应用规范药物治疗对控制其蔓延意义重大。本文对常用抗结核药物耐药现状、耐药机制和新型抗结核药物进行了总结,以期为结核病的预防及临床抗结核药物的合理应用提供参考和借鉴。

关键词：结核分枝杆菌耐药新型抗结核药物

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Unraveling the significance of cobalt on transformation kinetics,crystallography and impact toughness in high-strength steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 380-390页

作者： Yishuang Yu Jingxiao zhao Xuelin wang Hui Guo Zhenjia Xie Chengjia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

This work reveals the significant effects of cobalt(Co)on the microstructure and impact toughness of as-quenched highstrength steels by experimental characterizations and thermo-kinetic *** results show that the Co-bearing steel exhibits finer blocks and a lower ductile-brittle transition temperature than the steel without ***,the Co-bearing steel reveals higher transformation rates at the intermediate stage with bainite volume fraction ranging from around 0.1 to *** improved impact toughness of the Co-bearing steel results from the higher dense block boundaries dominated by the V1/V2 variant ***,the addition of Co induces a larger transformation driving force and a lower bainite start temperature(BS),thereby contributing to the refinement of blocks and the increase of the V1/V2 variant *** findings would be instructive for the composition,microstructure design,and property optimization of high-strength steels.

关键词： high-strength steel cobalt transformation kinetics crystallography impact toughness

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Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanlong wang Pengyang wang Yali Liu Shanshan Qi Biao Shi Ying zhao Xiaodan Zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Haihe Laboratory of Sustainable Chemical Transformations Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells （IPSCs）,which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid （5-MVA） was introduced as a strain buffer to release the residual strain of *** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb2+through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI2.85Br0.15perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI2.85Br0.15,resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI2.85Br0.15perovskite films and devices.

关键词： Inverted inorganic perovskite solar cells Flexible molecules Strain release Crystallization Energy barrier High PCE

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Atomically precise nickel-sulfur clusters for efficient electrochemical 2,5-hydroxymethylfurfural oxidation

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Nano Research 2025年第1期18卷 140-148页

作者： fen wang Lu-Yu Liu Sha-Sha Cui Ting-Ting Li Xiao-Meng Yang Zhijuan Liu Yanyong wang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Nickel sulfide exhibits excellent catalytic activity in the electrochemical 2,5-hydroxymethylfurfural oxidation reaction(HMFOR).However,due to the polydispersity of nanoparticles,it is difficult to establish a clear structure-activity relationship at the atomic *** this work,we have successfully synthesized atomically precise Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)clusters(PET:2-phenylethanethiol)for ***^(2+)and S_(2)-with atomic ratio of 1:2 was mainly existed in Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)to form Ni-S *** electrochemical test results have suggested both Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)displayed outstanding electrocatalytic ability for *** Ni_(6)(PET)_(12)exhibited better electrocatalytic ability than Ni_(4)(PET)_(8)with higher current density,lower overpotential and faster reaction *** superior electrochemical ability of Ni_(6)(PET)_(12)may be due to the enhanced adsorption towards HMF molecule with strong interaction towards hydroxyl group and furan ***,it found that the Ni^(2+)species in Ni_(6)(PET)_(12)could rapidly oxidized into Ni^(3+)species,which could spontaneously capture electron and proton from HMF for *** theoretical calculation demonstrated that the Ni_(6)(PET)_(12)process lower free energy barrier than Ni_(4)(PET)_(8)to display excellent electrocatalytic *** work is of great significance for designing efficient electrocatalysts for HMFOR.

关键词： atomically precise nickel nanoclusters 2 5-hydroxymethylfurfural electro-oxidation Ni3+species

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结核分枝杆菌102株临床分离株的磷脂酶C编码基因多态性

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中华传染病杂志 2011年第6期39卷 334-336页

作者：王兆芬 Michael R.Barer 青海大学医学院流行病学教研室西宁810001 Leicester University Leic Leicester LE1 9HN

目的分析临床分离的结核分枝杆菌中磷脂酶C（PLC）编码基因plcABCD的突变情况，以进一步了解结核分枝杆菌的致病力。方法102株菌株均分离于结核病患者并准确鉴定。增菌后提取DNA，并对plcABCD4个基因同时扩增，扩增产物经电泳后分析基... 详细信息

目的分析临床分离的结核分枝杆菌中磷脂酶C（PLC）编码基因plcABCD的突变情况，以进一步了解结核分枝杆菌的致病力。方法102株菌株均分离于结核病患者并准确鉴定。增菌后提取DNA，并对plcABCD4个基因同时扩增，扩增产物经电泳后分析基因的突变或缺失。结果根据pLcABCD4个基因的存在或缺失情况，102株菌可以分为13个基因型，其中31株含有完整的plcABCD所有基因，为plc野生株，占30．39％；71株菌有不同plc基因的缺失，为plc突变株，突变率为69．61％。71株突变型菌株中，只缺失任意1个plc基因的有48株，发生任意2个plc基因缺失或突变的共有14株，发生任意3个plc基因缺失或突变的共有8株，plcABCD基因全缺失的菌株1株。61株菌plcD基因发生了突变，占全部菌株的59．80％，而plcABC基因发生突变则相对较低，分别为全部菌株的15．69％（16／102）、9．80％（10／102）和16．67％（17／102）。结论临床分离的结核分枝杆菌中plcABCD基因存在多态性，其中plcD基因缺失的最多。

关键词：分枝杆菌,结核多态现象,遗传 C型磷脂酶类基因缺失

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L1-Norm-Based 2DLPP

L1-Norm-Based 2DLPP

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2011 Chinese Control and Decision Conference（CCDC）

作者： Hao-Xin zhao,Hong-Jie Xing,Xi-zhao wang,and Jun-fen Chen the Key Laboratory of Machine Learning and Computational Intelligence,College of Mathematics and Computer Science,Hebei University,Baoding,071002,China.

In this paper,we propose a new L1-Norm-Based two-dimensional locality preserving projections (2DLPP-L1).Traditional 2D-LPP can preserve local structure and extract feature directly form matrices,which shows great ***,it is based on L2 *** is well known that L2-norm-based criterion is sensitive to *** generalize 2D-LPP to its corresponding L1-norm-based version,i.e.2DLPP-L1,which is more robust against *** evaluate the performance of 2DLPP-L1,several experiments are performed on the ORL face *** results demonstrate that 2DLPP-L1 has better performance than its related methods.

关键词： L1 norm 2DLPP outliers two dimensional projections

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Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi wang Mengke zhao Dong Fu Meina wang Chao Han Zhongyue Lv Liang wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

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Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

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Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan wang Yuanyuan Ran Zihan Li Tianyuan zhao Fangfang Zhang Juan wang Zongjian Liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

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